EDC Science Weekly, July 21 – 27, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed or published this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Innovate beyond PFAS.

Protecting Future Generations By Regulatory Approaches

Does REACH provide sufficient information to regulate substances toxic to reproduction?

Air quality policy should quantify effects on disparities.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Cutting-edge computational chemical exposure research at the U.S. Environmental Protection Agency.

New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens-a PARC project.

A perspective on In vitro developmental neurotoxicity test assay results: An expert panel review

Computational Construction of Toxicant Signaling Networks.

Development of the integrated Fish Endocrine Disruptor Test (iFEDT) – Part A: Merging of existing fish test guidelines.

CTD Tetramers: a new online tool that computationally links curated chemicals, genes, phenotypes, and diseases to inform molecular mechanisms for environmental health.

Comparison of in silico, in vitro, and in vivo toxicity benchmarks suggests a role for ToxCast data in ecological hazard assessment.

AndroPred: an artificial intelligence-based model for predicting androgen receptor inhibitors.

Tracking end-of-life stage of chemicals: A scalable data-centric and chemical-centric approach.

Knowledge graph aids comprehensive explanation of drug and chemical toxicity.

Improving interventional causal predictions in regulatory risk assessment.

Microplastics are overestimated due to poor quality control of reagents.

More tools, reports, and resources

Commentaries

Editorial: Is it time to stick it to PFAS? [Intro to a research topic in Frontiers in Toxicology]

Sunrise of PFAS Replacements: A Perspective on Fluorine-Free Foams.

Invited Perspective: The Continuing Debate-Is Glyphosate a Problem, and Can an Organic Diet Protect Us from Exposures? [re Urinary Glyphosate Concentrations among Pregnant Participants in a Randomized, Crossover Trial of Organic and Conventional Diets.]

Pesticide exposure and human health: Toxic legacy.

Another Call for RCTs of Interventions to Reduce Particulate Matter 2.5 Associated Cardiovascular Health Effects.

4.2 million and counting… The animal toll for REACH systemic toxicity studies.

Reviews

Numerous Chemicals/Mixtures

Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy

Interdisciplinary strategies to assess the relationship between exposure to complex chemical mixtures and thyroid hormone system disruption

Deciphering the Roles of Aryl Hydrocarbon Receptor (AHR) in Regulating Carcinogenesis.

DNA damage resulting from human endocrine disrupting chemical exposure: Genotoxicity, detection and dietary phytochemical intervention.

Human biomonitoring of environmental contaminants in gulf countries – current status and future directions.

Bisphenols/Phthalates

Endocrine disruptors in dialysis therapies: A literature review.

Toxicological evaluation of bisphenol analogues: preventive measures and therapeutic interventions.

Pesticides

Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review.

The bitter side of teas: Pesticide residues and their impact on human health.

Metals/Metalloids

Association between heavy metals exposure (cadmium, lead, arsenic, mercury) and child autistic disorder: a systematic review and meta-analysis.

Metabolomics: a promising tool for deciphering metabolic impairment in heavy metal toxicities.

Impacts of heavy metal exposure on the prostate of murine models: mechanisms of toxicity.

Microplastics/Nanomaterials

Recent progress and future directions of the research on nanoplastic-induced neurotoxicity.

Interactions between microplastics and contaminants: A review focusing on the effect of aging process.

Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics?

Miscellaneous

Tire wear particles in different water environments: occurrence, behavior, and biological effects-a review and perspectives.

Emissions and mitigation potential of endocrine disruptors during outdoor exercise: Fate, transport, and implications for human health.

Human Health Studies

Numerous Chemicals/Mixtures

Hippocampal and amygdala volumes vary with residential proximity to toxicants at Birmingham, Alabama’s 35th Avenue Superfund site.

Cross-sectional associations between phthalates, phenols, and parabens with metabolic syndrome risk during early-to-mid adolescence among a cohort of Mexican youth.

Environmental exposures in early-life and general health in childhood.

BPA/Phenols

Associations among bisphenol A, its analogs, and chlorinated derivatives in placenta and risk for neural tube defects: A case-control study.

Phthalates

Individual and joint associations of urinary phthalate metabolites with polycystic ovary and polycystic ovary syndrome: Results from the TREE cohort.

Associations of phthalates, phthalate replacements, and their mixtures with eicosanoid biomarkers during pregnancy.

Parabens/Triclosan/Antimicrobials

Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation.

Perfluoroalkyl Substances

6:2 Chlorinated Polyfluoroalkyl Ether Sulfonates Exert Stronger Thyroid Homeostasis Disruptive Effects in Newborns than Perfluorooctanesulfonate: Evidence Based on Bayesian Benchmark Dose Values from a Population Study.

PFAS association with kisspeptin and sex hormones in teenagers of the HBM4EU aligned studies.

Fetal Glucocorticoid Mediates the Association between Prenatal Per- and Polyfluoroalkyl Substance Exposure and Neonatal Growth Index: Evidence from a Birth Cohort Study.

Exposure to per- and polyfluoroalkyl substances in early pregnancy and risk of cerebral palsy in children.

Flame Retardants

Association between brominated flame retardants exposure and markers of oxidative stress in US adults: An analysis based on the National Health and Nutrition Examination Survey 2007-2016.

Urinary concentrations of organophosphate esters and associated health outcomes in Korean firefighters.

Pesticides

Lipid metabolic links between serum pyrethroid levels and the risk of incident type 2 diabetes: A mediation study in the prospective design.

Association between Glyphosate Exposure and Erythrograms in a Representative Sample of US Adults: NHANES 2013-2014.

Biomarkers of organophosphate insecticides exposure and asthma in general US adults: findings from NHANES 1999-2018 data.

Integrating NHANES and toxicity forecaster data to compare pesticide exposure and bioactivity by farmwork history and US citizenship.

Association of indoor use of pesticides with CKD of unknown origin.

Metals/Metalloids

Additive interaction of urinary total arsenic concentrations with being overweight/obesity on the risk of insulin resistance: NHANES 2007-2016.

Urinary cadmium and endometriosis prevalence in a US nationally representative sample: results from NHANES 1999-2006.

Air Pollution

Independent and interactive effects of ozone and thermal inversion exposure on the risk of gestational diabetes mellitus in Wuhan, China.

Association between exposure to air pollution during preconception and risk of gestational diabetes mellitus: The role of anti-inflammatory diet.

Polycyclic aromatic hydrocarbons and changes in brain cortical thickness and an Alzheimer’s disease-specific marker for cortical atrophy in adults: A longitudinal neuroimaging study of the EPINEF cohort.

Longitudinal associations between metabolites and immediate, short- and medium-term exposure to ambient air pollution: Results from the KORA cohort study.

Miscellaneous

Early prenatal sex steroids and sex-typed play behavior at 4 years of age.

Laboratory Studies

Numerous Chemicals/Mixtures

Developmental programming: Impact of preconceptional and gestational exposure to a real-life environmental chemical mixture on maternal steroid, cytokine and oxidative stress milieus in sheep.

The impaired swim bladder via ROS-mediated inhibition of the Wnt / Hedgehog pathway in zebrafish embryos exposed to eight toxic chemicals and binary chemical mixtures.

BPA/Phenols

Low-dose bisphenols exposure sex-specifically induces neurodevelopmental toxicity in juvenile rats and the antagonism of EGCG.

Bisphenol analogues induce thyroid dysfunction via the disruption of the thyroid hormone synthesis pathway.

Phthalates

Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from Penicillium citrinum XT6 on adipogenesis and expression of PPARγ and GLUT4 in 3T3-L1 adipocytes.

Exposure to di-isononyl phthalate during early pregnancy disrupts decidual angiogenesis and placental development in mice.

Phthalate acid esters contribute to the cytotoxicity of mask leachate: Cell-based assay for toxicity assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Fingerprinting of chlorinated paraffins and their transformation products in plastic consumer products.

Stress Response in the Honeybee (Apis mellifera L.) Gut Induced by Chlorinated Paraffins at Residue Levels Found in Bee Products.

Perfluoroalkyl Substances

Xeno-estrogenic activity of real-life mixtures of perfluoroalkylated substances in human placenta homogenates.

First determination on two kinds of microplastic-air partition coefficients of seven per- and polyfluoroalkyl substances under environmentally relative conditions: Experiment measurement and model prediction.

Flame Retardants

The epigenetic hallmark of early-life α-hexabromocyclododecane exposure: From cerebellar 6-mA levels to locomotor performance in adulthood.

Pesticides

The effects of glyphosate-based herbicide on the hypothalamic-pituitary thyroid axis are tissue-specific and dependent on age exposure.

Exposure to Dichlorvos pesticide alters the morphology of and lipid metabolism in the ventral prostate of rats.

Tralomethrin causes cardiovascular toxicity in zebrafish (Danio rerio) embryos.

Toxicity of glyphosate and aminomethylphosphonic acid (AMPA) to the early stages of development of Steindachneridion melanodermatum (), an endangered endemic species of Southern Brazil.

Exploring the binding mechanism and adverse toxic effects of degradation metabolites of pyrethroid insecticides to human serum albumin: Multi-spectroscopy, calorimetric and molecular docking approaches.

Avermectin reduces bone mineralization via the TGF-β signaling pathway in zebrafish.

Methylated and ethylated dialkylphosphate metabolites of organophosphate pesticides: DNA damage in bone marrow cells of Balb/c mice.

Detrimental consequences of tebuconazole on redox homeostasis and fatty acid profile of honeybee brain.

Metals/Metalloids

Paternal cadmium exposure induces glucolipid metabolic reprogramming in offspring mice via PPAR signaling pathway.

Effects of postnatal exposure to cadmium on male sexual incentive motivation and copulatory behavior: estrogen and androgen receptors expression in adult brain rat.

Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.

Maternal genetic intergenerational and transgenerational effects on hormone synthesis in ovarian granulosa cells of offspring exposed to cadmium during pregnancy.

Chronic exposure to inorganic arsenic and fluoride induces redox imbalance, inhibits the transsulfuration pathway, and alters glutamate receptor expression in the brain, resulting in memory impairment in adult male mouse offspring.

Impact of Early Arsenic Exposure on the Mineral Content and Oxidative Status of the Liver and Kidney of Pubescent and Adult Rats.

Microplastics/Nanomaterials/Plastics

Endocrine disruptor responses in the embryos of marine medaka (Oryzias melastigma) after exposure to aged plastic leachates.

Gut Microbiota Participates in Polystyrene Microplastics-Induced Hepatic Injuries by Modulating the Gut-Liver Axis.

Pharmaceuticals/Personal Care Products

Prenatal exposure to Diethylstilbestrol has long-lasting, transgenerational impacts on fertility and reproductive development.

PPCPs in coastal wastewater treatment plant effluent and uptake by Pacific oysters (Crassostrea gigas): Findings from a laboratory experiment.

Miscellaneous

Benzo[b]fluoranthene induces male reproductive toxicity and apoptosis via Akt-Mdm2-p53 signaling axis in mouse Leydig cells: Integrating computational toxicology and experimental approaches.

Occurrence and Release of Organophosphite Antioxidants and Novel Organophosphate Esters from Plastic Food Packaging.

Brand-Specific Toxicity of Tire Tread Particles Helps Identify the Determinants of Toxicity.

In vitro evaluation for estrogenic mechanisms of the disinfectant benzalkonium chloride as an emerging contaminant.

3-tert-Butyl-4-hydroxyanisole Perturbs Differentiation of C3H10T1/2 Mesenchymal Stem Cells into Brown Adipocytes through Regulating Smad Signaling. [a food additive]

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Associations between lifestyle factors and levels of per- and polyfluoroalkyl substances (PFASs), phthalates and parabens in follicular fluid in women undergoing fertility treatment.

Per-and polyfluoroalkyl substances (PFAS) and mercury in Arctic Alaska coastal fishes of subsistence importance.

Hormonal biomarkers provide insights into the reproductive biology and pollutants-associated health hazards of endangered dolphins.

Identification of key features relating to the coexistence mechanisms of trace elements and per- and polyfluoroalkyl substances (PFASs) in marine mammals.

Cracked and shucked: GC-APCI-IMS-HRMS facilitates identification of unknown halogenated organic chemicals in French marine bivalves.

BPA/Phenols

Large-scale biomonitoring of bisphenol analogues and their metabolites in human urine from Guangzhou, China: Implications for health risk assessment.

Twelve natural estrogens and ten bisphenol analogues in eight drinking water treatment plants: Analytical method, their occurrence and risk evaluation.

Bisphenols and alternative developers in thermal paper receipts from the U.S. market assessed by fourier transform infrared spectroscopy.

Phthalates

Measurement of 24 phthalate metabolites in 1st trimester urine samples: The MIREC study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in adipose tissue of women from Grand Tunis and their association with demographic factors and dietary habits.

Polybrominated diphenyl ether (PBDEs), polychlorinated biphenyls (PCBs), organochlorines pesticides (OCPs) in human breast milk from Colombia: A probabilistic risk assessment approach.

Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain).

Occurrence and carcinogenic potential of airborne PBDD/Fs and PCDD/Fs around a large-scale municipal solid waste incinerator: A long-term passive air sampling study.

Fatty acids and organohalogen contaminants in seafood from the Pearl River Estuary, China: Risk-benefit analyses of seafood consumption.

Spatial and Temporal Trends of Persistent Organic Pollutants across Europe after 15 Years of MONET Passive Air Sampling.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances (PFAS) measured in seafood from a cross-section of retail stores in the United States.

Environmental exposure and ecological risk of perfluorinated substances (PFASs) in the Shaying River Basin, China.

Large-scale assessment of PFAS compounds in drinking water sources using machine learning.

Flame Retardants

Regional variation of polybrominated diphenyl ethers in East Asian finless porpoises in the East China Sea.

Organophosphate diesters (DAPs) and hydroxylated organophosphate flame retardants (HO-OPFRs) as biomarkers of OPFR contamination in a typical freshwater food chain.

Pesticides

Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica.

Estrogens and xenoestrogen residues in manure-based fertilizers and their potential ecological risks.

A critical review on the accumulation of neonicotinoid insecticides in pollen and nectar: Influencing factors and implications for pollinator exposure.

Metals/Metalloids

Human biomonitoring of inorganic elements in a representative sample of the general population from Cape Verde: Results from the PERVEMAC-II study.

Air Pollution

You exhaust me! Air pollution exposure near schools during pick-up and drop-off times.

Pharmaceuticals/Personal Care Products

Occurrence and removal rate of typical pharmaceuticals and personal care products (PPCPs) in an urban wastewater treatment plant in Beijing, China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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