EDC Science Weekly, Jan. 5-11, 2024

Post author:HEEDS
Post published:January 11, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Regulating flame retardants as a class; personal care product use and phthalates during pregnancy; prenatal exposure to EDCs and postpartum depression; BADGE in Japanese infants in the NICU; applying Key Characteristics to identify potential breast carcinogens.

More science highlights

Events

Course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) This two-week course in May at Woods Hole is accepting applications, due Jan. 15. Financial aid is available.

Symposium Jan. 22-24: USA Exposome Symposium: Children’s Health, Environmental Justice, and the Exposome [Mt Sinai and Meharry Medical College]

Webinar Jan. 25: CHE Café: Multisolving for climate, chemicals & health [CHE and the New School at Commonweal]

CME course Feb. 13: How Environmental Health Research Guides Clinical Care: PFAS, Obesity, and Bone Health [The Pediatric Environmental Health Center at Boston Children’s Hospital and the New England Region Pediatric Environmental Health Specialty Unit]

Webinar Feb. 20: How NY is Holding Pepsi Accountable for Its Plastic Pollution – & Your State Can, Too [Beyond Plastics]

Webinar Feb. 22: Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024. Abstracts are due Feb. 1.

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Regulations/Policy

Opportunities in Assessing and Regulating Organohalogen Flame Retardants (OFRs) as a Class in Consumer Products.

Metabolites in the regulatory risk assessment of pesticides in the EU.

Pesticide active substances that do not require a review of the existing maximum residue levels under Article 12 of Regulation (EC) No 396/2005.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly Available in Vivo, in Vitro, and in Silico Data. [see related Invited Perspective: New Motivations and Future Directions for Investigating Environmental Risk Factors for Breast Cancer and More than 900 common chemicals linked to breast cancer risk: Study]

TISBE: A Public Web Platform for the Consensus-Based Explainable Prediction of Developmental Toxicity.

NeuTox: A weighted ensemble model for screening potential neuronal cytotoxicity of chemicals based on various types of molecular representations.

Examining animal testing for risk assessment: A WC-12 workshop report.

Alternative methods go green! Green toxicology as a sustainable approach for assessing chemical safety and designing safer chemicals

Halogenation of common phenolic household and personal care product ingredients enhances their AhR-modulating capacity.

Predictive value of the ToxCast/Tox21 high throughput toxicity screening data for approximating in vivo ecotoxicity endpoints and ecotoxicological risk in eco- surveillance applications.

Control list of high-priority chemicals based on 5-HT-RI functionality and the human health interference effects selective CNN-GRU deep learning model.

Development of an adverse outcome pathway network for nephrotoxicity.

An integrated new approach methodology for inhalation risk assessment of safe and sustainable by design nanomaterials.

More tools, reports, and resources

Commentaries

Fertility in indigenous communities: An environmental justice perspective.

Scrutinizing the effect of BPS on adipose tissue.

Endocrine-disrupting chemicals and epigenetic reprogramming in developmental origin of uterine fibroids.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine disruptors and male sexual health.

Cardiovascular Disease in Low-and Middle-Income Countries Associated with Environmental Factors.

Emerging contaminants and their potential impacts on estuarine ecosystems: Are we aware of it?

BPA/Phenols

Bisphenol A and polycystic ovary syndrome in human: A systematic review.

Phthalates

Effect of prenatal exposure to phthalates on birth weight of offspring: A meta-analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxins emissions from bio-medical waste incineration: A systematic review on emission factors, inventories, trends and health risk studies.

Pesticides

Systematic review of residual toxicity studies of pesticides to bees and veracity of guidance on pesticide labels.

Metals/Metalloids

Exploring the Potential Link between Aluminum-Containing Deodorants/Antiperspirants and Breast Cancer: A Comprehensive Review.

Arsenic toxicity: sources, pathophysiology and mechanism.

Mechanism of Cadmium-induced nephrotoxicity.

Microplastics/Nanomaterials

Systematic review of microplastics and nanoplastics in indoor and outdoor air: identifying a framework and data needs for quantifying human inhalation exposures.

Global occurrence characteristics, drivers, and environmental risk assessment of microplastics in lakes: A meta-analysis.

Understanding microplastic pollution: Tracing the footprints and eco-friendly solutions.

Air Pollution

Long-term exposure to air pollution and risk of insulin resistance: A systematic review and meta-analysis.

Maternal health outcomes associated with ambient air pollution: An umbrella review of systematic reviews and meta-analyses.

Pharmaceuticals/Personal Care Products

Antidepressants – The new endocrine disruptors? The case of crustaceans.

Miscellaneous

Removal of emergent pollutants: A review on recent updates and future perspectives on polysaccharide-based composites vis-à-vis traditional adsorbents.

The environmental health impacts of Russia’s war on Ukraine.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to Nonpersistent Environmental Chemicals and Postpartum Depression. (phenols, phthalate metabolites, parabens, or triclocarban)

Prenatal dietary exposure to mixtures of chemicals is associated with allergy or respiratory diseases in children in the ELFE nationwide cohort.

Exposure to biocides and its association with atopic dermatitis among children and adolescents: A population-based cross-sectional study in South Korea. (triclosan, parabens, and 3-phenoxybenzoic acid (3-PBA))

Endocrine Disruptors and Metabolic Changes: Impact on Puberty Control.

BPA/Phenols/Parabens

Prenatal Phenol and Paraben Exposures and Adverse Birth Outcomes: A Prospective Analysis of U.S. Births.

Sex-specific associations of bisphenol A and its substitutes with body fat distribution among US adults: NHANES 2011-2016.

Phthalates

Prenatal exposures to phthalates and life events stressors in relation to child behavior at age 4-6: A combined cohort analysis.

Impact of phthalate metabolites on vitamin D levels and subclinical inflammation: national health and nutrition examination survey, 2013-2018.

Telomere length as a modifier in the relationship between phthalate metabolites exposure and glucose homeostasis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The association of exposure to polychlorinated biphenyls with lipid profile and liver enzymes in umbilical cord blood samples.

OMICs Signatures Linking Persistent Organic Pollutants to Cardiovascular Disease in the Swedish Mammography Cohort.

The Association of Agent Orange Exposure with the progression of monoclonal gammopathy of undetermined significance to multiple myeloma: a population-based study of Vietnam War Era Veterans.

PFAS

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study.

Association of PFDeA exposure with hypertension (NHANES, 2013-2018).

Flame Retardants

Exposure of children to brominated flame retardants and heavy metals in Morocco: Urine and blood levels in association with global cytosine and adenine methylation.

Pesticides

Ingested nitrate and nitrite and end-stage renal disease in licensed pesticide applicators and spouses in the Agricultural Health Study.

Agricultural exposure and risk of ovarian cancer in the AGRIculture and CANcer (AGRICAN) cohort.

Metals/Metalloids

Blood Cadmium Affects the Association between Serum 25-Hydroxyvitamin D₃ and Diabetic Retinopathy Severity in the U.S. Population with Type 2 Diabetes.

Blood Pb levels are associated with prostate cancer prevalence among general adult males: Linking National Cancer Registry (2002-2017) and KNHANES (2008-2017) databases of Korea.

Air Pollution

Prenatal air pollution exposure and childhood obesity: Effect modification by maternal fruits and vegetables intake.

Air Pollutants and Risk of Parkinson’s Disease among Women in the Sister Study.

Particulate matters (PM_2.5, PM₁₀) and the risk of depression among middle-aged and older population: analysis of the Korean Longitudinal Study of Aging (KLoSA), 2016-2020 in South Korea.

Long-term PM_2.5 exposure and early-onset diabetes: Does BMI link this risk?

PM_2.5 constituents associated with childhood obesity and larger BMI growth trajectory: A 14-year longitudinal study.

Exposure to air pollution and ovarian reserve parameters.

Maternal PM2.5 exposure is associated with preterm birth and gestational diabetes mellitus, and mitochondrial OXPHOS dysfunction in cord blood.

Wildfire smoke exposure during pregnancy and perinatal, obstetric, and early childhood health outcomes: A systematic review and meta-analysis.

Exploring spatiotemporal pattern in the association between short-term exposure to fine particulate matter and COVID-19 incidence in the continental United States: a Leroux-conditional-autoregression-based strategy.

Miscellaneous

Association between polycyclic aromatic hydrocarbons exposure with red cell width distribution and ischemic heart disease: insights from a population-based study.

Laboratory Studies

Numerous Chemicals/Mixtures

Dose addition in mixtures of compounds with dissimilar endocrine modes of action in in vitro receptor activation assays and the zebrafish sexual development test.

Chemical mixture that targets the epidermal growth factor pathway impairs human trophoblast cell functions.

Metabolic effects of nuclear receptor activation in vivo after 28-day oral exposure to three endocrine-disrupting chemicals. [BPA, PFOA, PCN)

Estradiol and Benzo[a]pyrene Co-Exposure Contributes to Lung Cancer Cell A549 Proliferation through AHR/AKT/ERK1/2 Pathway.

BPA/Phenols

Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice.

Maternal exposure to bisphenol S reduces anxiety and impairs collective antipredator behavior of male zebrafish (Danio rerio) offspring through dysregulation of their serotonergic system.

Halogenated bisphenol A derivatives potently inhibit human and rat 11β-hydroxysteroid dehydrogenase 1: Structure-activity relationship and molecular docking.

Bisphenol a downregulates GLUT4 expression by activating aryl hydrocarbon receptor to exacerbate polycystic ovary syndrome.

Phthalates

Disrupting the gut microbiota/metabolites axis by Di-(2-ethylhexyl) phthalate drives intestinal inflammation via AhR/NF-κB pathway in mice.

ARTS is essential for di-2-ethylhexyl phthalate (DEHP)-induced apoptosis of mouse Leydig cells.

Di-2-ethylhexyl phthalate disrupts hepatic lipid metabolism in obese mice by activating the LXR/SREBP-1c and PPAR-α signaling pathways.

Parabens/Triclosan/Antimicrobials

Effects of chronic triclosan exposure on nephrotoxicity and gut microbiota dysbiosis in adult mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Insight into the mechanism of melatonin in attenuating PCB126-induced liver injury: Resistance to ROS-dependent NETs formation to alleviate inflammation and lipid metabolism dysfunction.

Persistent Organic Pollutants released from decomposed adipose tissue affect mitochondrial enzyme function in the brain and eyes other than the liver.

PFAS

Per- and polyfluoroalkyl substance (PFAS) mixtures induce gut microbiota dysbiosis and metabolic disruption in silkworm (Bombyx mori L.).

Assessment of perfluorocarboxylic acids in fluorinated high-density polyethylene containers and estimation of potential non-cancer risks associated with anticipated use scenarios.

Distinct bile acid alterations in response to a single administration of PFOA and PFDA in mice.

Single-cell RNA sequencing reveals the role of mitochondrial dysfunction in the cardiogenic toxicity of perfluorooctane sulfonate in human embryonic stem cells.

Perfluorooctanoic acid induces Leydig cell injury via inhibition of autophagosomes formation and activation of endoplasmic reticulum stress.

HNF4A as a potential target of PFOA and PFOS leading to hepatic steatosis: Integrated molecular docking, molecular dynamic and transcriptomic analyses.

Flame Retardants

Derivation of aquatic predicted no-effect concentration and ecological risk assessment for triphenyl phosphate and tris(1,3-dichloro-2-propyl) phosphate.

Hepatic glucuronidation of tetrabromobisphenol A and tetrachlorobisphenol A: interspecies differences in humans and laboratory animals and responsible UDP-glucuronosyltransferase isoforms in humans.

The mechanism of photodegradation reaction of different dissociation forms of tetrabromobisphenol S in water with free radicals and the ecotoxicity evaluation of related products.

Bioaccumulation and thyroid endocrine disruption of 2-ethylhexyl diphenyl phosphate at environmental concentration in zebrafish larvae.

Chronic neurotoxicity of Tetrabromobisphenol A: Induction of oxidative stress and damage to neurons in Caenorhabditis elegans.

Integrated Studies on Male Reproductive Toxicity of Bis(2-ethylhexyl)-tetrabromophthalate: in Silico, in Vitro, ex Vivo, and in Vivo.

Pesticides

Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells.

Enantioselective Toxicity and Potential Endocrine-Disruptive Effects of the Insecticides Flufiprole and Ethiprole on Danio rerio.

Metals/Metalloids

Intrauterine arsenic exposure induces glucose metabolism disorders in adult offspring by targeting TET2-mediated DNA hydroxymethylation reprogramming of HNF4α in developing livers, an effect alleviated by ascorbic acid.

Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations.

Developmental exposure to methylmercury alters GAD67 immunoreactivity and morphology of endothelial cells and capillaries of midbrain and hindbrain regions of adult rat offspring.

Microplastics/Nanomaterials

Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF-κB pathway.

Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals.

Realistic microplastics harness bacterial presence and promote impairments in early zebrafish embryos: Behavioral, developmental, and transcriptomic approaches.

New Sight of Renal Toxicity Caused by UV-Aged Polystyrene Nanoplastics: Induced Ferroptosis via Adsorption of Transferrin.

Combined toxic effects of polystyrene microplastics and 3,6-dibromocarbazole on zebrafish (Danio rerio) embryos.

Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics-instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment.

Surface functional groups on nanoplastics delay the recovery of gut microbiota after combined exposure to sulfamethazine in marine medaka (Oryzias melastigma).

An Atomic-Level Perspective on the interactions between Organic Pollutants and PET particles: A Comprehensive Computational and DFT Investigation.

Miscellaneous

Neurological impairment is crucial for tire rubber-derived contaminant 6PPDQ-induced acute toxicity to rainbow trout.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

First determination of elevated levels of plastic additives in finless porpoises from the South China Sea. (flame retardants and phthalates)

Characterization of organic contaminants in hair for biomonitoring purposes. [phthalates, pyrethroids and organophosphate flame retardants]

BPA/Phenols

Measurement of Bisphenol A Diglycidyl Ether (BADGE), BADGE derivatives, and Bisphenol F Diglycidyl Ether (BFDGE) in Japanese infants with NICU hospitalization history.

Phthalates

Personal care product use patterns in association with phthalate and replacement biomarkers across pregnancy.

Ultra-processed and fast food consumption, exposure to phthalates during pregnancy, and socioeconomic disparities in phthalate exposures.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Monk seals (Monachus monachus) in the Mediterranean Sea: The threat of organochlorine contaminants and polycyclic aromatic hydrocarbons.

Four Years of Active Sampling and Measurement of Atmospheric Polycyclic Aromatic Hydrocarbons and Oxygenated Polycyclic Aromatic Hydrocarbons in Dronning Maud Land, East Antarctica.

Polychlorinated Naphthalenes in Foods from the French Market: Occurrence, Dietary Exposure, and Evaluation of Relative Contributions to Dioxin-like Contaminants.

PFAS

Per- and polyfluoroalkyl ether acids in well water and blood serum from private well users residing by a fluorochemical facility near Fayetteville, North Carolina.

Assessing potential human health and ecological implications of PFAS from leave-in dental products.

New PFASs Identified in AFFF Impacted Groundwater by Passive Sampling and Nontarget Analysis.

Legacy and emerging per- and polyfluoroalkyl substances in the Shuidong bay of South China: Occurrence, partitioning behavior, and ecological risks.

Occurrence, source apportionment, and ecological risk of legacy and emerging per- and poly-fluoroalkyl substances (PFASs) in the Dahei river basin of a typical arid region in China.

Transport and dispersion of PFOA and PFOS in the Black Sea.

Flame Retardants

Twenty years later: PBDEs in fish from U.S. sites with historically extreme contamination.

Organophosphate esters in the urban atmosphere of Thessaloniki city, Greece.

Pesticides

Pesticides in Greenhouse Airborne Particulate Matter: Occurrence, Distribution, Transformation Products, and Potential Human Exposure Risks.

[Determination of 118 pesticide residues in urine by ultra-high performance liquid chromatography-tandem mass spectrometry]. [Chinese]

Biomonitoring and risk assessment of human exposure to triazole fungicides.

Laboratory measurements underestimate persistence of the aquatic herbicide fluridone in lakes.

Sublethal effects of imidacloprid-contaminated honey stores on colony performance, queens, and worker activities in fall and early winter colonies.

Metals/Metalloids

A comparison of the effects of two cooking methods on arsenic species and nutrient elements in rice.

Effect of Community Water Service on Lead in Drinking Water in an Environmental Justice Community.

Assessment of sources and health risks of heavy metals in metropolitan household dust among preschool children: The LEAPP-HIT study.

Microplastics/Nanomaterials

Rapid single-particle chemical imaging of nanoplastics by SRS microscopy [this got a lot of press, e.g., Bottled Water Can Contain Hundreds of Thousands of Previously Uncounted Tiny Plastic Bits, Study Finds]

Comprehensive assessment of microplastics in Australian biosolids: Abundance, seasonal variation and potential transport to agroecosystems.

Potential environmental risks of field bio/non-degradable microplastic from mulching residues in farmland: Evidence from metagenomic analysis of plastisphere.

Are we underestimating stormwater? Stormwater as a significant source of microplastics in surface waters.

Air Pollution

Sociodemographic inequities in the burden of carcinogenic industrial air emissions in the United States.

Pharmaceuticals/Personal Care Products

[Determination of 145 pharmaceuticals and personal care products in eleven categories in water by ultra-high performance liquid chromatography-triple quadrupole mass spectrometry]. [Chinese]

Miscellaneous

Organic toxicants and emerging contaminants in hospital interiors before and during the SARS-CoV2 pandemic: alkanes and PAHs.

Association between gut health and gut microbiota in a polluted environment.

Legacy coal mining impacts downstream ecosystems for decades in the Canadian Rockies.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.