EDC Science Weekly, Feb. 16 – 22, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Reducing PFAS levels in humans; microplastics in human placenta; blueprint for a plastic and phthalate-minimized laboratory.

More science highlights

Events

Webinar Feb. 22 (today!): Tattoo Inks, Cancer and Other Chronic Diseases: Gaps in research and regulation [in Spanish and English, via CHE]

Feb. 28: ECHA’s Shaping Tomorrow conference [watch live on YouTube]

Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024.

Webinar Mar. 19: Obesogens: A unifying theory for the global rise in obesity [EDC Strategies Partnership]

Meeting Mar. 22: HEEDS EDC- North Carolina annual meeting [free and open to anyone]

Gordon Research Conference on EDCs June 23-28, Tuscany Italy.

More events

Regulations/Policy

US regulators escalate PFAS controls. [World Report in The Lancet]

How nanoparticles are counted in global regulatory nanomaterial definitions

More EDC policy and regulations open for comment

Methods/Tools/Screening

Blueprint for the design, construction, and validation of a plastic and phthalate-minimised laboratory.

Demonstrating the reliability of in vivo metabolomics based chemical grouping: towards best practice.

Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure list.

Toxicogenomics of the C-C chemokine receptor type 5 (CCR5): Exploring the potential impacts of chemical-CCR5 interactions on inflammation and human health.

Qualitative and quantitative concentration-response modelling of gene co-expression networks to unlock hepatotoxic mechanisms for next generation chemical safety assessment.

To spread or not to spread? Assessing the suitability of sewage sludge and other biogenic wastes for agriculture reuse.

More tools, reports, and resources

Commentaries

The 10th international symposium on flame retardants (BFR2022), Athens, Greece.

Editorial: Exploring causal risk factors for metabolic and endocrine disorders. [intro to a research topic in Frontiers in Endocrinology; does not include EDCs]

Buried microplastics complicate efforts to define the Anthropocene. [News item in Nature]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Endocrine disruption in crustaceans: New findings and perspectives.

The hidden threat: Environmental toxins and their effects on gut microbiota.

Phthalates

Impact of DEHP Exposure on Female Reproductive Health: Insights into Uterine Effects.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Complex roles for sulfation in the toxicities of polychlorinated biphenyls.

PFAS

Reproductive toxicity of PFOA, PFOS and their substitutes: A review based on epidemiological and toxicological evidence.

Flame Retardants

The neurotoxicity of organophosphorus flame retardant tris (1,3-dichloro-2-propyl) phosphate (TDCPP): Main effects and its underlying mechanisms.

Pesticides

Systemic Analysis of Glyphosate Impact on Environment and Human Health.

Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer’s disease.

Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals’ models to humans’ studies.

Progress in environmental monitoring and mitigation strategies for herbicides and insecticides: A comprehensive review.

Microplastics/Nanomaterials

Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis.

Microplastic interactions in the agroecosystems: methodological advances and limitations in quantifying microplastics from agricultural soil.

Microplastic pollution: a review of techniques to identify microplastics and their threats to the aquatic ecosystem.

Pharmaceuticals/Personal Care Products

A systematic review of association between use of hair products and benign and malignant gynecological conditions.

Human Health Studies

Numerous Chemicals/Mixtures

Urinary phenol and paraben concentrations in association with markers of inflammation during pregnancy in Puerto Rico.

Identifying critical windows of prenatal phenol, paraben, and pesticide exposure and child neurodevelopmental: Findings from a prospective cohort study.

Metabolomics perspectives into the co-exposure effect of polycyclic aromatic hydrocarbons and metals on renal function: A meet-in-the-middle approach.

Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children.

BPA/Phenols

Association between prenatal exposure to alkylphenols and intelligence quotient among preschool children: sex-specific effects.

[Association analysis between mixed exposure to phenols and semen quality]. [in Chinese]

Phthalates

Subpopulations of children with multiple chronic health outcomes in relation to chemical exposures in the ECHO-PATHWAYS consortium.

Prenatal phthalate exposure and neurodevelopmental differences in twins at 2 years of age.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to Short- and Medium-Chain Chlorinated Paraffins and the Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study in Eastern China.

PFAS

Substantial decrease of PFAS with anion exchange resin treatment – A clinical cross-over trial.

Association of per- and polyfluoroalkyl substances (PFAS) with periodontitis: the mediating role of sex hormones.

The association between per-/polyfluoroalkyl substances in serum and thyroid function parameters: A cross-sectional study on teenagers living near a Chinese fluorochemical industrial plant.

Integrated Analysis of Per- and Polyfluoroalkyl Substance Exposure and Metabolic Profiling of Elderly Residents Living near Industrial Plants.

Effect of liver cancer on the accumulation and hepatobiliary transport of per- and polyfluoroalkyl substances.

[Determination of seven perfluoroalkyl and polyfluoroalkyl substances in serum of pregnant women and evaluation of neonatal neurobehavior based on high performance liquid chromatography-tandem mass spectrometry]. [in Chinese]

Metals/Metalloids

An Industry-Relevant Metal Mixture, Iron Status, and Reported Attention-Related Behaviors in Italian Adolescents. [see related Invited Perspective: Studying Metal Impacts on Neurobehavior during the Critical but Challenging Window of Adolescence.]

Joint associations among non-essential heavy metal mixtures and nutritional factors on glucose metabolism indexes in US adults: evidence from the NHANES 2011-2016.

Serum 25-hydroxyvitamin D mediates the association between heavy metal exposure and cardiovascular disease.

Air Pollution

The mediation effect of asprosin on the association between ambient air pollution and diabetes mellitus in the elderly population in Taiyuan, China.

The association of in-utero exposure to air pollution and atherogenic index of plasma in newborns.

Urban environment in pregnancy and postpartum depression: An individual participant data meta-analysis of 12 European birth cohorts.

Early-life exposure to ambient air pollution with cardiovascular risk factors in adolescents: Findings from the “Children of 1997” Hong Kong birth cohort.

Association between ambient PM₁ and the prevalence of chronic kidney disease in China: A nationwide study.

Laboratory Studies

Numerous Chemicals/Mixtures

Ecotoxicological responses of juvenile Sparus aurata to BDE-99 and BPA exposure: A multi-biomarker approach integrating immune, endocrine and oxidative endpoints.

BPA/Phenols

Exposure to environmentally relevant concentrations of Bisphenol-A linked to loss of visual lateralization in adult zebrafish (Danio rerio).

Bisphenol A affects microbial interactions and metabolic responses in sludge anaerobic digestion.

Gut microbiota contributes to bisphenol A-induced maternal intestinal and placental apoptosis, oxidative stress, and fetal growth restriction in pregnant ewe model by regulating gut-placental axis.

Rapamycin protects Sertoli cells against BPA-induced autophagy disorders.

Bisphenols and brominated bisphenols induced endothelial dysfunction via its disruption of endothelial nitric oxide synthase.

Beauvericin, produced by Fusarium oxysporum inhibits bisphenol A-induced proliferation of human breast cancer cell line by regulating ERα/p38 pathway.

Bisphenol A regulates bladder cells responses via control of G2/M-phase cell cycle, apoptotic signaling, MAPK pathway, and transcription factor-associated MMP modulation.

Regulatory mechanism of perinatal nonylphenol exposure on cardiac mitochondrial autophagy and the PINK1/Parkin signaling pathway in male offspring rats.

Phthalates

Mitochondrial dysfunction mediated by thioredoxin-interacting protein: A crucial determinant in di(2-ethylhexyl) phthalate-induced liver failure.

Use of in vitro methodology to investigate phthalate effects on the differentiation of seminiferous tubule-associated stem cells to form Leydig cells and on the Leydig cells derived from the stem cells.

Butyl Benzyl Phthalate (BBP) Disrupts Neuromast Development in Embryonic Zebrafish.

Exposure to environmentally relevant phthalate mixture during pregnancy alters the physical and hemato-biochemical parameters in Black Bengal goats.

Phthalate drives splenic inflammatory response via activating HSP60/TLR4/NLRP3 signaling axis-dependent pyroptosis.

Parabens/Triclosan/Antimicrobials

Triclosan induces liver injury in long-life exposed mice via activation of TLR4/NF-κB/NLRP3 pathway.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity.

PFAS

Combined exposure with microplastics increases the toxic effects of PFOS and its alternative F53B in adult zebrafish.

Hepatotoxicity induced in rats by chronic exposure to F-53B, an emerging replacement of perfluorooctane sulfonate (PFOS).

GenX caused liver injury and potential hepatocellular carcinoma of mice via drinking water even at environmental concentration.

Investigating the effects of PFOA accumulation and depuration on specific phospholipids in zebrafish through imaging mass spectrometry.

Flame Retardants

Impact of Exposure to a Mixture of Organophosphate Esters on Adrenal Cell Phenotype, Lipidome, and Function.

RNA-Seq analysis offers insight into the TBBPA-DHEE-induced endocrine-disrupting effect and neurotoxicity in juvenile zebrafish (Danio rerio).

Pesticides

Developmental toxicity and metabolomics analyses of zebrafish (Danio rerio) embryos exposed to Fenoxaprop-p-ethyl.

Roles of oxidative stress/JNK/ERK signals in paraquat-triggered hepatic apoptosis.

Metals/Metalloids

Gestational α-ketoglutarate supplementation ameliorates arsenic-induced hepatic lipid deposition via epigenetic reprogramming of β-oxidation process in female offspring.

Differential effect of the duration of exposure on the carcinogenicity of cadmium in MCF10A mammary epithelial cells.

Microplastics/Nanomaterials

Exposure to polystyrene nanoplastics induces apoptosis, autophagy, histopathological damage, and intestinal microbiota dysbiosis of the Pacific whiteleg shrimp (Litopenaeus vannamei).

Interaction Between Endocrine Disruptors and Polyethylene Nanoplastic by Molecular Dynamics Simulations.

Low-dose polystyrene microplastics exposure impairs fertility in male mice with high-fat diet-induced obesity by affecting prostate function.

Potential Effects of Orally Ingesting Polyethylene Terephthalate Microplastics on the Mouse Heart.

Polystyrene microplastic-induced extracellular vesicles cause kidney-related effects in the crosstalk between tubular cells and fibroblasts.

The effect and mechanism of variable particle size microplastics and levofloxacin on the neurotoxicity of Rana nigromaculata based on the microorganism-intestine-brain axis.

Damage of polyethylene microplastics on the intestine multilayer barrier, blood cell immune function and the repair effect of Leuconostoc mesenteroides DH in the large-scale loach (Paramisgurnus dabryanus).

Effects of different concentrations and particle sizes of nanoplastics on gut microbiology, metabolism, and immunity in Chiromantes dehaani.

Nanoplastics and chrysene pollution: Potential new triggers for nonalcoholic fatty liver disease and hepatitis, insights from juvenile Siniperca chuatsi.

Pharmaceuticals/Personal Care Products

Branching morphogenesis of the mouse mammary gland after exposure to benzophenone-3.

Miscellaneous

Effects of a TAML catalyst on mice exposed during pregnancy and lactation. [TAMLs are products that can degrade pollutants]

Testing androgen-induced immunosuppression: Environmental androgens as a model system for steroid-immune interaction.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

[Exposure characteristics and health risk assessment of 97 typical chemical pollutants in human serum]. [in Chinese]

Exposure to and Biomarker Responses From Legacy and Emerging Contaminants Along Three Drainages in the Milwaukee Estuary, Wisconsin, USA.

A multi-scenario risk assessment strategy applied to mixtures of chemicals of emerging concern in the River Aconcagua basin in Central Chile.

BPA/Phenols

Distribution and potential risk factors of bisphenol a in serum and urine among Chinese from 2004 to 2019.

Occurrence and exposure evaluation of bisphenol A and its analogues in indoor and outdoor dust from China.

Spatiotemporal distribution, source apportionment, and ecological risk of bisphenol analogues in a highly urbanized river basin.

Phthalates

Phthalate levels in common sea anemone Actinia equina and Anemonia viridis: A proxy of short-term microplastic interaction?

PFAS

Occurrence, bioaccumulation and trophic dynamics of per- and polyfluoroalkyl substances in two tropical freshwater lakes.

Can PFAS threaten the health of fish consumers? A comprehensive analysis linking fish consumption behaviour and health risk.

Transport and health risk of legacy and emerging per-and polyfluoroalkyl substances in the water cycle in an urban area, China: Polyfluoroalkyl phosphate esters are of concern.

Assessing the impact of immobilisation on the bioavailability of PFAS to plants in contaminated Australian soils.

Fate and effects of a new generation fluorosurfactant (cC₆O₄) in freshwater mesocosms.

[Contamination levels of perfluorinated and polyfluoroalkyl compounds in breast milk and assessment of their exposure risk to infants]. [in Chinese]

Flame Retardants

Investigation of alkyl, aryl, and chlorinated OPFRs in sediments from estuarine systems: Seasonal variation, spatial distribution and ecological risks assessment.

Polybrominated diphenyl ethers in dust, hair and urine: Exposure, excretion.

Pesticides

Comprehensive analysis of neonicotinoids in Chinese commercial honey and pollen: A corresponding health risk assessment for non-targeted organisms.

A pilot study of chlormequat in food and urine from adults in the United States from 2017 to 2023

Microplastics/Nanomaterials

Quantitation and identification of microplastics accumulation in human placental specimens using pyrolysis gas chromatography mass spectrometry.

Human Exposure to Ambient Atmospheric Microplastics in a Megacity: Spatiotemporal Variation and Associated Microorganism-Related Health Risk.

Characterization of microplastics in outdoor and indoor air in Ranchi, Jharkhand, India: First insights from the region.

Are vehicle tires major contributors to microplastic emissions into the China seas? A simple model perspective.

Air Pollution

Exploring the triple burden of social disadvantage, mobility poverty, and exposure to traffic-related air pollution.

Miscellaneous

Historical Redlining Is Associated with Disparities in Environmental Quality across California.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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