EDC Science Weekly, Jan. 13-19, 2022

Post author:HEEDS
Post published:January 19, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Jan. 25: The role of epidemiology in risk assessment: A case study of five ortho-phthalates (EDC Strategies Partnership)

Webinar Jan. 27: Environmental Health Impacts of Synthetic Turf and Safer Alternatives (CHE)

Methods/Tools/Screening

Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals.

Sub-structure-based category formation for the prioritisation of genotoxicity hazard assessment for pesticide residues: Sulphonyl ureas.

Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology.

Implementation of in silico toxicology protocols within a visual and interactive hazard assessment platform.

In silico assessment of genotoxicity. Combinations of sensitive structural alerts minimize false negative predictions for all genotoxicity endpoints and can single out chemicals for which experimentation can be avoided.

Probabilistic risk assessment – the keystone for the future of toxicology.

Commentaries/Conference Summaries

Gut Microbiota Provides a New Mechanism for Explaining Agrochemical-Induced Synergistic Effects on Bee Mortality.

Off to a Rough Start: Environmental Exposures May Alter Germ Cell Development. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis.

The role of endocrine-disrupting phthalates and bisphenols in cardiometabolic disease: the evidence is mounting.

Emerging Contaminant Exposure To Aquatic Systems In The Southern African Developmental Community.

BPA/Phenols

The impact of bisphenol a (BPA) on the placenta.

Parabens/Triclosan/Antimicrobials

The implication of parabens in cosmetics and cosmeceuticals: advantages and limitations.

Perfluoroalkyl Substances

A worldwide evaluation of trophic magnification of per- and polyfluoroalkyl substances in aquatic ecosystems.

Framework for risk assessment of PFAS utilizing experimental studies and in-silico models.

Potentially Toxic Elements

A Clinical Perspective on Arsenic Exposure and Development of Atherosclerotic Cardiovascular Disease.

Invasive plants as biosorbents for environmental remediation: a review.

On-going consequences of in utero exposure of Pb: An epigenetic perspective.

Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis.

Biomonitoring metals and metalloids in wild mammals: invasive versus non-invasive sampling.

Microplastics

The micro-, submicron-, and nanoplastic hunt: A review of detection methods for plastic particles.

Critical review of microplastics removal from the environment.

Remediation of microplastics using bionanomaterials: A review.

Plastic accumulation during COVID-19: call for another pandemic; bioplastic a step towards this challenge?

Microplastics waste in environment: A perspective on recycling issues from PPE kits and face masks during the COVID-19 pandemic.

From properties to toxicity: Comparing microplastics to other airborne microparticles.

Occurrence, toxicity and remediation of polyethylene terephthalate plastics. A review.

Miscellaneous

Children’s exposure to polycyclic aromatic hydrocarbon (PAHs): a review on urinary 1-hydroxypyrene and associated health effects.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence.

Phthalates

Association Between Phthalate Exposure in Pregnancy and Gestational Diabetes: A Chinese Cross-Sectional Study.

Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones.

Pregnancy exposure to phthalates and DNA methylation in male placenta – An epigenome-wide association study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Airborne lead and polychlorinated biphenyls (PCBs) are associated with amyotrophic lateral sclerosis (ALS) risk in the U.S.

Pesticides

Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer.

Pesticide residue intake from fruit and vegetable consumption and risk of glioma.

Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors.

Potentially Toxic Elements

Associations of Childhood and Perinatal Blood Metals with Children’s Gut Microbiomes in a Canadian Gestation Cohort.

Influence of Environmental Factors on Salivary Microbiota and Their Metabolic Pathway: Next-Generation Sequencing Approach.

Identification of the hormetic dose-response and regulatory network of multiple metals co-exposure-related hypertension via integration of metallomics and adverse outcome pathways.

Association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in a US population: A cross-sectional study.

Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh.

Associations of multiple plasma metals with the risk of metabolic syndrome: A cross-sectional study in the mid-aged and older population of China.

Association of peripubertal blood lead levels with reproductive hormones and semen parameters in a longitudinal cohort of Russian men.

Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China.

Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor.

Air Pollution

A longitudinal study of exposure to fine particulate matter during pregnancy, small-for-gestational age births, and birthweight percentile for gestational age in a statewide birth cohort.

A method for identifying critical time windows of maternal air pollution exposures associated with low birth weight in offspring using massive geographic data.

Associations of antidepressant medication with its various predictors including particulate matter: Machine learning analysis using national health insurance data.

Uncertainty in Health Impact Assessments of Smoke From a Wildfire Event.

Co-creating a local environmental epidemiology study: the case of citizen science for investigating air pollution and related health risks in Barcelona, Spain.

Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences. [see related: Invited Perspective: Air Pollution and Autism Spectrum Disorder: Are We There Yet?]

Laboratory Studies

Numerous Chemicals/Mixtures

Combined effects of arsenic and 2,2-dichloroacetamide on different cell populations of zebrafish liver.

BPA/Phenols

The effect of nonylphenol exposure on the stimulation of melanomacrophage centers, estrogen and testosterone level, and ERα gene expression in goldfish.

Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats.

Bisphenol A-sulfate conjugate disrupts AURKA transcription and cell cycle in BeWo cytotrophoblasts.

Cell components, interaction types and functional groups involved in the in vitro binding of bisphenol A by Lactiplantibacillus plantarum RS20D and DL7X.

Bisphenol A affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster.

Phthalates

Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice.

Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.

Di-(2-ethylhexyl) phthalate triggers DNA methyltransferase 1 expression resulting in elevated CpG-methylation and enrichment of MECP2 in the p21 promoter in vitro.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine contamination enriches virus-encoded metabolism and pesticide degradation associated auxiliary genes in soil microbiomes.

Perfluoroalkyl Substances

Exposure to perfluorooctanoic acid leads to promotion of pancreatic cancer.

Flame Retardants

Tricresyl phosphate inhibits fertilization in Japanese medaka (Oryzias latipes): Emphasizing metabolic toxicity.

Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats.

Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies.

Short-term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF-beta signaling.

Long term exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in reproductive hormones, vitellogenin, antioxidant enzymes, and histology of gonads in zebrafish (Danio rerio): In vivo and computational analysis.

Organotins

Reproductive toxicity of environmental levels of triphenyltin to the marine rotifer, Brachionus plicatilis.

Pesticides

A Combined LD50 for Agrochemicals and Pathogens in Bumblebees (Bombus terrestris [Hymenoptera: Apidae]).

Thiamethoxam-induced hematological, biochemical, and genetic alterations and the ameliorated effect of Moringa oleifera in male mice.

Early detection of cyanide, organophosphate and rodenticide pollution based on locomotor activity of zebrafish larvae.

Lifelong exposure to pyrethroid insecticide cypermethrin at environmentally relevant doses causes primary ovarian insufficiency in female mice.

Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin.

Sex-Dependent Environmental Health Risk Analysis of Flupyradifurone.

Potentially Toxic Elements

Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model.

Exposure to aluminium chloride during the peripuberal period induces prostate damage in male rats.

Effects of Lead on Reproduction Physiology and Liver and Gonad Histology of Male Cyprinus carpio.

Multi-biomarker approach to assess chromium, pH and temperature toxicity in fish.

Ghrelin attenuates methylmercury-induced oxidative stress in neuronal cells.

Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats.

Microplastics

Microplastics and nanoplastics: Size, surface and dispersant – What causes the effect?

PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion.

Effects of polyvinyl chloride microplastics on reproduction, oxidative stress and reproduction and detoxification-related genes in Daphnia magna.

Less impact than suspected: Dietary exposure of three-spined sticklebacks to microplastic fibers does not affect their body condition and immune parameters.

Ingested microplastics impair the metabolic relationship between the giant clam Tridacna crocea and its symbionts.

Polystyrene nanoplastics and wastewater displayed antagonistic toxic effects due to the sorption of wastewater micropollutants.

Increased transfer of trace metals and Vibrio sp. from biodegradable microplastics to catfish Clarias gariepinus.

Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat.

Miscellaneous

Genistein-based reactive oxygen species-responsive nanomaterial site-specifically relieves the intestinal toxicity of endocrine-disrupting chemicals.

Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice.

Surgical face masks as a source of emergent pollutants in aquatic systems: Analysis of their degradation product effects in Danio rerio through RNA-Seq.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Risk of exposure to Hg and pesticides residues in a traditional fishing community in the Amazon: a probabilistic approach based on dietary pattern.

Application of a novel prioritisation strategy using non-target screening for evaluation of temporal trends (1969-2017) of contaminants of emerging concern (CECs) in archived lynx muscle tissue samples.

TrendProbe: Time profile analysis of emerging contaminants by LC-HRMS non-target screening and deep learning convolutional neural network.

Site- and individual-level contamination affects infection prevalence of an emerging infectious disease of amphibians.

Assessment of automated off-line solid-phase extraction LC-MS/MS to monitor EPA priority endocrine disruptors in tap water, surface water, and wastewater.

BPA/Phenols

Development of a high-performance liquid chromatography method to assess bisphenol F levels in milk.

Phthalates

Toxicokinetic assessment of inhalatory absorption of Diisobutyl phthalate (DiBP) using a novel thermal desorption-GC-MS method to determine phthalate diesters in blood plasma.

A Pilot Study: Nails as a Non-invasive Biospecimen of Human Exposure to Phthalate Esters.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCBs in indoor air and human blood in Pittsfield, Massachusetts.

Aerobic polychlorinated biphenyl-degrading bacteria isolated from the Tohoku region of Japan are not regionally endemic.

Telomere length in relation to persistent organic pollutant exposure in white-tailed eagle (Haliaeetus albicilla) nestlings from Sweden sampled in 1995-2013.

Evidence of complementarity between targeted and non-targeted analysis based on liquid and gas-phase chromatography coupled to mass spectrometry for screening halogenated persistent organic pollutants in environmental matrices.

PCDD/Fs and Dioxin-like PCBs in Chicken Eggs and Soils in Dong Nai Province, Southern Vietnam: Impacts of Raising Methods and Nearby Pollution Sources.

Microbial Communities Along 2,3,7,8-tetrachlorodibenzodioxin Concentration Gradient in Soils Polluted with Agent Orange Based on Metagenomic Analyses.

Seaweed as bioindicators of organic micropollutants polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs).

Perfluoroalkyl Substances

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples.

Bioaccumulation and impact of maternal PFAS offloading on egg biochemistry from wild-caught freshwater turtles (Emydura macquarii macquarii).

PFAS in soil and groundwater following historical land application of biosolids.

Analysis of hydrophilic per- and polyfluorinated sulfonates including trifluoromethanesulfonate using solid phase extraction and mixed-mode liquid chromatography-tandem mass spectrometry.

Flame Retardants

Changes in levels of legacy and emerging organophosphorus flame retardants and plasticizers in indoor dust from a former e-waste recycling area in South China: 2013-2017.

Key factors controlling colloids-bulk soil distribution of polybrominated diphenyl ethers (PBDEs) at an e-waste recycling site: Implications for PBDE mobility in subsurface environment.

Organotins

Organotin compounds (OTs) in surface sediments, bivalves and algae from the Russian coast of the Barents Sea (Kola Peninsula) and the Fram Strait (Svalbard Archipelago).

Pesticides

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine.

Quantifiable urine glyphosate levels detected in 99% of the French population, with higher values in men, in younger people, and in farmers.

Evaluation of chiral triticonazole in three kinds of fruits: enantioseparation, degradation, and dietary risk assessment.

Sublethal toxicity of carbofuran in cattle egret (Bubulcus ibis coromandus): hematological, biochemical, and histopathological alterations.

Pesticide toxicity assessment and geographic information system (GIS) application in small-scale rice farming operations, Thailand.

Peer review of the pesticide risk assessment for the active substance penthiopyrad in light of confirmatory data submitted.

A comprehensive approach using multiple biomarkers to detect damage induced by pesticides in broad-snouted caiman (Caiman latirostris) under ex-situ conditions.

Determination of multi-class pesticides residues of cow and human milk samples from Iran using UHPLC-MS/MS and GC-ECD: A probabilistic health risk assessment.

Potentially Toxic Elements

Temporal distribution patterns of metals in water, sediment, and components of the trophic structure in a tropical coastal lagoon of the Gulf of Mexico.

Heavy metal toxicity, ecological risk assessment, and pollution sources in a hydropower reservoir.

Science Lessons from a Mercury Site.

Spatial and sex differences in mercury contamination of skuas in the Southern Ocean.

Case studies on longitudinal mercury content in humpback whale (Megaptera novaeangliae) baleen.

Analysis of lead, cadmium, and arsenic in colored cosmetics marketed in Pakistan.

Antibiotic application may raise the potential of methylmercury accumulation in fish.

Appraisal of groundwater arsenic on opposite banks of River Ganges, West Bengal, India, and quantification of cancer risk using Monte Carlo simulations.

Possible health risk assessment for heavy metal concentrations in water, sediment, and fish species and Turkmen pregnant women’s biomonitoring in Miankaleh Peninsula, Iran.

Caribbean Lead and Mercury Pollution Archived in a Crater Lake.

Ecological and human health risks from pseudo-total and bio-accessible metals in street dusts.

Trace element content in commercial complementary food formulated for infants and toddlers: Health risk assessment.

Microplastics

Influence of catastrophic flood on microplastics organization in surface water of the Three Gorges Reservoir, China.

An enhanced risk assessment framework for microplastics occurring in the Westerscheldt estuary.

Microplastics can alter phytoplankton community composition.

Air Pollution

Air pollution exposure disparities across US population and income groups.

Pharmaceuticals/Personal Care Products

Occurrence, sources and environmental risk assessment of pharmaceuticals in the Sea of Marmara, Turkey.

Miscellaneous

Groundwaters in Northeastern Pennsylvania near intense hydraulic fracturing activities exhibit few organic chemical impacts.

One-century sedimentary record, sources, and ecological risk of polycyclic aromatic hydrocarbons in Dianchi Lake, China.

Bacteria are better predictive biomarkers of environmental estrogen transmission than fungi.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.