EDC Science Weekly, Jan. 24-30, 2025

Post author:HEEDS
Post published:January 30, 2025
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Jan. 30 webinar (today!): Product data for public health: Clearya case studies [CHE]

Jan. 30 and Feb. 13 webinars: EDC exposure and gonadal function: consequences and interventions [Endocrine Society EDC Special Interest Group]

Feb. 5 webinar: Science Café: The Massachusetts PFAS and Your Health Study [Silent Spring Institute]

Feb. 10-13: Childhood cancer prevention symposium, in person in Houston TX [CEHN and others]

Feb. 13-14 workshops: How to Conduct Systematic Reviews and Meta-Analyses to Improve Environmental Health Policy and Decision-Making, free and in person at UCSF [UCSF EaRTH Center]

Feb. 19 webinar: Ultrashort-chain PFAS: The global threat of trifluoracetic acid [EDC Strategies Partnership]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting

More events

Regulations/Policy

The Critical Role of Commercial Analytical Reference Standards in the Control of Chemical Risks: The Case of PFAS and Ways Forward and related Invited Perspective: Reference Standards Are Key to Environmental and Human Health Research-The Case of PFAS.

The European Partnership PARC’s Role in Actively Promoting the Uptake of New Approach Methodologies and Next-Generation Risk Assessment into Regulatory Risk Assessment Practice

Opportunities and Challenges of a Cap-and-Trade System for Plastics.

REACH assessment of humans exposed to chemicals indirectly via the environment: screening modeling in EUSES versus state of the science. [by industry]

The European regulatory system for plant protection products-cause of a “Silent Spring” or highly advanced and protective? [by industry]

More EDC policy and regulations open for comment

Methods/Tools/Screening

Thyroid disrupting chemicals during pregnancy: an invitation to collaborate in the consortium on thyroid and pregnancy.

An Overview of Potential Alternatives for the Multiple Uses of Per- and Polyfluoroalkyl Substances.

Determination of the Zebrafish Embryo Developmental Toxicity Assessment (ZEDTA) as an Alternative Non-Mammalian Approach for the Safety Assessment of Agrochemicals.

Evaluation of interspecies correlation estimation models to increase taxonomic diversity while reducing reliance on animal testing for chemicals evaluated under the Toxic Substances Control Act.

Development of the fish invitrome for animal-free environmental risk assessment of chemicals.

Freshwater ecotoxicity characterization factors for PFASs.

Commentaries

Editorial: Emerging topics on chemical safety assessment. [intro to a research topic in Frontiers in Toxicology]

ASPIS Definition of New Approach Methodologies.

High Potential Harm, Questionable Fire-Safety Benefit: Why Are Flame Retardants in Lithium-Ion Battery Enclosures?

Call to introduce environmental preventive medicine courses to the medical curriculum. An initial experience of an education program at the Faculty of Medicine of Nice, University of Côte d’Azur.

Closing the Gaps in Understanding PFAS Toxicology and Metabolism.

Integrating New Approach Methodologies to Address Environmental Pancreatic Toxicity and Metabolic Disorders

Nanoplastics in focus: Exploring interdisciplinary approaches and future directions.

Microplastic and nanoplastic exposure and risk of diabetes mellitus.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Pathophysiological Features of Remodeling in Vascular Diseases: Impact of Inhibitor of DNA-Binding/Differentiation-3 and Estrogenic Endocrine Disruptors.

Epigenetic Mechanisms of Endocrine-Disrupting Chemicals in Breast Cancer and Their Impact on Dietary Intake.

Endocrine-Disrupting Chemicals and Female Reproductive Aging.

Endocrine Disruptors Chemicals: Impacts of Bisphenol A, Tributyltin and Lead on Thyroid Function.

Thematic Review of Endocrine Disruptors and Their Role in Shaping Pubertal Timing.

Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants.

Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health

Food supply toxicants and additives alter the gut microbiota and risk of metabolic disease.

Systematic review on Endocrine Disrupting Chemicals in breastmilk and neuro-behavioral development: insight into the early ages of life.

BPA/Phenols

Endocrine Disrupting Toxicity of Bisphenol A and Its Analogs: Implications in the Neuro-Immune Milieu.

Phthalates

Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles.

The AhR pathway regulation in phthalates-induced cancer promotion, progression and metastasis: a scoping review.

Review of pretreatment and analytical methods for environmental endocrine disruptors: Phthalates.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyls induced toxicities upon cell lines and stem cells: a review.

Dioxins and their impact: a review of toxicity, persistence, and novel remediation strategies.

PFAS

Toxicity of Per- and Polyfluoroalkyl Substances and Their Substitutes to Terrestrial and Aquatic Invertebrates-A Review.

Flame Retardants

A review on oxidative stress in organophosphate-induced neurotoxicity

Updated Mini-Review on Polychlorinated Diphenyl Ethers (PCDEs) in Food: Levels and Dietary Intake.

Organotins

Effects of tributyltin on placental and reproductive abnormalities in offspring.

Pesticides

A Systematic Review of Parental Occupational Pesticide Exposure and Geographical Proximity to Agricultural Fields in Association with Neural Tube Defects.

Evaluation of developmental toxicity of chlorpyrifos through new approach methodologies: a systematic review.

Metals/Metalloids

Comparison of fluoride level between mother’s milk and infant formula milk – a global systematic review and dental fluorosis risk assessment.

Prenatal metal(loid) exposure and preterm birth: a systematic review of the epidemiologic evidence.

Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach.

Microplastics/Nanomaterials

Penetration of Microplastics and Nanoparticles Through Skin: Effects of Size, Shape, and Surface Chemistry.

Microplastics in Agricultural Crops and Their Possible Impact on Farmers’ Health: A Review.

Would the Oceans Become Toxic to Humanity Due to Use and Mismanagement of Plastics?

The micro(nano)plastics perspective: exploring cancer development and therapy.

Impact of microplastics on the human digestive system: From basic to clinical.

Miscellaneous

Blood Trihalomethanes and Human Cancer: A Systematic Review and Meta-Analysis.

Human Health Studies

Numerous Chemicals/Mixtures

Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.

Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma’anshan birth cohort.

Association between exposure to 35 environmental pollutants and mortality from cerebrovascular diseases: A long-term prospective study.

BPA/Phenols

Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity.

The negative impacts of bisphenols on thyroid function in adults with bisphenol A exposure level exceeding the tolerable daily intake.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations Between Prenatal Dioxin-like Polychlorinated Biphenyls Exposure and Glucocorticoid and Androgenic Hormones in Umbilical Cord Blood.

Association of pentachlorophenol in urine and follicular fluid with ovarian reserve and reproductive outcomes among women undergoing in vitro fertilization based on a prospective cohort study.

PFAS

Maternal exposure to legacy PFAS compounds PFOA and PFOS is associated with disrupted cytokine homeostasis in neonates: The Upstate KIDS study (2008-2010).

Placental PFAS concentrations are associated with perturbations of placental DNA methylation.

Longitudinal Associations of PFAS Exposure With Insulin Sensitivity and β-Cell Function Among Hispanic Women With Gestational Diabetes Mellitus History.

Exposure to specific polyfluoroalkyl chemicals is associated with cardiovascular disease in US adults: a population-based study.

Relationship of perfluoroalkyl chemicals with chronic obstructive pulmonary disease: A cross-sectional study.

Pesticides

Premature thelarche and pesticide exposure: A case-control study in an intensive agricultural area.

BMI-mediated association between glyphosate exposure and increased risk of atherosclerotic heart disease: A large-scale cross-sectional study.

Effect of glyphosate on renal function: A study integrating epidemiological and experimental evidence.

Association between mixed exposure of non-persistent pesticides and liver fibrosis in the general US population: NHANES 2013-2016.

Disrupting effects of neonicotinoids and their interaction with metals on thyroid hormone, an evidence of children in a rural area, South China

Metals/Metalloids

Vitamin E Intake Attenuated the Association Between Elevated Blood Heavy Metal (Pb, Cd, and Hg) Concentrations and Diabetes Risk in Adults Aged 18-65 Years: Findings from 2007-2018 NHANES.

Associations Between Lead and Cadmium Exposure and Subclinical Cardiovascular Disease in U.S. Adults.

Air Pollution

Associations Between Ambient PM_2.5 and Thyroid Hormones in Pregnant Persons in Puerto Rico.

Industrial air emissions and breast cancer incidence in a United States-wide prospective cohort

Ambient Toxic Air Contaminants in the Maternal Residential Area during Pregnancy and Cerebral Palsy in the Offspring.

Incense Use and the Risk of Chronic Limb-Threatening Ischemia Among Middle-Aged and Older Adults in the Singapore Chinese Health Study. and related Invited Perspective: Incense Burning and Cardiovascular Risk-A Rising Concern.

Pharmaceuticals/Personal Care Products

Exposure experiments and machine learning revealed that personal care products can significantly increase transdermal exposure of SVOCs from the environment.

Miscellaneous

Associations of Urinary Perchlorate, Nitrate, and Thiocyanate with Female Infertility and Mediation of Obesity: Insights from NHANES 2013-2018.

Laboratory Studies

Numerous Chemicals/Mixtures

Deciphering the phenotypic, inflammatory, and endocrine disrupting impacts of e-waste plastic-associated chemicals.

Combined Effects of Arsenic and Bisphenol-A on Locomotor Activity and Oxidative Stress Mediated Neurotoxicity in Mice.

Combined BPA and DIBP Exposure Induced Intestinal Mucosal Barrier Impairment Through the Notch Pathway and Gut Microbiota Dysbiosis in Mice

Exposure to leachates of plastic food containers disturbs glucose and lipid metabolism: Insights from models mimicking real-exposure scenarios.

Exploring the reproductive exposure risks of phthalates and organophosphates in atmospheric particulate matter based on quantitative structure-activity relationships and network toxicology models.

Maternal deposition of hormones and contaminants shape the gonadal transcriptome in American alligators.

BPA/Phenols

Maternal exposure to bisphenol A induces congenital heart disease through mitochondrial dysfunction.

Prenatal exposure to bisphenol A causes reproductive damage in F1 male rabbits due to inflammation and oxidative stress.

In vitro bisphenol A impairs testicular energy metabolism and spermatogenesis through nuclear estrogen receptors activation in zebrafish

Environmental Exposure to Bisphenol A Enhances Invasiveness in Papillary Thyroid Cancer.

Bisphenol A-Induced Cancer-Associated Adipocytes Promotes Breast Carcinogenesis Via CXCL12/AKT Signaling.

Mammary Gland Reactive Stroma Characterization at Aging After Bisphenol A Exposure During Hormonal Susceptibility Windows.

Bisphenol S Induces Lipid Metabolism Disorders in HepG2 and SK-Hep-1 Cells via Oxidative Stress.

Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1.

Bisphenol F (BPF) exposure impairs sperm quality and offspring development in male zebrafish.

Trans-sodium crocetinate ameliorates Parkinson-like disease caused by bisphenol A through inhibition of apoptosis and reduction of α-synuclein in rats.

Investigating the role and mechanisms of bisphenol compounds in premature ovarian insufficiency using computational biology and bioinformatics.

The impact of bisphenol A on gill health: A focus on mitochondrial dysfunction induced disorders of energy metabolism and apoptosis in Meretrix petechialis.

Selenium modulates bisphenol A-induced intestinal apoptosis, oxidative stress and autophagy in rats: A biochemical, histological and immunohistochemical study.

Phthalates

Age-Dependent Effects of Butyl Benzyl Phthalate Exposure on Lipid Metabolism and Hepatic Fibrosis in Mice.

Exposure to environmentally relevant levels of DEHP during development modifies the distribution and expression patterns of androgen receptors in the anterior pituitary in a sex-specific manner.

Prepubertal phthalate exposure can cause histopathological alterations, DNA methylation and histone acetylation changes in rat brain.

Di (2-ethylhexyl) phthalate reduces sperm motility by decreasing sperm tail energy supply.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Investigating the Multigenerational Effects of DDT Residues Exposure on Dental Development in Wistar Rats.

Flame Retardants

Estrogenic and anti-estrogenic assessment of the flame retardant, 2-ethylhexyl diphenyl phosphate (EHDPP), and its metabolites: Evidence from in vitro, in silico, and transcriptome studies.

Pesticides

Chlorpyrifos Acts as a Positive Modulator and an Agonist of N-Methyl-d-Aspartate (NMDA) Receptors: A Novel Mechanism of Chlorpyrifos-Induced Neurotoxicity.

Effects of Environmentally Relevant Concentrations of Roundup on Oxidative-Nitrative Stress, Cellular Apoptosis, Prooxidant-Antioxidant Homeostasis, Renin and CYP1A Expressions in Goldfish: Molecular Mechanisms Underlying Kidney Damage During Roundup Exposure.

Subchronic Exposure to Low-Dose Chlorfenapyr and Emamectin Benzoate Disrupts Kidney Metabolism in Rats.

Sub-lethal exposures to bifenthrin impact stress responses and behavior of juvenile Chinook Salmon.

Environmentally-Relevant Concentrations of Atrazine Had Minor Impacts on Gut Microbiota and Liver Metabolite in Juvenile Turtles.

Microplastics/Nanomaterials

Nanoplastic-Induced Developmental Toxicity in Ascidians: Comparative Analysis of Chorionated and Dechorionated Phallusia mammillata Embryos.

Ingestion of polyethylene microplastics impacts cichlid behaviour despite having low retention time.

The risk of short-term microplastic exposure on female reproductive function: A rat model study

Polylactic acid microplastics before and after aging induced neurotoxicity in zebrafish by disrupting the microbiota-gut-brain axis.

Polylactic Acid Micro/Nanoplastic Exposure Induces Male Reproductive Toxicity by Disrupting Spermatogenesis and Mitochondrial Dysfunction in Mice.

Reproductive toxicity and transgenerational effects of co-exposure to polystyrene microplastics and arsenic in zebrafish.

Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease.

Why do microplastics aggravate cholestatic liver disease? The NLRP3-mediated intestinal barrier integrity damage matter.

Novel probiotics adsorbing and excreting microplastics in vivo show potential gut health benefits.

Single and Synergistic Effects of Microplastics and Difenoconazole on Oxidative Stress, Transcriptome, and Microbiome Traits in Honey Bees.

Air Pollution

Maternal exposure to ozone during implantation promotes a feminized transcriptomic profile in the male adolescent liver

Pharmaceuticals/Personal Care Products

Thyroid Endocrine Disrupting Potential of Fluoxetine in Zebrafish Larvae.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Changes in urinary concentrations of contemporary and emerging chemicals in commerce during the COVID-19 pandemic: Insights from the Environmental influences on Child Health Outcomes (ECHO) program.

Associations Between Daily-Use Products and Urinary Biomarkers of Endocrine-Disrupting Chemicals in Adults of Reproductive Age

Assessing Variability in Children’s Exposure to Contaminants in Food: A Longitudinal Non-Targeted Analysis Study in Miami, Florida.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs, PBDEs

The pollution fast-track to the arctic: how Southern wintering areas contribute to organochlorine loads in a migrant seabird breeding in the arctic.

Current level, sources, and risk of human exposure to PAHs, PBDEs and PCBs in South American outdoor air: A critical review.

Contaminant-Associated Disruption of the Skin Transcriptome in the Endangered St. Lawrence Estuary Beluga.

Fatty Acid Profiles Linked to Organohalogen Exposure in Cetaceans from the Northern South China Sea.

PFAS

Per- and Polyfluoroalkyl Substances (PFAS) Exposure in the U.S. Population: NHANES 1999-March 2020.

Environment-wide association study of five per- and polyfluoroalkyl substance (PFASs) exposure pathways in Korean adolescents from the Korean National Environmental Health Survey (2018-2020).

Emerging Per- and Polyfluoroalkyl Substances in Tap Water from the American Healthy Homes Survey II.

Bioaccumulation of perfluorooctane sulfonic acid (PFOS) and oxidative stress in snapping turtles in New York, USA.

Organotins

Decreases in TBT concentrations in southern Chesapeake Bay: Evidence for long-term TBT degradation and reduced imposex in the invasive gastropod, Rapana venosa.

Pesticides

Profiles and predictor of pesticide and metal mixtures in urine among solar greenhouse workers: findings from the measures of environment and the health outcomes study.

Metals/Metalloids

Infants’ Exposure to Toxic Trace Elements in Teethers.

Microplastics/Nanomaterials

Preliminary study on the ejection of microplastics from different types of face masks.

Factors affecting microplastic pollution of sandboxes in urban residential areas: Simple methodology for quality control in the context of potential exposure assessment for children.

Pharmaceuticals/Personal Care Products

Exposure profiles, determinants, and health risks of chemicals in personal care products among healthy older adults from the China BAPE study.

High prevalence of veterinary drugs in bird’s nests.

Miscellaneous

Child exposure to N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources, and health effect assessment

Higher potential leaching of inorganic and organic additives from biodegradable compared to conventional agricultural plastic mulch film.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on February 14, 2025 at 3:36 pm
The agenda is now available for the March 14-15 Lou Guillette Jr. Memorial Symposium, hosted by HEEDS, at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the endocrine disruption research that Lou made famous. Information and agenda here.
North Carolina EDC working group 5th annual meeting
by Sarah Howard on February 13, 2025 at 12:46 pm
On Friday, April 25, 2025, Healthy Environment and Endocrine Disruptor Strategies (HEEDS) is hosting the 5th Annual Meeting of EDC-NC, its North Carolina working group on endocrine disrupting chemicals (EDCs). Attendance is open to anyone and the cost is free. More information.
Webinar: Ultrashort-chain PFAS: the global threat of trifluoroacetic acid
by Sarah Howard on February 11, 2025 at 4:41 pm
This Feb. 19, 2025 webinar features Dr. Hans Peter Arp discussing TFA, a degradation product of many refrigerants and a widespread contaminant in the environment. Shorter-chain PFAS have been assumed to be less hazardous than longer-chain PFAS, but widespread exposures have not been taken into account in making this assessment. Sponsored by the EDC Strategies Partnership.

EHN EHN

HEEDS publishes timeline on the history of the EDC field
by Sarah Howard on February 14, 2025 at 3:30 pm
Healthy Environment and Endocrine Disruptor Strategies (HEEDS) now provides a comprehensive history of the endocrine disruptor scientific field via an online timeline. Complete with citations, it covers industrial and scientific developments from the 1800s until today. Let us know what you think!
Natural antioxidants in food may help reduce microplastics' reproductive harm
by Katherine McMahon,Sarah Howard on February 13, 2025 at 7:14 pm
According to a recent review published in Journal of Pharmaceutical Analysis, anthocyanins - a plant compound responsible for the vibrant colors in fruits and flowers - may counteract some of the harmful reproductive impacts of micro- and nanoplastic (MNP) exposure. “The accumulation of [MNPs] contaminants across ecosystems raises significant concerns for human health due to their potential dispersion within the human body through respiratory, integumentary, and digestive systems.”
Microplastics may disrupt blood flow in the brain, study finds
by EHN Curators on February 13, 2025 at 8:47 am
Tiny plastic particles can accumulate in brain blood vessels, creating blockages that may reduce blood flow and impair motor function, according to new research in mice. Tom Perkins reports for The Guardian.

EHN EHN

“A once-in-a-lifetime opportunity”: Independent scientists advocate for an effective Global Plastics Treaty
by Sarah Howard,Katherine McMahon on February 18, 2025 at 5:11 pm
Members of the Scientists’ Coalition for an Effective Plastics Treaty, over 70 of whom attended the 5th negotiation session for the UN Plastics Treaty (INC5) in November, argue in a new article published in Cambridge Prisms: Plastics that the treaty must address the full life cycle of plastics and include production reduction targets. “It is critical that the treaty negotiations continue to be informed by independent science, to better ensure that when consensus is reached we have a global approach leading to reduced negative impacts from plastics across their entire life cycle."
Opinion: RFK Jr.’s disinformation is a rallying cry for women in STEM
by Kathryn Rodgers on February 14, 2025 at 7:58 pm
I have never been so motivated and grateful to be a woman in science as while watching Robert F. Kennedy Jr.’s Senate Finance Committee nomination hearing. As an environmental health researcher, I know there is strong evidence that industrial and commercial chemicals are linked to increasing rates of neurodevelopmental disorders, cancer, asthma, and many other chronic diseases. However, RFK Jr. has clearly demonstrated he has very little understanding of public health, science, or women.
California law is pushing companies to ditch toxic chemicals
by EHN Curators on February 14, 2025 at 2:52 pm
California’s landmark warning-label law may be doing what critics said was impossible — getting companies to pull dangerous chemicals from their products. Hiroko Tabuchi reports for The New York Times.