EDC Science Weekly, July 7 – 13, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

July 14: Inaugural PFAS Conference (EWG)

July 15 webinar: Throwaway Packaging, Forever Chemicals: European wide survey of PFAS in disposable food packaging and tableware and efforts to phase it out at top US Grocery and Fast-food Chains (EDC Strategies Partnership)

July 20 webinar: The Science on Toxic Chemicals in the Built Environment: Environmental Health Disparities and Equity-Driven Solutions (CHE)

July 27 webinar: Climate Change and Reproductive Health (the final webinar in the Generation Chemical webinar series)

Methods/Tools/Screening

Applicability Domains Enhance Application of PPARγ Agonist Classifiers Trained by Drug-like Compounds to Environmental Chemicals.

SepPCNET: Deeping Learning on a 3D Surface Electrostatic Potential Point Cloud for Enhanced Toxicity Classification and Its Application to Suspected Environmental Estrogens.

Commentaries/Conference Summaries

The True Cost of PFAS and the Benefits of Acting Now.

Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms.

Protect pollinators – reform pesticide regulations. [letter]

Reviews

Numerous EDCs

Impact of endocrine disruptors on neurons expressing GnRH or kisspeptin and pituitary gonadotropin.

BPA/Phenols

Association of BPA exposure during pregnancy with risk of preterm birth and changes in gestational age: A meta-analysis and systematic review.

Phthalates

Unravelling the link between phthalate exposure and endometriosis in humans: a systematic review and meta-analysis of the literature.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Perinatal effects of persistent organic pollutants on thyroid hormone concentration in placenta and breastmilk.

Perfluoroalkyl Substances

The relationship between maternal perfluoroalkylated substances exposure and low birth weight of offspring: a systematic review and meta-analysis.

The association between maternal perfluoroalkyl substances exposure and early attention deficit hyperactivity disorder in children: a systematic review and meta-analysis.

Per- and polyfluoroalkyl substances exposure during pregnancy and adverse pregnancy and birth outcomes: A systematic review and meta-analysis.

Flame Retardants

A review on organophosphate flame retardants in the environment: Occurrence, accumulation, metabolism and toxicity.

Polybrominated diphenyl ethers in the environment: a wake-up call for concerted action in India.

Pesticides

Glyphosate-based herbicides: Evidence of immune-endocrine alteration.

Cardiotoxicity of some pesticides and their amelioration.

Potentially Toxic Elements

Arsenic exposure promotes the emergence of cardiovascular diseases.

Mitigating the impact of mercury contaminants in fish and other seafood-A review.

Microplastics

Ecotoxicological effects of microplastics on aquatic organisms: a review.

Micro/nanoplastics effects on organisms: A review focusing on ‘dose’.

Effects of microplastics on bivalves: Are experimental settings reflecting conditions in the field?

Air Pollution

Association between long-term ambient air pollution exposure and the risk of breast cancer: a systematic review and meta-analysis.

Impact of Inhaled Pollutants on Response to Viral Infection in Controlled Exposures.

Maternal air pollution exposure increases the risk of preterm birth: Evidence from the meta-analysis of cohort studies.

Miscellaneous

The smoking estrogens – a potential synergy between estradiol and benzo(a)pyrene.

Human Health Studies

BPA/Phenols

Prenatal urinary concentrations of phenols and risk of preterm birth: exploring windows of vulnerability.

Phthalates

Associations of prenatal exposure to phthalates and one phthalate substitute with anthropometric measures in early life: Results from the German LIFE Child cohort study.

Perfluoroalkyl Substances

Prenatal and childhood exposure to per- and polyfluoroalkyl substances (PFAS) and child executive function and behavioral problems.

Perfluoroalkyl substances (PFASs) exposure and kidney damage: Causal interpretation using the US 2003-2018 National Health and Nutrition Examination Survey (NHANES) datasets.

Identification of Novel Environmental Substances Relevant to Pediatric Graves’ Disease.

Flame Retardants

Thyroid hormones in relation to polybrominated diphenyl ether and metals exposure among rural adult residents along the Yangtze River, China.

Potentially Toxic Elements

Lead Levels in Non-Occupationally Exposed Women with Preeclampsia.

Is cadmium a risk factor for breast cancer – results from a nested case-control study using data from the Malmö Diet and Cancer Study.

Environmental metal exposure and growth to 10 years of age in a longitudinal mother-child cohort in rural Bangladesh.

Registration status, mercury exposure biomarkers, and neuropsychological assessment of artisanal and small-scale gold miners (ASGM) from the Western Region of Ghana.

Air Pollution

Portable HEPA filter air cleaner use during pregnancy and children’s behavior problem scores: a secondary analysis of the UGAAR randomized controlled trial.

Prenatal PM2.5 exposure in the second and third trimesters predicts neurocognitive performance at age 9-10 years: A cohort study of Mexico City children.

Exposure to low-dose ambient fine particulate matter PM2.5 and Alzheimer’s disease, non-Alzheimer’s dementia, and Parkinson’s disease in North Carolina.

Laboratory Studies

BPA/Phenols

Structural Compactness in Hen Egg White Lysozyme Induced by Bisphenol S: A Spectroscopic and Molecular Dynamics Simulation Approach.

Influence of Bisphenol Compounds at Nanomolar Concentrations on Chromosome Damage Induced by Metabolically Activated Carcinogens in HepG2 Cells.

Physiologically detectable bisphenol A impairs human sperm functions by reducing protein-tyrosine phosphorylation.

Single and mixture toxicity evaluation of three phenolic compounds to the terrestrial ecosystem.

Phthalates

Early-life chronic di(2-ethylhexyl)phthalate exposure worsens age-related long-term associative memory decline associated with insulin/IGF-1 signaling and CRH-1/CREB in Caenorhabditis elegans.

MEHP induces pyroptosis and autophagy alternation by cathepsin B activation in INS-1 cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

In vitro effect of DDE exposure on the regulation of B-TC-6 pancreatic Beta Cell insulin secretion: a potential role in Beta Cell dysfunction and Type 2 Diabetes Mellitus.

Enantioselective Toxicity Effects of 2,2′,3,5′,6-Pentachloro Biphenyl (PCB-95) on Developing Brains in Zebrafish Larvae.

Perfluoroalkyl Substances

Varied thyroid disrupting effects of perfluorooctanoic acid (PFOA) and its novel alternatives hexafluoropropylene-oxide-dimer-acid (GenX) and ammonium 4,8-dioxa-3H-perfluorononanoate (ADONA) in vitro.

Perfluorononanoic acid impedes mouse oocyte maturation by inducing mitochondrial dysfunction and oxidative stress.

Patterns in Serum Toxicokinetics in Peromyscus Exposed to PFAS.

Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.

Flame Retardants

Effects of Tris (2-chloroethyl) phosphate (TCEP) on survival, growth, histological changes and gene expressions in juvenile yellow catfish Pelteobagrus fulvidraco.

2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) activates Aryl hydrocarbon receptor (AhR) mediated ROS and NLRP3 inflammasome/p38 MAPK pathway inducing necrosis in cochlear hair cells.

Organotins

The ameliorative effect of Moringa oleifera oil on tributyltin-induced brain toxicity in albino rats.

Potent inhibition of tributyltin (TBT) and triphenyltin (TPT) against multiple UDP-glucuronosyltransferases (UGT): A new potential mechanism underlying endocrine disrupting actions.

Effect of Trimethyltin chloride on proliferation and cell cycle of intestinal porcine epithelial cells.

Triphenyltin exposure causes changes in health-associated gut microbiome and metabolites in marine medaka.

Pesticides

Caprylic acid ameliorates rotenone induced inflammation and oxidative stress in the gut-brain axis in Zebrafish.

The effect of atrazine on intestinal histology, microbial community and short chain fatty acids in Pelophylax nigromaculatus tadpoles.

Short exposure to glyphosate induces locomotor, craniofacial, and bone disorders in zebrafish (Danio rerio) embryos.

Thymol alleviates imidacloprid-induced testicular toxicity by modulating oxidative stress and expression of steroidogenesis and apoptosis-related genes in adult male rats.

A common fungicide, Pristine®, impairs olfactory associative learning performance in honey bees (Apis mellifera).

Potentially Toxic Elements

Arsenic (III) and/or Antimony (III) induced disruption of calcium homeostasis and endoplasmic reticulum stress resulting in apoptosis in mice heart.

Microglia-derived IL-1β promoted neuronal apoptosis through ER stress-mediated signaling pathway PERK/eIF2α/ATF4/CHOP upon arsenic exposure.

Endocrine disruption caused by the aquatic exposure to aluminum and manganese in Astyanax altiparanae (Teleostei: Characidae) females during the final ovarian maturation.

Exposure to arsenic at different life-stages and DNA methylation meta-analysis in buccal cells and leukocytes.

Imbalanced inflammatory response in subchronic arsenic-induced liver injury and the protective effects of Ginkgo biloba extract in rats: Potential role of cytokines mediated cell-cell interactions.

Prolonged cadmium exposure alters benign uterine fibroid cell behavior, extracellular matrix components, and TGFB signaling.

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain.

Microplastics

Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload.

Mixtures

Histology and multi-omic profiling reveal the mixture toxicity of tebuconazole and difenoconazole in adult zebrafish.

Exposure/Environment Studies

BPA/Phenols

The internal exposure of bisphenol analogues in South China adults and the associated health risks.

Phthalates

Does heated erythrocyte suspension transfusion with medical devices containing phthalates increase DEHP and MEHP levels?

The spatiotemporal distribution and potential risk assessment of 19 phthalate acid esters in wastewater treatment plants in China.

Parabens/Triclosan/Antimicrobials

Monitoring and risk assessment of hazardous chemicals in toy-slime and putty in The Netherlands. [parabens and more]

Perfluoroalkyl Substances

Long-term behavior of PFAS in contaminated agricultural soils in Germany.

LC-HRMS screening of per- and polyfluorinated alkyl substances (PFAS) in impregnated paper samples and contaminated soils.

Perfluoroalkyl substances (PFAS) adsorption in drinking water by granular activated carbon: Influence of activated carbon and PFAS characteristics.

Perfluoroalkyl substances (PFASs) in leachate, fly ash, and bottom ash from waste incineration plants: Implications for the environmental release of PFAS.

Pesticides

Association between occupational and environmental pesticide exposure in Cukurova region by hair and blood biomonitoring.

Worldwide survey of pesticide residues in citrus-flavored soft drinks.

Potentially Toxic Elements

Human biomarkers associated with low concentrations of arsenic (As) and lead (Pb) in groundwater in agricultural areas of Thailand.

Implementation of mercury biomonitoring in German adults using dried blood spot sampling in combination with direct mercury analysis.

Blood Mercury in Three Populations of Endangered Whooping Crane (Grus americana).

Microplastics

Domestic laundry and microfiber pollution: Exploring fiber shedding from consumer apparel textiles.

Spatio-temporal distribution of microplastics in a Mediterranean river catchment: The importance of wastewater as an environmental pathway.

Pharmaceuticals/Personal Care Products

Methamphetamine pollution elicits addiction in wild fish.

Mixtures

Synergistic effects of contaminants in Lombardy waters.

Occurrence, spatial distribution and risk assessment of high concern endocrine-disrupting chemicals in Jiangsu Province, China.

Miscellaneous

Screening ecological risk of pesticides and emerging contaminants under data limited conditions – Case study modeling urban and agricultural watersheds with OrganoFate. [also flame retardants, triclocarban, etc.]

Suspect and non-target screening of contaminants of emerging concern in streams in agricultural watersheds.

FishChoice 2.0: Information on health benefits / risks and sustainability for seafood consumers.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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