EDC Science Weekly, Jan. 22 – 28, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: New EDC Resource, Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

New EDC Resource

Let’s Talk EDCs: Resources for Clinicians and Patients

A new video series from The Endocrine Society.

Regulations/Policy

Toward a Global Understanding of Chemical Pollution: A First Comprehensive Analysis of National and Regional Chemical Inventories. [“Over 350,000 chemicals and mixtures of chemicals have been registered for production and use, up to three times as many as previously estimated and with substantial differences across countries/regions. … the identities of many chemicals remain publicly unknown because they are claimed as confidential (over 50,000) or ambiguously described (up to 70,000).”]

Overhaul environmental risk assessment for pesticides.

Methods/Screening

The exposome – a new approach for risk assessment.

Screening ToxCast™ for Chemicals That Affect Cholesterol Biosynthesis: Studies in Cell Culture and Human Induced Pluripotent Stem Cell-Derived Neuroprogenitors.

Computational systems biology as an animal-free approach to characterize toxicological effects of persistent organic pollutants.

The value of avian gross pathology in identifying endocrine disrupting properties.

Mixture effects of chemicals: The difficulty to choose appropriate mathematical models for appropriate conclusions.

Screening anti-predator behaviour in fish larvae exposed to environmental pollutants

Reviews

Persistent Organic Pollutants

Is Technical-grade Chlordane an Obesogen?

A Systematic Review of Environmental Health Outcomes in Selected American Indian and Alaska Native Populations. [POPs and metals]

Perfluoroalkyl Substances

Perfluoroalkyl chemicals in neurological health and disease: Human concerns and animal models.

Pesticides

Synthetic Pesticides and Health in Vulnerable Populations: Agricultural Workers.

Chloropicrin-induced toxicity in the respiratory system.

Potentially Toxic Elements

The effects of manganese overexposure on brain health.

Nickel: Human Health and Environmental Toxicology.

Air Pollution

Biomarkers of exposure, effect, and susceptibility in occupational exposure to traffic-related air pollution: A review.

Longitudinal relationships between lung cancer mortality rates, smoking, and ambient air quality: a comprehensive review and analysis.

Mixtures

Tracking complex mixtures of chemicals in our changing environment.

Miscellaneous

Nonpersistent endocrine disrupting chemicals and reproductive health of women.

Chemical Exposures, Health, and Environmental Justice in Communities Living on the Fenceline of Industry.

Invertebrates facing environmental contamination by endocrine disruptors: Novel evidences and recent insights.

Human Health Studies

BPA/Phenols

Relationship between the environmental endocrine disruptor bisphenol A and dyslipidemia: A five-year propsective study

Phthalates

Urinary concentrations of phthalate metabolites during gestation and intrahepatic cholestasis of pregnancy: a population-based birth cohort study.

Triclosan/Personal Care Products

Early life triclosan exposure and neurodevelopment of children at 3 years in a prospective birth cohort.

The association between gestational use of personal care products and neonatal urological abnormality at birth: The Japan Environment and Children’s Study.

Persistent Organic Pollutants: PCBs, PFAS

Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women.

Higher circulating plasma polychlorinated biphenyls (PCBs) in fit and lean children: The European youth heart study.

Prenatal β-Hexachlorocyclohexane (β-HCH) Exposure and 7-Year Child IQ in the CHAMACOS Birth Cohort.

Flame Retardants

Multi-exposures to suspected endocrine disruptors in electronic waste recycling workers: Associations with thyroid and reproductive hormones. [metals and flame retardants]

Pesticides

Assessment of Primary Health Care for rural workers exposed to pesticides. [Brazil. Found 20% poisoned, none of which had been previously diagnosed.]

Potentially Toxic Elements

Positive association between soil arsenic concentration and mortality from alzheimer’s disease in mainland China.

Evaluation of Pb concentrations in selected vegetables and portable drinking water, and intelligent quotients of school children in Ishiagu-a Pb mining community: health risk assessment using predictive modelling.

Evaluation of heavy metals and metabolites in the urine of patients with breast cancer.

Association of intronic polymorphisms (rs1549339, rs13402242) and mRNA expression variations in PSMD1 gene in arsenic-exposed workers.

Environmental Exposure of Arsenic in Groundwater Associated to Carcinogenic Risk in Underweight Children Exposed to Fluorides.

Evaluating associations between early pregnancy trace elements mixture and 2nd trimester gestational glucose levels: A comparison of three statistical approaches.

Air Pollution

Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts.

Short-term effect of PM1 on hospital admission for ischemic stroke: A multi-city case-crossover study in China.

Fine particulate matter and cause-specific mortality in the Hong Kong elder patients with chronic kidney disease.

Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study.

Association between in vitro fertilization success rate and ambient air pollution: a possible explanation of within-year variation of in vitro fertilization success rate.

The Association of Childhood Pneumonia with Household Air Pollution in Nepal: Evidence from Nepal Demographic Health Surveys.

A prospective pilot study of the T-lymphocyte response to fine particulate matter exposure.

Seasonal response of the synergism of maternal comorbidities and long-term air pollution exposure on birth outcomes.

Association between maternal exposure to ambient PM10 and neural tube defects: A case-control study in Liaoning Province, China.

Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts.

Fine particulate matter: An underestimated cardiovascular risk factor?

Pharmaceuticals

Gender Identity and Sexual Orientation Identity in Women and Men Prenatally Exposed to Diethylstilbestrol.

Miscellaneous

Childhood type 1 diabetes: an environment-wide association study across England.

Integrating exposure knowledge and serum suspect screening as a new approach to biomonitoring: An application in firefighters and office workers. [numerous chemicals]

Occupational exposures and odds of gastric cancer: a StoP project consortium pooled analysis.

Occupational chemical exposures in pregnancy and fetal growth: evidence from the Born in Bradford Study. [pesticides and phthalates]

Laboratory Studies

BPA/Phenols

Bisphenol A exposure inhibits contrast sensitivity in cats involving increased response noise and inhibitory synaptic transmission.

Use of embryonic stem cell-derived cardiomyocytes to study cardiotoxicity of bisphenol AF via the GPER/CAM/eNOS pathway.

Phthalates

Aryl Hydrocarbon Receptor as a target for lycopene preventing DEHP-induced spermatogenic disorders.

Refined reference doses and new procedures for phthalate mixture risk assessment focused on male developmental toxicity.

Triclosan

Toxicological responses, bioaccumulation, and metabolic fate of triclosan in Chlamydomonas reinhardtii.

Biochemical markers for prolongation of the acute stress of triclosan in the early life stages of four food fishes.

Persistent Organic Pollutants

Identification and characterization of differentially expressed lncRNA in 2,3,7,8-tetrachlorodibenzo-p–dioxin-induced cleft palate.

Organotins

Triphenyltin disrupts intracellular Zn2+ homeostasis in rat thymic lymphocytes.

Pesticides

Transgenerational reproductive and developmental toxicity of tebuconazole in Caenorhabditis elegans.

The effects of combinations of limited ration and diazinon exposure on acetylcholinesterase activity, growth and reproduction in Oryzias latipes, the Japanese medaka.

Multifunctional compounds Lithium Chloride and Methylene Blue attenuate the negative effects of diisopropylfluorophosphate on axonal transport in rat cortical neurons.

Growth performance and hemato-immunological responses of Nile tilapia (Oreochromis niloticus) exposed to deltamethrin and fed immunobiotics.

Fucoidan protects against subacute diazinon-induced oxidative damage in cardiac, hepatic, and renal tissues.

The endoplasmic reticulum stress and related signal pathway mediated the glyphosate-induced testosterone synthesis inhibition in TM3 cells.

Carnosic acid alleviates chlorpyrifos-induced oxidative stress and inflammation in mice cerebral and ocular tissues.

Effects of metazachlor and its major metabolite metazachlor OA on early life stages of marbled crayfish.

Effects of imidacloprid, a neonicotinoid insecticide, on the echolocation system of insectivorous bats.

Immunotoxicity evaluation by subacute oral administration of clothianidin in Sprague-Dawley rats.

Potentially Toxic Elements

Chronic exposure to arsenite enhances influenza virus infection in cultured cells.

Characterization of Arsenic-Induced Cancer Stem-Like Cells.

Serum metabonomics analysis of quercetin against the toxicity induced by cadmium in rats.

Effects of Aluminum on the Integrity of the Intestinal Epithelium: An in Vitro and in Vivo Study.

Dietary cadmium chloride impairs shell biomineralization by disrupting the metabolism of the eggshell gland in laying hens.

Microplastics

Adverse effects of plastic ingestion on the Mediterranean small-spotted catshark (Scyliorhinus canicula).

Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae.

Microplastics enhance Daphnia magna sensitivity to the pyrethroid insecticide deltamethrin: Effects on life history traits.

Influence of polystyrene microplastics on the growth, photosynthetic efficiency and aggregation of freshwater microalgae Chlamydomonas reinhardtii.

Air Pollution

Protective effect of Lactobacillus casei HY2782 against particulate matter toxicity in human intestinal CCD-18Co cells and Caenorhabditis elegans.

Metabolomics analysis of urine from healthy wild type mice exposed to ambient PM2.5.

Vinyl Chloride and High-Fat Diet as a Model of Environment and Obesity Interaction.

Exposure to diesel exhaust particles increases susceptibility to invasive pneumococcal disease.

Pharmaceuticals

Hidden in the sand: Alteration of burying behaviour in shore crabs and cuttlefish by antidepressant exposure.

Influence of pH on the toxicity of ionisable pharmaceuticals and personal care products to freshwater invertebrates.

Mixtures

Toxic Effects of the Mixture of Phthalates and Bisphenol A-Subacute Oral Toxicity Study in Wistar Rats.

Microplastics and copper effects on the neotropical teleost Prochilodus lineatus: Is there any interaction?

How microplastics affect chiral illicit drug methamphetamine in aquatic food chain? From green alga (Chlorella pyrenoidosa) to freshwater snail (Cipangopaludian cathayensis).

Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function.

In vitro assessment of the combination of cylindrospermopsin and the organophosphate chlorpyrifos on the human neuroblastoma SH-SY5Y cell line.

Biological responses to climate change and nanoplastics are altered in concert: full-factorial screening reveals effects of multiple stressors on primary producers.

Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice.

Miscellaneous

Developmental instability is associated with estrogenic endocrine disruption in the Chilean native fish species, Trichomycterus areolatus.

Exposure/Environment Studies

BPA/Phenols

Plasticizers and bisphenol A in Adyar and Cooum riverine sediments, India: occurrences, sources and risk assessment.

Parabens

Influence of Vegetarian Dietary Intervention on Urinary Paraben Concentrations: A Pilot Study with ‘Temple Stay’ Participants.

Profiles of parabens and their metabolites in paired maternal-fetal serum, urine and amniotic fluid and their implications for placental transfer.

Persistent Organic Pollutants

Predictors of Beta-Hexachlorocyclohexane blood levels among people living close to a chemical plant and an illegal dumping site.

Polychlorinated biphenyls (PCB) and organochlorine pesticides (OCP) in blood plasma – Results of the German environmental survey for children and adolescents 2014-2017 (GerES V).

Organochlorine Pesticides and PCBs in Traditionally and Industrially Smoked Pork Meat Products from Bosnia and Herzegovina.

Background levels of polycyclic aromatic hydrocarbons and legacy organochlorine pesticides in wheat sampled in 2017 and 2018 in Poland.

Tissue contaminants and wild fish health in the St. Clair River Area of Concern – Part 2: Spatial trends and temporal declines in organics.

The use of PAH, metabolite and lipid profiling to assess exposure and effects of produced water discharges on pelagic copepods.

PCB in serum and hand wipes from exposed residents living in contaminated high-rise apartment buildings and a reference group.

Flame Retardants

Indoor polybrominated diphenyl ethers in urban China: An exposure and risk assessment based on settled dust from selected urban regions.

Occupational and dietary differences in hydroxylated and methoxylated PBDEs and metals in plasma from Puget Sound, Washington, USA region volunteers.

Concentrations and distributions of polybrominated diphenyl ethers (PBDEs) in surface soils and tree bark in Inner Mongolia, northern China, and the risks posed to humans.

Pesticides

County-level analysis reveals a rapidly shifting landscape of insecticide hazard to honey bees (Apis mellifera) on US farmland.

Ten-year temporal trends (2006-2015) and seasonal-differences in urinary metabolite concentrations of novel, hygiene-used pyrethroids in Japanese children.

Systematic probabilistic risk assessment of pesticide residues in tea leaves.

Dietary Pyrethroid Exposures and Intake Doses for 188 Duplicate-Single Solid Food Items Consumed by North Carolina Adults.

Potentially Toxic Elements

Exposure assessment of the population in Poland to the toxic effects of nickel from vegetable and their products

Total mercury and methylmercury concentrations in native and invasive fish species in Shadegan International Wetland, Iran, and health risk assessment.

Occurrence and risk assessment of total mercury and methylmercury in surface seawater and sediments from the Jiaozhou Bay, Yellow Sea.

Effects of Essential Trace Elements and Oxidative Stress on Endemic Arsenism Caused by Coal Burning in PR China.

Health risks of heavy metal exposure and microbial contamination through consumption of vegetables irrigated with treated wastewater at Dubai, UAE.

Five decades of declining methylmercury concentrations in boreal foodwebs suggest pivotal role for sulphate deposition.

Legacy groundwater pollution as a source of mercury enrichment in marine food web, Haifa Bay, Israel.

Contamination of soil with potentially toxic metals and their bioaccumulation in wheat and associated health risk.

Spatial Variation and Source of Dissolved Heavy Metals in the Lancangjiang River, Southwest China.

Bioaccessibility and health risk assessment of Pb and Cd in urban dust in Hangzhou, China.

Heavy metal accumulation, geochemical fractions, and loadings in two agricultural watersheds with distinct climate conditions.

Total and methylmercury concentrations in ground and surface waters in natural and restored freshwater wetlands in northern New York.

Mercury isotope compositions in large anthropogenically impacted Pearl River, South China.

Concentrations of heavy metals in muscle and edible offal of pork in Nanjing city of China and related health risks.

Arsenic Uptake and Accumulation Mechanisms in Rice Species.

Microplastics

Characteristics of microplastics ingested by zooplankton from the Bohai Sea, China.

The rapid increases in microplastics in urban lake sediments.

Pharmaceuticals

Occurrence, distribution, and ecological risk of pharmaceuticals in a seasonally ice-sealed river: From ice formation to melting.

Mixtures

Assessment of the potential ecological risk of residual endocrine-disrupting chemicals from wastewater treatment plants.

Ecotoxicological risk assessment of micropollutants from treated urban wastewater effluents for watercourses at a territorial scale: Application and comparison of two approaches.

Seasonal distribution, risks, and sources of endocrine disrupting chemicals in coastal waters: Will these emerging contaminants pose potential risks in marine environment at continental-scale?

Miscellaneous

Regional variations in human chemical exposures in Canada: A case study using biomonitoring data from the Canadian Health Measures Survey for the provinces of Quebec and Ontario. [numerous chemicals]

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.