EDC Science Weekly, July 4-11, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: metals in tampons; PFAS in lithium-ion batteries; toxicity of moldable plastics; knowledge of endocrine disruptors in pediatrics; PBDEs and PCBs cause “plant diabetes” (?!); are quats EDCs?

More science highlights

Events

July 12 and 31: Virtual symposium: Measuring Microplastics register for July 12; register for July 31 [NYU Langone Center for the Investigation of Environmental Hazards (CIEH)]

July 16 roundtable: Understanding of Environmental Exposures in Cancer by Strengthening Clinical, Government, and Community Partnerships [Biden Cancer Moonshot/CDC/ATSDR]

July 23 webinar: CHE Café: Protecting scientists from industry intimidation [Collaborative for Health and Environment (CHE)]

July 24 webinar: 3M’s decades-long cover-up of the “forever chemicals” in your blood [Beyond Plastics]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

More events

Regulations/Policy

Resource and animal use implications of the proposed REACH information requirements for endocrine disruptor assessment.

Beyond the urgency: Pesticide Emergency Authorisations’ exposure, toxicity, and risk for humans and the environment.

A systems-based analysis to rethink the European environmental risk assessment of regulated chemicals using pesticides as a pilot case.

The deep pockets of health-harming industries

More EDC policy and regulations open for comment

Methods/Tools/Screening

Knowledge and beliefs of endocrine disruptors in pediatrics: all hands on deck!

Combined Exposures and Mixtures Research: An Enduring NIEHS Priority.

Evaluating non-monotonic dose-response relationships in ecotoxicological risk assessment: a case study based on a systematic review of data on fluoxetine.

Identification of Neural-Relevant ToxCast High-Throughput Assay Intended Gene Targets: Applicability to Neurotoxicity and Neurotoxicant Putative Molecular Initiating Events.

Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole.

Historical control data of rare events: issues, chronological patterns and their relevance for toxicological evaluations.

Can Next Generation Ecological Risk Assessment Decisions Be Made Today?-A Case Study of Regulatory Risk Assessment in the United States.

Bridging the Gap Between Human Toxicology and Ecotoxicology Under One Health Perspective by a Cross-Species Adverse Outcome Pathway Network for Reproductive Toxicity.

A database of chemical absorption in human skin with mechanistic modeling applications.

Effect of Short-term Sample Storage and Preparatory Conditions on Losses of 18 Per- and Polyfluoroalkyl Substances (PFAS) to Container Materials.

Commentaries

Letter: Real-world bisphenol A exposure not linked to microbiota dynamics in childhood obesity [funded by Coca-cola] and response: Reply to Prueitt and Goodman, “Real-world bisphenol A exposure not linked to microbiota dynamics in childhood obesity”.

Wildfires and Human Health

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Scoping Review.

Carcinogenic health outcomes associated with endocrine disrupting chemicals exposure in humans: A wide-scope analysis.

The impact of environmental factors and contaminants on thyroid function and disease from fetal to adult life: current evidence and future directions.

The human health effects of unconventional oil and gas (UOG) chemical exposures: a scoping review of the toxicological literature.

Is it time to revise the fighting strategy toward Type 2 Diabetes? Sex and Pollution as New Risk Factors.

A Global Inventory of Natural and Synthetic Estrogens in Aquatic Systems.

Occurrence and risks of pharmaceuticals, personal care products, and endocrine-disrupting compounds in Chinese surface waters.

The general external exposome and the development or progression of chronic kidney disease: a systematic review and meta-analyses.

Phthalates

The concentrations and behavior of classic phthalates and emerging phthalate alternatives in different environmental matrices and their biological health risks.

PFAS

Childhood PFAS exposure and immunotoxicity: a systematic review and meta-analysis of human studies.

A research synthesis of humans, animals, and environmental compartments exposed to PFAS: A systematic evidence map and bibliometric analysis of secondary literature.

Pesticides

Pesticides and the Gut Microbiota: Implications for Parkinson’s Disease.

Microplastics/Nanomaterials

Primary Microplastics in the Ecosystem: Ecological Effects, Risks, and Comprehensive Perspectives on Toxicology and Detection Methods.

The effects of plastisphere on the physicochemical properties of microplastics.

Microplastics supply contaminants in food chain: non-negligible threat to health safety.

Beyond microbeads: Examining the role of cosmetics in microplastic pollution and spotlighting unanswered questions.

Exploring the risk of microplastics to pollinators: focusing on honey bees.

Research priorities on microplastics in marine and coastal environments: An Australian perspective to advance global action.

Microplastics from petroleum-based plastics and their effects: A systematic literature review and science mapping of global bioplastics production.

Air Pollution

Air Pollution and Stroke: What Nurses Need to Know.

Miscellaneous

Reproductive & Developmental Toxicity of quaternary ammonium compounds.

E-waste: mechanisms of toxicity and safety testing.

Updated review on contaminant communication experiences in the circumpolar Arctic.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal blood metals, per- and polyfluoroalkyl substances and antigen- or mitogen-stimulated cord blood lymphocyte proliferation and cytokine secretion.

Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells.

Prenatal exposure to polycyclic aromatic hydrocarbons and phthalate acid esters and gestational diabetes mellitus: A prospective cohort study.

Prenatal EDC exposure, DNA Methylation, and early childhood growth: A prospective birth cohort study.

Associations between Historical Redlining and the Risk of Pregnancy Complications and Adverse Birth Outcomes in Massachusetts, 1995-2015.

Associations between co-exposure to Per- and Polyfluoroalkyl Substances and Organophosphate Esters and Erythrogram in Chinese Adults.

Associations of insulin sensitivity and immune inflammatory responses with child blood lead (Pb) and PM_2.5 exposure at an e-waste recycling area during the COVID-19 lockdown.

Impact of antenatal exposure to a mixture of persistent organic pollutants on intellectual development.

BPA/Phthalates

Association of prenatal exposure to phthalates and synthetic phenols with pubertal development in three European cohorts.

Prenatal exposure to environmental phenols and phthalates and altered patterns of DNA methylation in childhood.

Longitudinal associations between urinary biomarkers of phthalates and replacements with novel in vivo measures of placental health.

Prenatal exposure to environmental phenols and fetal growth across pregnancy in the LIFECODES fetal growth study.

Association of alkylphenols exposure with serum liver function markers in pregnant women in Guangxi, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Possible associations between prenatal exposure to environmental pollutants and neurodevelopmental outcome in children.

Breast cancer immunophenotypes and serum organochlorine pesticides in Mexican women: mixture exposure approach.

Associations of exposure to organochlorine pesticides and polychlorinated biphenyls with chronic kidney disease among adults: the modifying effects of lifestyle.

Serum metabolism distribution in individuals exposed to dioxins: A case study of residents near the municipal solid waste incinerators in China.

PFAS

A case-cohort study of per- and polyfluoroalkyl substance concentrations and incident prostate cancer in the Cancer Prevention Study-II LifeLink Cohort study.

Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study.

Flame Retardants

Organophosphate Ester Flame Retardants and Plasticizers in Relation to Fetal Growth in the LIFECODES Fetal Growth Study.

Gestational organophosphate esters (OPEs) exposure in association with placental DNA methylation levels of peroxisome proliferator-activated receptors (PPARs) signaling pathway-related genes.

Association between organophosphate esters exposure and all-cause and cause-specific mortality: a national population-based cohort study.

Pesticides

Childhood and adolescent residential and farm pesticide exposures and inflammatory bowel disease incidence in a U.S. cohort of women.

Metals/Metalloids

Exposure to heavy metals in utero and autism spectrum disorder at age 3: a meta-analysis of two longitudinal cohorts of siblings of children with autism.

Urine manganese, cadmium, lead, arsenic, and selenium among autism spectrum disorder children in Kuala Lumpur.

Association of urinary metal element with semen quality: a cross-sectional study from Eastern China.

A prospective cohort study of multimetal exposure and risk of gestational diabetes mellitus.

Exposure to metal mixtures and telomere length in Bangladeshi children.

The arsenic eaters of Styria, the toxicophagi.

Air Pollution

Residential air pollution, greenspace, and adverse mental health outcomes in the U.S. Gulf Long-term Follow-up Study.

Exposure to air pollution and cardiovascular risk in young children – a pilot project.

Miscellaneous

Environmental Toxicant Exposure and Depressive Symptoms.

Effect of occupational exposure to vat-textile dyes on follicular and luteal hormones in female dye workers in Abeokuta, Nigeria.

Evaluation of mortality among Marines, Navy personnel, and civilian workers exposed to contaminated drinking water at USMC base Camp Lejeune: a cohort study.

Laboratory Studies

Numerous Chemicals/Mixtures

A second hit by PFOS exposure exacerbated developmental defects in medaka embryos with a history of ancestral BPA exposure.

Environmental endocrine disruptor risks in the central nervous system: Neurotoxic effects of PFOS and glyphosate.

Polybrominated diphenyl ethers and polychlorinated biphenyls induced rice “diabetes” by disturbing the transport and decomposition of soluble sugars.

BPA/Phenols

Disruptive effects of plasticizers bisphenol A, F, and S on steroidogenesis of adrenocortical cells.

Cardiovascular and renal oxidative stress-mediated toxicities associated with bisphenol-A exposures are mitigated by Curcuma longa in rats.

The Protective Effect of Gallic Acid Against Bisphenol A-Induced Ovarian Toxicity and Endocrine Disruption in Female Rats.

Distinct gut flora profile induced by postnatal trans-fat diet in gestationally bisphenol A-exposed rats.

Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway.

Phthalates

Effects of maternal LPS and developmental exposure to an environmentally relevant phthalate mixture on neuron number in the rat medial prefrontal cortex.

Impact of DEHP on mitochondria-associated endoplasmic reticulum membranes and reproductive toxicity in ovary.

Parabens/Triclosan/Antimicrobials

Inhibitory Effects of Parabens on Human and Rat 17β-Hydroxysteroid Dehydrogenase 1: Mechanisms of Action and Impact on Hormone Synthesis.

PFAS

Lithium-ion battery components are at the nexus of sustainable energy and environmental release of per- and polyfluoroalkyl substances.

Immunotoxicity of legacy and alternative per- and polyfluoroalkyl substances on zebrafish larvae.

Perfluorooctane Sulfonamide Induced Autotoxic Effects on the Zebrafish Immune System.

Disruption of zebrafish sex differentiation by emerging contaminants hexafluoropropylene oxides at environmental concentrations via antagonizing androgen receptor pathways.

Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure.

Examining effects of a novel estrogenic perfluoro-alcohol, 1H,1H,8H,8H-Perfluorooctane-1,8-diol (FC8-diol), using the fathead minnow EcoToxChip.

The pollutant perfluorohexane sulfonate (PFHxS) reduces serum thyroxine but does not alter thyroid action in the postnatal rat brain.

Hepatic Transcriptomic Assessment of Sprague Dawley Rats in Response to Dietary Perfluorobutane Sulfonate (PFBS) Ingestion.

Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y).

Flame Retardants

Integrated biomarker-based ecological risks assessment of tadpole responses to tris(2-chloroethyl) phosphate, tris(1-chloro-2-propyl) phosphate, and their combined environmental exposure.

Pesticides

Eco(geno)toxicity of the new commercial insecticide Platinum Neo, a mixture of the neonicotinoid Thiamethoxam and the pyrethroid Lambda-Cyhalothrin.

Pyraclostrobin induces developmental toxicity and cardiotoxicity through oxidative stress and inflammation in zebrafish embryos.

Network toxicological and molecular docking to investigate the mechanisms of toxicity of agricultural chemical Thiabendazole.

Neurotoxicity assessment of the herbicide pethoxamid in zebrafish (Danio rerio) embryos/larvae.

Effects of captan, mancozeb and azoxystrobin fungicides on motility, oxidative stress and fatty acid profiles in rainbow trout (Oncorhynchus mykiss) spermatozoa.

Low-Level Dietary Clothianidin Exposure Preferentially Causes Prepupal Mortality of Monarch Butterflies (Danaus plexippus).

Beyond the urgency: Pesticide Emergency Authorisations’ exposure, toxicity, and risk for humans and the environment.

Changes in the proteome of Apis mellifera acutely exposed to sublethal dosage of glyphosate and imidacloprid.

Microplastics/Nanomaterials

Polystyrene microplastics trigger testosterone decline via GPX1.

Moldable Plastics (Polycaprolactone) can be Acutely Toxic to Developing Zebrafish and Activate Nuclear Receptors in Mammalian Cells.

Bio-based microplastic polylactic acid exerts the similar toxic effects to traditional petroleum-based microplastic polystyrene in mussels.

Adsorption behaviors of perfluorooctanoic acid on aged microplastics.

Behavioral impairments and disrupted mitochondrial energy metabolism induced by polypropylene microplastics in zebrafish larvae.

Air Pollution

Disease types and pathogenic mechanisms induced by PM_2.5 in five human systems: An analysis using omics and human disease databases.

Miscellaneous

Bioenergetic Shifts in Humpback Whale Fibroblasts Upon Chemical Exposure.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Concentrations of potentially endocrine disrupting chemicals in car cabin air and dust – Effect of temperature and ventilation.

Chemical threats for the sentinel Pygoscelis adeliae from the Ross Sea (Antarctica): Occurrence and levels of persistent organic pollutants (POPs), perfluoroalkyl substances (PFAS) and mercury within the largest marine protected area worldwide.

A Decade of Data and Hundreds of Analytes: Legacy and Emerging Chemicals in North American Herring Gull Plasma.

BPA/Phenols

Wastewater-based epidemiology methodology to investigate human exposure to bisphenol A, bisphenol F and bisphenol S.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

An investigation of some persistent organic pollutants in loggerhead sea turtles (Caretta caretta).

Monitoring of Organochlorine Pesticides (OCP) in Hair Samples of Wild Herbivorous Mammals Living in Remote and Protected Areas of the Far East and Siberia of Russia.

PFAS

Combining Advanced Analytical Methodologies to Uncover Suspect PFAS and Fluorinated Pharmaceutical Contributions to Extractable Organic Fluorine in Human Serum (Tromsø Study).

Thermal desorption – gas chromatography – mass spectrometry (TD-GC-MS) analysis of PFAS used in food contact materials.

Non-target discovery and risk prediction of per- and polyfluoroalkyl substances (PFAS) and transformation products in wastewater treatment systems.

Impacts of rapidly urbanizing watershed comprehensive management on per- and polyfluoroalkyl substances pollution: Based on PFAS “diversity” assessment.

Flame Retardants

Traditional and Novel Organophosphate Esters in Plastic Greenhouse: Occurrence, Multimedia Migration, and Exposure Risk via Vegetable Consumption.

Pesticides

Environmental exposure patterns to 94 current-use pesticides in women of reproductive age who are preparing for pregnancy.

Metals/Metalloids

Predictors of Toxic Metal/Metalloid Exposures Among Mexican Americans in Starr County, Texas.

Tampons as a source of exposure to metal(loid)s.

Microplastics/Nanomaterials

Visible intruders: Tracing (micro-) plastic in organic fertilizers.

Microplastic pollution in the North-east Atlantic Ocean surface water: How the sampling approach influences the extent of the issue.

Miscellaneous

Urinary polycyclic aromatic hydrocarbon (PAH) metabolite concentrations in three pregnancy cohorts from 7 U.S. study sites.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.