EDC Science Weekly, Feb. 3 – 9, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Feb 10: CHE Café: What’s Next in Environmental Health? (Collaborative for Health and Environment, CHE)

Webinar Feb 15: Office Workers’ Exposures: Hormonal Activity of Chemicals Detected with Silicone Wristbands (EDC Strategies Partnership)

Webinar Feb 23: Environmental Justice and the Built Environment: Protecting Children and Families (CHE)

Regulations/Policy

Emerging environmental contaminants: A global perspective on policies and regulations.

An equity and environmental justice assessment of anti-science actions during the Trump administration.

Public preferences for marine plastic litter management across Europe.

Unfolding the science behind policy initiatives targeting plastic pollution.

Herbicide Use in the Era of Farm to Fork: Strengths, Weaknesses, and Future Implications.

Methods/Tools/Screening

The use of new approach methodologies for the environmental risk assessment of food and feed chemicals.

Algorithm for environmental risk assessment of cosmetics to reduce their environmental impact.

A proposed reporting framework for microplastic-metal mixtures research, with emphasis on environmental considerations known to influence metals.

Caenorhabditis elegans: a model organism in the toxicity assessment of environmental pollutants.

Commentaries

Editorial: Getting to the heart of developmental toxicities.

Invited Perspective: Metals and Menarche.

Occupational exposure to PFAS: Research and protection needed.

Reviews

Numerous Chemicals/Mixtures

Environmental factors affecting pregnancy outcomes.

Environment and the development of severe asthma in inner city population.

Mitochondrial Toxicant-Induced Neuronal Apoptosis in Parkinson’s Disease: What We Know so Far.

Biomonitoring of firefighting forces: a review on biomarkers of exposure to health-relevant pollutants released from fires.

Present and future challenges for the investigation of transgenerational epigenetic inheritance.

BPA/Phenols

Health Risk Assessment of Exposure to Bisphenol A in Polymeric Baby Bottles.

Parabens/Triclosan/Antimicrobials

Triclosan and related compounds in the environment: Recent updates on sources, fates, distribution, analytical extraction, analysis, and removal techniques.

Metals/Metalloids

The interplay of arsenic, silymarin, and NF-ĸB pathway in male reproductive toxicity: A review.

Microplastics/Nanomaterials

Microplastics may increase the environmental risks of Cd via promoting Cd uptake by plants: A meta-analysis.

Insights into the potential carcinogenicity of micro- and nano-plastics.

Plastic microfibers as a risk factor for the health of aquatic organisms: A bibliometric and systematic review of plastic pandemic.

Air Pollution

Pre- and postnatal particulate matter exposure and blood pressure in children and adolescents: A systematic review and meta-analysis.

Air pollution exposure and auto-inflammatory and autoimmune diseases of the musculoskeletal system: a review of epidemiologic and mechanistic evidence.

Miscellaneous

A review of the endocrine disrupting effects of micro and nano plastic and their associated chemicals in mammals.

Human Health Studies

Numerous Chemicals/Mixtures

Reduction of daily-use parabens and phthalates reverses accumulation of cancer-associated phenotypes within disease-free breast tissue of study subjects.

Association of Endocrine-Disrupting Chemicals with All-Cause and Cause-Specific Mortality in the U.S.: A Prospective Cohort Study.

Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms.

Paternal occupational exposures and infant congenital heart defects in the Japan Environment and Children’s Study.

Individual blood concentrations of persistent organic pollutants and chemical elements, and COVID-19: A prospective cohort study in Barcelona.

Phthalates

Phthalates and Incident Diabetes in Midlife Women: The Study of Women’s Health Across the Nation (SWAN).

Maternal phthalate exposure during pregnancy and testis function of young adult sons.

Butyl benzyl phthalate as a key component of phthalate ester in relation to cognitive impairment in NHANES elderly individuals and experimental mice.

Parabens/Triclosan/Antimicrobials

Paraben exposure and couple fecundity: a preconception cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Individual blood concentrations of persistent organic pollutants and chemical elements, and COVID-19: A prospective cohort study in Barcelona

Pesticide exposure and Alzheimer’s disease: A case-control study.

Perfluoroalkyl Substances

Effect of PFOA exposure on diminished ovarian reserve and its metabolism.

Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study.

Pesticides

Glyphosate in house dust and risk of childhood acute lymphoblastic leukemia in California.

Environmental pesticide exposure and the risk of irritable bowel syndrome: A case-control study.

Metals/Metalloids

Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother-Child Cohort Study in Bangladesh.

Canonical analysis of concentrations of toxic metals in endometrium of women with gynecological disorders.

Effects of mixed heavy metals on kidney function in premenopausal and postmenopausal women.

Association of blood mercury levels with bone mineral density in adolescents aged 12-19.

Associations of arsenic exposure with liver injury in US adults: NHANES 2003-2018.

Metabolomic changes associated with chronic arsenic exposure in a Bangladeshi population.

Early Life Environmental Exposure to Cadmium, Lead, and Arsenic and Age at Menarche: A Longitudinal Mother-Child Cohort Study in Bangladesh.

Microplastics/Nanomaterials

Release of microplastics from breastmilk storage bags and assessment of intake in infants: A preliminary study.

Air Pollution

Association of exposure to air pollutants with gestational diabetes mellitus in Chiayi City, Taiwan.

Global, regional, and national burden of preterm birth attributable to ambient and household PM_2.5 from 1990 to 2019: Worsening or improving?

Miscellaneous

Sex-specific effect of urinary metabolites of polycyclic aromatic hydrocarbons on thyroid profiles: results from NHANES 2011-2012.

Laboratory Studies

Numerous Chemicals/Mixtures

Toxicoproteomics of Mono(2-ethylhexyl) phthalate and Perfluorooctanesulfonic Acid in Models of Prostatic Diseases.

BPA/Phenols

Bisphenol A and bisphenol S both disrupt ovine granulosa cell steroidogenesis but through different molecular pathways.

Effects of perinatal exposure to bisphenol A or S in EAE model of multiple sclerosis.

2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors.

Phthalates

Environmentally Relevant Perinatal Exposure to DBP Accelerated Spermatogenesis by Promoting the Glycolipid Metabolism of Sertoli Cells in Male Offspring Mice.

Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway.

DEHP mediates drug resistance by metabolic reprogramming in colorectal cancer cells.

Parabens/Triclosan/Antimicrobials

Application of microdialysis combined with UHPLC-QTOF/MS to screen for endogenous metabolites in aquatic organisms as biomarkers of exposure to an emerging contaminant, triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification of key genes in hepatocellular carcinoma associated with exposure to TCDD and α-endosulfan by WGCNA.

Perfluoroalkyl Substances

High-content analysis shows synergistic effects of low perfluorooctanoic acid (PFOS) and perfluorooctane sulfonic acid (PFOA) mixture concentrations on human breast epithelial cell carcinogenesis.

Perfluorooctanoic acid induces tight junction injury of Sertoli cells by blocking autophagic flux.

Short-chain per- and polyfluoralkyl substances (PFAS) effects on oxidative stress biomarkers in human liver, kidney, muscle, and microglia cell lines.

Nafion by-product 2 disturbs lipid homeostasis in zebrafish embryo.

Flame Retardants

2,2′,4,4′,5,5′-Hexabromophenyl ether (BDE-153) causes abnormal insulin secretion and disorders of glucose and lipid metabolism in mice.

Growth inhibition of offspring larvae caused by the maternal transfer effects of tetrabromobisphenol A in zebrafish.

BDE-209 disrupted the blood-testis barrier integrity by inhibiting estrogen receptor α signaling pathway in Sprague-Dawley rats.

Organotins

miR-223 Plays A Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity.

Co-expression analysis of lncRNA and mRNA identifies potential adipogenesis regulatory non-coding RNAs involved in the transgenerational effects of tributyltin.

Toxicity of tributyltin to the European flat oyster Ostrea edulis: Metabolomic responses indicate impacts to energy metabolism, biochemical composition and reproductive maturation.

Pesticides

Integrate transcriptomic and metabolomic analysis reveals the underlying mechanisms of behavioral disorders in zebrafish (Danio rerio) induced by imidacloprid.

Single-cell transcriptome analysis reveals liver injury induced by glyphosate in mice.

Complex mixtures of pesticides and metabolites modulate the malignant phenotype of murine melanoma B16-F1 cells.

Metamifop as an estrogen-like chemical affects the pituitary-hypothalamic-gonadal (HPG) axis of female rice field eels (Monopterus albus).

In silico and in vivo assessment of developmental toxicity, oxidative stress response & Na⁺/K⁺-ATPase activity in zebrafish embryos exposed to cypermethrin.

Different effects of pesticides on transcripts of the endocrine regulation and energy metabolism in honeybee foragers from different colonies.

Metals/Metalloids

Paternal genetic intergenerational and transgenerational effects of cadmium exposure on hormone synthesis disorders in progeny ovarian granulosa cells.

Microplastics/Nanomaterials

The effect and a mechanistic evaluation of polystyrene nanoplastics on a mouse model of type 2 diabetes.

A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo.

Ferroptosis Is Involved in Sex-Specific Small Intestinal Toxicity in the Offspring of Adult Mice Exposed to Polystyrene Nanoplastics during Pregnancy.

Polystyrene microplastics arrest skeletal growth in puberty through accelerating osteoblast senescence.

Multi-generation exposure to polystyrene nanoplastics showed no major adverse effects in Daphnia magna.

Miscellaneous

Does dietary exposure to 17α-ethinylestradiol alter biomarkers related with endocrine disruption and oxidative stress in the adult triploid of Danio rerio?

Comparison and quantification of estrogen receptor-mediated responsiveness to endocrine disruptors in bivalves by using complementary model and a novel yeast assay approach.

Transgenerational effects of benzotriazole on the gene expression, growth, and reproduction of Daphnia magna.

Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Results of the Austrian Children’s Biomonitoring Survey 2020 part A: Per- and polyfluorinated alkylated substances, bisphenols, parabens and other xenobiotics.

BPA/Phenols

Occurrence of emerging bisphenol S analogues in urine from five occupational populations in South China.

Broadening the lens on bisphenols in coastal waters: Occurrence, partitioning, and input fluxes of multiple novel bisphenol S derivatives along with BPA and BPA analogues in the Pearl River Delta, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Assessment of organohalogenated pollutants in breast milk from the Czech Republic.

Good News: Some Insecticides Have Been Virtually Eliminated in Air near the Great Lakes.

Determinants of exposure to polychlorinated biphenyls in the Italian population in the last decades.

Distribution of organochlorine pesticides in surface and deep waters of the Southern Indian Ocean and coastal Antarctic waters.

Perfluoroalkyl Substances

Penetration of Perfluorooctanesulfonate Isomers and Their Alternatives from Maternal Blood to Milk and Its Associations with Chemical Properties and Milk Primary Components.

Comprehensive target analysis and TOP assay of per- and polyfluoroalkyl substances (PFAS) in wild boar livers indicate contamination hot-spots in the environment.

Underestimation of Per- and Polyfluoroalkyl Substances in Biosolids: Precursor Transformation During Conventional Treatment.

Flame Retardants

Polybrominated diphenyl ethers and bromophenols in paired serum, hair, and urine samples of e-waste dismantlers: Insights into hair as an indicator of endogenous exposure.

Pesticides

Cocktails of pesticide residues in Prochilodus lineatus fish of the Salado River (South America): First record of high concentrations of polar herbicides.

Metals/Metalloids

Relationships between maternally-transferred mercury and hatchling development, behavior, and survival in the American alligator (Alligator mississippiensis).

Microplastics/Nanomaterials

Plastic waste generation and emissions from the domestic open burning of plastic waste in Guatemala.

Miscellaneous

Do cats mirror their owner? Paired exposure assessment using silicone bands to measure residential PAH exposure.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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