EDC Science Weekly, Feb. 3 – 9, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week. [Note I’ll be on vacation next week so will send the next update out in 2 weeks]

Contents: Events, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Open meeting Feb 11: First Open Session of the Committee to Review the IRIS Assessment Handbook

Symposium Feb 12: Innovations in Relating Real Life Exposures to Chemicals and Chemical Mixtures to Health Outcomes

Webinar Feb 16: Action on PFAS as part of the EU Chemicals Strategy for Sustainability: an opportunity for disease prevention

Webinar Feb 18: Intersectionality and Environmental Justice

Webinar Feb 23: Count Down: How Our Modern World Is Threatening Sperm Counts, Altering Male and Female Reproductive Development, and Imperiling the Future of the Human Race

Webinar Mar 3: Endocrine Disrupting Chemicals: Effects on Mothers, and Interactions with Lifestyle

Methods/Tools/Screening

High-Throughput Transcriptomics Platform for Screening Environmental Chemicals.

Human Pluripotent Stem Cells: A Unique Tool for Toxicity Testing in Pancreatic Progenitor and Endocrine Cells.

The E-Morph Assay: Identification and characterization of environmental chemicals with estrogenic activity based on quantitative changes in cell-cell contact organization of breast cancer cells.

Evaluation of an in vitro assay to screen for the immunotoxic potential of chemicals to fish.

European Food Safety Authority open access tools to estimate dietary exposure to food chemicals.

Commentaries/Conference Summaries

From Evidence of Harm to Public Health Policy: Is There Light at the End of the Tunnel? Response to: “Update on the Health Effects of bisphenol A: Overwhelming Evidence of Harm”.

FutureTox IV Workshop Summary: Predictive Toxicology for Healthy Children.

Can Microbes Save Us from PFAS?

Arsenic as an environmental toxicant and a therapeutic agent: Foe and friend.

Reviews

Numerous EDCs/Mixtures

Environmental Pollution and Chronic Kidney Disease.

Scoping Review-The Association between Asthma and Environmental Chemicals.

Environmental toxicants in the brain: a review of astrocytic metabolic dysfunction.

Endocrine-Disrupting Compounds in Fish Physiology, with Emphasis on their Effects on the Arginine Vasotocin/Isotocin System.

[Type 2 diabetes and endocrine disrupting environmental chemical pollutants]. [in French]

Effects of Chemical Mixtures on the Ovary.

Perfluoroalkyl Substances

Thyroid Disrupting Effects of Old and New Generation PFAS.

Source, transportation, bioaccumulation, distribution and food risk assessment of perfluorinated alkyl substances in vegetables: A review.

Pesticides

Peer review of a cancer weight of evidence assessment based on updated toxicokinetics, genotoxicity, and carcinogenicity data for 1,3-dichloropropene using a blinded, virtual panel of experts.

The herbicide paraquat-induced molecular mechanisms in the development of acute lung injury and lung fibrosis.

Potentially Toxic Elements

Cognitive Impairment Induced by Lead Exposure during Lifespan: Mechanisms of Lead Neurotoxicity.

Blood donation and heavy metal poisoning in developing nations: Any link?

Microplastics

Understanding plastic degradation and microplastic formation in the environment: A review.

Distribution of microplastics in soil and freshwater environments: Global analysis and framework for transport modeling.

Plastic pollution: A focus on freshwater biodiversity.

Air Pollution

Long-Term Effects of Fine Particles on Mortality: Insights from 1984.

Air pollutants and impairments of male reproductive health-an overview.

Pharmaceuticals/Personal Care Products

Hair chemicals may increase breast cancer risk: A meta-analysis of 210319 subjects from 14 studies.

A Critical Review of Organic Ultraviolet Filter Exposure, Hazard, and Risk to Corals.

Sunscreens: UV filters to protect us: Part 1: Changing regulations and choices for optimal sun protection.
Sunscreens: UV filters to protect us: Part 2-Increasing awareness of UV filters and their potential toxicities to us and our environment.

Miscellaneous

Health disparities: Intracellular consequences of social determinants of health.

Human Health Studies

Numerous Chemicals

Urinary levels of phthalate esters and heavy metals in adolescents with thyroid colloid cysts.

Mixtures

Bayesian Weighted Sums: A Flexible Approach to Estimate Summed Mixture Effects. [PBDEs]

BPA/Phenols

Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age-Cross-Sectional Study.

Environmental exposure to urinary Bisphenol-A in North Indian children aged between 6 and 16 years and its association with body mass index.

Associations of serum bisphenol A levels with incident chronic kidney disease risk.

Phthalates

Exposure to prenatal phthalate mixtures and neurodevelopment in the Conditions Affecting Neurocognitive Development and Learning in Early childhood (CANDLE) study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of aryl hydrocarbon receptor transactivating activity, a potential biomarker for persistent organic pollutants, with the risk of gestational diabetes mellitus.

Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy.

Impact of organochlorine pollutants on semen parameters of infertile men in Pakistan.

Perfluoroalkyl Substances

Prenatal exposure to poly- and perfluoroalkyl substances (PFAS) and neurobehavior in US children through 8 years of age: the HOME Study.

Perfluoroalkyl substances and sex hormones in postmenopausal women: NHANES 2013-2016.

Flame Retardants

Women with high plasma levels of PBDE-47 are at increased risk of preterm birth.

Pesticides

Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development.

Household mold, pesticide use, and childhood asthma: A nationwide study in the U.S.

Profiles of neonicotinoid insecticides and their metabolites in paired saliva and periodontal blood samples in human from South China: Association with oxidative stress markers.

Potentially Toxic Elements

Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes.

Antagonistic effect of early stage zinc on arsenic toxicity induced preterm birth during pregnancy: evidence from a rural Bangladesh birth cohort.

Association between blood cadmium levels and the risk of osteopenia and osteoporosis in Korean post-menopausal women.

A longitudinal study of rural Bangladeshi children with long-term arsenic and cadmium exposures and biomarkers of cardiometabolic diseases.

Proximity to sources of airborne lead is associated with reductions in Children’s executive function in the first four years of life.

Association of microRNA expression with changes in immune markers in workers with cadmium exposure.

Blood lead level and risk of hypertension in the United States National Health and Nutrition Examination Survey 1999-2016.

Association between body mass index and arsenic methylation in three studies of Bangladeshi adults and adolescents .

Stratification of population in NHANES 2009-2014 based on exposure pattern of lead, cadmium, mercury, and arsenic and their association with cardiovascular, renal and respiratory outcomes.

A Positive Relationship between Exposure to Heavy Metals and Development of Chronic Diseases: A Case Study from Chile.

Blood lead and mercury levels are associated with low resting heart rate in community adolescent boys.

Air Pollution

Joint exposure to various ambient air pollutants and incident heart failure: a prospective analysis in UK Biobank.

Short-Term Effects of Air Pollution on Cardiovascular Hospitalizations in the Pisan Longitudinal Study.

Correlation between total air pollutant emissions and incidence of type 1 diabetes in the Russian Federation.

Short-term personal PM_2.5 exposure and change in DNA methylation of imprinted genes: Panel study of healthy young adults in Guangzhou city, China.

Associations between PM_2.5 metal components and QT interval length in the Normative Aging Study.

Individual exposure to urban air pollution and its correlation with placental angiogenic markers in the first trimester of pregnancy, in São Paulo, Brazil.

SOS! Summer of Smoke: a retrospective cohort study examining the cardiorespiratory impacts of a severe and prolonged wildfire season in Canada’s high subarctic.

Metabolomics analysis of maternal serum exposed to high air pollution during pregnancy and risk of autism spectrum disorder in offspring.

Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State.

Maternal exposure to air pollutants, PCSK9 levels, fetal growth and gestational age – An Italian cohort.

Acute associations between air pollution on premature rupture of membranes in Hefei, China.

Laboratory Studies

BPA/Phenols

Effect of bisphenol A on craniofacial cartilage development in zebrafish (Danio rerio) embryos: A morphological study.

Comparative responses of cell growth and related extracellular polymeric substances in Tetraselmis sp. to nonylphenol, bisphenol A and 17α-ethinylestradiol.

Phthalates

Di-(2-ethylhexyl) phthalate-induced tumor growth is regulated by primary cilium formation via the axis of H₂O₂ production-thymosin beta-4 gene expression.

Perfluoroalkyl Substances

Unveiling the binding mode of perfluorooctanoic acid to human serum albumin.

Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy.

Toxicology and carcinogenesis studies of perfluorooctanoic acid administered in feed to Sprague Dawley (Hsd:Sprague Dawley SD) rats. [by NTP]

Flame Retardants

Comprehensive analysis of organophosphorus flame retardant-induced mitochondrial abnormalities: Potential role in lipid accumulation.

Polybrominated Diphenyl Ethers in Human Follicular Fluid Dysregulate Mural and Cumulus Granulosa Cell Gene Expression.

Organotins

Potent Inhibition of Tributyltin (TBT) and Triphenyltin (TPT) against multiple UDP-glucurpnosyltranseferases (UGT): a new potential mechanism underlying endocrine disrupting actions.

Pesticides

Multiple toxicity of propineb in developing zebrafish embryos: Neurotoxicity, vascular toxicity, and notochord defects in normal vertebrate development.

Effects of dietary cypermethrin exposure on swimming performance and expression of lipid homeostatic genes in livers of juvenile Chinook salmon, Oncorhynchus tshawytscha.

Potential role of a newly AChE reactivator in the depressive-like behavior induced by malathion.

Influence of temperature on biomarker responses and histology of the liver of American bullfrog tadpoles (Lithobates catesbeianus, Shaw, 1802) exposed to the herbicide Tebuthiuron.

Prenatal exposure to low doses of fungicides corrupts neurogenesis in neonates.

Low-dose exposure of glyphosate-based herbicides disrupt the urine metabolome and its interaction with gut microbiota.

Growth performance and reproductive function impairment of glyphosate-based herbicide in male guinea pig (Cavia porcellus).

Mitochondria of teleost radial glia: A novel mechanism of neuroendocrine disruption by environmental chemicals?

Histopathological features of low-dose organophosphate exposure.

Microplastics

Polystyrene microplastics lead to pyroptosis and apoptosis of ovarian granulosa cells via NLRP3/Caspase-1 signaling pathway in rats.

Air Pollution

Particulate Matter Exposure Exacerbates Amyloid-β Plaque Deposition and Gliosis in APP/PS1 Mice.

Pharmaceuticals/Personal Care Products

Influences of sex, rhythm and generation on the obesogenic potential of erythromycin to Drosophila melanogaster.

Exposure to four chemical UV filters through contaminated sediment: impact on survival, hatching success, cardiac frequency, and aerobic metabolic scope in embryo-larval stage of zebrafish.

Mixtures

Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect.

Miscellaneous

In vitro human cell-based TTR-TRβ CALUX assay indicates thyroid hormone transport disruption of short-chain, medium-chain, and long-chain chlorinated paraffins.

Exposure/Environment Studies

Numerous Chemicals

Determination of bisphenols, parabens, and benzophenones in placenta by dispersive liquid-liquid microextraction and gas chromatography-tandem mass spectrometry.

Infant total diet study in France: Exposure to substances migrating from food contact materials. [BPA, phthalates, etc.]

Indicator Compounds Representative of Contaminants of Emerging Concern (CECs) Found in the Water Cycle in the United States.

A systematic review and meta-analysis of human biomonitoring studies on exposure to environmental pollutants in Iran.

Phthalates

Phthalate exposure in association with the use of personal care products among general population from Shanghai.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticide accumulation in fish and catchment sediments of Lake St Lucia: Risks for Africa’s largest estuary.

Software-Assisted Pattern Recognition of Persistent Organic Pollutants in Contaminated Human and Animal Food.

Chronic exposure to environmental DDT/DDE in two species of small rodents: measures of contaminant load, immune dysfunction and oxidative stress.

Average transfer factors are not enough: The influence of growing cattle physiology on the transfer rate of polychlorinated biphenyls from feed to adipose.

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances (PFAS) and total fluorine in fire station dust.

Household low pile carpet usage was associated with increased serum PFAS concentrations in 2005-2006.

Flame Retardants

A critical review of human exposure to organophosphate esters with a focus on dietary intake.

Preliminary results on polybrominated diphenyl ether contamination status in Croatian households and insights into children’s exposure.

Organophosphorus flame retardants in breast milk from Beijing, China: Occurrence, nursing infant’s exposure and risk assessment.

Pesticides

Consumption of field-realistic doses of a widely used mito-toxic fungicide reduces thorax mass but does not negatively impact flight capacities of the honey bee (Apis mellifera).

Neonicotinoid residues in honey from urban and rural environments.

Neonicotinoid pesticides exert metabolic effects on avian pollinators.

Tracking Pesticide Exposure to Operating Workers for Risk Assessment in Seed Coating with Tebuconazole and Carbofuran.

Widespread Occurrence of Pesticides in Organically Managed Agricultural Soils-the Ghost of a Conventional Agricultural Past?

Potentially Toxic Elements

Combining analytical and in vitro techniques for comprehensive assessments of chemical exposure and effect in green sea turtles (Chelonia mydas).

Understanding Food Web Mercury Accumulation Through Trophic Transfer and Carbon Processing along a River Affected by Recent Run-of-river Dams.

Chronic dietary exposure to inorganic arsenic.

Concentrations of arsenic and vanadium in environmental and biological samples collected in the neighborhood of petrochemical industries: A review of the scientific literature.

Snake scales record environmental metal(loid) contamination.

Assessment of In Vitro Bioaccessibility and In Vivo Oral Bioavailability as Complementary Tools to Better Understand the Effect of Cooking on Methylmercury, Arsenic, and Selenium in Tuna.

Air Pollution

Effect of air pollution on health care expenditure: Evidence from respiratory diseases.

Pandemic induced lockdown as a boon to the Environment: trends in air pollution concentration across India.

Miscellaneous

Modeling estrogenic activity in streams throughout the Potomac and Chesapeake Bay watersheds.

No Butts on the Beach: Aquatic Toxicity of Cigarette Butt Leachate Chemicals.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.