EDC Science Weekly, July 15-21, 2020 – HEEDS

EDC Science Weekly, July 15-21, 2020

Post author:HEEDS
Post published:July 21, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Today, Tues July 21 webinar: Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies on the newly released publication of the same name.

Methods/Tools/Screening

Leveraging the Comparative Toxicogenomics Database to fill in knowledge gaps for environmental health: a test case for air pollution-induced cardiovascular disease.

High-multiplexed monitoring of protein biomarkers in the sentinel Gammarus fossarum by targeted scout-MRM assay, a new vision for ecotoxicoproteomics. [pesticides]

“Good Epidemiology Practice” Guidelines for Pesticide Exposure Assessment.

Non-targeted detection and differentiation of agonists versus antagonists, directly in bioprofiles of everyday products.

Interference: A Much-Neglected Aspect in High-Throughput Screening of Nanoparticles.

Commentaries

Is It Realistic to Propose Determination of a Lifetime Internal Exposome?

The health toll of air pollution: Despite global efforts to clean up the air, outdoor and indoor air pollution still have a drastic negative effect on public health. [News item]

Linkages Between Air Pollution and the Health Burden from COVID-19: Methodological Challenges and Opportunities.

Vitamin D Deficiency and Air Pollution Exacerbate COVID-19 Through Suppression of Antiviral Peptide LL37. [Hypothesis]

Reviews

BPA/Phenols

Bisphenol-A and polycystic ovary syndrome: a review of the literature.

A systematic review of microRNA expression studies with exposure to bisphenol A.

Effect of nonylphenol on spermatogenesis: A systematic review.

Phthalates

Biomonitoring of occupational exposure to phthalates: A systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Influence of polychlorinated biphenyls and organochlorine pesticides on the inflammatory milieu. A systematic review of in vitro, in vivo and epidemiological studies.

Flame Retardants

Review of emerging contaminant tris(1,3-dichloro-2-propyl)phosphate: Environmental occurrence, exposure, and risks to organisms and human health.

A review on organophosphate flame retardants in indoor dust from China: Implications for human exposure.

Pesticides

Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies.

Peer review of the pesticide risk assessment of the active substance clodinafop (variant evaluated clodinafop-propargyl).

Effects of agrochemical pollution on schistosomiasis transmission: a systematic review and modelling analysis.

Potentially Toxic Elements

Mercury exposure and toxicological consequences in fish and fish-eating wildlife from anthropogenic activity in Latin America.

Methylmercury toxic mechanism related to protein degradation and chemokine transcription.

Metals and Molecular Carcinogenesis.

Microplastics/Nanomaterials

Health impacts of environmental contamination of micro- and nanoplastics: a review.

Effects of Airborne Nanoparticles on the Nervous System: Amyloid Protein Aggregation, Neurodegeneration and Neurodegenerative Diseases.

Environmental distribution, transport and ecotoxicity of microplastics: A review.

Air Pollution

Associations between particulate matter air pollution, presence and progression of subclinical coronary and carotid atherosclerosis: A systematic review.

Numerous Chemicals/Mixtures

Mechanisms and pathogenesis underlying environmental chemical-induced necroptosis.

Adrenal gland response to endocrine disrupting chemicals in fishes, amphibians and reptiles: a comparative overview.

Fate of Environmental Pollutants: A Review.

Effects of Pollution on Marine Organisms.

Environmental and ecological factors of stomach cancer incidence and mortality: a systematic review study on ecological studies.

Miscellaneous

Association between dietary intake and risk of ovarian cancer: a systematic review and meta-analysis. [includes some chemicals]

Epigenetic clocks may come out of rhythm-implications for the estimation of chronological age in forensic casework.

DNA methylation reprogramming in medaka fish, a promising animal model for environmental epigenetics research.

Greenspace with overweight and obesity: A systematic review and meta-analysis of epidemiological studies up to 2020.

Human Health Studies

BPA/Phthalates

Fetal exposure to bisphenols and phthalates and childhood bone mass: a population-based prospective cohort study.

Co-exposure to polycyclic aromatic hydrocarbons and phthalates and their associations with oxidative stress damage in school children from South China.

Exposure to organophosphate esters, phthalates, and alternative plasticizers in association with uterine fibroids.

The association of bisphenol A exposure with premature ovarian insufficiency: a case-control study.

Prenatal and early childhood exposure to phthalates and childhood behavior at age 7 years.

Parabens

Weight and head circumference at birth in function of placental paraben load in Belgium: an ENVIRONAGE birth cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental chemical burden in metabolic tissues and systemic biological pathways in adolescent bariatric surgery patients: A pilot untargeted metabolomic approach.

Genome-wide DNA methylation differences and polychlorinated biphenyl (PCB) exposure in a US population.

Association of Polychlorinated Biphenyls and Organochlorine Pesticides with Autism Spectrum Disorder in Jamaican Children.

Flame Retardants

Exposure to Organophosphate esters and metabolic syndrome in adults.

Pesticides

An epigenome-wide association study of ambient pyrethroid pesticide exposures in California’s central valley.

Pesticide Risk and Recurrent Pregnancy Loss in Females of Subhumid Region of India.

Potentially Toxic Elements

Relationship between urinary β2-microglobulin concentration and mortality in a cadmium-polluted area in Japan: A 35-year follow-up study.

The association between mercury concentrations and lipid profiles in the Korean National Environmental Health Survey (KoNEHS) cycle 3.

Maternal cadmium exposure and neurobehavior in children: The HOME study.

Multiple-element exposure and metabolic syndrome in Chinese adults: A case-control study based on the Beijing population health cohort.

The Effect of Whole Blood Lead (Pb-B) Levels on Changes in Peripheral Blood Morphology and Selected Biochemical Parameters, and the Severity of Depression in Peri-Menopausal Women at Risk of Metabolic Syndrome or with Metabolic Syndrome.

Air Pollution

Prenatal airshed pollutants and preterm birth in an observational birth cohort study in Detroit, Michigan, USA.

The impact of weather and air pollution on viral infection and disease outcome among pediatric pneumonia patients in Chongqing, China from 2009 to 2018: a prospective observational study.

Temporal association between particulate matter pollution and case fatality rate of COVID-19 in Wuhan.

Association of climate factors and air pollutants with pneumonia incidence in Lampang province, Thailand: findings from a 12-year longitudinal study.

The factors associated with distress following exposure to smoke from an extended coal mine fire.

The mediating effect of air quality on the association between human mobility and COVID-19 infection in China.

Identifying critical exposure windows for ambient air pollution and semen quality in Chinese men.

Association between exposure to fine particulate matter and obesity in children: A national representative cross-sectional study in China.

Involvement of fine particulate matter exposure with gene expression pathways in breast tumor and adjacent-normal breast tissue.

Ambient air pollution and male fecundity: A retrospective analysis of longitudinal data from a Chinese human sperm bank (2013-2018).

Analysis of incidence of air quality on human health: a case study on the relationship between pollutant concentrations and respiratory diseases in Kennedy, Bogotá.

Miscellaneous

Autism spectrum disorder in the United Arab Emirates: potential environmental links.

Parental occupational exposure pre- and post-conception and development of asthma in offspring.

Rare cancers of unknown etiology: lessons learned from a European multi-center case-control study.

Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort.

Organic UV filter exposure and pubertal development: A prospective follow-up study of urban Chinese adolescents.

Flaring from Unconventional Oil and Gas Development and Birth Outcomes in the Eagle Ford Shale in South Texas.

Laboratory Studies

BPA/Phenols/Phthalates

Data integration, analysis, and interpretation of eight academic CLARITY-BPA studies.

Long-Term Exposure of Early-Transformed Human Mammary Cells to Low Doses of Benzo[a]pyrene and/or Bisphenol A Enhances Their Cancerous Phenotype via an AhR/GPR30 Interplay.

Mass Spectrometry Imaging Combined with Metabolomics Reveal the Proliferative Effect of Environmental Pollutants on Multicellular Tumor Spheroids. [BPS]

Combined effects of di (2-ethylhexyl) phthalate and bisphenol A on thyroid hormone homeostasis in adolescent female rats.

Oxidative stress response associates with the teratogenic effects of benzyl butyl phthalate (BBP).

Triclosan

The pH-dependent toxicity of triclosan on developing zebrafish (Danio rerio) embryos using metabolomics.

Triclosan changes community composition and selects for specific bacterial taxa in marine periphyton biofilms in low nanomolar concentrations.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Assessing anti-estrogenic effects of AHR ligands in primary human and rat endometrial epithelial cells.

Alternative Evaluation to Earthworm Toxicity Test in Polychlorinated Biphenyls Spiked and Remediated Soils.

Neonatal exposure to chlordecone alters female social behaviors and central estrogen alpha receptor expression in socially monogamous mandarin voles.

Flame Retardants

Comparative assessment of neurotoxicity impacts induced by alkyl tri-n-butyl phosphate and aromatic tricresyl phosphate in PC12 cells.

Triphenyl phosphate is a selective PPARγ modulator that does not induce brite adipogenesis in vitro and in vivo.

Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL/6 mice inoculated with B16-F10 cells.

Comparative Toxicity and Liver Transcriptomics of Legacy and Emerging Brominated Flame Retardants following 5-Day Exposure in the Rat.

Pesticides

Death of guppy fish (Poecilia reticulata) leukocytes induced by in vivo exposure to temephos and spinosad.

Evaluation of buccal damage associated with acute inhalation exposure to 2,4-dichlorophenoxyacetic acid (2,4-D) in mice.

Enantioselective disposition and metabolic products of isofenphos-methyl in rats and the hepatotoxic effects.

Bifenthrin impairs the functions of Leydig and Sertoli cells in mice via mitochondrion-endoplasmic reticulum dysregulation.

Insecticides cause transcriptional alterations of endocrine related genes in the brain of honey bee foragers.

Anthropogenic stressors impact fish sensory development and survival via thyroid disruption.

Imbalance of gut microbiota and fecal metabolites in offspring female mice induced by nitenpyram exposure during pregnancy.

Potentially Toxic Elements

Rosmarinic acid attenuates chromium-induced hepatic and renal oxidative damage and DNA damage in rats.

Prenatal exposure to excess chromium attenuates transcription factors regulating expression of androgen and follicle stimulating hormone receptors in Sertoli cells of prepuberal rats.

Hypomethylation of LINE-1 retrotransposons is associated with cadmium-induced testicular injury.

The role of soil arsenic fractionation in the bioaccessibility, transformation, and fate of arsenic in the presence of human gut microbiota.

Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.

Chronic arsenic exposure enhances metastatic potential via NRF2-mediated upregulation of SOX9.

Effects of curcumin, D-pinitol alone or in combination in cytotoxicity induced by arsenic in PC12 Cells.

Metabolic adaptability in liver and gastrocnemius muscle of mice following subacute lead toxicity.

Transcriptome analysis reveals the mechanism of common carp brain injury after exposure to lead.

Effect of lead on proliferation, oxidative stress and genotoxic damage of 3T3-L1 fibroblasts.

Oxidative stress and apoptotic effects of copper and cadmium in the zebrafish liver cell line ZFL.

Microplastics/Nanoplastics

Impact of nanoplastics on hemolymph immune parameters and microbiota composition in Mytilus galloprovincialis.

Effects of long-term exposure to microfibers on ecosystem services provided by coastal mussels.

Microplastics induce dose-specific transcriptomic disruptions in energy metabolism and immunity of the pearl oyster Pinctada margaritifera.

Air Pollution

Exposure to fine particulate matter induces self-recovery and susceptibility of oxidative stress and inflammation in rat lungs.

Ambient PM Toxicity is Correlated with Expression Levels of Specific MicroRNAs.

Environmental six-ring polycyclic aromatic hydrocarbons are potent inducers of the AhR-dependent signaling in human cells.

Pharmaceuticals

Sex-Specific Differences of Steroid Receptors Following Exposure to Environmentally Relevant Concentrations of Phenothiazine in Fundulus heteroclitus.

Mixtures

Grass carps co-exposed to environmentally relevant concentrations of cypermethrin and sulfamethoxazole bear immunodeficiency and are vulnerable to subsequent Aeromonas hydrophila infection.

Effects of environmental steroid mixtures are regulated by individual steroid receptor signaling.

Combined toxicity of microplastics and cadmium on the zebrafish embryos (Danio rerio).

Exposure/Environment Studies

BPA/Phenols

The migration of bisphenols from beverage cans and reusable sports bottles.

Phthalates

Aggregate exposure assessment using cosmetic co-use scenarios: II. Application and validation for phthalates.

Percutaneous penetration and metabolism of plasticizers by skin cell and its implication in dermal exposure to plasticizers by skin wipe.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dietary habits associated with the presence of organochlorine pesticides in human milk.

Levels and sources of PBDEs and PCBs in human nails from e-waste, urban, and rural areas in South China.

Perfluoroalkyl Substances

Removal of legacy PFAS and other fluorotelomers: Optimized regeneration strategies in DOM-rich waters.

Are melamine and its derivatives the alternatives for per- and polyfluoroalkyl substance (PFAS) fabric treatments in infant clothes?

Cooking methods affect the intake of per- and polyfluoroalkyl substances (PFASs) from grass carp.

Per- and polyfluoroalkyl substances in ducks and the relationship with concentrations in water, sediment, and soil.

Flame Retardants

A noninvasive environmental monitoring tool for brominated flame-retardants (BFRs) assisted by conservation detection dogs.

Potentially Toxic Elements

Metal mixtures in pregnant women and umbilical cord blood at urban populations-Rio de Janeiro, Brazil.

Seasonal Dynamics and Interannual Variability in Mercury Concentrations and Loads through a Three-Reservoir Complex.

Potentially toxic elements in the Middle East oldest oil refinery zone soils: source apportionment, speciation, bioaccessibility and human health risk assessment.

Wildfire-driven changes in hydrology mobilize arsenic and metals from legacy mine waste.

Quantification and health risk assessment of heavy metals in residual floor dust at an indoor firing range: A case study in Trinidad, WI.

Heavy metal concentrations in Brazilian port areas and their relationships with microorganisms: can pollution in these areas change the microbial community?

A critical evaluation of the use and ‘misuse’ of As and Pb bioaccessibility data in human health risk assessments.

Evaluating Spatiotemporal Resolution of Trace Element Concentrations and Pb Isotopic Compositions of Honeybees and Hive Products as Biomonitors for Urban Metal Distribution.

Microplastics

Atmospheric transport is a major pathway of microplastics to remote regions.

Towards control strategies for microplastics in urban water.

EXPRESS: Steps Scientists Can Take to Inform Aquatic Microplastics Management: A Perspective Informed by the California Experience.

Evidence of selective enrichment of bacterial assemblages and antibiotic resistant genes by microplastics in urban rivers.

The efficiency of devices intended to reduce microfibre release during clothes washing.

Mussels facilitate the sinking of microplastics to bottom sediments and their subsequent uptake by detritus-feeders.

Air Pollution

Indoor Air Quality Monitoring Systems Based on Internet of Things: A Systematic Review.

Air Quality during COVID-19 in Four Megacities: Lessons and Challenges for Public Health.

Mixtures/Numerous Chemicals

Ecological changes as a plausible explanation for differences in uptake of contaminants between European perch and eelpout in a coastal area of the Baltic Sea. [mercury and organic pollutants]

Human dietary exposure to chemicals in sub-Saharan Africa: safety assessment through a total diet study.

Preying on seals pushes killer whales from Norway above pollution effects thresholds.

Supporting dataset on the validation and verification of the analytical method for the biomonitoring of 360 toxicologically relevant pollutants in whole blood.

Miscellaneous

Health risks associated with the polycyclic aromatic hydrocarbons in indoor dust collected from houses in Kuwait.

Improved prediction of sediment toxicity using a combination of sediment and overlying water contaminant exposures.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.