EDC Science Weekly: Jan. 6-12, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Jan. 19: Maternal exposure to air pollution nanoparticles and adverse birth outcomes [EDC Strategies Partnership]

Webinar Feb. 2: A Science-Based Agenda for Health-Protective Chemical Assessments and Decisions [re the publication under “Regulations/Policy” below; PRHE’s Science Action Network]

Webinar Feb. 10: CHE Café: What’s Next in Environmental Health?

Regulations/Policy

A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement [see PRHE’s related infographics and related webinar]

Methods/Tools/Screening

Methods

FDA and industry collaboration: Identifying opportunities to further reduce reliance on nonhuman primates for nonclinical safety evaluations

Toxicity Rank Order (TRO) As a New Approach for Toxicity Prediction by QSAR Models.

Advances in research strategies and approaches for toxicity testing of environmental exposures.

Internal relative potency factors based on immunotoxicity for the risk assessment of mixtures of per- and polyfluoroalkyl substances (PFAS) in human biomonitoring.

A Proposed approach to defining per- and polyfluoroalkyl substances (PFAS) based on molecular structure and formula.

Radiolabelling and in vivo radionuclide imaging tracking of emerging pollutants in environmental toxicology: A review.

The ATTAC guiding principles to openly and collaboratively share wildlife ecotoxicology data.

Screening

Interferences in the yeast estrogen screen (YES) assay for evaluation of estrogenicity in environmental samples, chemical mixtures, and individual substances.

Screening of Metabolism-Disrupting Chemicals on Pancreatic α-Cells Using In Vitro Methods.

Immunotoxicity In Vitro Assays for Environmental Pollutants under Paradigm Shift in Toxicity Tests.

Commentaries

Paternal Inheritance Is an Important, but Overlooked, Factor Affecting the Adverse Effects of Microplastics and Nanoplastics on Subsequent Generations.

Environmental Justice: Where It Has Been, and Where It Might Be Going.

Reviews

Numerous Chemicals/Mixtures

Endocrine Disrupting Chemicals in Polycystic Ovary Syndrome: The Relevant Role of the Theca and Granulosa Cells in the Pathogenesis of the Ovarian Dysfunction.

Environmental toxicants and male fertility.

Characterization of different contaminants and current knowledge for defining chemical mixtures in human milk: A review.

BPA/Phenols

Bisphenol A and its substitutes in the aquatic environment: Occurrence and toxicity assessment.

Perfluoroalkyl Substances

Contact to perfluoroalkyl substances and thyroid health effects: A meta-analysis directing on pregnancy.

Pesticides

Amyotrophic Lateral Sclerosis Pathoetiology and Pathophysiology: Roles of Astrocytes, Gut Microbiome, and Muscle Interactions via the Mitochondrial Melatonergic Pathway, with Disruption by Glyphosate-Based Herbicides.

Neonicotinoid insecticides in global agricultural surface waters – Exposure, risks and regulatory challenges.

Agriculture without paraquat is feasible without loss of productivity-lessons learned from phasing out a highly hazardous herbicide.

Metals/Metalloids

Metal Profiles in Autism Spectrum Disorders: A Crosstalk between Toxic and Essential Metals.

Association between Environmental Cadmium Exposure and Osteoporosis Risk in Postmenopausal Women: A Systematic Review and Meta-Analysis.

A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis.

Microplastics/Nanomaterials

Impact of Nanoparticles on Male Fertility: What Do We Really Know? A Systematic Review.

Microplastics in Fish and Fishery Products and Risks for Human Health: A Review.

Understanding the Interplay between Antimicrobial Resistance, Microplastics and Xenobiotic Contaminants: A Leap towards One Health?

Microplastic Interactions and Possible Combined Biological Effects in Antarctic Marine Ecosystems.

Is Wild Marine Biota Affected by Microplastics?

Co-occurrence of microplastics and organic/inorganic contaminants in organisms living in aquatic ecosystems: A review.

Air Pollution

Neurotoxic effects of air pollution: an urgent public health concern.

Human Health Studies

Numerous Chemicals/Mixtures

Oestrogenic Activity in Girls with Signs of Precocious Puberty as Exposure Biomarker to Endocrine Disrupting Chemicals: A Pilot Study.

Co-Exposure to Bisphenols, Parabens, and Antimicrobials and Association with Coronary Heart Disease: Oxidative Stress as a Potential Mediating Factor?

BPA/Phthalates/Parabens

A Case-Control Study on the Effects of Plasticizers Exposure on Male Fertility.

The Association between the Bisphenols Residues in Amniotic Fluid and Fetal Abnormalities in Polish Pregnant Women-Its Potential Clinical Application.

Prospective association between phthalate exposure in childhood and liver function in adolescence: the Ewha Birth and Growth Cohort Study.

The effects of phthalate exposure on metabolic parameters in polycystic ovary syndrome.

Urinary phenol concentrations and fecundability and early pregnancy loss.

Exposure to bisphenols, parabens and phthalates during pregnancy and postpartum anxiety and depression symptoms: Evidence from women with twin pregnancies.

Maternal paraben exposure and intra-pair thyroid-stimulating hormone difference in twin neonates.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Networks of placental DNA methylation correlate with maternal serum PCB concentrations and child neurodevelopment.

Perfluoroalkyl Substances

Prenatal perfluoroalkyl substances exposure and maternal sex steroid hormones across pregnancy.

Effect of lifestyle-based lipid lowering interventions on the relationship between circulating levels of per-and polyfluoroalkyl substances and serum cholesterol.

Associations between per and polyfluoroalkyl ether sulfonic acids and vitamin D biomarker levels in Chinese newborns.

Prenatal exposure to per- and polyfluoroalkyl substances and childhood autism-related outcomes.

Pesticides

Glyphosate Exposure and Urinary Oxidative Stress Biomarkers in the Agricultural Health Study.

First evidence of neonicotinoid insecticides in human bile and associated hepatotoxicity risk.

Effects of Pesticide Intake on Gut Microbiota and Metabolites in Healthy Adults.

Evaluating How Occupational Exposure to Organophosphates and Pyrethroids Impacts ADHD Severity in Egyptian Male Adolescents.

Metals/Metalloids

Follicle-stimulating hormone and blood lead levels with bone mineral density and the risk of fractures in pre- and postmenopausal women.

Associations between mercury exposure with blood pressure and lipid levels: A cross-sectional study of dental professionals.

Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease.

Prenatal mercury exposure, fish intake and child emotional behavioural regulation in the Norwegian Mother, Father and Child Cohort Study.

Chronic Exposure to Drinking Water Arsenic and Gallbladder Cancer Risk: Preliminary Evidence from Endemic Regions of India.

Long-term exposure to low-level arsenic in drinking water is associated with cause-specific mortality and hospitalization in the Mt. Amiata area (Tuscany, Italy).

The relationship between co-exposure to multiple heavy metals and liver damage.

Air Pollution

Effects of Ambient Air Pollution on Precocious Puberty: A Case-Crossover Analysis in Nanjing, China.

Prenatal exposure to tailpipe and non-tailpipe tracers of particulate matter pollution and autism spectrum disorders.

Long-term effects of ambient PM_2.5 constituents on metabolic syndrome in Chinese children and adolescents.

Miscellaneous

Association between acrylamide exposure and sex hormones among premenopausal and postmenopausal women: NHANES, 2013-2016.

The association analysis between exposure to volatile organic chemicals and obesity in the general USA population: A cross-sectional study from NHANES program.

The association between urinary polycyclic aromatic hydrocarbon metabolites and liver function among US population: a cross-sectional study.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of single and combined exposure to priority pollutants on gene expression and post-embryonic development in Drosophila melanogaster.

First approach to assess the effects of nanoplastics on the soil species Folsomia candida: A mixture design with bisphenol A and diphenhydramine.

BPA/Phenols

Resveratrol ameliorates bisphenol A-induced testicular toxicity in adult male rats: a stereological and functional study.

Effects of the long-term influence of bisphenol A and bisphenol S on the population of nitrergic neurons in the enteric nervous system of the mouse stomach.

Effects of short-term exposure to low doses of bisphenol A on cellular senescence in the adult rat kidney.

The Comparison of the Influence of Bisphenol A (BPA) and Its Analogue Bisphenol S (BPS) on the Enteric Nervous System of the Distal Colon in Mice.

Bisphenol A exposure inhibits vascular smooth muscle cell responses: involvement of proliferation, migration, and invasion.

Ameliorative Effect of Structurally Divergent Oleanane Triterpenoid, 3-Epifriedelinol from Ipomoea batatas against BPA-Induced Gonadotoxicity by Targeting PARP and NF-κB Signaling in Rats.

Products of Bisphenol A Degradation Induce Cytotoxicity in Human Erythrocytes (In Vitro).

Effect of Moringa oleifera Leaves against Hepatotoxicity Induced by Bisphenol A.

Phthalates

DNA methylation-mediated inhibition of MGARP is involved in impaired progeny testosterone synthesis in mice exposed to DBP in utero.

Endocrine adverse effects of mono(2-ethylhexyl) phthalate and monobutyl phthalate in male pubertal rats.

Effect of di(n-butyl) phthalate on the blood-testis barrier during puberty onset.

The role of small GTPases in bisphenol AF -induced multinucleation in comparison with dibutyl phthalate in the male germ cells.

Parabens/Triclosan/Antimicrobials

Transcriptional profiling efficacy to define biological activity similarity for cosmetic ingredients’ safety assessment based on next-generation read-across.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Thymol co-administration abrogates hexachlorobenzene-induced reproductive toxicities in male rats.

Perfluoroalkyl Substances

Perfluorooctane sulfonate-induced oxidative stress contributes to pancreatic β-cell apoptosis by inhibiting cyclic adenosine monophosphate pathway: Prevention by pentoxifylline.

Assessment of the mode of action underlying development of liver lesions in mice following oral exposure to HFPO-DA and relevance to humans.

Flame Retardants

Eucalyptol antagonized the apoptosis and immune dysfunction of grass carp hepatocytes induced by tetrabromobisphenol A by regulating ROS/ASK1/JNK pathway.

Continuous and discontinuous multi-generational disturbances of tetrabromobisphenol A on longevity in Caenorhabditis elegans.

Pesticides

Glyphosate based-herbicide disrupts energy metabolism and activates inflammatory response through oxidative stress in mice liver.

Disruption of the developmental programming of the gonad of the broad snouted caiman (Caiman latirostris) after in ovo exposure to atrazine.

Plantain-based diet decreases oxidative stress and inflammatory markers in the testes of rats exposed to atrazine.

Ipconazole Disrupts Mitochondrial Homeostasis and Alters GABAergic Neuronal Development in Zebrafish.

Roundup in the Reproduction of Crucian Carp (Carassius carassius): An In Vitro Effect on the Pituitary Gland and Ovary.

Alterations in cell viability, reactive oxygen species production, and modulation of gene expression involved in mitogen-activated protein kinase/extracellular regulating kinase signaling pathway by glyphosate and its commercial formulation in hepatocellular carcinoma cells.

Metals/Metalloids

Alpha-lipoic acid inhibits sodium arsenite-mediated autophagic death of rat insulinoma cells.

Derivation of Benchmark Doses for Male Reproductive Toxicity in a Subacute Low-level Pb Exposure Model in Rats.

Melatonin ameliorates arsenic-induced cardiotoxicity through the regulation of the Sirt1/Nrf2 pathway in rats.

Oxidative Stress of Cadmium and Lead at Environmentally Relevant Concentrations on Hepatopancreas of Macrobrachium nipponensis and Their Mixture Interactivity: Implications for Water Quality Criteria Amendment.

Microplastics/Nanomaterials

Mechanistic insights into the adsorption of endocrine disruptors onto polystyrene microplastics in water.

Bioaccumulation of functionalized polystyrene nanoplastics in sea cucumber Apostichopus japonicus (Selenka, 1867) and their toxic effects on oxidative stress, energy metabolism and mitochondrial pathway.

Polystyrene microplastics significantly facilitate influenza A virus infection of host cells.

Higher toxicity induced by co-exposure of polystyrene microplastics and chloramphenicol to Microcystis aeruginosa: Experimental study and molecular dynamics simulation.

Micro-sized polyethylene particles affect cell viability and oxidative stress responses in human colorectal adenocarcinoma Caco-2 and HT-29 cells.

Pharmaceuticals/Personal Care Products

Identification of Biomarkers and Outcomes of Endocrine Disruption in Human Ovarian Cortex Using In Vitro Models. [DES]

Miscellaneous

Antiandrogenic and Estrogenic Activity Evaluation of Oxygenated and Nitrated Polycyclic Aromatic Hydrocarbons Using Chemically Activated Luciferase Expression Assays.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Risk ranking of chemical hazards in foods: comparison of aggregating methods using infant formula as an example.

Wild fish responses to wastewater treatment plant upgrades in the Grand River, Ontario.

BPA/Phenols

Application of High-Performance Liquid Chromatography Combined with Fluorescence Detector and Dispersive Liquid-Liquid Microextraction to Quantification of Selected Bisphenols in Human Amniotic Fluid Samples.

Parabens/Triclosan/Antimicrobials

Triclosan and Methyl Triclosan in Prey Fish in a Wastewater-influenced Estuary.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent Organic Pollutant Levels in Maternal and Cord Blood Plasma and Breast Milk: Results from the Rio Birth Cohort Pilot Study of Environmental Exposure and Childhood Development (PIPA Study).

Assessment of endocrine disrupting chemicals in breast milk: Association with dietary habits and duration of lactation.

Biomonitoring of organic pollutants in pet dog plasma samples in North-Western Spain.

Emerging and legacy contaminants in common minke whale from the Barents sea.

Codeployment of Passive Samplers and Mussels Reveals Major Source of Ongoing PCB Inputs to the Anacostia River in Washington, DC.

Perfluoroalkyl Substances

High density polyethylene (HDPE) and thermoplastic polyurethane (TPU) wristbands as personal passive samplers monitoring per- and polyfluoroalkyl substances (PFASs) exposure to postgraduate students.

Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Human Milk: First Survey from Lebanon.

First Discovery of Iodinated Polyfluoroalkyl Acids by Nontarget Mass-Spectrometric Analysis and Iodine-Specific Screening Algorithm.

Automated and fast online method for simultaneously determining a broad spectrum of per- and polyfluoroalkyl substances in a small volume of cerebrospinal fluid.

Does contaminant exposure disrupt maternal hormones deposition? A study on per- and polyfluoroalkyl substances in an Arctic seabird.

Flame Retardants

Differences in mirex [dechlorane] and dechlorane plus [syn- and anti-] concentrations observed in Canadian human milk.

Disentangling Source Profiles and Time Trends of Halogenated Flame Retardants in the Great Lakes.

Atmospheric deposition contributed mostly to organophosphorus flame retardant entering into the Bohai Sea, China.

Pesticides

Missing the mark — new methods needed to detect and address high-risk pesticide residues in the global food supply.

Metals/Metalloids

Community Perceptions of Arsenic Contaminated Drinking Water and Preferences for Risk Communication in California’s San Joaquin Valley.

Temporal changes of blood mercury concentrations in Chinese newborns and the general public from 1980s to 2020s.

Microplastics/Nanomaterials

Microplastics in polystyrene-made food containers from China: abundance, shape, size, and human intake.

Beached microplastics at the Bahia Blanca Estuary (Argentina): Plastic pellets as potential vectors of environmental pollution by POPs.

Pharmaceuticals/Personal Care Products

Dermal exposure and hair dye: Assessing potential bladder cancer risk from permanent hair dye.

Miscellaneous

Occurrence and risk assessment of 3-monochloropropanediols esters (3-MCPDE), 2-monochloropropanediol esters (2-MCPDE), and glycidyl esters (GE) in commercial infant formula samples from Malaysia.

Global assessment of chemical quality of drinking water: The case of trihalomethanes.

Endocrine disrupting activity in sewage sludge: Screening method, microbial succession and cost-effective strategy for detoxification.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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