EDC Science Weekly: July 19 – Aug. 1, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed over the past two weeks.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Science-based recommendations to inform an effective global plastic treaty; PFAS in pesticides; intervention study on BPA and blood pressure; EDCs in early life and neuroimaging in children; microplastics in human bone marrow; pesticides comparable to smoking for cancer risk.

More science highlights

Events

Aug 6 webinar: Protecting Children’s Developing Brains: Hazards of Plastics and Chemicals in Plastics [CHE-Alaska]

Aug 7 webinar: Potential Approaches to Plastic Products and Chemicals of Concern in the Plastics Treaty [Geneva Environment Network]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due today, Aug. 1]

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

More events

Regulations/Policy

The time for ambitious action is now: Science-based recommendations for plastic chemicals to inform an effective global plastic treaty

The Stockholm Convention at a Crossroads: Questionable Nominations and Inadequate Compliance Threaten Its Acceptance and Utility.

Scientific support for preparing an EU position in the 55th Session of the Codex Committee on Pesticide Residues (CCPR).

Basic Principles for Setting MRLs for Pesticides in Food Commodities in Japan.

Does environmental regulation matter for healthcare utilisation in China? An interrupted time series study.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Evaluating the conduct and reporting of the T-cell dependent antibody response in the Extended One-Generation Reproductive Toxicity study provided under the EU REACH regulation.

Differences in endocrine and reproductive responses to substance exposure across generations: highlighting the importance of complementary findings.

Highly sensitive response to the toxicity of environmental chemicals in transparent casper zebrafish.

ICP-MS As a Contributing Tool to Nontarget Screening (NTS) Analysis for Environmental Monitoring.

Advancing PFAS risk assessment: Integrative approaches using agent-based modelling and physiologically-based kinetic for environmental and health safety

Using Zebrafish to Screen Developmental Toxicity of Per- and Polyfluoroalkyl Substances (PFAS).

A Machine-Learning-Driven Pathophysiology-Based New Approach Method for the Dose-Dependent Assessment of Hazardous Chemical Mixtures and Experimental Validations.

The investigation of the toxicity of organophosphorus flame retardants (OPFRs) by using in silico toxicity prediction platform ProTox- 3.0.

Human and fish differences in steroid receptors activation: A review

Computational Insights into Reproductive Toxicity: Clustering, Mechanism Analysis, and Predictive Models.

Next Generation Risk Assessment approaches for advanced nanomaterials: Current status and future perspectives.

Investigating the mechanisms of action of thyroid disruptors: A multimodal approach that integrates in vitro and metabolomic analysis.

Commentaries

Forever Pesticides: A Growing Source of PFAS Contamination in the Environment and related Invited Perspective: The Far Reach of PFAS—Inert Ingredients and Adjuvants in Pesticide Formulations

From “forever chemicals” to fluorine-free alternatives.

Introduction to “Effects of per- and polyfluoroalkyl substances (PFAS) within a developmental context”. [intro to a special issue of Neurotoxicology and Teratology]

After the Smoke Clears: Wildland-Urban Interface Fires and Residues in Nearby Homes [Focus in EHP]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Exposure to Endocrine Disruptors in Early life and Neuroimaging Findings in Childhood and Adolescence: a Scoping Review.

Exposure to Synthetic Endocrine-Disrupting Chemicals in Relation to Maternal and Fetal Sex Steroid Hormones: A Scoping Review.

The contribution of environmental pollutants to the risk of autism and other neurodevelopmental disorders: a systematic review of case-control studies.

Advances in immunology of male reproductive toxicity induced by common environmental pollutants

Analytical challenges and opportunities in the study of endocrine disrupting chemicals within an exposomics framework.

BPA/Phenols

Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy.

Phthalates

Health hazards of preconception phthalate exposure: A scoping review of epidemiology studies.

Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder.

Effect of prenatal phthalate exposure on fetal development and maternal/neonatal health consequences: A systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The mode of action of different organochlorine pesticides families in mammalians.

PFAS

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction.

Per- and polyfluoroalkyl substances (PFAS) exposure and thyroid cancer: systematic review and meta-analysis

Hunting Metabolic Biomarkers for Exposure to Per- and Polyfluoroalkyl Substances: A Review.

Surface Science View of Perfluoroalkyl Acids (PFAAs) in the Environment.

Ultrashort pfas: a review of the topic.

Association between perfluoroalkyl substances and breast cancer on the National Health and Nutrition Examination Survey Database and meta-analysis.

Elucidating the degradation mechanisms of perfluorooctanoic acid and perfluorooctane sulfonate in various environmental matrices: a review of green degradation pathways.

Pesticides

Effects of glyphosate exposure on intestinal microbiota, metabolism and microstructure: a systematic review.

Sublethal pesticide exposure in non-target terrestrial ecosystems: from known effects on individuals to potential consequences on trophic interactions and network functioning.

Is the Biopesticide from Tea Tree Oil an Effective and Low-Risk Alternative to Chemical Pesticides? A Critical Review.

Metals/Metalloids

The Association between Cadmium Exposure and Thyroid Function in Animals: A Systematic Review.

Harnessing Magnetic Nanoparticles for the Effective Removal of Micro- and Nanoplastics: A Critical Review.

Alzheimer’s Disease and Circulatory Imbalance of Toxic Heavy Metals: A Systematic Review and Meta-analysis of Clinical Studies.

Microplastics/Nanomaterials

Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption.

Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms.

Understanding and addressing microplastic pollution: Impacts, mitigation, and future perspectives.

Research Progress on Micro (Nano)Plastics Exposure-Induced miRNA-Mediated Biotoxicity.

Health effects of microplastics and nanoplastics: review of published case reports.

Interaction of microplastics with perfluoroalkyl and polyfluoroalkyl substances in water: A review of the fate, mechanisms and toxicity.

Transitioning to Microplastic-Free Seed Coatings: Challenges and Solutions.

Air Pollution

Toxicity of airborne nanoparticles: Facts and challenges.

Air Pollution-Linked Epigenetic Modifications in Placental DNA: Prognostic Potential for Identifying Future Foetal Anomalies.

Neuroendocrine contribution to sex-related variations in adverse air pollution health effects.

Pharmaceuticals/Personal Care Products

Metformin as an Emerging Pollutant in the Aquatic Environment: Occurrence, Analysis, and Toxicity.

Safety Implications of Modulating Nuclear Receptors: A Comprehensive Analysis from Non-Clinical and Clinical Perspectives.

Miscellaneous

Potential human health risk of the emerging environmental contaminant 6-PPD quinone.

A review of tire wear particles: Occurrence, adverse effects, and control strategies.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to endocrine disrupting chemicals including phthalates, phenols, and parabens in infancy: Associations with neurodevelopmental outcomes in the MARBLES study

Association between United States Environmental Contaminants and the Prevalence of Psoriasis Derived from the National Health and Nutrition Examination Survey.

Gender- and Obesity-Specific Association of Co-Exposure to Personal Care Product and Plasticizing Chemicals and Short Sleep Duration among Adults: Evidence from the National Health and Nutrition Examination Survey 2011-2016.

Exposome Profiling of Environmental Pollutants in Seminal Plasma and Novel Associations with Semen Parameters.

Association of exposure to a mixture of phenols, parabens, and phthalates with altered serum thyroid hormone levels and the roles of iodine status and thyroid autoantibody status: A study among American adults

Sex-Specific and Trimester-Specific Associations of Prenatal Exposure to Bisphenols, Parabens, and Triclosan with Neonatal Birth Size and Gestational Age.

BPA/Phenols

Evaluation of Exposure to Bisphenol Analogs through Canned and Ready-to-Eat Meal Consumption and Their Possible Effects on Blood Pressure and Heart Rate [an intervention study]

The mediating role of steroid hormones in the relationship between bisphenol A and its alternatives bisphenol S and F exposure and preeclampsia.

Phthalates

Prenatal exposure to non-persistent chemicals and fetal-to-childhood growth trajectories.

Association between prenatal phthalate exposure and ano-genital indices among offsprings in an Israeli cohort.

Association between phthalates exposure and myocardial damage in the general population: a cross-sectional study.

Endocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study.

Assessment of maternal phthalate exposure in urine across three trimesters and at delivery (umbilical cord blood and placenta) and its influence on birth anthropometric measures.

Parabens/Triclosan/Antimicrobials

Urinary paraben exposure increases the risk of a low estimated glomerular filtration rate in Taiwanese general population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Correlation between environmental pollutant exposure and cardiopulmonary health by serum biomarker analysis in the Swedish elderly population.

Exploring the levels of persistent organic pollutants in umbilical cord blood and their connection to gestational age and birth weights in Şanlıurfa, Turkey.

PFAS

Prenatal Exposure of PFAS in Cohorts of Pregnant Women: Identifying the Critical Windows of Vulnerability and Health Implications

Examining the Impact of Polyfluoroalkyl Substance Exposure on Erythrocyte Profiles and Its Related Nutrients: Insights from a Prospective Study on Young Taiwanese.

Association between mixed exposure to per- and polyfluoroalkyl substances and metabolic syndrome in Korean adults: Data from the Korean National environmental health survey cycle 4.

Intrauterine Exposure to Long-Chain Perfluorocarboxylic Acids (PFCAs) Were Associated with Reduced Primary Bile Acids in Three-Year-Old Children: Findings from a Prospective Birth Cohort Study.

Associations between prenatal exposure to per- and polyfluoroalkyl substances and plasma immune molecules in three-year-old children in China.

Flame Retardants

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among adults in Wuhan, China.

Association between exposure to organophosphate flame retardants and epidermal growth factor receptor expression in lung cancer patients.

Age, Gender, and BMI Modulate the Hepatotoxic Effects of Brominated Flame Retardant Exposure in US Adolescents and Adults: A Comprehensive Analysis of Liver Injury Biomarkers.

Pesticides

Comprehensive assessment of pesticide use patterns and increased cancer risk

Unraveling the pesticide-diabetes connection: A case-cohort study integrating Mendelian randomization analysis with a focus on physical activity’s mitigating effect.

Association between organophosphorus pesticides and obesity among American adults.

Integrative Approach to Address Male Infertility: A Case Study on Organophosphorus Compound Exposure and Traditional Medicinal Interventions.

Insecticide exposure and associated acute health effects in farmers in a rice growing district of India.

Associations between DEET, Organophosphorus Insecticides, and Handgrip Strength in Diabetes: An NHANES Analysis.

Association between exposure to organophosphate pesticides and cytokine levels in a population of flower workers in Mexico”.

Metals/Metalloids

First trimester prenatal metal mixtures, vitamins, and hypertensive disorders of pregnancy in the project viva cohort.

Association between blood lead levels and parathyroid hormone among United States adolescents aged 12-19: a cross-sectional study.

Association between exposure to heavy metals and the risk of breast cancer: A case-control study in Tanzania.

Exposure to Toxic Chemical Elements among People Living with HIV/AIDS in Northern Tanzania.

Racialized experience, biomarkers of lead exposure, and later-life cognition: a mediation analysis.

Vitamin C Alleviates the Risk of Gestational Diabetes Mellitus Associated With Exposure to Metals.

Mortality risk associated to arsenic exposure after a major disaster. Results from the Manfredonia occupational cohort study 1976-2021.

Prenatal Arsenic Exposure on DNA Methylation of C18ORF8 and ADAMTS9 Genes of Newborns from the POSGRAD Birth Cohort Study.

Microplastics/Nanomaterials

Detection of Microplastics in Human Breast Milk and Its Association with Changes in Human Milk Bacterial Microbiota.

Air Pollution

The Association between Exposure to Fine Particulate Matter and MRI-Assessed Locus Coeruleus Integrity in the Vietnam Era Twin Study of Aging (VETSA). [see related Invited Perspective: Blue Skies and Alzheimer’s Disease.]

Association between Personal Abiotic Airborne Exposures and Body Composition Changes among Healthy Adults (60-69 Years Old): A Combined Exposome-Wide and Lipidome Mediation Approach from the China BAPE Study.

Social cohesion as a modifier of joint air pollution exposure and incident dementia.

Pharmaceuticals/Personal Care Products

Benign and Malignant Outcomes in the Offspring of Females Exposed In Utero to Diethylstilbestrol (DES): An Update from the NCI Third Generation Study.

Hair Dye and Relaxer Use among Cisgender Women in Embu and Nakuru Counties, Kenya: Associations with Perceived Risk of Breast Cancer and Other Health Effects.

Miscellaneous

Association of blood trihalomethane concentrations with diabetes mellitus in older adults in the US: a cross-sectional study of NHANES 2013-2018.

Childhood exposure to polycyclic aromatic hydrocarbons is associated with emotional and behavioral problems in adolescence: a longitudinal study in China.

Urinary polycyclic aromatic hydrocarbon metabolites in Chinese pregnant women: Concentrations, variability, predictors, and association with oxidative stress biomarkers.

Laboratory Studies

Numerous Chemicals/Mixtures

AOP-based framework for predicting the joint action mode of di-(2-ethylhexyl) phthalate and bisphenol A co-exposure on autism spectrum disorder.

Combined toxicity of pristine or artificially aged tire wear particles and bisphenols to Tigriopus japonicus.

Subacute exposure to a mixture of tributyltin plus mercury impairs reproductive axis function, exacerbating premature ovarian insufficiency features and reducing fertility in female rats.

MPs and PFOS single and combined exposure significantly alter genetic expressions of growth hormone and insulin growth factor-related biomarkers during zebrafish embryonic development.

BPA/Phenols

Medaka liver developed Human NAFLD-NASH transcriptional signatures in response to ancestral bisphenol A exposure.

Gene expression patterns and DNA methylation of neuron and pancreatic β-cell developments in zebrafish embryos treated with bisphenol F and AF

Bisphenol S (BPS) induces glioblastoma progression via regulation of EZH2-mediated PI3K/AKT/mTOR pathway in U87-MG cells.

Melatonin’s Protective Role Against Bisphenol F and S-Induced Skeletal Damage: A Morphometric and Histological Study in Rat.

BPA Exposure Affects Mouse Gastruloids Axial Elongation by Perturbing the Wnt/β-Catenin Pathway.

Evaluation of effects of bisphenol analogs AF, S, and F on viability, proliferation, production of selected cancer-related factors, and expression of selected transcripts in Caov-3 human ovarian epithelial cell line.

Bisphenol A and bisphenol AF co-exposure induced apoptosis of human ovarian granulosa cells via mitochondrial dysfunction.

Phthalates

Transcriptome-centric approach to the derivation of adverse outcome pathway networks of vascular dysfunction after long-term low-level exposure of human endothelial cells to dibutyl phthalate.

Elucidating the mechanisms and mitigation strategies for six-phthalate-induced toxicity in male germ cells

Parabens/Triclosan/Antimicrobials

Long-life triclosan exposure induces ADHD-like behavior in rats via prefrontal cortex dopaminergic deficiency

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Tyrosinase inhibition prevents non-coplanar polychlorinated biphenyls and polybrominated diphenyl ethers-induced hyperactivity in developing zebrafish: Interaction between pigmentation and neurobehavior.

Microglial responses to inflammatory challenge in adult rats altered by developmental exposure to polychlorinated biphenyls in a sex-specific manner.

Upregulation of Fatty Acid Synthesis Genes in the Livers of Adolescent Female Rats Caused by Inhalation Exposure to PCB52 (2,2′,5,5′-Tetrachlorobiphenyl).

Developmental exposure to the Fox River PCB mixture modulates behavior in juvenile mice.

PFAS

Investigation of Peroxisome Proliferator-Activated Receptor Genes as Requirements for Visual Startle Response Hyperactivity in Larval Zebrafish Exposed to Structurally Similar Per- and Polyfluoroalkyl Substances (PFAS).

Perfluorooctanesulfonic acid (PFOS) induced cancer related DNA methylation alterations in human breast cells: A whole genome methylome study.

Perfluorooctane Sulfonate Exposure Induces Cardiovascular Dysfunction in Female Rats: Role of Ovaries.

Rank-In Integrated Machine Learning and Bioinformatic Analysis Identified the Key Genes in HFPO-DA (GenX) Exposure to Human, Mouse, and Rat Organisms.

In vitro cytotoxicity of six per- and polyfluoroalkyl substances (PFAS) in human immune cell lines

Mechanisms of colon toxicity induced by long-term perfluorooctanoic acid exposure in mice

Systemic and immunotoxicity induced by topical application of perfluoroheptane sulfonic acid (PFHpS) or perfluorooctane sulfonic acid (PFOS) in a murine model.

Comparative toxicity assessment of alternative versus legacy PFAS: Implications for two primary trophic levels in freshwater ecosystems.

Developmental neurotoxicity of PFOA exposure on hiPSC-derived cortical neurons.

PFOS impairs cardiac function and energy metabolism under high-fat diet: Insights into role of circulating macrophage emphasized by exposure distribution.

Flame Retardants

Underexplored Organohalide-Respiring Bacteria in Sewage Sludge Debrominating Polybrominated Diphenyl Ethers.

The Brominated Flame Retardant Hexabromocyclododecane Causes Systemic Changes in Polyunsaturated Fatty Acid Incorporation in Mouse Lipids.

Tris (2-chloroisopropyl) phosphate and Tris (nonylphenyl) phosphite Promote Human Renal Cell Apoptosis through the ERK/CEPBA/Long Non-Coding RNA Cytoskeleton Regulator Axis.

Hexabromocyclododecane (HBCD) exposure induced premature testicular aging via NCOA4/Fe²⁺/ROS mediation.

Embryonic Exposure to Organophosphate Flame Retardants (OPFRs) Differentially Induces Cardiotoxicity in Rare Minnow (Gobiocypris rarus).

Organotins

Effects of Carvacrol on Cognitive Function and Apoptotic Gene Expression in Trimethyltin- Induced Hippocampal Injury in Rats.

Pesticides

Female Mice Exposed to Pyriproxyfen Since Prepuberty Showed Reproductive Impairment During Sexual Maturity and Increased Fetal Death in Their Offspring.

Role of IRE1α/XBP1/CHOP/NLRP3 Signalling Pathway in Neonicotinoid Imidacloprid-Induced Pancreatic Dysfunction in Rats and Antagonism of Lycopene: In Vivo and Molecular Docking Simulation Approaches.

Glyphosate-based herbicide exposure affects cognitive flexibility and social cognition in adult mice.

In vitro genomic damage caused by Glyphosate and its metabolite AMPA.

Altered Ovarian Reserve in Ewe Lambs Exposed to a Glyphosate-Based Herbicide.

scL-2PAM: A Novel Countermeasure That Ameliorates Neuroinflammation and Neuronal Losses in Mice Exposed to an Anticholinesterase Organophosphate.

Resveratrol ameliorates atrazine-induced caspase-dependent apoptosis and fibrosis in the testis of adult albino rats.

Atrazine promotes cholangiocarcinoma cell proliferation and migration via GPER-mediated PI3K/Akt/NF-κB pathway.

The effect of chlorpyrifos oral exposure on the histomorphometric and kidney function in Wistar rat.

Effect of chlorpyrifos on cypermethrin-induced dopaminergic neurotoxicity in rats.

Epoxiconazole disturbed metabolic balance and gut microbiota homeostasis in juvenile zebrafish.

Impact of sub chronic administration of deltamethrin on autoimmune activity in rat.

Metals/Metalloids

Developmental exposure to arsenic reduces anxiety levels and leads to a depressive-like behavior in female offspring rats: molecular changes in the prefrontal cortex.

Microplastics/Nanomaterials

Lactating exposure to microplastics at the dose of infants ingested during artificial feeding induced reproductive toxicity in female mice and their offspring.

Early-life exposure to five biodegradable plastics impairs eye development and visually-mediated behavior through disturbing hypothalamus-pituitary-thyroid (HPT) axis in zebrafish larvae.

PLA plastic particles disrupt bile acid metabolism leading to hepatic inflammatory injury in male mice.

Internalization of nano- and micro-plastics in human erythrocytes leads to oxidative stress and estrogen receptor-mediated cellular responses.

Microplastics exposure altered hematological and lipid profiles as well as liver and kidney function parameters in albino rats (Rattus norvegicus).

Plastic Fly: What Drosophila melanogaster Can Tell Us about the Biological Effects and the Carcinogenic Potential of Nanopolystyrene.

Female zebrafish (Danio rerio) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring.

Untargeted Lipidomics Uncover Hepatic Lipid Signatures Induced by Long-term Exposure to Polystyrene Microplastics in Vivo.

Miscellaneous

An in vitro comparison of the toxicological profiles of ground tire particles (TP) and actual tire and road wear particles (TRWP) emissions.

Estrogenic, Genotoxic, and Antibacterial Effects of Chemicals from Cryogenically Milled Tire Tread.

Exposure to 6-PPD quinone disrupted glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans.

The Role of Oxidative Stress and DNA Hydroxymethylation in the Pathogenesis of Benzo[a]pyrene-Impaired Reproductive Function in Male Mice.

Maternal exposure to phenanthrene induces testicular apoptosis and Sertoli cell dysfunction in F1 adult male mice: a histological and molecular study.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Climate Justice Implications of Natech Disasters: Excess Contaminant Releases during Hurricanes on the Texas Gulf Coast.

Urinary and Fecal Excretion of 121 Environmental Chemicals in Pet Dogs and Cats: Significance of Feces in Biomonitoring of Exposures.

Organochlorine pesticide residues and urinary arsenic and fluoride levels in mothers and their newborns who are residents of rural areas in Durango State, Mexico.

Addressing the need for individual-level exposure monitoring for firefighters using silicone samplers.

A Personalized Intervention to Increase Environmental Health Literacy and Readiness to Change in a Northern Nevada Population: Effects of Environmental Chemical Exposure Report-Back.

BPA/Phenols

Occurrence of bisphenol analogues and their conjugated metabolites in foodstuff.

Bisphenol S and Its Chlorinated Derivatives in Indoor Dust and Human Exposure.

Phthalates

Longitudinal mass loads of phthalate esters in sewage sludge and their association with public health and social measures for COVID-19 control in Beijing.

Parabens/Triclosan/Antimicrobials

Co-exposure of Parabens, Benzophenones, Triclosan, and Triclocarban in Human Urine from Children and Adults in South China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of persistent organic pollutants in urban and peri-urban wastewater sludge: environmental and carcinogenic human risk assessment in the case of land application.

Impact of legacy and unintentionally produced polychlorinated biphenyls (PCBs) in effluents from two wastewater treatment plants in rivers near Barcelona, Spain.

Overlooked Highly Volatile Persistent Organic Pollutants in the Atmosphere.

PFAS

Risk assessment for perfluorooctanoic acid (PFOA) in air, blood serum and water: mortality from liver and kidney disease.

A 50 year record for perfluoroalkyl acids in the high arctic: implications for global and local transport.

Combined screening and retroactive data mining for emerging perfluoroethers in wildlife and pets in the Cape Fear Region of North Carolina.

Legacy and alternative perfluoroalkyl acids in the Yellow River on the Qinghai-Tibet Plateau: Levels, spatiotemporal characteristics, and multimedia transport processes.

Risks associated with the presence of PFAS in FCM: An investigation of the Belgian market.

Cortisol Levels Reveal Species-Specific Stress Condition in Fish from PFAS Polluted Rivers.

Ecological risk of per- and polyfluorinated alkyl substances in the phytoremediation process: a case study for ecologically keystone species across two generations.

Is Japan at low risk for PFAS immunotoxicity?: human biomonitoring study in contaminated areas in Japan.

Co-emissions of fluoride ion, fluorinated greenhouse gases, and per- and polyfluoroalkyl substances (PFAS) from different fluorochemical production processes.

Adapting to PFAS contamination of private drinking water wells near a PFAS production facility in the US Atlantic Coastal Plain of North Carolina.

Occurrence, Concentration, and Distribution of 35 PFASs and Their Precursors Retained in 20 Stormwater Biofilters.

Flame Retardants

Organophosphate flame retardants in air from formal e-waste recycling workshops in China: Size-distribution, gas-particle partitioning and exposure assessment.

Brominated Flame Retardants (BFRs) in China Over the Past Half-Century: Stocks, Flows, Fates, and Ecological Risks

Physiology and fertility of two gull species in relation to plastic additives’ exposure. [PBDEs]

Pesticides

Biomonitoring of pesticide exposure and its health implications in agricultural areas of Telangana, India: A brief data report.

Exposure of Young Children to Permethrin and Cypermethrin Insecticides in the Residential Environment.

Temporal Trends of Exposure to the Herbicide Glyphosate in the United States (2013-2018): Data from the National Health and Nutrition Examination Survey.

Metals/Metalloids

Metal exposure in the Greenlandic ACCEPT cohort: follow-up and comparison with other Arctic populations.

Impact of COVID-19 on Temporal Trends and Health Risks of Urinary Metal Concentrations among Residents of Guangzhou, China.

Microplastics/Nanomaterials

Discovery and analysis of microplastics in human bone marrow.

First occurrence and risk assessment of microplastics in enteral nutrition formulas

Are microplastics a new cardiac threat? A pilot study with wild fish from the North East Atlantic Ocean.

Pharmaceuticals/Personal Care Products

Occurrence and human risk assessment of pharmaceutically active compounds (PhACs) in indoor dust from homes, schools and offices.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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