EDC Science Weekly, July 7-13, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Proposal for regulatory risk mitigation measures for human pharmaceutical residues in the environment.

Plastics today: Key challenges and EU strategies towards carbon neutrality: A review

More EDC policy and regulations open for comment

Methods/Tools/Screening

Comprehensive Evaluation System for Post-Metabolic Activity of Potential Thyroid-Disrupting Chemicals.

New approach methodologies in human regulatory toxicology – Not if, but how and when!

In vitro to in vivo extrapolation for predicting human equivalent dose of phenolic endocrine disrupting chemicals: PBTK model development, biological pathways, outcomes and performance.

Advancing the weight-of-evidence approach to enable chemical environmental risk assessment for decision making and achieving protection goals.

Is periventricular heterotopia a useful endpoint for developmental thyroid hormone system disruption in mouse toxicity studies?

Wildlife Ecological Risk Assessment in the 21^st Century: Promising Technologies to Assess Toxicological Effects.

Recent progresses in compound specific isotope analysis of halogenated persistent organic pollutants. Assessing the transformation of halogenated persistent organic pollutants at contaminated sites.

Characterisation of the risk associated with chronic lifetime exposure to mixture of chemical hazards: case study of trace elements.

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies.

Methods for estimating no-effect toxicity concentrations in ecotoxicology.

Adding open spectral data to MassBank and PubChem using open source tools to support non-targeted exposomics of mixtures.

More tools, reports, and resources

Commentaries

Commentary: “No Where to Hide… From Endocrine Disrupting Chemical Exposures”.

Improving environmental health in schools.

We Need a “Keeling Curve” Approach for Contaminants of Emerging Concern.

Reviews

Numerous Chemicals/Mixtures

Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism.

Perfluoroalkyl Substances and POPs

Systematic review and meta-analysis of breast cancer risks in relation to 2,3,7,8-tetrachlorodibenzo-p-dioxin and per- and polyfluoroalkyl substances.

Polychlorinated biphenyls and thyroid function: a scoping review.

A State-of-the-Science Review of Interactions of Per- and Polyfluoroalkyl Substances (PFAS) with Renal Transporters in Health and Disease: Implications for Population Variability in PFAS Toxicokinetics.

Trends in the Analysis and Exploration of per- and Polyfluoroalkyl Substances (PFAS) in Environmental Matrices: A Review.

Pesticides

Toxicity analysis of endocrine disrupting pesticides on non-target organisms: A critical analysis on toxicity mechanisms.

Effects of pyrethroids on the cerebellum and related mechanisms: a narrative review.

Metals/Metalloids

Heavy metals contamination of seafood from the crude oil-impacted Niger Delta Region of Nigeria: A systematic review and meta-analysis.

Microplastics/Nanomaterials

Effects of nano and microplastics on the reproduction system: In vitro and in vivo studies review.

Toxicity assessment of microplastic (MPs); a threat to the ecosystem.

Microplastic pollution in coastal areas of Colombia: Review.

Interaction between antibiotics and microplastics: Recent advances and perspective.

Microplastics: a review of their impacts on different life forms and their removal methods.

Pharmaceuticals/Personal Care Products

Occurrence, fate, and potential risk of pharmaceutical pollutants in agriculture: Challenges and environmentally friendly solutions.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to multiple environmental chemicals and birth size.

Sex-specific interactive effect of melamine and DEHP on a marker of early kidney damage in Taiwanese adults: A national population-based study from the Taiwan Biobank.

Genetic association between the APOE ε4 allele, toxicant exposures and Gulf war illness diagnosis.

Arsenic, polycyclic aromatic hydrocarbons, and metal exposure and risk assessment of stroke.

Phthalates

Association between urinary phthalate metabolites and nephrolithiasis in adults: A cross-sectional analysis with NHANES 2007-2018.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of accumulated persistent organic pollutants in breast adipose tissue with the evolution of breast cancer after surgery.

Maternal serum dioxin-like activity and gestational age at birth and indices of foetal growth: The Aarhus birth cohort.

Perfluoroalkyl Substances

Association between prenatal exposure to perfluoroalkyl substance mixtures and intrauterine growth restriction risk: A large, nested case-control study in Guangxi, China.

Firefighters and the liver: Exposure to PFAS and PAHs in relation to liver function and serum lipids (CELSPAC-FIREexpo study).

Per- and polyfluoroalkyl substances and the associated thyroid cancer risk: A case-control study in China.

Exposures to perfluoroalkyl substances and asthma phenotypes in childhood: an investigation of the COPSAC2010 cohort.

Assessment of exposure to perfluorinated industrial substances and risk of immune suppression in Greenland and its global context: a mixed-methods study.

Flame Retardants

Exposure to dust organophosphate and replacement brominated flame retardants during infancy and risk of subsequent adverse respiratory outcomes.

Pesticides

Exploring associations between residential exposure to pesticides and birth outcomes using the Dutch birth registry.

Exposure to pesticides and risk of Hodgkin lymphoma in an international consortium of agricultural cohorts (AGRICOH).

Dietary omega-6/omega-3 fatty acids and risk of prostate cancer; Is there any potential interaction by organophosphate insecticides among the agricultural health study population.

Metals/Metalloids

Effects of preterm birth and postnatal exposure to metal mixtures on neurodevelopment in children at 24 months of age.

Associations of gestational and early-life exposure to toxic metals and fluoride with a diagnosis of food allergy or atopic eczema at 1 year of age.

Effects of heavy metal exposure on hypertension: A machine learning modeling approach.

Independent and combined associations of urinary metals exposure with markers of liver injury: Results from the NHANES 2013-2016.

Metal mixture exposure and the risk for immunoglobulin A nephropathy: Evidence from weighted quantile sum regression.

Microplastics/Nanomaterials

Detection of microplastics in patients with allergic rhinitis.

Air Pollution

The effects of long-term exposure to air pollution on incident mental disorders among patients with prediabetes and diabetes: Findings from a large prospective cohort.

Association of joint exposure to various ambient air pollutants during adolescence with blood pressure in young adulthood.

Long-term exposure to air pollution and anti-mullerian hormone rate of decline: a population-based cohort study in Tehran, Iran.

Long-term exposure to air pollution and risk of SARS-CoV-2 infection and COVID-19 hospitalisation or death: Danish nationwide cohort study.

Miscellaneous

Exposure to volatile organic compounds is a risk factor for diabetes: A cross-sectional study.

The Environmental Exposures in Lebanese Infants (EELI) birth cohort: an investigation into the Developmental Origins of Health and Diseases (DOHaD).

Urinary polycyclic aromatic hydrocarbon metabolites were associated with short sleep duration and self-reported trouble sleeping in US adults: data from NHANES 2005-2016 study population.

Laboratory Studies

Numerous Chemicals/Mixtures

Bisphenols and perfluoroalkyls alter human stem cells integrity: A possible link with infertility.

BPA/Phenols

Bisphenol A increases the size of primary mammary tumors and promotes metastasis in a murine model of breast cancer.

Additive cardiotoxicity of a bisphenol mixture in zebrafish embryos: The involvement of calcium channel and pump.

Bisphenol P and bisphenol M promote triple-negative breast cancer metastasis through activation of AKT pathways.

Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring.

Multi- and transcriptomic changes of chronic exposure to bisphenol A reveals reproductive toxicity in male zebrafish.

Exposure and hazard of bisphenol A, S and F: a multi-biomarker approach in three-spined stickleback.

The effect of long-term exposure to nonylphenol at environmentally relevant levels on mouse liver and adipose tissue.

Phthalates

Phthalate induced hormetic effect reveals susceptibility of gill compared to muscle tissue after depuration in commercially important fish (Etroplus suratensis).

Parabens/Triclosan/Antimicrobials

Parabens Promote Protumorigenic Effects in Luminal Breast Cancer Cell Lines With Diverse Genetic Ancestry.

Disruption of type I interferon pathway and reduced production of IFN-α by parabens in virus-infected dendritic cells.

Spatial Metabolomics and Lipidomics Reveal the Mechanisms of the Enhanced Growth of Breast Cancer Cell Spheroids Exposed to Triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Microbiota dysbiosis associated with type 2 diabetes-like effects caused by chronic exposure to a mixture of chlorinated persistent organic pollutants in zebrafish.

2,3,7,8-tetrachlorodibenzo-p-dioxin induces multigenerational testicular toxicity and biosynthetic disorder of testosterone in BALB/C mice: Transcriptional, histopathological and hormonal determinants.

Investigating the effects of long-term Aroclor 1260 exposure on fatty liver disease in a diet-induced obesity mouse model.

Perfluoroalkyl Substances

Effect of dietary antioxidants on excretion of perfluorooctanoic acid (PFOA) via regulating uptake transporters expression and intestinal permeability in mice.

Hepatic and ovarian effects of perfluorooctanoic acid exposure differ in lean and obese adult female mice.

Comparative toxicity of seven aqueous film forming foams (AFFFs) to in vitro systems and Mus.

Flame Retardants

Investigation on the interaction of aromatic organophosphate flame retardants with human serum albumin via computer simulations, multispectroscopic techniques and cytotoxicity assay.

The mechanism underlying pentabromoethylbenzene-induced adipogenesis and the obesogenic outcome in both cell and mouse model.

BDE-47 flame retardant exposure induces microglial pyroptosis and cognitive deficits by activating the mtROS-NLRP3 axis via Sirt3 downregulation and is salvaged by honokiol.

Pesticides

Trichlorfon blocks androgen synthesis and metabolism in rat immature Leydig cells.

Environmentally relevant exposure to cypermethrin aggravates diet-induced diabetic symptoms in mice: The interaction between environmental chemicals and diet.

Effect of chlorpyrifos on freshwater microbial community and metabolic capacity of zebrafish.

Glyphosate-based herbicide (GBH) challenged thermoregulation in lizards (Eremias argus), compensatory warming could mitigate this effect.

Comparative toxicity assessment of glyphosate and two commercial formulations in the planarian Dugesia japonica.

Metals/Metalloids

Selenium and zinc alleviate quaternary metal mixture -induced neurotoxicity in rats by inhibiting oxidative damage and modulating the expressions of NF-kB and Nrf2/Hmox-1 pathway.

Vitellaria paradoxa Inhibits Arsenic-induced Toxicity in Drosophila melanogaster Via the Augmentation of Antioxidant System.

Synergistic effects of low-dose arsenic and N-methyl-N’-nitro-N-nitrosoguanidine co-exposure by altering gut microbiota and intestinal metabolic profile in rats.

Lead exposure suppresses the Wnt3a/β-catenin signaling to increase the quiescence of hematopoietic stem cells via reducing the expression of CD70 on bone marrow-resident macrophages.

Microplastics/Nanomaterials

Synergetic Effects of Polyethylene Microplastic and Abamectin Pesticides on the Eyes of Zebrafish Larvae and Adults Through Activation of Apoptosis Signaling Pathways.

Single and combined toxicity effects of microplastics and perfluorooctanoic acid on submerged macrophytes and biofilms.

Toxicity of mixture of polyethylene microplastics and Up Grade® pesticide on Oreochromis niloticus juvenile: I. Hemato-biochemical and histopathological alterations.

Elevated temperature decreases cardiovascular toxicity of nanoplastics but adds to their lethality: A case study during zebrafish (Danio rerio) development.

Adsorption behaviors and bioavailability of tetrabromobisphenol A in the presence of polystyrene microplastic in soil: Effect of microplastics aging.

Effect of bio-based microplastics on earthworms Eisenia andrei.

Air Pollution

Particulate matter induces arrhythmia-like cardiotoxicity in zebrafish embryos by altering the expression levels of cardiac development- and ion channel-related genes.

Pharmaceuticals/Personal Care Products

Water contamination by delorazepam induces epigenetic defects in the embryos of the clawed frog Xenopus laevis.

Miscellaneous

Prepubertal oral exposure to relevant doses of acrylamide impairs the testicular antioxidant system in adulthood, increasing protein carbonylation and lipid peroxidation.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence of emerging contaminants in pet hair and indoor air: integrative health risk assessment using multiple ToxCast endpoints.

Temporal trends in urinary concentrations of phenols, phthalate metabolites and phthalate replacements between 2000 and 2017 in Boston, MA.

BPA/Phenols

First evidence of occupational and residential exposure to bisphenols associated with an e-waste dismantling site: A case study in China.

Bisphenol A in Surface Waters in Germany: Part I. Reassessment of Sources and Emissions Pathways for FlowEQ Modeling.

Bisphenol A in German Watersheds: Part II: FlowEQ Model Based Characterization of Sources and Current/Future Conditions.

Ten bisphenol analogues in Chinese fresh dairy milk: high contribution ratios of conjugated form, importance of enzyme hydrolysis and risk evaluation.

Phthalates

Levels and health risk assessments of Phthalate acid esters in indoor dust of some microenvironments within Ikeja and Ota, Nigeria.

Assessment of phthalic acid esters plasticizers in sediments of coastal Alabama, USA: Occurrence, source, and ecological risk.

Perfluoroalkyl Substances

Evidence of large-scale deposition of airborne emissions of per- and polyfluoroalkyl substances (PFASs) near a fluoropolymer production plant in an urban area.

Occurrences and fates of per- and polyfluoralkyl substances in textile dyeing wastewater along full-scale treatment processes.

Linking drivers of plant per- and polyfluoroalkyl substance (PFAS) uptake to agricultural land management decisions.

An LC-MS/MS method for the quantitative determination of 57 per- and polyfluoroalkyl substances at ng/kg levels in different food matrices.

Target and non-target analysis of per- and polyfluoroalkyl substances in representative chrome mist suppressants on the Chinese market.

Tracking down unknown PFAS pollution – The direct TOP assay in spatial monitoring of surface waters in Germany.

Per- and polyfluoroalkyl substances (PFASs) in consumable species and food products.

Survey on the Current Leachate Treatments of Public Municipal Solid Waste Landfills and the Potential Impact of Per- and Polyfluorinatedalkyl Substances in the Eastern and Northwestern United States.

Flame Retardants

Contamination characteristics and potential health risk of brominated flame retardants in paddy soils and rice plants around a typical e-waste recycling site in south China.

Metals/Metalloids

Lead and mercury in historical books and their contribution to dust contamination.

Microplastics/Nanomaterials

The dark side of artificial greening: Plastic turfs as widespread pollutants of aquatic environments

Elder fish means more microplastics? Alaska pollock microplastic story in the Bering Sea.

Microplastics in the Gulf of Guinea: An analysis of concentrations and distribution in sediments, gills, and guts of fish collected off the coast of Ghana.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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