EDC Science Weekly, Jan. 9-15, 2026

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Jan. 15 (today!): application due date for May 26 – June 9 course, Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [Marine Biological Laboratory]

Jan. 15: application due date for travel awards for the June 8 – 10 National PFAS Conference, in person in Tucson AZ. Abstracts are due Jan. 31.

Jan. 15 – May 5, Spring seminar series (livestreamed) [Duke Integrated Toxicology and Environmental Health Program]

Jan. 16 webinar: 3D Models and Technologies to Illuminate Biological Effects of Contaminants [NIEHS Superfund Research Program (SRP)]

Jan. 21 webinar: The Race to Research: Plastic, Microplastics, and Human Health [Mid-Atlantic Center for Children’s Health and the Environment]

Jan. 21 webinar: Innovative Methods for Understanding Chemical Toxicity [NIEHS SRP]

Jan. 22 webinar: CHE Café: How states can lead on environmental health [CHE]

Jan. 23: application due date for the Endocrine Society’s Research Experiences for Graduate and Medical Students program.

Jan. 27 webinar: Policy, Prevention & Protection: Opportunities for states to lead on toxic chemicals & plastics [CHE-Alaska]

Feb. 5-6 conference: Forever Ends Here: PFAS & Policy for Worker Health and Safety [Berkeley Center for Occupational and Environmental Health]

Feb. 10 – June 9: Environment and Health webinar series [Mount Sinai]

Feb. 12 webinar: EDCs & Reproductive Health: Effects of chemical mixtures on ovarian function [EDC Strategies Partnership]

Feb. 27 application due date for the Endocrine Society’s Kaiser-Goldberg Research Fellowship program.

Mar. 1-2: 2026 Our Planet, Our Health Convention, hybrid/Arlington VA [Medical Society Consortium on Climate and Health]

June 28 – July 3: New and emerging threats, approaches, and mitigation strategies for environmental endocrine disruptors [Gordon Research Conference] and accompanying Gordon Research Seminar June 27 – 28, Harnessing interdisciplinary evidence for endocrine disruption. Abstracts due Jan 20, submit here.

Save the date: Oct. 12-16, conference: MICRO 2026: Plastic pollution from macro to nano [in Cadiz, Spain]

Regulations/Policy

How credible is REACH regulation without transparency, quality criteria, assurance, and control?

The UK pesticide load indicator: development toward a policy tool.

More EDC policy, FPF’s regulations open for comment, and Science’s Trump-Tracker.

Methods/Tools/Screening

Improving micro-/nanoplastics (MNPs) ecotoxicity assessment: A harmonised ecotoxicity testing approach with Daphnia magna.

Commentaries

Special Issue “Progress in Research on Endocrine-Disrupting Chemicals” in Int J Mol Sci.

Unforeseen risks due to the use of fluorinated materials for per- and polyfluoroalkyl substance removal

Human Cancers Derived from Either Genetic or Lifestyle Factors Are Initiated by Impaired Estrogen Signaling.

Comment on “Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality” and Reply to “Comment on ‘Polyethylene and Polyvinyl Chloride Nanoplastics in Human Follicular Fluid and Seminal Plasma: Impact on Fertilization and Sperm Quality”‘.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Toxicoepigenomics: Epigenetic disruption by environmental exposures and implications for biomarker development.

The rising tide of plastic pollutants: implications for schizophrenia onset, a mini-review.

Pollutant-regulated mitophagy: new perspectives in environmental toxicology.

Current risk factors for male infertility and semen parameters: an umbrella review of systematic reviews and meta-analyses.

Bisphenols

The Effects of Probiotic Supplementation on Bisphenol A Toxicity: A Systematic Literature Review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organic Pollutants and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis.

Piecing Together the Puzzles: Aryl Hydrocarbon Receptor-Mediated Genetic and Epigenetic Signatures in Dioxin-Induced Carcinogenicity- A Systematic Review and Meta-Analysis.

PFAS

Association study of umbilical cord serum per- and polyfluoroalkyl substances (PFAS) exposure with birth outcomes: A meta-analysis.

Pesticides

Tissue-specific oxidative stress and protective interventions in malathion-induced toxicity in rodent models: A comprehensive review.

A Review on the Effects of Atrazine on Male Rat Reproductive System Cytoarchitecture, Steroidogenesis and Oxidative Pathway.

Metals/Metalloids

Developmental Toxicity of Metals: Three Decades of Insights into Mechanisms, Epigenetics, and Transgenerational Inheritance.

Microplastics/Nanomaterials

Unraveling the impact of microplastics on autoimmune diseases: hidden dangers and environmental triggers.

Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications.

Microplastics in Early Onset Carcinogenesis.

Microplastics: A Modifiable Cardiac Risk Factor.

Micro- and Nanoplastics and Functional Nutrients in Human Health: Epigenetic Mechanisms and Cellular Resilience Signaling in Brain Insulin Resistance and the Risk of Alzheimer’s Disease.

From the Gut to the Brain: Microplastic-Associated Neurovascular Dysfunction and Implications for Stroke Risk.

Comparative Metabolomic Approaches to Nanoplastic Toxicity in Mammalian and Aquatic Systems.

The Impact of Nanoplastics on the Quality of Fish Sperm: A Review.

Miscellaneous

Comprehensive review on environmental pollution caused by 6PPD-quinone and remediation strategies.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal occupational exposure to endocrine-disrupting chemicals during pregnancy and adult male reproductive hormones.

Bisphenols/Phenols

Associations of maternal exposure to nonylphenol and bisphenols with precocious puberty in girls: A nested case-control study.

Phthalates

Investigating the impact of phthalate exposure on endocrine function in women with polycystic ovary syndrome.

PFAS

Prenatal exposure to long-chain, short-chain and emerging PFASs and cognitive development in young children: Evidence from the Wuxi Birth Cohort.

Association Study of Internal Exposure Levels of Perfluoroalkyl Substances and Blood Lipid Levels in the Elderly Population and Adverse Outcome Pathway Analysis.

Flame Retardants

Joint association of organophosphate esters exposure and gestational diabetes mellitus history with glycometabolism in the early postnatal period.

Associations of internal exposure to organophosphate esters and their metabolites with cognitive functions in middle-aged and elderly people: the mediating effects of inflammation.

Pesticides

High pesticide exposure events and subjective cognitive complaints among US farmers.

Association of 2,4-dichlorophenoxyacetic acid exposure with all-cause and cancer mortality risk: a comprehensive study of 9198 participants.

Metals/Metalloids

Cross-sectional association of arsenic exposure with thyroid function in Bangladeshi children aged 5 to 7 years.

Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.

Air Pollution

Associations of Proximity to Superfund Sites and Air Pollution with Breast Cancer Subtypes: Clues from a Case-Case Study and Call for Longitudinal Studies.

Impact of Wildland Fire Smoke PM_2.5 on Birth Weight in California.

The impact of perinatal exposure to ambient air pollution on childhood body mass index trajectories.

Miscellaneous

Association between urinary perchlorate and malignancies of endocrine-related tissues in U.S. adults: analysis of National Health and Nutrition Examination Survey (NHANES) data.

Laboratory Studies

Numerous Chemicals/Mixtures

Synergistic thyroid disruption and reproductive toxicity induced by co-exposure of triadimefon and copper in zebrafish embryos.

Bisphenols

Bisphenol AF induces mouse spermatogonia apoptosis via reactive oxygen species-mediated Beclin-1 cleavage.

Developmental exposure to Bisphenol S causes neurobehavioural deficits in larval zebrafish (Danio rerio).

Molecular mechanisms of environmental bisphenol exposure in major depressive disorder: A multimodal analysis.

Reproductive physiological amelioration of BPA – induced toxicity by resveratrol: Sperm quality preservation, DNA damage mitigation, and testicular protection.

Phthalates

Metabolic Profiling of the Maternal Liver in Pregnant Mice Exposed to Di(2-ethylhexyl) Phthalate (DEHP).

Chronic exposure to environmentally relevant doses of butyl benzyl phthalate promotes development of breast tumor Via the tricarboxylic acid cycle and fatty acid β -oxidation.

Lycopene Prevents DEHP-Induced Ferroptosis in Cerebellar Microglia by Regulating the PEBP1/ALOX15 Axis.

Parabens/Triclosan/Antimicrobials

Guarding the Ovarian Reserve: Maternal Methyl Donor Supplementation Protects Against Propylparaben-Induced Ovarian Aging in Offspring.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Impaired Morphological and Functional Maturation of the Spleen during Puberty in Rats Exposed to Low Doses of Endocrine Disruptor DDT.

Single-cell transcriptomics showed that maternal polychlorinated biphenyl exposure dysregulated cell type-specific metabolic responses in the livers of female mouse offsprings.

PFAS

Unveiling the toxic effects of perfluorooctanoic acid on osteoblast function and extracellular matrix deposition using 2D and 3D models.

Per- and polyfluoroalkyl substances (PFAS) alter immune responses from THP-1 human monocytes.

PFHxS exposure causes osteoarthritis through the innate immune signaling pathway mediated by lipid peroxidation.

Elucidating the molecular mechanisms of perfluorodecanoic acid and perfluorooctane sulfonic acid on glioblastoma through network toxicology and bioinformatics.

Flame Retardants

Decabromodiphenyl ethane, a flame retardant, acts as a thyroid hormone receptor antagonist.

Pesticides

Developmental exposure to a mixture of propiconazole and glyphosate induces histopathological lesions in the prostate of postpubertal rats.

Low-Level Exposure to Dinotefuran May Induce Damage to Ovarian and Female Germ Stem Cells of Adolescent Mice via ZBP1- and RIPK1-PANoptosome.

Dysregulation of atrazine-associated core gene networks and risk prediction in human cancers: Insights from integrated transcriptomics and network toxicology analyses.

Environmental glyphosate exposure compromises sperm quality in mice by impairing acrosome biogenesis via GOLPH3-mediated golgiphagy.

Molecular and histopathological mechanisms underlying pesticide-induced disruption of the hypothalamic-pituitary-gonadal axis in Japanese medaka.

Metals/Metalloids

Early developmental lead exposure disrupts skeletal development in zebrafish.

Unveiling the gut-brain axis: How chronic exposure to arsenic-induced microglial pyroptosis drives Alzheimer’s disease-like pathology.

Combined effects of chronic high glucose and fluoride exposure on kidney cells: exploratory in vitro and in vivo study.

Melatonin Alleviated Cadmium Induced Microbiota-Gut-Brain Disorder in Adult Zebrafish: Insights from Transcriptomic and Microbiome Analysis.

Microplastics/Nanomaterials

Polystyrene Microplastics Disrupt Vertical Transmission of the Breast Milk Microbiome, Impairing Early-Life Gut Colonization and Immune Development in Offspring.

Shape-driven toxicity of polystyrene microplastics: Impacts on physiology and gut microbiota in Daphnia magna.

Synergistic assault of DEHP and MPs: Unmasking the ER stress-triggered autophagic injury male fertility.

Impact of Conventional vs. Biodegradable and Compostable Microplastics on Eisenia fetida S.: An Ecopathological Approach.

Vinyl chloride oligomers: On the road to understand the potential toxicity of PVC nanoplastics.

Nanoplastic exposure damages neural plasticity, cognitive abilities, and ecological adaptability of marine medaka Oryzias melastigma.

Toxicity of High-Density Polyethylene Nanoparticles in Combination with Silver Nanoparticles to Caco-2 and HT29MTX Cells Growing in 2D or 3D Culture.

Air Pollution

Time-restricted feeding ameliorates hepatic lipid and glucose metabolism dysregulation induced by PM_2.5 exposure in mice.

Pharmaceuticals/Personal Care Products

Multi-omics and in silico evidence reveal perospirone-induced developmental neurotoxicity in zebrafish via AKT/FOXO3a-mediated apoptosis.

Chronic paternal or maternal exposure to florfenicol causes reproductive and developmental toxicity in marine medaka (Oryzias melastigma).

Molecular interactions and biomarker responses to pharmaceutical contaminants in aquatic species.

Miscellaneous

Mechanistic insights into cardiovascular toxicity induced by polycyclic aromatic hydrocarbons using Benzo[a]pyrene (BaP) as an example.

Rubber-Derived Contaminants N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine and N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine-quinone Alter Intergenerational Cholesterol Metabolism in F1 Offspring of Exposed Mice.

6PPD impairs liver growth through inflammatory pathways: Insights from zebrafish and human cell models.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Development, validation, and application of an innovative UHPLC-Orbitrap-HRMS method for multi-class analysis of endocrine disruptors in bottled water: Influence of bottle material, water source, and retail price.

Phthalates

Quantification of phthalate and DINCH metabolites in human urine and maternal breast milk: Assessing maternal body burden and infant exposure.

PFAS

Residential proximity to transport facilities as urban determinants of individual-level per- and poly-fluoroalkyl substance (PFAS) exposures: Analysis of two longitudinal cohorts in Singapore.

Assessment of per- and polyfluoroalkyl substances (PFAS) in consumer food packaging.

PFAS in commercially available organic amendments and food-contact paper products.

PFAS occurrence in food in Luxembourg (2022-2024) and dietary exposure.

Challenges and Opportunities in PFAS Waste Management for Semiconductor Manufacturing.

Whales Contribute to Novel Insight on Poly- and Perfluoroalkyl Substances Bioaccumulation in the East China Sea.

Flame Retardants

A novel potential toxic target of PBDEs in cetaceans: Impaired wound healing demonstrated in Indo-Pacific finless porpoise fibroblasts.

Pesticides

Large scale biomonitoring of glyphosate and AMPA by analysis of human and animal feces and comparison with urine.

Pesticide prioritization based on risk and model diet proposals for assessing cumulative exposure to pesticide residues in the Brazilian population through food consumption.

Microplastics/Nanomaterials

Brewing plastics: OCT reveals microplastic release from nylon tea bags in simulated brewed tea infusions.

Quantitative and qualitative assessment of microplastics contamination in plastic-wrapped candies and estimation of dietary exposure in early childhood.

Microplastic contamination of donated blood and red cell concentrates.

Miscellaneous

Prevalence of plastic waste as a household fuel in low-income communities of the Global South.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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