EDC Science Weekly: Jan. 13 – 19, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb. 2: A Science-Based Agenda for Health-Protective Chemical Assessments and Decisions [re the publications under “Regulations/Policy” below]

Webinar Feb. 10: CHE Café: What’s Next in Environmental Health?

Feb 14: Deadline to apply for course, ECHO: Endocrine-Disrupting Chemicals – Hazards and Opportunities [Marine Biological Laboratory, Woods Hole, to be held May 21 – June 4]

Regulations/Policy

A Science-Based Agenda for Health-Protective Chemical Assessments and Decisions [supplement in Environmental Health]. Including:

A walk in the PARC: developing and implementing 21st century chemical risk assessment in Europe.

Artificial turf and crumb rubber infill: An international policy review concerning the current state of regulations.

Methods/Tools/Screening

Methods

Occurrence and implications of per and polyfluoroalkyl substances in animal feeds used in laboratory toxicity testing.

Analytical method interferences for perfluoropentanoic acid (PFPeA) and perfluorobutanoic acid (PFBA) in biological and environmental samples

The contribution of larval zebrafish transcriptomics to chemical risk assessment.

Tools

Power and sample size analysis for longitudinal mixed models of health in populations exposed to environmental contaminants: a tutorial.

The use of a simple model for the regulatory environmental risk assessment of pesticides in Ethiopia.

Screening

Replacing animal-derived components in in vitro test guidelines OECD 455 and 487.

Interlaboratory prevalidation of a new in vitro transcriptional activation assay for the screening of (anti-)androgenic activity of chemicals using the UALH-hAR cell line.

Commentaries

Code OB: We need urgent action on climate change and toxic chemicals.

Cardiotoxicity of chemicals: Current regulatory guidelines, knowledge gaps, and needs. [Letter]

Reviews

Numerous Chemicals/Mixtures

Does environmental pollution affect male reproductive system in naturally exposed vertebrates? A systematic review.

Phthalates

The occurrence, fate, toxicity, and biodegradation of phthalate esters: An overview.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Assessing the health risk of hyperuricemia in participants with persistent organic pollutants exposure – a systematic review and meta-analysis.

Perfluoroalkyl Substances

The role of PFAS in unsettling ocean carbon sequestration.

Flame Retardants

Current status of indoor dust PBDE pollution and its physical burden and health effects on children.

Metals/Metalloids

Does maternal low-dose cadmium exposure increase the risk of offspring to develop metabolic syndrome and/or type 2 diabetes?

Integrated review of the nexus between toxic elements in the environment and human health.

Miscellaneous

Food Color Additives in Hazardous Consequences of Human Health: An Overview.

Human Health Studies

Numerous Chemicals/Mixtures

The combined effect of heavy metals and polycyclic aromatic hydrocarbons on arthritis, especially osteoarthritis, in the U.S. adult population.

BPA/Phenols

Environmental phenol exposure associates with urine metabolome alteration in young Northeast Indian females.

Sex-specific associations between urinary bisphenols concentrations during pregnancy and problematic child behaviors at age 2 years.

Urinary concentrations of bisphenols and parabens and their association with attention, hyperactivity and impulsivity at adolescence.

Phthalates

Association between urinary phthalate metabolites and hyperuricemia in US adults.

Associations of Phthalates with Prostate Cancer among the US Population.

Associations between exposure to phthalates and subclinical hypothyroidism in pregnant women during early pregnancy: A pilot case-control study in China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Residential proximity to dioxin emissions and risk of breast cancer in the sister study cohort.

Perfluoroalkyl Substances

In utero exposure to perfluoroalkyl substances and early childhood BMI trajectories: A mediation analysis with neonatal metabolic profiles.

Pesticides

Urine glyphosate exposure and serum sex hormone disruption within the 2013-2014 National Health and Nutrition Examination survey (NHANES).

Metals/Metalloids

Potentially toxic elements in the brains of people with multiple sclerosis.

Effects of cadmium and lead co-exposure on glucocorticoid levels in rural residents of northwest China.

Associations of blood metals with liver function: Analysis of NHANES from 2011 to 2018.

Laboratory Studies

Numerous Chemicals/Mixtures

How do different arsenic species affect the joint toxicity of perfluorooctanoic acid and arsenic to earthworm Eisenia fetida: A multi-biomarker approach.

Combined toxicity of acetamiprid and cadmium to larval zebrafish (Danio rerio) based on metabolomic analysis.

BPA/Phenols

BPA and its alternatives BPF and BPAF exaggerate hepatic lipid metabolism disorders in male mice fed a high fat diet.

New Insights into How Melatonin Ameliorates Bisphenol A-Induced Colon Damage: Inhibition of NADPH Oxidase.

Interactions of Bisphenol A with Artemia franciscana and the ameliorative effect of probiotics.

Development of human dermal PBPK models for the bisphenols BPA, BPS, BPF, and BPAF with parallel-layered skin compartment: Basing on dermal administration studies in humans.

Biotransformation of Bisphenol by Human Cytochrome P450 2C9 Enzymes: A Density Functional Theory Study.

Phthalates

Bis (2-butoxyethyl) Phthalate Delays Puberty Onset by Increasing Oxidative Stress and Apoptosis in Leydig Cells in Rats.

Effects of plasticizer diisobutyl adipate on the Japanese medaka (Oryzias latipes) endocrine system.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Luteolin protects against adipogenic and lipogenic potency induced by human relevant mixtures of persistent organic pollutants (POPs) in the 3T3-L1 model.

Toxicity Impacts on Human Adipose Mesenchymal Stem/Stromal Cells Acutely Exposed to Aroclor and Non-Aroclor Mixtures of Polychlorinated Biphenyl.

Perfluoroalkyl Substances

Generation Mechanism of Perfluorohexanesulfonic Acid from Polyfluoroalkyl Sulfonamide Derivatives During Chloramination in Drinking Water.

Per- and polyfluoroalkyl substances (PFAS) inhibit cytochrome P450 CYP3A7 through direct coordination to the heme iron and water displacement.

Organotins

Subacute and Low Dose of Tributyltin Exposure Leads to Brown Adipose Abnormalities in Male Rats.

An integrative investigation of developmental toxicities induced by triphenyltin in a larval coral reef fish, Amphiprion ocellaris.

Pesticides

Exposure to the herbicide fluridone induces cardiovascular toxicity in early developmental stages of zebrafish.

Effect of zinc supplementation on immunotoxicity induced by subchronic oral exposure to glyphosate-based herbicide (GOBARA®) in Wistar rats.

Maternal exposure to chiral triazole fungicide tebuconazole induces enantioselective thyroid disruption in zebrafish offspring.

Herbicides widely used in the world: an investigation of toxic effects on Caenorhabditis elegans.

Adult exposure of atrazine alone or in combination with carbohydrate diet hastens the onset/progression of type 2 diabetes in Drosophila.

Chronic exposure to metam sodium-based pesticide in mice during adulthood elevated anxiety and depression-like behaviors: involvement of serotoninergic depletion and gut microbiota dysbiosis.

Accentuated Hippo Pathway and Elevated miR-132 and miR-195a Lead to Changes of Uteri and Ovaries in Offspring Mice Following Prenatal Exposure to Vinclozolin.

Different developmental insecticide exposure windows trigger distinct locomotor phenotypes in the early life stages of zebrafish.

Comparison of the chronic and multigenerational toxicity of racemic glufosinate and l-glufosinate to Caenorhabditis elegans at environmental concentrations.

Ameliorative effect of ellagic acid and Vitamin C against malathion-induced toxicity in testis of adult Wistar rats.

Metals/Metalloids

Behavioural response to toxic elements, detoxification and organ accumulation are time-of-day-dependent in zebrafish.

Pregnancy and lactation mixed exposure to lead, cadmium, and mercury alters maternal-offspring single heavy metal load: A factorial design.

Microplastics/Nanomaterials

Sorption of representative organic contaminants on microplastics: Effects of chemical physicochemical properties, particle size, and biofilm presence.

Exposure to polystyrene microplastics triggers lung injury via targeting toll-like receptor 2 and activation of the NF-κB signal in mice.

Transcriptome sequencing and metabolite analysis reveal the single and combined effects of microplastics and di-(2-ethylhexyl) phthalate on Peneaus vannamei.

Polystyrene microplastics induced inflammation with activating the TLR2 signal by excessive accumulation of ROS in hepatopancreas of carp (Cyprinus carpio).

Chironomus riparius molecular response to polystyrene primary microplastics.

Microplastic-induced gut microbiota and serum metabolic disruption in Sprague-Dawley rats.

Transcriptome-wide m6A modification mediates cardiotoxicity in mice after chronic exposure to microplastics.

Microplastics incorporated by honeybees from food are transferred to honey, wax and larvae.

Pharmaceuticals/Personal Care Products

Ecological risk assessment of environmentally relevant concentrations of propofol on zebrafish (Danio rerio) at early life stage: Insight into physiological, biochemical, and molecular aspects.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Are human exposure assessment the same for non-persistent organic chemicals? -from the lens of urinary variability and predictability.

Characterizing changes in behaviors associated with chemical exposures during the COVID-19 pandemic.

BPA/Phenols

Occurrence, spatial distributions, and temporal trends of bisphenol analogues in an E-waste dismantling area: Implications for risk assessment.

Temporal trends in bisphenol exposures and associated health risk among Japanese women living in the Kyoto area from 1993 to 2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Typical organic contaminants in hair of adult residents between inland and coastal capital cities in China: Differences in levels and composition profiles, and potential impact factors.

Perfluoroalkyl Substances

EOF and target PFAS analysis in surface waters affected by sewage treatment effluents in Berlin, Germany.

Identification and characterization of diverse isomers of per- and polyfluoroalkyl substances in Chinese municipal wastewater.

Flame Retardants

Distribution and exposure risk assessment of chlorinated paraffins and novel brominated flame retardants in toys.

Metals/Metalloids

Toxic metals in Loggerhead sea turtles (Caretta caretta) stranded freshly dead along Sicilian coasts.

Microplastics/Nanomaterials

Drinking hot beverages from paper cups: Lifetime intake of microplastics.

Occurrence of microplastics in commercially sold bottled water.

Pharmaceuticals/Personal Care Products

Comprehensive profiling of the distribution, risks and priority of pharmaceuticals and personal care products: A large-scale study from rivers to coastal seas.

Miscellaneous

Comparison of Melamine Exposure by Feeding Practices in Babies Aged 0-6 Months.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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