EDC Science Weekly, Jan. 13-19, 2022

Post author:HEEDS
Post published:January 19, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Jan. 25: The role of epidemiology in risk assessment: A case study of five ortho-phthalates (EDC Strategies Partnership)

Webinar Jan. 27: Environmental Health Impacts of Synthetic Turf and Safer Alternatives (CHE)

Methods/Tools/Screening

Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals.

Sub-structure-based category formation for the prioritisation of genotoxicity hazard assessment for pesticide residues: Sulphonyl ureas.

Biological system considerations for application of toxicogenomics in next-generation risk assessment and predictive toxicology.

Implementation of in silico toxicology protocols within a visual and interactive hazard assessment platform.

In silico assessment of genotoxicity. Combinations of sensitive structural alerts minimize false negative predictions for all genotoxicity endpoints and can single out chemicals for which experimentation can be avoided.

Probabilistic risk assessment – the keystone for the future of toxicology.

Commentaries/Conference Summaries

Gut Microbiota Provides a New Mechanism for Explaining Agrochemical-Induced Synergistic Effects on Bee Mortality.

Off to a Rough Start: Environmental Exposures May Alter Germ Cell Development. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Effects of perinatal exposure to endocrine-disrupting chemicals on the reproductive system of F3 generation male rodents: a meta-analysis.

The role of endocrine-disrupting phthalates and bisphenols in cardiometabolic disease: the evidence is mounting.

Emerging Contaminant Exposure To Aquatic Systems In The Southern African Developmental Community.

BPA/Phenols

The impact of bisphenol a (BPA) on the placenta.

Parabens/Triclosan/Antimicrobials

The implication of parabens in cosmetics and cosmeceuticals: advantages and limitations.

Perfluoroalkyl Substances

A worldwide evaluation of trophic magnification of per- and polyfluoroalkyl substances in aquatic ecosystems.

Framework for risk assessment of PFAS utilizing experimental studies and in-silico models.

Potentially Toxic Elements

A Clinical Perspective on Arsenic Exposure and Development of Atherosclerotic Cardiovascular Disease.

Invasive plants as biosorbents for environmental remediation: a review.

On-going consequences of in utero exposure of Pb: An epigenetic perspective.

Assessment of Serum Elements Concentration and Polycystic Ovary Syndrome (PCOS): Systematic Review and Meta-analysis.

Biomonitoring metals and metalloids in wild mammals: invasive versus non-invasive sampling.

Microplastics

The micro-, submicron-, and nanoplastic hunt: A review of detection methods for plastic particles.

Critical review of microplastics removal from the environment.

Remediation of microplastics using bionanomaterials: A review.

Plastic accumulation during COVID-19: call for another pandemic; bioplastic a step towards this challenge?

Microplastics waste in environment: A perspective on recycling issues from PPE kits and face masks during the COVID-19 pandemic.

From properties to toxicity: Comparing microplastics to other airborne microparticles.

Occurrence, toxicity and remediation of polyethylene terephthalate plastics. A review.

Miscellaneous

Children’s exposure to polycyclic aromatic hydrocarbon (PAHs): a review on urinary 1-hydroxypyrene and associated health effects.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence.

Phthalates

Association Between Phthalate Exposure in Pregnancy and Gestational Diabetes: A Chinese Cross-Sectional Study.

Urinary phthalate metabolites in pregnant women: occurrences, related factors, and association with maternal hormones.

Pregnancy exposure to phthalates and DNA methylation in male placenta – An epigenome-wide association study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Airborne lead and polychlorinated biphenyls (PCBs) are associated with amyotrophic lateral sclerosis (ALS) risk in the U.S.

Pesticides

Exposure to neonicotinoid insecticides and their characteristic metabolites: Association with human liver cancer.

Pesticide residue intake from fruit and vegetable consumption and risk of glioma.

Epidemiology of Birth Defects in Eastern China and the Associated Risk Factors.

Potentially Toxic Elements

Associations of Childhood and Perinatal Blood Metals with Children’s Gut Microbiomes in a Canadian Gestation Cohort.

Influence of Environmental Factors on Salivary Microbiota and Their Metabolic Pathway: Next-Generation Sequencing Approach.

Identification of the hormetic dose-response and regulatory network of multiple metals co-exposure-related hypertension via integration of metallomics and adverse outcome pathways.

Association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in a US population: A cross-sectional study.

Arsenic exposure during pregnancy and postpartum maternal glucose tolerance: evidence from Bangladesh.

Associations of multiple plasma metals with the risk of metabolic syndrome: A cross-sectional study in the mid-aged and older population of China.

Association of peripubertal blood lead levels with reproductive hormones and semen parameters in a longitudinal cohort of Russian men.

Effects of lead and cadmium co-exposure on liver function in residents near a mining and smelting area in northwestern China.

Association between Arsenic Level, Gene Expression in Asian Population, and In Vitro Carcinogenic Bladder Tumor.

Air Pollution

A longitudinal study of exposure to fine particulate matter during pregnancy, small-for-gestational age births, and birthweight percentile for gestational age in a statewide birth cohort.

A method for identifying critical time windows of maternal air pollution exposures associated with low birth weight in offspring using massive geographic data.

Associations of antidepressant medication with its various predictors including particulate matter: Machine learning analysis using national health insurance data.

Uncertainty in Health Impact Assessments of Smoke From a Wildfire Event.

Co-creating a local environmental epidemiology study: the case of citizen science for investigating air pollution and related health risks in Barcelona, Spain.

Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences. [see related: Invited Perspective: Air Pollution and Autism Spectrum Disorder: Are We There Yet?]

Laboratory Studies

Numerous Chemicals/Mixtures

Combined effects of arsenic and 2,2-dichloroacetamide on different cell populations of zebrafish liver.

BPA/Phenols

The effect of nonylphenol exposure on the stimulation of melanomacrophage centers, estrogen and testosterone level, and ERα gene expression in goldfish.

Bisphenol AF blocks Leydig cell regeneration from stem cells in male rats.

Bisphenol A-sulfate conjugate disrupts AURKA transcription and cell cycle in BeWo cytotrophoblasts.

Cell components, interaction types and functional groups involved in the in vitro binding of bisphenol A by Lactiplantibacillus plantarum RS20D and DL7X.

Bisphenol A affects neurodevelopmental gene expression, cognitive function, and neuromuscular synaptic morphology in Drosophila melanogaster.

Phthalates

Role of Hepatocyte- and Macrophage-Specific PPARγ in Hepatotoxicity Induced by Diethylhexyl Phthalate in Mice.

Maternal Perinatal Exposure to Dibutyl Phthalate Promotes Ovarian Dysfunction in Adult Female Offspring via Downregulation of TGF-β2 and TGF-β3.

Di-(2-ethylhexyl) phthalate triggers DNA methyltransferase 1 expression resulting in elevated CpG-methylation and enrichment of MECP2 in the p21 promoter in vitro.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine contamination enriches virus-encoded metabolism and pesticide degradation associated auxiliary genes in soil microbiomes.

Perfluoroalkyl Substances

Exposure to perfluorooctanoic acid leads to promotion of pancreatic cancer.

Flame Retardants

Tricresyl phosphate inhibits fertilization in Japanese medaka (Oryzias latipes): Emphasizing metabolic toxicity.

Developmental exposure to the DE-71 mixture of polybrominated diphenyl ether (PBDE) flame retardants induce a complex pattern of endocrine disrupting effects in rats.

Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies.

Short-term tetrabromobisphenol A exposure promotes fibrosis of human uterine fibroid cells in a 3D culture system through TGF-beta signaling.

Long term exposure to tris (2-chloroethyl) phosphate (TCEP) causes alterations in reproductive hormones, vitellogenin, antioxidant enzymes, and histology of gonads in zebrafish (Danio rerio): In vivo and computational analysis.

Organotins

Reproductive toxicity of environmental levels of triphenyltin to the marine rotifer, Brachionus plicatilis.

Pesticides

A Combined LD50 for Agrochemicals and Pathogens in Bumblebees (Bombus terrestris [Hymenoptera: Apidae]).

Thiamethoxam-induced hematological, biochemical, and genetic alterations and the ameliorated effect of Moringa oleifera in male mice.

Early detection of cyanide, organophosphate and rodenticide pollution based on locomotor activity of zebrafish larvae.

Lifelong exposure to pyrethroid insecticide cypermethrin at environmentally relevant doses causes primary ovarian insufficiency in female mice.

Motor, memory, and anxiety-like behavioral impairments associated with brain-derived neurotrophic factor and dopaminergic imbalance after inhalational exposure to deltamethrin.

Sex-Dependent Environmental Health Risk Analysis of Flupyradifurone.

Potentially Toxic Elements

Cadmium exposure decreases fasting blood glucose levels and exacerbates type-2 diabetes in a mouse model.

Exposure to aluminium chloride during the peripuberal period induces prostate damage in male rats.

Effects of Lead on Reproduction Physiology and Liver and Gonad Histology of Male Cyprinus carpio.

Multi-biomarker approach to assess chromium, pH and temperature toxicity in fish.

Ghrelin attenuates methylmercury-induced oxidative stress in neuronal cells.

Stem cell-derived exosomes and copper sulfide nanoparticles attenuate the progression of neurodegenerative disorders induced by cadmium in rats.

Microplastics

Microplastics and nanoplastics: Size, surface and dispersant – What causes the effect?

PET microplastics affect human gut microbiota communities during simulated gastrointestinal digestion, first evidence of plausible polymer biodegradation during human digestion.

Effects of polyvinyl chloride microplastics on reproduction, oxidative stress and reproduction and detoxification-related genes in Daphnia magna.

Less impact than suspected: Dietary exposure of three-spined sticklebacks to microplastic fibers does not affect their body condition and immune parameters.

Ingested microplastics impair the metabolic relationship between the giant clam Tridacna crocea and its symbionts.

Polystyrene nanoplastics and wastewater displayed antagonistic toxic effects due to the sorption of wastewater micropollutants.

Increased transfer of trace metals and Vibrio sp. from biodegradable microplastics to catfish Clarias gariepinus.

Exposure to microplastics leads to a defective ovarian function and change in cytoskeleton protein expression in rat.

Miscellaneous

Genistein-based reactive oxygen species-responsive nanomaterial site-specifically relieves the intestinal toxicity of endocrine-disrupting chemicals.

Paternal acrylamide exposure induces transgenerational effects on sperm parameters and learning capability in mice.

Surgical face masks as a source of emergent pollutants in aquatic systems: Analysis of their degradation product effects in Danio rerio through RNA-Seq.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Risk of exposure to Hg and pesticides residues in a traditional fishing community in the Amazon: a probabilistic approach based on dietary pattern.

Application of a novel prioritisation strategy using non-target screening for evaluation of temporal trends (1969-2017) of contaminants of emerging concern (CECs) in archived lynx muscle tissue samples.

TrendProbe: Time profile analysis of emerging contaminants by LC-HRMS non-target screening and deep learning convolutional neural network.

Site- and individual-level contamination affects infection prevalence of an emerging infectious disease of amphibians.

Assessment of automated off-line solid-phase extraction LC-MS/MS to monitor EPA priority endocrine disruptors in tap water, surface water, and wastewater.

BPA/Phenols

Development of a high-performance liquid chromatography method to assess bisphenol F levels in milk.

Phthalates

Toxicokinetic assessment of inhalatory absorption of Diisobutyl phthalate (DiBP) using a novel thermal desorption-GC-MS method to determine phthalate diesters in blood plasma.

A Pilot Study: Nails as a Non-invasive Biospecimen of Human Exposure to Phthalate Esters.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCBs in indoor air and human blood in Pittsfield, Massachusetts.

Aerobic polychlorinated biphenyl-degrading bacteria isolated from the Tohoku region of Japan are not regionally endemic.

Telomere length in relation to persistent organic pollutant exposure in white-tailed eagle (Haliaeetus albicilla) nestlings from Sweden sampled in 1995-2013.

Evidence of complementarity between targeted and non-targeted analysis based on liquid and gas-phase chromatography coupled to mass spectrometry for screening halogenated persistent organic pollutants in environmental matrices.

PCDD/Fs and Dioxin-like PCBs in Chicken Eggs and Soils in Dong Nai Province, Southern Vietnam: Impacts of Raising Methods and Nearby Pollution Sources.

Microbial Communities Along 2,3,7,8-tetrachlorodibenzodioxin Concentration Gradient in Soils Polluted with Agent Orange Based on Metagenomic Analyses.

Seaweed as bioindicators of organic micropollutants polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs).

Perfluoroalkyl Substances

Exposure of Preconception Couples to Legacy and Emerging Per- and Polyfluoroalkyl Substances: Variations Within and Between Couples.

Bioaccumulation and impact of maternal PFAS offloading on egg biochemistry from wild-caught freshwater turtles (Emydura macquarii macquarii).

PFAS in soil and groundwater following historical land application of biosolids.

Analysis of hydrophilic per- and polyfluorinated sulfonates including trifluoromethanesulfonate using solid phase extraction and mixed-mode liquid chromatography-tandem mass spectrometry.

Flame Retardants

Changes in levels of legacy and emerging organophosphorus flame retardants and plasticizers in indoor dust from a former e-waste recycling area in South China: 2013-2017.

Key factors controlling colloids-bulk soil distribution of polybrominated diphenyl ethers (PBDEs) at an e-waste recycling site: Implications for PBDE mobility in subsurface environment.

Organotins

Organotin compounds (OTs) in surface sediments, bivalves and algae from the Russian coast of the Barents Sea (Kola Peninsula) and the Fram Strait (Svalbard Archipelago).

Pesticides

Multiple neonicotinoids in children’s cerebro-spinal fluid, plasma, and urine.

Quantifiable urine glyphosate levels detected in 99% of the French population, with higher values in men, in younger people, and in farmers.

Evaluation of chiral triticonazole in three kinds of fruits: enantioseparation, degradation, and dietary risk assessment.

Sublethal toxicity of carbofuran in cattle egret (Bubulcus ibis coromandus): hematological, biochemical, and histopathological alterations.

Pesticide toxicity assessment and geographic information system (GIS) application in small-scale rice farming operations, Thailand.

Peer review of the pesticide risk assessment for the active substance penthiopyrad in light of confirmatory data submitted.

A comprehensive approach using multiple biomarkers to detect damage induced by pesticides in broad-snouted caiman (Caiman latirostris) under ex-situ conditions.

Determination of multi-class pesticides residues of cow and human milk samples from Iran using UHPLC-MS/MS and GC-ECD: A probabilistic health risk assessment.

Potentially Toxic Elements

Temporal distribution patterns of metals in water, sediment, and components of the trophic structure in a tropical coastal lagoon of the Gulf of Mexico.

Heavy metal toxicity, ecological risk assessment, and pollution sources in a hydropower reservoir.

Science Lessons from a Mercury Site.

Spatial and sex differences in mercury contamination of skuas in the Southern Ocean.

Case studies on longitudinal mercury content in humpback whale (Megaptera novaeangliae) baleen.

Analysis of lead, cadmium, and arsenic in colored cosmetics marketed in Pakistan.

Antibiotic application may raise the potential of methylmercury accumulation in fish.

Appraisal of groundwater arsenic on opposite banks of River Ganges, West Bengal, India, and quantification of cancer risk using Monte Carlo simulations.

Possible health risk assessment for heavy metal concentrations in water, sediment, and fish species and Turkmen pregnant women’s biomonitoring in Miankaleh Peninsula, Iran.

Caribbean Lead and Mercury Pollution Archived in a Crater Lake.

Ecological and human health risks from pseudo-total and bio-accessible metals in street dusts.

Trace element content in commercial complementary food formulated for infants and toddlers: Health risk assessment.

Microplastics

Influence of catastrophic flood on microplastics organization in surface water of the Three Gorges Reservoir, China.

An enhanced risk assessment framework for microplastics occurring in the Westerscheldt estuary.

Microplastics can alter phytoplankton community composition.

Air Pollution

Air pollution exposure disparities across US population and income groups.

Pharmaceuticals/Personal Care Products

Occurrence, sources and environmental risk assessment of pharmaceuticals in the Sea of Marmara, Turkey.

Miscellaneous

Groundwaters in Northeastern Pennsylvania near intense hydraulic fracturing activities exhibit few organic chemical impacts.

One-century sedimentary record, sources, and ecological risk of polycyclic aromatic hydrocarbons in Dianchi Lake, China.

Bacteria are better predictive biomarkers of environmental estrogen transmission than fungi.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.