EDC Science Weekly, June 10 – 16, 2020 – HEEDS

EDC Science Weekly, June 10 – 16, 2020

Post author:HEEDS
Post published:June 16, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Regulations/Policy

The Need for a Tighter Particulate-Matter Air-Quality Standard.

Methods/Screening

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment.

Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs.

QSAR modeling the toxicity of pesticides against Americamysis bahia.

Reviews

Commentaries/Conference Summaries

The sustained undermining of science by the EPA’s leaders is a travesty. [Editorial in Nature]

Bisphenol A shapes children’s brain and behavior: towards an integrated neurotoxicity assessment including human data. [Commentary in Environ Health]

The global odyssey of plastic pollution. [Perspective in Science]

Recent advances in mercury research. [Editorial in Sci Total Environ] [also see Dedication of STOTEN Special Issue: Recent Advances in Mercury Research to Dr. Grant Carleton Edwards.]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Aryl hydrocarbon receptor (AHR) functions: balancing opposing processes including inflammatory reactions.

Perfluoroalkyl Substances

Review on perfluoroalkyl and polyfluoroalkyl substances (PFASs) in the Chinese atmospheric environment.

Potentially Toxic Elements

When Poisons Cure: The Case of Arsenic in Acute Promyelocytic Leukemia.

A review on the potential sources and health implications of fluoride in groundwater of Sub-Saharan Africa.

Mercury as a hapten: A review of the role of toxicant-induced brain autoantibodies in autism and possible treatment considerations.

A review of the application of sea material shells as low cost and effective bio-adsorbent for removal of heavy metals from wastewater.

Toxicological Effects of Cadmium on Mammalian Testis.

Microplastics/Nanomaterials

The plastic brain: neurotoxicity of micro- and nanoplastics.

Research Progress of Microplastics in Freshwater Sediments in China.

Toxicity of different types of quantum dots to mammalian cells in vitro: An update review.

Review of Copper and Copper Nanoparticle Toxicity in Fish.

Cadmium-Induced Oxidative Stress: Focus on the Central Nervous System.

Air Pollution

Traffic-related metrics and adverse birth outcomes: A systematic review and meta-analysis.

Review of epidemiological studies on air pollution and health effects in children.

Chemical identity and cardiovascular toxicity of hydrophobic organic components in PM2.5.

Miscellaneous

Epigenetic Transgenerational Inheritance of Obesity Susceptibility.

Interference on Iodine Uptake and Human Thyroid Function by Perchlorate-Contaminated Water and Food.

Environmental and health impacts due to e-waste disposal in China – A review.

A framework for assessing the impact of chemical exposures on neurodevelopment in ECHO: Opportunities and challenges.

Biomonitoring in firefighters for volatile organic compounds, semivolatile organic compounds, persistent organic pollutants, and metals: A systematic review.

Recent applications of covalent organic frameworks and their multifunctional composites for food contaminant analysis.

A Scoping Review of Non-Occupational Exposures to Environmental Pollutants and Adult Depression, Anxiety, and Suicide. [air pollution, metals, pesticides, POPs, etc.]

Environmental Toxic Exposures Using Companion Animals as an Indicator of Human Toxicity: A Case Report and Discussion. [From canaries in coal mines to mercury, lead, Teflon, herbicides, etc.]

Early-life exposure to widespread environmental toxicants and maternal-fetal health risk: A focus on metabolomic biomarkers. [metals, air pollutants, POPs, etc.]

Human Health Studies

Phthalates/Phenols/Parabens

Urinary Concentrations of Phthalate Metabolite Mixtures in Relation to Serum Biomarkers of Thyroid Function and Autoimmunity among Women from a Fertility Center.

Phthalate metabolites and biomarkers of oxidative stress in the follicular fluid of women undergoing in vitro fertilization.

The sex-specific association of phthalate exposure with DNA methylation and characteristics of body fat in children.

Exposure to Endocrine Disrupting Chemicals in the Dutch general population is associated with adiposity-related traits. [phthalates, bisphenols, parabens]

Effects of prenatal exposure to five parabens on neonatal thyroid function and birth weight: Evidence from SMBCS study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to a mixture of persistent organic pollutants (POPs) and child reading skills at school age.

Associations between intrauterine exposure to polychlorinated biphenyls on neonatal ano-genital distance.

Serum Dioxin Levels and Sperm DNA Methylation Age: Findings in Vietnam War Veterans Exposed to Agent Orange.

In utero exposure to organochlorine pesticide residues and their potential impact on birth outcomes and fetal gender.

Serum levels of polychlorinated biphenyls and stroke risk among Chinese: a hospital-based case-control study.

Perfluoroalkyl Substances

Association between Prenatal Exposure to PFAS and Fetal Sex Hormones: Are the Short-chain PFAS Safer?

Pesticides

Prenatal exposure to pesticides and risk for holoprosencephaly: a case-control study.

Exercise attenuates the association between household pesticide exposure and depressive symptoms: Evidence from NHANES, 2005-2014.

Potentially Toxic Elements

Association of arsenic with recurrence of urinary bladder cancer.

The Association Between Maternal Prenatal Fish Intake and Child Autism-Related Traits in the EARLI and HOME Studies.

Prenatal Mercury Exposure in Pregnant Women from Suriname’s Interior and Its Effects on Birth Outcomes.

Exposure to multiple heavy metals associate with aberrant immune homeostasis and inflammatory activation in preschool children.

The sustaining effects of e-waste-related metal exposure on hypothalamus-pituitary-adrenal axis reactivity and oxidative stress.

Exposure to Toenail Heavy Metals and Child Behavior Problems in Nine-Year-Old Children: A Cross-Sectional Study.

Air Pollution

Inflammatory cytokines and DNA methylation in healthy young adults exposure to fine particulate matter: A randomized, double-blind crossover trial of air filtration.

Association between air pollution and lung development in schoolchildren in China.

A Multifactorial Evaluation of the Effects of Air Pollution and Meteorological Factors on Asthma Exacerbation.

Acute effects of air pollution on all-cause mortality: a natural experiment from haze control measures in Chiang Mai Province, Thailand.

Short-Term Effects of Ambient Ozone, PM2.5, and Meteorological Factors on COVID-19 Confirmed Cases and Deaths in Queens, New York.

Long-term exposure to PM2.5 and its constituents and risk of Non-Hodgkin lymphoma in Denmark: A population-based case-control study.

Maternal exposure to ambient particulate matter 10 μm or less in diameter before and after pregnancy, and anencephaly risk: A population-based case-control study in China.

Long-term effects of ambient air pollutants on suicidal ideation in China: The Henan Rural Cohort Study.

Modifiable areal unit problem and environmental factors of COVID-19 outbreak.

Sperm quality and ambient air pollution exposure: A retrospective, cohort study in a Southern province of China.

Spatiotemporal variability in long-term population exposure to PM2.5 and lung cancer mortality attributable to PM2.5 across the Yangtze River Delta (YRD) region over 2010-2016: A multistage approach.

Mixtures

The Nexus between Workplace Exposure for Wood, Welding, Motor Mechanic, and Oil Refinery Workers and the Prevalence of Prediabetes and Type 2 Diabetes Mellitus.

Laboratory Studies

BPA/Phenols

Prenatal exposure to bisphenol A alters the transcriptome-interactome profiles of genes associated with Alzheimer’s disease in the offspring hippocampus.

Resveratrol diminishes bisphenol A-induced oxidative stress through TRPM2 channel in the mouse kidney cortical collecting duct cells.

The Effect of Exposure to Bisphenol A on Spermatozoon and the Expression of Tight Junction Protein Occludin in Male Mice.

Phthalates

Taxifolin attenuates the developmental testicular toxicity induced by di-n-butyl phthalate in fetal male rats.

Phthalate exposure causes browning-like effects on adipocytes in vitro and in vivo.

Maternal exposure to di-n-butyl phthalate promotes the formation of testicular tight junctions through down-regulation of NF-κB/COX-2/PGE2/MMP-2 in mouse offspring.

In-utero Exposure to Low Doses of Genistein and Di-(2-ethylhexyl) Phthalate (DEHP) Alters Innate Immune Cells in Neonatal and Adult Rat Testis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure of either parent enhances the risk of necrotizing enterocolitis in neonatal mice.

Assessing the cytotoxic effect of hexabromocyclododecane (HBCD) on liver tissue cultures from fathead minnow (Pimephales promelas).

Perfluoroalkyl Substances

Perfluorinated alkyl substances impede growth, reproduction, lipid metabolism and lifespan in Daphnia magna.

Pharmacokinetic profile of Perfluorobutane Sulfonate and activation of hepatic nuclear receptor target genes in mice.

Organotins

Sex-specific effects of triphenyltin chloride (TPT) on thyroid disruption and metabolizing enzymes in adult zebrafish (Danio rerio).

Pesticides

Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor.

Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae.

Evaluation of genotoxicity induced by herbicide pendimethalin in fresh water fish Clarias batrachus (linn.) and possible role of oxidative stress in induced DNA damage.

Effects of subchronic inhalation exposure to an organophosphorus insecticide compound containing dichlorvos on wistar rats’ otoacoustic emissions.

Ameliorative Effects of Honey, Propolis, Pollen, and Royal Jelly Mixture against Chronic Toxicity of Sumithion Insecticide in White Albino Rats.

Potentially Toxic Elements

Single cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection.

Effects of Inorganic Arsenic on Human Prostate Stem-Progenitor Cell Transformation, Autophagic Flux Blockade, and NRF2 Pathway Activation.

Attenuation of arsenic induced high fat diet exacerbated oxidative stress mediated hepatic and cardiac injuries in male Wistar rats by piperine involved antioxidative mechanisms.

Studies of selenium and arsenic mutual protection in human HepG2 cells.

Assessment of arsenic-induced modifications in the DNA methylation of insulin-related genes in rat pancreatic islets.

Impact of ageing and soil contaminants on telomere length in the land snail.

Effects of ecologically relevant concentrations of cadmium on locomotor activity and microbiota in zebrafish.

Microplastics/Nanomaterials

Integrated response of growth, antioxidant defense and isotopic composition to microplastics in juvenile guppy (Poecilia reticulata).

Size-dependent cellular internalization and effects of polystyrene microplastics in microalgae P. helgolandica var. tsingtaoensis and S. quadricauda.

Effects of nanoplastics on antioxidant and immune enzyme activities and related gene expression in juvenile Macrobrachium nipponense.

Exposure of CuO nanoparticles and their metal counterpart leads to change in the gut microbiota and resistome of collembolans.

Air Pollution

Hepatoprotective Effects of Streptococcus thermophilus LM1012 in Mice Exposed to Air Pollutants.

Pharmaceuticals

Maternal exposure to environmental antibiotic mixture during gravid period predicts gastrointestinal effects in zebrafish offspring.

Mixtures

Long term transcriptional and behavioral effects in mice developmentally exposed to a mixture of endocrine disruptors associated with delayed human neurodevelopment.

Application of the sea urchin embryo test in toxicity evaluation and effect directed analysis of wastewater treatment plant effluents.

Effects of alkylphenols mixture on the adrenal gland of the lizard Podarcis sicula.

Microplastics aggravate the bioaccumulation of two waterborne veterinary antibiotics in an edible bivalve species: potential mechanisms and implications for human health.

Individual and mixture toxicity of carbofuran and diuron to the protozoan Paramecium caudatum and the cladoceran Ceriodaphnia silvestrii.

Exposure/Environment Studies

BPA/Phenols

Gas chromatography-mass spectrometry analysis of nine bisphenols in canned meat products and human risk estimation.

Phthalates

Pollution characteristics, spatial variation, and potential risks of phthalate esters in the water-sediment system of the Yangtze River estuary and its adjacent East China Sea.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Human milk contamination by nine organochlorine pesticide residues (OCPs).

Utilization of PCB-contaminated Hudson River sediment by thermal processing and phytoremediation.

History traces of HCHs and DDTs by groundwater dating and their behaviours and ecological risk in northeast China.

Levels of polychlorinated biphenyls and organochlorine pesticides in donkey milk: Correlation with the infection level by intestinal strongyles.

Relevance of current PCB concentrations in edible fish species from the Mediterranean Sea.

Perfluoroalkyl Substances

Ecological and health risk assessment of perfluorooctane sulfonate in surface and drinking water resources in China.

Bioaccumulation of perfluoroalkyl substances in greenhouse vegetables with long-term groundwater irrigation near fluorochemical plants in Fuxin, China.

Organotins

RXR Expression in Marine Gastropods with Different Sensitivity to Imposex Development.

Pesticides

Occurrence of perchlorate, chlorate and polar herbicides in different baby food commodities.

Pyrethroid Insecticides in Households from Urban Areas: An Association of the 3-PBA Metabolite and Hand Wipes.

Selected antibiotics and current-use pesticides in riverine runoff of an urbanized river system in association with anthropogenic stresses.

Community composition modifies direct and indirect effects of pesticides in freshwater food webs.

Pollinator exposure to systemic insecticides and fungicides applied in the previous fall and pre-bloom period in apple orchards.

Sublethal acetamiprid doses negatively affect the lifespans and foraging behaviors of honey bee (Apis mellifera L.) workers.

Potentially Toxic Elements

Global impact of atmospheric arsenic on health risk: 2005 to 2015.

Arsenic exposure in northern Mexican women.

Urinary profiles of selected metals and arsenic and their exposure pathway analysis in four large floodplains of Pakistan.

Mercury from crematoriums: human health risk assessment and estimate of total emissions in British Columbia.

Relationship Between Heavy Metal Accumulation in Fish Muscle and Heavy Metal Resistance Genes in Bacteria Isolated from Fish.

Multi-pathway human exposure risk assessment using Bayesian modeling at the historically largest mercury mining district.

Reduction in drinking water arsenic exposure and health risk through arsenic treatment among private well households in Maine and New Jersey, USA.

Seasonal variation of total mercury and condition indices of Arctic charr (Salvelinus alpinus) in Northern Québec, Canada.

Drivers of declines in common loon (Gavia immer) productivity in Ontario, Canada.

Lead and cadmium-resistant bacterial species isolated from heavy metal-contaminated soils show plant growth-promoting traits.

Direct determination of Al and Pb in waste printed circuit boards (PCB) by laser-induced breakdown spectroscopy (LIBS): Evaluation of calibration strategies and economic – environmental questions.

An integrated assessment of land-use change impact, seasonal variation of pollution indices and human health risk of selected toxic elements in sediments of River Atuwara, Nigeria.

Assessment and monitoring of soil and plant contamination with trace elements around Europe’s largest copper ore tailings impoundment.

Permo-Triassic boundary carbon and mercury cycling linked to terrestrial ecosystem collapse.

Microplastics

Influential factors on microplastics occurrence in river sediments.

Dataset on microplastics and associated trace metals and phthalate esters in sandy beaches of tropical Atlantic ecosystems, Nigeria.

Air Pollution

SARS-Cov-2RNA found on particulate matter of Bergamo in Northern Italy: First evidence.

Particulate Matter Emissions Associated with Marcellus Shale Drilling Waste Disposal and Transport.

The Impact of COVID-19 Partial Lockdown on Primary Pollutant Concentrations in the Atmosphere of Rio de Janeiro and São Paulo Megacities (Brazil).

Air Quality Variation in Wuhan, Daegu, and Tokyo during the Explosive Outbreak of COVID-19 and Its Health Effects.

Pharmaceuticals

Occurrence and risk assessment of fluoroquinolone antibiotics in reclaimed water and receiving groundwater with different replenishment pathways.

Miscellaneous

Contaminant screening and tissue distribution in the critically endangered Brazilian guitarfish Pseudobatos horkelii. [numerous chemicals]

Discovery of firefighter chemical exposures using military-style silicone dog tags.

Selection of assay, organism, and approach in biomonitoring significantly affects the evaluation of genotoxic potential in aquatic environments.

Observed and Potential Impacts of the COVID-19 Pandemic on the Environment.

Sulfur-aided composting facilitates ammonia release mitigation, endocrine disrupting chemicals degradation and biosolids stabilization.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.