EDC Science Weekly, Feb. 28 – Mar. 6, 2025

Post author:HEEDS
Post published:March 6, 2025
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Summer courses: Skills for Health and Research Professionals (SHARP) Training scholarship deadline March 7 [Columbia University]

Mar. 6 webinar (today!): How plastics fueled the LA wildfires and how to rebuild better [Plastic Pollution Coalition]

Mar. 11 Grand Rounds: Childhood Cancer and the Environment: Prevention to Survivorship Objectives [Boston Children’s Hospital and New England PEHSU]

Mar. 11 webinar: Reducing single use plastics [National Academy of Medicine]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville AND via zoom! [HEEDS]

Mar. 26 webinar: Impacts of Fracking in North & South America: Resources in English & Spanish [CHE]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 25: HEEDS EDC-North Carolina group 5th Annual Meeting, in person in Raleigh [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 10-13: EDC sessions at European endocrinology society meeting [ESPE and ESE]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [ECHA]

July 30 – Aug. 1 conference: U.S. DOHaD Society Annual Meeting.

More events

Regulations/Policy

Evaluation of reproductive toxicology studies according the OECD Guideline 443 – Claim and reality [industry perspective]

More EDC policy and regulations open for comment and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

Development of the Navigation Guide Evidence-to-Decision Framework for Environmental Health: Version 1.0.

Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) “New Approach Methodologies (NAMs) User Forum Kick-off Workshop”

TAME 2.0: expanding and improving online data science training for environmental health research.

From High Resolution Tandem Mass Spectrometry to Pollutant Toxicity AI-Based Prediction: A Case Study of 7 Endocrine Disruptors Endpoints.

Novel Approach to Screen Endocrine-Disrupting Chemicals via Endocrine-Enhanced Reduced Human Transcriptome.

Toward Product Safety and Circularity: Understanding the Information Structure of Global Databases on Chemicals in Products and Articles

MLinvitroTox reloaded for high-throughput hazard-based prioritization of high-resolution mass spectrometry data

Development and characterization of a double-crested cormorant hepatic cell line, DCH22, for chemical screening.

Leveraging Zebrafish Embryo Phenotypic Observations to Advance Data-Driven Analyses in Toxicology.

Pioneering an effect-based early warning system for hazardous chemicals in the environment

Commentaries

Forever Chemicals (PFAS): An Overview for Maternity and Pediatric Health Care Professionals.

Report on the European Partnership for Alternative Approaches to Animal Testing (EPAA) “New Approach Methodologies (NAMs) User Forum Kick-off Workshop”.

Microplastics and Nanoplastics: The Next Frontier of Cardiovascular Risk?

An effective plastics treaty for marine life.

Editorial: Leveraging artificial intelligence and open science for toxicological risk assessment. [intro to a research topic in Frontiers in Toxicology]

Critical considerations on the study “Adolescent exposure to bisphenol a antagonizes androgen regulation of social behavior in male mice” (): The importance of locomotor and anxiety assessments.

Medpage Today: Will They Come for PubMed Next?

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Environmental factors trigger pubertal development.

Prostate as a target of endocrine disrupting chemicals: relevance, pathways, assays.

PFAS

Per- and polyfluoroalkyl substances: toxicokinetics, exposure and health risks.

Evidence of the occurrence, detection, and ecotoxicity studies of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in aqueous environments.

Per- and polyfluoroalkyl substances in environment and potential health impacts: Sources, remediation treatment and management, policy guidelines, destructive technologies, and techno-economic analysis.

Metals/Metalloids

Association of environmental metallic and metalloid contaminants with cardiovascular and all-cause mortality: An umbrella review of systematic reviews and meta-analyses.

Microplastics/Nanomaterials

Micro-nanoplastics pollution and mammalian fertility: A systematic review and meta-analysis.

Microplastics/nanoplastics contribute to aging and age-related diseases: mitochondrial dysfunction as a crucial role.

Effects of Micro- and Nanoplastics on Blood Cells In Vitro and Cardiovascular Parameters In Vivo, Considering Their Presence in the Human Bloodstream and Potential Impact on Blood Pressure.

Role of microplastics in the tumor microenvironment (Review).

Ocean plastic pollution: a human and biodiversity loop.

Bioplastics and biodegradable plastics: A review of recent advances, feasibility and cleaner production.

Microplastics in marine systems: A review of sources and sinks, typical environmental behaviors, and biological effects.

Human Health Studies

Numerous Chemicals/Mixtures

The See-saw effect of Neuroactive Steroids and Endocrine Disrupting Compounds on Maternal Mental Health Status.

Comprehensive Nontargeted Analysis of Drinking Water Supplies to Identify Chemicals Associated with Estrogen Receptor Agonism or Present in Regions of Elevated Breast Cancer Occurrence.

BPA/Phenols

Evaluation of the Relationship Between Thyroid Hormone Levels and Bisphenol A in Children Aged 6-14 Years.

Phthalates

Fetal exposure to phthalates and body mass index from infancy to adolescence. The Generation R Study.

One year respiratory and neurodevelopmental outcome of premature neonates after exposure to plasticizers in the neonatal intensive care unit – a prospective cohort study.

Associations between urinary and follicular fluid concentrations of phthalate metabolites and reproductive outcomes in Brazilian women undergoing fertility treatment.

Moderating effects of insomnia on the association between urinary phthalate metabolites and depressive symptoms in Chinese college students: focus on gender differences.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Using simulations to explore the conditions under which “true” dose-response relationships are detectable for environmental exposures: polychlorinated biphenyls (PCBs) and birthweight: a case study.

PFAS

Associations of PFAS and OH-PCBs with risk of multiple sclerosis onset and disability worsening.

Higher PFOS Exposure Associated with Higher SHBG in Third Trimester. The Odense Child Cohort.

Cord serum metabolomic profiling associated with in utero exposure to per- and polyfluoroalkyl substances and birthweight discordance in twins: Findings from Wuhan Twin Birth Cohort.

Assessing the utility of healthcare claims data to determine potential health impacts of PFAS exposure with public drinking water.

Flame Retardants

Gestational PBDE concentrations and executive function in adolescents with self- and caregiver-report: The HOME study.

Pesticides

Exposure to organophosphates, pyrethroids, neonicotinoids, and pentachlorophenol: Spatial variations in urinary biomarkers and associations with oxidative stress based on a repeated-measure study.

A birth cohort observational study to assess the association of prenatal biomarkers of organophosphates with visual attention, recognition memory and information processing among Thai infants.

Urinary glyphosate, selenium status, and their impact on mortality: Evidence from NHANES 2013-2018.

Metals/Metalloids

Prenatal and childhood exposure to fluoride and cognitive development: findings from the longitudinal MINIMat cohort in rural Bangladesh.

Exposure to a mixture of arsenic species and growth indicators in 6-12-year-old children from the cycles 2007-2020 NHANES.

Microplastics/Nanomaterials

Identification and analysis of microplastics in human penile cancer tissues.

Air Pollution

Health risk assessment to xenoestrogen through atmospheric PM_2.5 particles: A case study in Suzhou.

Laboratory Studies

Numerous Chemicals/Mixtures

Chronic Exposure to an Environmentally Relevant Mixture of Endocrine Disruptors Alters Nuclear Phenotype and Induces Renal Fibrosis in Rats.

Bisphenol A and DDT disrupt adipocyte function in the mammary gland: implications for breast cancer risk and progression.

BPA/Phenols

Embryonic exposure of estrogen and BPA in zebrafish leads to ADHD-like and ASD-like phenotypes, respectively.

Bisphenol AF induces lipid metabolism disorders, oxidative stress and upregulation of heat shock protein 70 in zebrafish.

Bisphenol A exposure enhances proliferation and tumorigenesis of papillary thyroid carcinoma through ROS generation and activation of NOX4 signaling pathways.

Exposure to bisphenol A and sodium nitrate found in processed meat induces endocrine disruption and dyslipidemia through PI3K/AKT/SREBP pathway in zebrafish larvae.

Tracing impacts of prenatal exposure to bisphenol analogues on child anogenital distance development: A birth-cohort study.

Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling.

Theoretical Investigation of Cytochrome P450 Enzyme-Mediated Biotransformation Mechanism of BHPF: Unveiling the Metabolic Safety Aspects of an Alternative to BPA.

Protective effect of modafinil in bisphenol A-induced lung injury in rats: roles of SIRT1-dependent signaling pathways.

Analysis of Toxicity and Mechanisms of Bisphenol Analogs in Male Infertility: Insights from Network Toxicology and Molecular Docking Approaches.

The deleterious effect of bisphenol S on early embryo development of mice.

Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.

Maternal exposure to bisphenol A has transgenerational effects on the development of experimental asthma through bromodomain-containing protein 4-zinc finger DHHC-type containing 1-stimulators of interferon genes axis.

The resveratrol attenuates reactive oxygen species mediated DNA damage in cardiac malformations caused by 4-tert-octylphenol.

Phthalates

Ecotoxicity assessment of phthalic acid di-alkyl ester mixtures toward aquatic organisms based on results from a series of Sub-chronic toxicity tests.

Evaluation of the endocrine disrupting potential of Di-isodecyl phthalate.

Phthalate plasticizer affects blood electrolytes, hormones, and reproductive parameters of black Bengal goats.

Proteomic analysis reveals the alleviation of follicular development defects in offspring mice under DEHP exposure by melatonin.

Parabens/Triclosan/Antimicrobials

Distinct Disruptive Effects of Methylparaben and Propylparaben on the Prostate and Gonads of Adult Gerbils.

Long-term and low-dose exposure to triclosan induces POI phenotype in female offspring mice.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Identification of polychlorinated biphenyls (PCBs) and PCB metabolites associated with changes in the gut microbiome of female mice exposed to an environmental PCB mixture.

PFAS

Effects of early-life F-53B exposure on thyroid function in juvenile rats: The role of the cAMP signaling pathway.

Deciphering PFAS Mode of Action: Comparative Gene Expression Analysis in Human Liver Spheroids.

Perfluorooctanoic acid increases serum cholesterol in a PPARα-dependent manner in female mice.

Exploring the neurodegenerative potential of per- and polyfluoroalkyl substances through an adverse outcome pathway network.

Promoted Translocation of Perfluorooctanoic Acid across the Blood-Retinal Barrier due to its Inhibition of Tight Junction Assembly by Antagonizing LPAR1.

Differential hepatic activation of mouse and human peroxisome proliferator-activated receptor-α by perfluorohexane sulfonate.

Pesticides

Imbalance of human CD4⁺ T lymphocyte subsets following atrazine treatment.

Exploring the Epigenetic Impacts of Atrazine in Zebrafish: Unveiling Mechanisms of Neurotoxicity, Reproductive Toxicity, and Implications for Human Health.

Developmental effects of fenpropathrin on zebrafish (Danio rerio) embryo-larvae: Toxic endpoints and potential mechanism.

Fenoxycarb induces cardiovascular, hepatic, and pancreatic toxicity in zebrafish larvae via ROS production, excessive inflammation, and apoptosis.

Paternal fenvalerate exposure causes depressive-like behaviour by altering Grb10 gene DNA methylation in adolescent offspring.

Cytoprotective effect of l-carnitine against mancozeb-induced oxidative damage in human erythrocytes.

Phytochemicals in pomegranate peel extract attenuate oxidative damage in rats exposed to fipronil.

Vitamin E alleviates zebrafish intestinal damage and microbial disturbances caused by pyraclostrobin.

Microplastics/Nanomaterials

Simulated Microplastic Release from Cutting Boards and Evaluation of Intestinal Inflammation and Gut Microbiota in Mice.

Exposure of the human placental primary cells to nanoplastics induces cytotoxic effects, an inflammatory response and endocrine disruption.

Polystyrene microplastics impaired the function of leydig cells via GRP78/PERK/CHOP mediated endoplasmic reticulum stress in vivo and in vitro.

Exposure to polystyrene nanoplastics causes anxiety and depressive-like behavior and down-regulates EAAT2 expression in mice.

Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis.

Low dose of micro-/nano-plastics mixture induced cardiac hypertrophy and reductive stress: The liver-heart crosstalk and hepatic-cardiac organoids-on-a-chip.

Toxicity and absorption of polystyrene micro-nanoplastics in healthy and Crohn’s disease human duodenum-chip models.

Biodegradable microplastics and dissemination of antibiotic resistance genes: an undeniable risk associated with plastic additives.

Tracking microplastics in the mouse brain.

Long-term effects of individual and combined exposure to microplastics and copper in zebrafish hypothalamic-pituitary-gonadal axis – A multi-biomarker evaluation.

Genotoxic and cytotoxic effects of polystyrene nanoplastics on human lymphocytes: A comprehensive analysis.

Air Pollution

Fine particulate matter (PM_2.5) and the blood-testis-barrier: an in vivo and in vitro mechanistic study.

Pharmaceuticals/Personal Care Products

Next Generation Risk Assessment of Hair Dye HC Yellow No. 13: Ensuring Protection From Liver Steatogenic Effects.

Toxicological assessment of exposure to pharmaceutical effluents in rats for 28 days by repeated oral dose.

Miscellaneous

Toxicokinetic insights into distinct mechanisms of action of two thyroid toxicants: Propylthiouracil and pregnenolone 16α‑carbonitrile.

Exposure/Environment Studies

Phthalates

How indoor decoration materials contribute to phthalates pollution: Uncovering occurrences, sources, and their implications for environmental burdens in households.

Analyzing exposure risks in warehousing due to the presence of phthalate contamination.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of chlorinated paraffins and olefins in plastic consumer products of the Swiss market.

PFAS

Family-based exposure assessment of legacy and alternative poly- and perfluoroalkyl substances (PFASs) by multiple pathways.

6:2 Fluorotelomer Ethoxylates in Human Serum and Residential Homes: A Growing Environmental Health Concern.

Characterizing Seasonal Patterns, Gas-Particle Partitioning, and Potential Sources of Airborne Per- and Polyfluoroalkyl Substances in Japan.

Distributions and partitioning of airborne Per- and Polyfluoroalkyl Substances (PFAS) in urban atmosphere of Northern New Jersey.

Ecosurveillance reveals subtle metabolic effects on the non-native cane toad (Rhinella marina) from low levels of accumulated environmental per- and polyfluoroalkyl substances.

Assessment of PFAS contamination in agricultural soils: Non-target identification of precursors, fluorine mass balance and microcosm studies.

Assessing Bivalves as Biomonitors of Per- and Polyfluoroalkyl Substances in Coastal Environments.

Uptake of Per- and Polyfluoroalkyl Substances into Concrete from Aqueous Film-Forming Foams: Experimental Investigations and Comparison to Field-Impacted Samples.

Flame Retardants

Extremely high levels of PBDEs in children’s toys from European markets: causes and implications for the circular economy

Identification of novel tetrabromobisphenol A byproducts in industrial chemicals and the environment near a manufacturing site: an overlooked source of novel pollutants.

Identification and spatial distribution of organophosphorus flame retardants in surface soils from typical petrochemical industry and flame retardant production parks in China.

Pesticides

Pesticide contamination detected across five wildlife refuges in the Sacramento Valley of California.

Metals/Metalloids

Maternal urinary fluoride levels of a large pregnancy cohort in the United States: findings from the ADORE study.

Arsenic content and exposure in brown rice compared to white rice in the United States.

Microplastics/Nanomaterials

Can Fish Escape the Evolutionary Trap Induced by Microplastics?

Pharmaceuticals/Personal Care Products

Man-made emerging contaminants in the High-Arctic fjord Kongsfjorden (Svalbard Archipelago, Norway): Occurrence, sources and risk assessment.

Miscellaneous

Tire-additive chemicals and their derivatives in urban road dust: Spatial distributions, exposures, and associations with tire and road wear particles.

Tyre wear particles and metals in highway roadside ditches: Occurrence and potential transport pathways.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on February 14, 2025 at 3:36 pm
The agenda is now available for the March 14-15 Lou Guillette Jr. Memorial Symposium, hosted by HEEDS, at the University of Florida and online via Zoom. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the endocrine disruption research that Lou made famous. Information and agenda here.
North Carolina EDC working group 5th annual meeting
by Sarah Howard on February 13, 2025 at 12:46 pm
On Friday, April 25, 2025, Healthy Environment and Endocrine Disruptor Strategies (HEEDS) is hosting the 5th Annual Meeting of EDC-NC, its North Carolina working group on endocrine disrupting chemicals (EDCs). Attendance is open to anyone and the cost is free. More information.
Webinar: Impacts of fracking in North and South America (in English and Spanish)
by Sarah Howard on February 11, 2025 at 4:04 pm
This March 26 webinar will be presented with simultaneous English/Spanish interpretation. It will discuss the 9th edition of the Compendium of Scientific, Medical, and Media Findings Demonstrating Risks and Harms of Fracking and Associated Gas and Oil Infrastructure, published in 2023 by Concerned Health Professionals of New York and Physicians for Social Responsibility. The webinar is hosted by the Collaborative on Health and Environment (CHE).

EHN EHN

Plastic water pipes leach dangerous chemicals when damaged in wildfires
by Katherine McMahon,Sarah Howard on March 7, 2025 at 10:18 pm
A new study published in Journal of Hazardous Materials demonstrates how plastic drinking water pipes break down when subjected to high temperatures. “Various VOCs, such as benzene… and vinyl chloride, have been detected in drinking water systems exceeding their health-based state and federal maximum contaminant levels.”
Standing up for science: Around the world, scientists protest Trump threats to their work
by EHN Curators on March 7, 2025 at 12:51 pm
Thousands of scientists worldwide are uniting against the Trump administration’s attacks on science, with major protests planned today to defend research funding, diversity initiatives, and academic freedom. Bob Berwyn reports for Inside Climate News.
Pesticide mixtures linked to higher rates of childhood cancer, study finds
by EHN Curators on March 7, 2025 at 11:04 am
Exposure to multiple pesticides significantly increases the risk of childhood cancers, with new research showing higher rates of brain cancer and leukemia in agricultural communities. Tom Perkins reports for The Guardian.

EHN EHN

Trump’s EPA moves to roll back chemical safety rules
by EHN Curators on March 7, 2025 at 12:52 pm
The Trump administration is pulling back on Biden-era rules that required chemical facilities to adopt stronger safety measures against disasters. Hiroko Tabuchi reports for The New York Times.
Canada moves to regulate PFAS as toxic chemicals
by EHN Curators on March 7, 2025 at 11:40 am
The Canadian government is adding per- and polyfluoroalkyl substances (PFAS) to its list of toxic substances, a move that could lead to restrictions on the chemicals, which have been linked to cancer and other health risks. Inayat Singh reports for CBC.
Tennessee bill could limit state regulation of PFAS and other chemicals
by EHN Curators on March 7, 2025 at 10:56 am
A proposed Tennessee bill would restrict state agencies from enacting regulations on hazardous chemicals, including PFAS, unless lawmakers prove the rules are based on “sound science.” Cassandra Stephenson reports for Tennessee Lookout.