EDC Science Weekly, Feb. 23-29, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: European Society of Endocrinology statement on EDCs; absorbing flame retardants from car seats via (artificial) skin; closing the loop of nonmonotonicity; the price we pay for plastics.

More science highlights

Events

Mar. 14: PlastChem: State-of-the-science on plastic chemicals [Report launch by the PlastChem project]

Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024.

Mar. 19 webinar: Obesogens: A unifying theory for the global rise in obesity [EDC Strategies Partnership]

Mar. 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

June 10-12: National PFAS Conference in Ann Arbor MI

June 23-28: Gordon Research Conference on EDCs June, in Tuscany Italy

More events

Regulations/Policy

Impact of Legislation on Brominated Flame Retardant Concentrations in UK Indoor and Outdoor Environments: Evidence for Declining Indoor Emissions of Some Legacy BFRs.

More EDC policy and regulations open for comment

Methods/Tools/Screening

In Vitro Toxicity Screening of Fifty Complex Mixtures in HepG2 Cells.

Replacing concurrent controls with virtual control groups in rat toxicity studies.

The role of trust in the use of artificial intelligence for chemical risk assessment.

Considerations for the development of guidance on dose level selection for developmental and reproductive toxicity studies.

Estrogenic activity in wastewater treatment plants through in vitro effect-based assays: Insights into extraction phase.

An artificial intelligence platform for automated PFAS subgroup classification: A discovery tool for PFAS screening.

Screening for contamination levels of select organic environmental chemicals in medical supplies used for human specimen collection.

Proof of concept for quantitative adverse outcome pathway modeling of chronic toxicity in repeated exposure.

Investigating open access new approach methods (NAM) to assess biological points of departure: A case study with 4 neurotoxic pesticides.

Development of an accreditation process for analytical methods to measure microplastics in drinking water for regulatory monitoring.

Integrating emerging science to improve estimates of risk to wildlife from chemical exposure: What are the challenges?

Commentaries

Endocrine disrupting chemicals are a threat to hormone health: a commentary on behalf of the ESE.

Invited Perspective: Closing the Loop of Nonmonotonicity-from Natural Hormones in Experimental Endocrinology to Endocrine Disruptors in Epidemiology. [re Total Effective Xenoestrogen Burden in Serum Samples and Risk of Endometrial Cancer in the Spanish Screenwide Case-Control Study. ]

The Price We Pay for the Convenience of Plastics.

Fluorocarbons (PFAS)-The Forever Chemicals.

Contrasting obesity: is something missing here?

Impact of DDT on women’s health in Bangladesh: escalating breast cancer risk and disturbing menstrual cycle.

Editorial: Endocrine disruptors: mechanism of action and implications for human health. [intro to a research topic in Frontiers in Cell and Developmental Biology]

The Bioethics of Environmental Injustice: Ethical, Legal, and Clinical Implications of Unhealthy Environments [one of dozens of articles on environmental justice in the new issue of the American Journal of Bioethics] including:

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Deciphering the Role of the Gut Microbiota in Exposure to Emerging Contaminants and Diabetes: A Review.

Decrease in Sperm Parameters in the 21st Century: Obesity, Lifestyle, or Environmental Factors? An Updated Narrative Review.

Analytical methods and biomonitoring results in hair for the assessment of exposure to endocrine-disrupting chemicals: A literature review.

Plastic compounds and liver diseases: Whether bisphenol A is the only culprit.

Parabens/Triclosan/Antimicrobials

Current state of knowledge of triclosan (TCS)-dependent reactive oxygen species (ROS) production.

PFAS

Exposure to Per- and Polyfluoroalkyl Substances and Breast Cancer Risk: A Systematic Review and Meta-analysis of Epidemiologic Studies.

Threats of per- and poly-fluoroalkyl pollutants to susceptible populations.

Association between exposure to per- and polyfluoroalkyl substances and levels of lipid profile based on human studies.

Recent advances in the application of magnetic materials for the management of perfluoroalkyl substances in aqueous phases.

Environmental occurrence, bioaccumulation and human risks of emerging fluoroalkylether substances: Insight into security of alternatives.

Flame Retardants

Association between brominated flame retardants and risk of endocrine-related cancer: A systematic review and meta-analysis.

Organophosphate triesters and their diester degradation products in the atmosphere-A critical review.

Pesticides

DsRNA-based pesticides: Considerations for efficiency and risk assessment.

Microplastics/Nanomaterials

An Emerging Role of Micro- and Nanoplastics in Vascular Diseases.

Microplastics release from face masks: Characteristics, influential factors, and potential risks.

Innovative overview of the occurrence, aging characteristics, and ecological toxicity of microplastics in environmental media.

Miscellaneous

Oxidative treatment of micropollutants present in wastewater: A special emphasis on transformation products, their toxicity, detection, and field-scale investigations.

Human Health Studies

BPA/Phthalates

Bisphenol A and cardiometabolic risk in adolescents: Data from the Generation XXI cohort.

Sex-Specific Associations between Prenatal Exposure to Di(2-ethylhexyl) Phthalate, Epigenetic Age Acceleration, and Susceptibility to Early Childhood Upper Respiratory Infections.

Association of maternal phthalates exposure and metabolic gene polymorphisms with congenital heart diseases: a multicenter case-control study.

Endocrine-Disrupting Chemicals and Hormonal Profiles in PCOS Women: A Comparative Study between Urban and Rural Environment. [BPA and phthalates]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The association between polychlorinated dibenzo-p-dioxin exposure and cancer mortality in the general population: a cohort study.

PFAS

PFASs in Cerebrospinal Fluids and Blood-CSF Barrier Permeability in Patients with Cognitive Impairment.

Association between prenatal exposure to per- and polyfluoroalkyl substances and infant anthropometry: A prospective cohort study.

Estimating effects of longitudinal and cumulative exposure to PFAS mixtures on early adolescent body composition.

Exposure to per- and polyfluoroalkyl substance and metabolic syndrome: A nationally representative cross-sectional study from NHANES, 2003-2018.

Prenatal exposure to per- and polyfluoroalkyl substances and child behavioral problems.

Association between Perfluoroalkyl Substances in Follicular Fluid and Polycystic Ovary Syndrome in Infertile Women.

Environmental exposure to per- and polyfluoroalkyl substances mixture and asthma in adolescents.

Flame Retardants

Prenatal exposure to polybrominated diphenyl ether (PBDE) and child neurodevelopment: The role of breastfeeding duration.

Exposure to OPFRs Is Associated with Obesity and Dysregulated Serum Lipid Profiles: Data from 2017-2018 NHANES.

Association between urinary organophosphate ester metabolite exposure and thyroid disease risk among US adults: National Health and Nutrition Examination Survey 2011-2014.

Metals/Metalloids

Infantile allergic diseases: a cohort study prenatal fish intake and mercury exposure context.

Assessment of salivary cadmium levels and breast density in the Marin Women’s Study.

Associations of arsenic exposure and arsenic metabolism with the risk of non-alcoholic fatty liver disease.

Microplastics/Nanomaterials

Revealing new insights: Two-center evidence of microplastics in human vitreous humor and their implications for ocular health.

Air Pollution

PM_2.5 threshold exceedances during the prenatal period and risk of intellectual disability.

Fresh evidence of the impact of economic complexity, health expenditure, natural resources, plastic consumption, and renewable energy in air pollution deaths in the USA? An empirical approach.

Laboratory Studies

BPA/Phenols

Tetra methyl bisphenol F: another potential obesogen.

Kaempferol alleviates bisphenol A reproductive toxicity in rats in a dose-dependent manner.

The effect of bisphenol A on antioxidant defense and the structure and function of the liver of Siberian sturgeon (Acipenser baerii).

Transcriptomic analysis reveals the effects of maternal exposure to bisphenol AF on hypothalamic development in male neonatal mice.

Toxicity of low dose bisphenols in human iPSC-derived cardiomyocytes and human cardiac organoids – Impact on contractile function and hypertrophy.

Phthalates

Exposure to the plasticizer dibutyl phthalate causes oxidative stress and neurotoxicity in brain tissue.

Phthalates Induce Neurotoxicity by Disrupting the Mfn2-PERK Axis-Mediated Endoplasmic Reticulum-Mitochondria Interaction.

Parabens/Triclosan/Antimicrobials

Early Developmental Exposure to Triclosan Impacts Fecal Microbial Populations, IgA and Functional Activities of the Rat Microbiome.

High-dose exposure to butylparaben impairs thyroid ultrastructure and function in rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Boron Compounds Mitigate 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Toxicity in Human Peripheral Blood Mononuclear Cells.

PFAS

Baseline Toxicity Model to Identify the Specific and Nonspecific Effects of Per- and Polyfluoroalkyl Substances in Cell-Based Bioassays.

PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model.

Increased Perfluorooctanesulfonate (PFOS) Toxicity and Accumulation Is Associated with Perturbed Prostaglandin Metabolism and Increased Organic Anion Transport Protein (OATP) Expression.

An Integrated Metabolomics-Based Model, and Identification of Potential Biomarkers, of Perfluorooctane Sulfonic Acid Toxicity in Zebrafish Embryos.

Derivation of Transcriptomics-Based Points of Departure for 20 Per- or Polyfluoroalkyl Substances Using a Larval Fathead Minnow (Pimephales promelas) Reduced Transcriptome Assay.

Flame Retardants

Behavioral toxicity of TDCPP in marine zooplankton: Evidence from feeding and swimming responses, molecular dynamics and metabolomics of rotifers.

Triphenyl phosphate induces cardiotoxicity through myocardial fibrosis mediated by apoptosis and mitophagy of cardiomyocyte in mice.

Chronic exposure to BDE-47 aggravates acute pancreatitis and chronic pancreatitis by promoting acinar cell apoptosis and inflammation.

Tris(2-chloroethyl) phosphate (TCEP) exposure inhibits the epithelial-mesenchymal transition (EMT), mesoderm differentiation, and cardiovascular development in early chicken embryos.

Pesticides

Herbicides and pesticides synergistically interact at low concentrations in complex mixtures.

Low doses of malathion impair ovarian, uterine, and follicular integrity by altering oxidative profile and gene expression of rats exposed during the peripubertal period.

Embryotoxic Effects of Pesticides in Zebrafish (Danio rerio): Diflubenzuron, Pyriproxyfen, and Its Mixtures.

Ecotoxicity studies reveal that organic cations in dicamba-derived ionic liquids can pose a greater environmental risk than the herbicide itself.

Disruption of spermatogenesis in testicular adult Wistar rats after short-term exposure to high dose of glyphosate based-herbicide: Histopathological and biochemical changes.

Maternal exposure to glyphosate-based herbicide causes vascular dysfunction in offspring female rats.

Impact of chronic exposure to field level glyphosate on the food consumption, survival, gene expression, gut microbiota, and metabolomic profiles of honeybees.

Metals/Metalloids

The emerging role of α7nAChRs/caspase-3/Nrf-2 signaling pathway in citicoline improved autistic behavior induced by thimerosal in mice.

Microplastics/Nanomaterials

Maternal exposure to polystyrene nanoplastics causes defective retinal development and function in progeny mice by disturbing metabolic profiles.

Nano-scale and micron-scale plastics amplify the bioaccumulation of benzophenone-3 and ciprofloxacin, as well as their co-exposure effect on disturbing the antioxidant defense system in mussels, Perna viridis.

Microplastics and TiO₂ nanoparticles mixture as an emerging threat to amphibians: A case study on bullfrog embryos.

Inhibiting ferroptosis in brain microvascular endothelial cells: A potential strategy to mitigate polystyrene Nanoplastics‒Induced blood‒Brain barrier dysfunction.

Co-exposure of butyl benzyl phthalate and TiO₂ nanomaterials (anatase) in Metaphire guillelmi: Gut health implications by transcriptomics.

Co-exposure to polystyrene nanoplastics and triclosan induces synergistic cytotoxicity in human KGN granulosa cells by promoting reactive oxygen species accumulation.

Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota.

Photoaged polystyrene microplastics result in neurotoxicity associated with neurotransmission and neurodevelopment in zebrafish larvae (Danio rerio).

Air Pollution

Neurodegenerative effects of air pollutant Particles: Biological mechanisms implicated for Early-Onset Alzheimer’s disease.

Pharmaceuticals/Personal Care Products

Benzophenone-3 alters expression of genes encoding vascularization and epithelial-mesenchymal transition functions during Trp53-null mammary tumorigenesis.

Miscellaneous

Chronic exposure to low levels of phenanthrene induces histological damage and carcinogenic risk in the uterus of female mice.

Evaluation of 6-PPD quinone toxicity on lung of male BALB/c mice by quantitative proteomics.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Urinary and household chemical exposures in pet dogs with urothelial cell carcinoma.

BPA/Phenols

Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.

Simultaneous determination of environmental endocrine disruptors bisphenol A and 4- nitrophenol bleached from food-contacting materials using the spin-ladder compound La₂Cu₂O₅ modified glassy carbon electrode.

Bisphenols in Aquatic Products from South China: Implications for Human Exposure.

Phthalates

Pollution characteristics, sources, and health risks of phthalate esters in ambient air: A daily continuous monitoring study in the central Chinese city of Nanchang.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent Organic Pollutants in Austrian Human Breast Milk Collected between 2013 and 2016.

Human biomonitoring of dioxins, furans, and non-ortho dioxin-like polychlorinated biphenyls (PCBs) in blood plasma from Old Crow, Yukon, Canada (2019).

HBM4EU E-waste study: Assessing persistent organic pollutants in blood, silicone wristbands, and settled dust among E-waste recycling workers in Europe.

Investigating the presence of dioxins in drinking water: implications for public health.

PFAS

Characterization of per- and polyfluoroalkyl substance (PFAS) concentrations in a community-based sample of infants from Samoa.

Changes in Concentrations of Polyfluoroalkyl Substances in Human Milk Over Lactation Time and Effects of Maternal Exposure via Analysis of Matched Samples.

Biological effects of perfluoroalkyl substances on running water ecosystems: A case study in Beiluo River, China.

Research Needs Regarding the Vapor Intrusion Potential of Volatile Per- and Polyfluoroalkyl Substances.

Influence of Area, Age and Sex on Per- and Polyfluorinated Alkyl Substances Detected in Roe Deer Muscle and Liver from Selected Areas of Northern Italy.

Suspect, Nontarget Screening, and Toxicity Prediction of Per- and Polyfluoroalkyl Substances in the Landfill Leachate.

Per- and polyfluoroalkyl substances in waterbird feathers around Poyang Lake, China: Compound and species-specific bioaccumulation.

Flame Retardants

Determination of potential dermal exposure rates of phosphorus flame retardants via the direct contact with a car seat using artificial skin.

Dynamic modeling of the occurrence, sources, and environmental behavior of polybrominated diphenyl ethers in Zhelin Bay, China.

Microplastics/Nanomaterials

Detection of nanoplastics released from consumer plastic food containers by electromagnetic heating pyrolysis mass spectrometry.

Hotspots of Floating Plastic Particles across the North Pacific Ocean.

Miscellaneous

Migration of Melamine and Its Derivatives from Melamine/Bamboo/Wheat Straw-Made Tableware Purchased from Internet Markets or Retail Shops in China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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