EDC Science Weekly, Jan. 27 – Feb. 2, 2022

Post author:HEEDS
Post published:February 2, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

A framework for chemical safety assessment incorporating new approach methodologies within REACH.

West Oakland’s Experience in Building Community Power to Confront Environmental Injustice Through California’s Assembly Bill 617.

Toxicity data are limited for acute criteriaData and Diversity in the Development of Acute Water Quality Criteria in the United States.

Characterization of ecotoxicological risks from unintentional mixture exposures calculated from European freshwater monitoring data: Forwarding prospective chemical risk management.

Methods/Tools/Screening

Estimation and false discovery control for the analysis of environmental mixtures.

Data-Driven Machine Learning in Environmental Pollution: Gains and Problems.

Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review.

Toward better assessments of developmental toxicity using stem cell-based in vitro embryogenesis models.

Identifying congeners and transformation products of organic contaminants within complex chemical mixtures in impacted surface waters with a top-down non-targeted screening workflow.

Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses.

Have you caught that outlier yet? Evaluate the utility of repeat testing in nutritional and toxic element assessment.

Estimating the health effects of environmental mixtures using principal stratification. [air pollution]

Utility of the avian sub-acute dietary toxicity test in ecological risk assessment and a path forward to reduce animal use.

Using adverse outcome pathways to contextualise (Q)SAR predictions for reproductive toxicity – A case study with aromatase inhibition.

Screening and prioritization of nano- and microplastic particle toxicity studies for evaluating human health risks – development and application of a toxicity study assessment tool.

Commentaries/Conference Summaries

Editorial: Emerging Chemical Risks for Human Health: Endocrine Disruption by Per- and Poly-Fluorinated Alkyl Substances (PFAS). [Editorial for a Frontiers in Endocrinology research topic, Emerging chemical risks for human health: endocrine disruption by per- and poly-fluorinated alkyl substances (PFAS)]

Brominated flame retardants, a cornelian dilemma.

A Children’s Health Perspective on Nano- and Microplastics.

Epigenetics, environment and epidemiology: an interview with Karl Kelsey.

What is an emergency? Neonicotinoids and emergency situations in plant protection in the EU.

Reviews

Numerous Chemicals/Mixtures

The Effects of Environmental Contaminant Exposure on Reproductive Aging and the Menopause Transition.

Integrated Genomic and Bioinformatics Approaches to Identify Molecular Links between Endocrine Disruptors and Adverse Outcomes.

Impacts of Environmental Insults on Cardiovascular Aging.

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota.

Comparative meta-analysis of organic contaminants in sewage sludge from the United States and China.

Phthalates

Prenatal phthalate exposure associated with age-specific alterations in markers of adiposity in offspring: A systematic review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Metabolic Activation and Hepatotoxicity of Furan-containing Compounds.

Perfluoroalkyl Substances

Bioremediation of perfluorochemicals: current state and the way forward.

Exposure pathways and bioaccumulation of per- and polyfluoroalkyl substances in freshwater aquatic ecosystems: Key considerations.

Flame Retardants

Environmental exposure to BFRs: Unraveling endocrine and mammary gland effects that may increase disease risk.

Industrial Production of Organophosphate Flame Retardants (OPFRs): Big Knowledge Gaps Need to Be Filled?

Comprehensive review of the impact of tris(2,3-dibromopropyl) isocyanurate (TBC or TDBP-TAZTO) on living organisms and the environment.

Pesticides

Endocrine disruption by azole fungicides in fish: A review of the evidence.

A Common Feature of Pesticides: Oxidative Stress-The Role of Oxidative Stress in Pesticide-Induced Toxicity.

Mechanisms of toxicity and residue considerations of rodenticide exposure in food Animals-a FARAD perspective.

miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review.

The effectiveness of educational interventions aimed at agricultural workers’ knowledge, behaviour, and risk perception for reducing the risk of pesticide exposure: a systematic review and meta-analysis.

Potentially Toxic Elements

Fluoride Toxicity.

Review of regulatory reference values and background levels for heavy metals in the human diet.

Integrated approaches to mitigate threats from emerging potentially toxic elements: A way forward for sustainable environmental management.

Microplastics

Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence.

Emerging investigator series: microplastic sources, fate, toxicity, detection, and interactions with micropollutants in aquatic ecosystems – a review of reviews.

Occurrence, impact, toxicity, and degradation methods of microplastics in environment-a review.

Micro/nano-plastics occurrence, identification, risk analysis and mitigation: challenges and perspectives.

Interactions of microplastics and main pollutants and environmental behavior in soils.

Air Pollution

Air Pollution and Perinatal Health in the Eastern Mediterranean Region: Challenges, Limitations, and the Potential of Epigenetics.

Pharmaceuticals/Personal Care Products

Differences between hairdressers and consumers in skin exposure to hair cosmetic products: a review.

Persistence, environmental hazards, and mitigation of pharmaceutically active residual contaminants from water matrices.

Miscellaneous

Telomeres and anthropogenic disturbances in wildlife: a systematic review and meta-analysis.

Human Health Studies

Numerous Chemicals/Mixtures

Environmental exposures to pesticides, phthalates, phenols and trace elements are associated with neurodevelopment in the CHARGE study.

BPA/Phenols

Association between urinary environmental phenols and the prevalence of cardiovascular diseases in US adults.

Phthalates

Urinary phthalate and DINCH metabolite concentrations and gradations of maternal glucose intolerance.

Prenatal phthalates, gestational weight gain, and long-term weight changes among Mexican women.

Exposure to Di-2-ethylhexyl Phthalate and Benign Prostatic Hyperplasia, NHANES 2001-2008.

Parabens/Triclosan/Antimicrobials

Measurement of Urinary Triclocarban and 2,4-Dichlorophenol Concentration and Their Relationship with Obesity and Predictors of Cardiovascular Diseases among Children and Adolescents in Kerman, Iran.

Associations between low-dose triclosan exposure and semen quality in a Chinese population.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effect of Low-Dose Persistent Organic Pollutants on Mitochondrial Function: Human and in Vitro Evidence.

Perfluoroalkyl Substances

Prenatal Exposure to Per- and Polyfluoroalkyl Substances and Facial Features at 5 Years of Age: A Study from the Danish National Birth Cohort. [see related: Invited Perspective: Using Facial Features as an Endophenotypic Marker of Susceptibility to Environmental Exposures.]

Pesticides

Pesticide residues levels as hematological biomarkers-a case study, blood serum of greenhouse workers in the city of Hamadan, Iran.

Association between maternal insecticide use and otitis media in one-year-old children in the Japan Environment and Children’s Study.

Environmental risk factors for amyotrophic lateral sclerosis: a case-control study in Canada and France.

Potentially Toxic Elements

Prenatal metal(loid) mixtures and birth weight for gestational age: A pooled analysis of three cohorts participating in the ECHO program.

Maternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico.

Associations among prenatal and postnatal arsenic, lead, and cadmium exposures and motor development in 3-year-old children: a longitudinal birth cohort study in Taiwan.

Relationship Between Serum Levels of Arsenic, Cadmium, and Mercury and Body Mass Index and Fasting Plasma Glucose in a Mexican Adult Population.

Serum cadmium is associated with hepatic steatosis and fibrosis: Korean national health and nutrition examination survey data IV-VII.

Chronic lead exposure induces fatty liver disease associated with the variations of gut microbiota. [human and animal study]

Air Pollution

Child Survival and Early Lifetime Exposures to Ambient Fine Particulate Matter in India: A Retrospective Cohort Study.

Urinary polycyclic aromatic hydrocarbon metabolites and depression: a cross-sectional study of the National Health and Nutrition Examination Survey 2005-2016.

Associations Between Symptoms of Depression and Air Pollutant Exposure Among Older Adults: Results From the Taiwan Longitudinal Study on Aging (TLSA).

Impact of Long-Term Exposure to Air Pollution on Cognitive Decline in Older Adults Without Dementia.

B vitamin intakes modify the association between particulate air pollutants and incidence of all-cause dementia: Findings from the Women’s Health Initiative Memory Study.

Miscellaneous

Association between urinary trans,trans-muconic acid and diabetes: a cross-sectional analysis of data from Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017).

Laboratory Studies

Numerous Chemicals/Mixtures

Adipogenic Activity of Chemicals Used in Plastic Consumer Products.

High throughput screening of bisphenols and their mixtures under conditions of low-intensity adipogenesis of human mesenchymal stem cells (hMSCs).

Sea Anemones Responding to Sex Hormones, Oxybenzone, and Benzyl Butyl Phthalate: Transcriptional Profiling and in Silico Modelling Provide Clues to Decipher Endocrine Disruption in Cnidarians.

Manipulation of cadmium and diethylhexyl phthalate on Rana chensinensis tadpoles affects the intestinal microbiota and fatty acid metabolism.

BPA/Phenols

Bisphenol A reveals its obesogenic effects through disrupting glucose tolerance, oxidant-antioxidant balance, and modulating inflammatory cytokines and fibroblast growth factor in zebrafish.

Endocrine disruption from plastic pollution and warming interact to increase the energetic cost of growth in a fish.

Phthalates

Toxicology and carcinogenesis studies of di(2-ethylhexyl) phthalate administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. [by NTP]

In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites. [a DEHP alternative]

Parabens/Triclosan/Antimicrobials

Evaluation of the effect of isobutyl paraben and 2-ethyl hexyl paraben on p-glycoprotein functional expression in rats: a pharmacokinetic study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

TCDD aggravates the formation of the atherosclerotic plaque in ApoE KO mice with a sexual dimorphic pattern.

Perfluoroalkyl Substances

In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor.

Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation.

Perfluorooctanoic acid (PFOA) disrupts ovarian steroidogenesis and folliculogenesis in adult mice.

Assessment of the migration of perfluorinated compounds and primary aromatic amines from PTFE-coated non-stick cookware marketed in Turkey.

Flame Retardants

Integrated assessment of endocrine disrupting potential of four novel brominated flame retardants.

Organotins

Potencies of organotin compounds in scallop RXRa responsive activity with a GAL4-based reconstituted yeast assay in vitro.

Pesticides

Realistic exposure to fipronil, 2,4-D, vinasse and their mixtures impair larval amphibian physiology.

Chlorothalonil alters the gut microbiota and reduces the survival of immature honey bees reared in vitro.

A cell-based electrochemical sensor for assessing immunomodulatory effects by atrazine and its metabolites.

Integrated metabolomics and transcriptomics analysis reveals new biomarkers and mechanistic insights on atrazine exposures in MCF‑7 cells.

Physiological and metabolic alterations induced by commercial neonicotinoid formulations in Daphnia magna.

Mechanisms and histopathological impacts of acetamiprid and azoxystrobin in male rats.

Changes in defense capacity to infectious hematopoietic necrosis virus (IHNv) in rainbow trout intergenerationally exposed to glyphosate.

Cypermethrin inhibits Leydig cell development and function in pubertal rats.

Potentially Toxic Elements

Intrauterine exposure of mice to arsenite induces abnormal and transgenerational glycometabolism.

Involvement of environmentally relevant toxic metal mixture in Alzheimer’s disease pathway alteration and protective role of berberine: Bioinformatics analysis and toxicogenomic screening.

Mercury impairs human primary endometrial stromal cell function.

Sex-specific effects of fluoride and lead exposures on histology, antioxidant physiology, and immune system in the liver of zebrafish (Danio rerio).

Prenatal Cadmium Exposure Alters Proliferation in Mouse CD4⁺ T Cells via LncRNA Snhg7.

Effects of intrauterine and lactational exposure to lanthanum nitrate on BALB/c offspring mice: Developmental immunotoxicity and self-recovery.

Transcriptomics and transmission ultrastructural examination reveals the nephrotoxicity of cadmium in laying hens.

Micro/Nanoplastics

A new discovery of polystyrene microplastics toxicity: The injury difference on bladder epithelium of mice is correlated with the size of exposed particles.

Effects of polyethylene microplastics on cell membranes: A combined stud y of experiments and molecular dynamics simulations.

Biodegradable and conventional microplastics posed similar toxicity to marine algae Chlorella vulgaris.

Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain.

Impacts of nanoplastics on life-history traits of marine rotifer (Brachionus plicatilis) are recovered after being transferred to clean seawater.

Bioaccumulation of additives and chemical contaminants from environmental microplastics in European seabass (Dicentrarchus labrax).

Classification and identification of polar pollutants on microplastics from freshwater using nontarget screening strategy.

Air Pollution

GLIS3 mediated by the Rap1/PI3K/AKT signal pathway facilitates real-ambient PM_2.5 exposure disturbed thyroid hormone homeostasis regulation.

Pharmaceuticals/Personal Care Products

Toxicological effects of atenolol and venlafaxine on zebrafish tissues: Bioaccumulation, DNA hypomethylation, and molecular mechanism.

Norethindrone alters growth, sex differentiation and gene expression in marine medaka (Oryzias melastigma).

Short-term exposure to pharmaceuticals negatively impacts marine flatfish species: histological, biochemical and molecular clues for an integrated ecosystem risk assessment.

Miscellaneous

Dispersed Crude Oil Induces Dysbiosis in the Red Snapper Lutjanus campechanus External Microbiota.

Exposure to N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) affects the growth and development of zebrafish embryos/larvae.

Insights into disruption of lipid metabolism in digestive gland of female scallop Chlamys farreri under B[a]P exposure.

Sulfite may disrupt estrogen homeostasis in human via inhibition of steroid arylsulfatase.

Assessment of eco-toxic effects of commonly used water disinfectant on zebrafish (Danio rerio) swimming behaviour and recovery responses: an early-warning biomarker approach.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Environmental endocrine disruptor concentrations in urine samples from Mexican Indigenous women.

Multiclass and multi-residue screening of mycotoxins, pharmacologically active substances, and pesticides in infant milk formulas through ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry analysis.

Non-target screening for the identification of migrating compounds from reusable plastic bottles into drinking water.

Assessment of migrating endocrine-disrupting chemicals in bottled acidic juice using type UVM-7 mesoporous silica modified with cyclodextrin.

Persistent, Bioaccumulative, and Toxic Chemicals in Wild Alpine Insects: A Methodological Case Study.

BPA/Phenols

Bisphenol S in individual and composite meat and meat products and implication for its sources.

Identification of bisphenols and derivatives in greenhouse dust as a potential source for human occupational exposure.

Patterns of environmental exposure to phenols in couples who plan to become pregnant.

Phthalates

Exposure to 15 phthalates and two substitutes (DEHTP and DINCH) assessed in trios of infants and their parents as well as longitudinally in infants exclusively breastfed and after the introduction of a mixed diet.

Parabens/Triclosan/Antimicrobials

The curious case of methylparaben: Anthropogenic contaminant or natural origin?

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Recent Progress on Toxicity and Detection Methods of Polychlorinated Biphenyls in Environment and Foodstuffs.

Behaviors and trophodynamics of o,p’-dichlorodiphenyltrichloroethane (o,p’-DDT) in the aquatic food web: Comparison with p,p’-DDT.

Perfluoroalkyl Substances

A review of PFAS fingerprints in fish from Norwegian freshwater bodies subject to different source inputs.

Per- and poly-fluoroalkyl substances in sediments from the water-level-fluctuation zone of the Three Gorges Reservoir, China: Contamination characteristics, source apportionment, and mass inventory and loadings.

Limitations of Current Approaches for Predicting Groundwater Vulnerability from PFAS Contamination in the Vadose Zone.

Particle size distribution, wet deposition and scavenging effect of per- and polyfluoroalkyl substances (PFASs) in the atmosphere from a subtropical city of China.

[Pollution Characteristics and Health Risk Assessment of Perfluorinated Compounds in PM_2.5 in Zhejiang Province].[Chinese]

Flame Retardants

Organophosphate esters in children and adolescents in Liuzhou city, China: concentrations, exposure assessment, and predictors.

Dermal uptake of chlorinated organophosphate flame retardants via contact with furniture fabrics; implications for human exposure.

Exposure of e-waste dismantlers from a formal recycling facility in Spain to inhalable organophosphate and halogenated flame retardants.

Pesticides

Prevalence of Pesticide Use and Occupational Exposure Among Small-Scale Farmers in Western Ethiopia.

Guidance on the assessment of exposure of operators, workers, residents and bystanders in risk assessment of plant protection products.

Potentially Toxic Elements

Balancing the health effect between risks of methylmercury and benefits of nutrients in consumption of Chinese mitten crab (Eriocheir sinensis) in China.

Comprehensive assessment of heavy elements and evaluation of potential human health risk in the urban environment: a case study from Novi Sad, Serbia.

Determination of a guidance value for the communication of individual-level biomonitoring data for urinary arsenic.

New insights into metal(loid) dynamics in the Doce River estuary (Brazil) after a massive iron ore-processing tailing dam collapse.

Microplastics

Microplastic concentration, distribution and dynamics along one of the largest Mediterranean-climate rivers: A whole watershed approach.

Plastic cutting boards as a source of microplastics in meat.

Fate and Effects of Macro- and Microplastics in Coastal Wetlands.

Pharmaceuticals/Personal Care Products

Occurrence and distribution of Pharmaceuticals and Personal Care Products (PPCPs) in wastewater related riverbank groundwater.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.