EDC Science Weekly, Jan. 27 – Feb. 2, 2023 – HEEDS

EDC Science Weekly, Jan. 27 – Feb. 2, 2023

Post author:HEEDS
Post published:February 2, 2023
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb 10: CHE Café: What’s Next in Environmental Health? (Collaborative for Health and Environment, CHE)

Webinar Feb 15: Office Workers’ Exposures: Hormonal Activity of Chemicals Detected with Silicone Wristbands (EDC Strategies Partnership)

Webinar Feb 23: Environmental Justice and the Built Environment: Protecting Children and Families (CHE)

For more events see the January 2023 issue of HEEDS News

Methods/Tools/Screening

Integrating high-throughput exposure assessment and in vitro screening data to prioritize endocrine-active potential and dietary risks of pesticides and veterinary drug residues in animal products.

Risk assessment of chemicals and their mixtures are hindered by scarcity and inconsistencies between different environmental exposure limits.

Combining time-resolved transcriptomics and proteomics data for Adverse Outcome Pathway refinement in ecotoxicology.

Think positive: Proposal of a simple method to create reference materials in the frame of microplastics research.

Big Question to Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022.

Commentaries

Can lipophilic pollutants in adipose tissue explain weight change-related risk in type 2 diabetes mellitus?

The Montreal Protocol and the fate of environmental plastic debris.

Global Beauty Hazard: Assessing Mercury in Skin-Lightening Products. [Science Selection in EHP]

Will Artificial Intelligence be Useful (or Mis-used) in Environmental Toxicology and Chemistry?

Reviews

Numerous Chemicals/Mixtures

The pollutome-connectome axis: A putative mechanism to explain pollution effects on neurodegeneration.

Molecular mechanisms of environmental exposures and human disease.

Use of wristbands to measure exposure to environmental pollutants in children: recent advances and future directions

Perfluoroalkyl Substances

Occupational exposures to airborne per- and polyfluoroalkyl substances (PFAS)-A review.

Pesticides

Paraquat and Parkinson’s disease: The molecular crosstalk of upstream signal transduction pathways leading to apoptosis.

Metals/Metalloids

Telomeres susceptibility to environmental arsenic exposure: Shortening or lengthening?

Microplastics/Nanomaterials

A critical review on recent research progress on microplastic pollutants in drinking water.

How plastic debris and associated chemicals impact the marine food web: A review.

Air Pollution

Indoor environment exposure and children health

Miscellaneous

Impact of polycyclic aromatic hydrocarbon exposure on cognitive function and neurodegeneration in humans: A systematic review and meta-analysis.

Tire wear particles: Trends from bibliometric analysis, environmental distribution with meta-analysis, and implications

Human Health Studies

Phthalates

Association between urinary phthalate biomarker concentrations and adiposity among postmenopausal women.

Transcriptional analysis in peripheral blood cells of individuals with elevated phthalate exposure – Results of the EuroMix study.

Ovarian volume partially explains associations of phthalate biomarkers with anti-Müllerian hormone and estradiol in midlife women.

Parabens/Triclosan/Antimicrobials

Urinary concentration of selected nonpersistent endocrine disrupting chemicals-reproductive outcomes among women from a fertility clinic.

Prenatal paraben exposures and birth size: Sex-specific associations in a healthy population – A study from the Odense Child Cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Cross-sectional associations of persistent organic pollutants measured in adipose tissue and metabolic syndrome in clinically diagnosed middle-aged adults.

Association of pre-pregnancy maternal overweight/obesity and dietary intake during pregnancy with the concentrations of persistent organic pollutants in the human milk of women from Rio de Janeiro, Brazil.

Risk of cardiovascular diseases following residential exposure to airborne polychlorinated biphenyls: A register-based cohort study.

Organochlorine pesticides, oxidative stress biomarkers, and leukemia: a case-control study.

Perfluoroalkyl Substances

Perfluoroalkyl Acids in Follicular Fluid and Embryo Quality during IVF: A Prospective IVF Cohort in China.

Red Blood Cell Folate Modifies the Association between Serum Per- and Polyfluoroalkyl Substances and Antibody Concentrations in U.S. Adolescents.

Poly- and perfluoroalkyl substances exposure during pregnancy and postpartum depression: Evidence from the Shanghai birth cohort.

Metals/Metalloids

An exposome connectivity paradigm for the mechanistic assessment of the effects of prenatal and early life exposure to metals on neurodevelopment.

Determination of potential sources of heavy metals in patients with urothelial carcinoma in central Taiwan: a biomonitoring case-control study.

Air Pollution

Decrease of air pollution during lockdown in Tuscany (Italy): An effect on sperm DNA fragmentation?

Gestational age-dependent decrease in fetal Hofbauer cells in placentas from pregnancies exposed to wildfire smoke in California.

Women with preeclampsia exposed to air pollution during pregnancy: Relationship between oxidative stress and neonatal disease – Pilot study.

Exposure to air pollution and gains in body weight and waist circumference among middle-aged and older adults.

Accumulation of Black Carbon Particles in Placenta, Cord Blood, and Childhood Urine in Association with the Intestinal Microbiome Diversity and Composition in Four- to Six-Year-Old Children in the ENVIRONAGE Birth Cohort.

Miscellaneous

Multiple statistical models reveal specific volatile organic compounds affect sex hormones in American adult male: NHANES 2013-2016.

Prenatal exposure to benzotriazoles and benzothiazoles and child neurodevelopment: A longitudinal study.

Laboratory Studies

BPA/Phenols

Developmental programming: Adipose depot-specific regulation of non-coding RNAs and their relation to coding RNA expression in prenatal testosterone and prenatal bisphenol-A -treated female sheep.

Lysosome-related exosome secretion mediated by miR-26b / Rab31 pathway was associated with the proliferation and migration of MCF-7 cells treated with BPA.

Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice.

Binding sites in the epidermal growth factor receptor are responsible for bisphenol S effects on trophoblast cell invasion.

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study.

Transcriptomic analysis reveals up-regulated histone genes may play a key role in zebrafish embryo-larvae response to Bisphenol A (BPA) exposure.

Morphological, immunohistochemical, and biochemical study on the ameliorative effect of gallic acid against bisphenol A-induced nephrotoxicity in male albino rats.

Impacts of bisphenol A on growth and reproductive traits of submerged macrophyte Vallisneria natans.

The toxicity of 4-tert-butylphenol in early development of zebrafish: morphological abnormality, cardiotoxicity, and hypopigmentation.

Phthalates

Effects of phthalates on human chorionic trophoblast cells and mouse embryonic development.

Paternal phthalate exposure-elicited offspring metabolic disorders are associated with altered sperm small RNAs in mice.

Intrauterine exposure to di(2-ethylhexyl) phthalate (DEHP) disrupts the function of the hypothalamus-pituitary-thyroid axis of the F1 rats during adult life.

Exposure to dipentyl phthalate in utero disrupts the adrenal cortex function of adult male rats by inhibiting SIRT1/PGC-1α and inducing AMPK phosphorylation.

Reproductive and Developmental Alterations on Zebrafish (Danio rerio) Upon Long-Term Exposure of Di-ethyl phthalate (DEP), Di-isononyl phthalate (DINP) and Di (2-ethylhexyl) phthalate (DEHP).

Parabens/Triclosan/Antimicrobials

Studying paraben-induced estrogen receptor- and steroid hormone-related endocrine disruption effects via multi-level approaches.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants affect steroidogenic and apoptotic activities in granulosa cells and reactive oxygen species concentrations in oocytes in the mouse.

AhR-mediated lipid peroxidation contributes to TCDD-induced cardiac defects in zebrafish.

2,3,7,8-Tetrachlorodibenzo-p-dioxin induces multigenerational alterations in the expression of microRNA in the thymus through epigenetic modifications.

Perfluoroalkyl Substances

Perfluorooctanoic acid exposure and its neurodegenerative consequences in C57BL6/J mice.

Dysfunction of liver-gut axis in marine medaka exposed to hypoxia and perfluorobutanesulfonate.

Flame Retardants

Bioaccumulation and Biotransformation of BDE-47 Using Zebrafish Eleutheroembryos (Danio rerio).

High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways.

Pesticides

Individual and joint effects of glyphosate and cypermethrin formulations on two human cell lines.

Bioaccumulation, metabolism and toxicological effects of chiral insecticide malathion and its metabolites in zebrafish (Danio rerio).

Maternal exposure to a glyphosate-based herbicide impairs placental development through endoplasmic reticulum stress in mice.

Chlorpyrifos-induced dysregulation of synaptic plasticity in rat hippocampal neurons.

Assessment of Global DNA Methylation in SH-SY5Y Cells Exposed to the Neonicotinoid Insecticides Imidacloprid and Thiamethoxam.

Honeybee queen exposure to a widely used fungicide disrupts reproduction and colony dynamic.

Metals/Metalloids

Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats.

Ameliorative effect of Brassica oleracea var. Italica extract on oxidative damage of arsenic in the rat’s brain: biochemical, pathological, and behavioral aspects.

Microplastics/Nanomaterials

Evaluation of nanoplastics toxicity to the human placenta in systems.

Effects of polystyrene nanoplastics on melanin interference toxicity and transgenerational toxicity of ethylhexyl salicylate based on DNA methylation sequencing.

Insights into sorption and molecular transport of atrazine, testosterone, and progesterone onto polyamide microplastics in different aquatic matrices.

Pharmaceuticals/Personal Care Products

The potent contraceptive gestodene exerts insulinotropic effects through its a-ring reduced metabolites with intrinsic estrogen-like activity in pancreatic β-cells.

Miscellaneous

Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induce hepatotoxicity in mice.

BPDE, the Migration and Invasion of Human Trophoblast Cells, and Occurrence of Miscarriage in Humans: Roles of a Novel lncRNA-HZ09.

Exposure/Environment Studies

Perfluoroalkyl Substances

Historical Trend of Exposure to Perfluoroalkyl Surfactants PFOA, ADV, and cC6O4 and its Management in Two Perfluoroalkyl Polymers Plants, Italy.

Levels and distribution profiles of Per- and Polyfluoroalkyl Substances (PFAS) in a high Arctic Svalbard ice core.

High-resolution temporal wastewater treatment plant investigation to understand influent mass flux of per- and polyfluoroalkyl substances (PFAS).

Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) in water and edible fish species of Karun River, Ahvaz, Iran: spatial distribution, human health, and ecological risk assessment.

Flame Retardants

Occurrence and tissue-specific partitioning of alternative brominated flame retardants in northwest Atlantic harbor seal pups (Phoca vitulina vitulina).

Pesticides

Prevalence of neonicotinoid insecticides in paired private-well tap water and human urine samples in a region of intense agriculture overlying vulnerable aquifers in eastern Iowa.

Metals/Metalloids

Mercury in multimedia system of Itacaiúnas Basin, Brazilian Amazon: An integrated approach to understand its distribution, origin, and ecological risk.

Review on distribution, fate, and management of potentially toxic elements in incinerated medical wastes.

Microplastics/Plastics

Are microplastics contributing to pollution-induced neurotoxicity? A pilot study with wild fish in a real scenario.

Greater willingness to reduce microplastics consumption in Mexico than in Spain supports the importance of legislation on the use of plastics.

A plastic world: A review of microplastic pollution in the freshwaters of the Earth’s poles.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.