EDC Science Weekly, Feb. 12 – 16, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Interesting Research of the Week, Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

I am sending this early this week due to the U.S. holiday tomorrow.

Interesting Research of the Week

Barriers and opportunities for breast cancer organizations to focus on environmental health and disease prevention: a mixed-methods approach using website analyses, interviews, and focus groups.

Regulations/Policy

Intent and Provision of REACH: An Overview.

Prospects for incorporation of epigenetic biomarkers in human health and environmental risk assessment of chemicals.

Application of the Food Quality Protection Act children’s health safety factor in the U.S. EPA pesticide risk assessments.

Potential of ToxCast data in the safety assessment of food chemicals.

Methods/Screening

The MCRA toolbox of models and data to support chemical mixture risk assessment.

High-throughput screening tools facilitate calculation of a combined exposure-bioactivity index for chemicals with endocrine activity.

A case study with triazole fungicides to explore practical application of next generation hazard assessment methods for human health.

Enhancing life cycle chemical exposure assessment through ontology modeling.

Reviews

Commentaries/Conference Summaries

Blood lead levels in children have fallen, but vigilance is still needed. [Editorial]

BPA/Phenols/Phthalates

Mechanisms of Testicular Disruption from Exposure to Bisphenol A and Phtalates.

Phthalate exposure and neurodevelopment: A systematic review and meta-analysis of human epidemiological evidence.

Pesticides

A comprehensive analysis of the animal carcinogenicity data for glyphosate from chronic exposure rodent carcinogenicity studies.

Potentially Toxic Elements

Heavy Metal Toxicity in Chronic Renal Failure and Cardiovascular Disease. Possible Role for Chelation Therapy.

Microplastics

Microplastics and the gut microbiome: How chronically exposed species may suffer from gut dysbiosis.

Air Pollution

Association between human health and indoor air pollution in the Gulf Cooperation Council (GCC) countries: a review.

Effect modification of the short-term effects of air pollution on morbidity by season: A systematic review and meta-analysis.

Impairment of mitochondrial function by particulate matter: Implications for the brain.

Miscellaneous

Synthetic Chemicals and Cardiometabolic Health Across the Life Course Among Vulnerable Populations: a Review of the Literature from 2018 to 2019.

Environmental toxins exposure in PCOS women and possible ovarian neoplastic repercussion.

Molecular mechanisms linking environmental toxicants to cancer development: Significance for protective interventions with polyphenols.

Worldwide Secular Trends in Age at Pubertal Onset Assessed by Breast Development Among Girls: A Systematic Review and Meta-analysis.

Reproductive and developmental health effects of prenatal exposure to tetrachloroethylene-contaminated drinking water.

Early Programming of Adult Systemic Essential Hypertension.

Human Health Studies

BPA/Phenols/Parabens

Bisphenol A Exposure Enhances Endometrial Stromal Cell Invasion and Has a Positive Association with Peritoneal Endometriosis. [human and lab study]

Associations of urinary levels of phenols and parabens with osteoarthritis among US adults in NHANES 2005-2014.

Maternal paraben exposure triggers childhood overweight development. [human and lab study]

Association between urinary paraben concentrations and gestational weight gain during pregnancy.

Relationship between urinary bisphenol a levels and cardiovascular diseases in the U.S. adult population, 2003-2014.

Phthalates

Associations between urine phthalate metabolites and thyroid function in pregnant women and the influence of iodine status.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations between persistent organic pollutants and endometriosis: A multipollutant assessment using machine learning algorithms.

Serum level of PCBs and OCPs and leukocyte telomere length among adults in Tehran, Iran.

Overexpression of the aryl hydrocarbon receptor in frontal fibrosing alopecia and lichen planopilaris: a potential pathogenic role for dioxins?- an investigational study of 38 patients.

Association between polychlorinated biphenyl 153 exposure and serum testosterone levels: analysis of the National Health and Nutrition Examination Survey.

Perfluoroalkyl Substances

Incidence of ocular conditions associated with perfluoroalkyl substances exposure: Isomers of C8 Health Project in China.

Pesticides

Dietary exposure to pesticide residues and associated health risks in infants and young children – Results of the French infant total diet study.

Potentially Toxic Elements

Associations of maternal arsenic exposure with adult fasting glucose and insulin resistance in the Strong Heart Study and Strong Heart Family Study.

Protective role of selenium in the shortening of telomere length in newborns induced by in utero heavy metal exposure.

Hematological parameters and hair mercury levels in adolescents from the Colombian Caribbean.

Comparison of Visual Functions of Two Amazonian Populations: Possible Consequences of Different Mercury Exposure.

Arsenic disturbs the gut microbiome of individuals in a disadvantaged community in Nepal.

Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children.

Association between prenatal arsenic exposure, birth outcomes, and pregnancy complications: An observational study within the National Children’s Study cohort.

Air Pollution

Short term association between ozone and mortality: global two stage time series study in 406 locations in 20 countries.

Premature mortality related to United States cross-state air pollution.

Health equity and burden of childhood asthma – related to air pollution in Barcelona.

Reduced repressive epigenetic marks, increased DNA damage and Alzheimer’s disease hallmarks in the brain of humans and mice exposed to particulate urban air pollution. [human and lab study]

Associations of maternal ozone exposures during pregnancy with maternal blood pressure and risk of hypertensive disorders of pregnancy: A birth cohort study in Guangzhou, China.

An association between air pollution and daily most frequently visits of eighteen outpatient diseases in an industrial city.

Association between cumulative social risk, particulate matter environmental pollutant exposure, and cardiovascular disease risk.

Association of short-term exposure to air pollution with myocardial infarction with and without obstructive coronary artery disease.

Association between microenvironment air quality and cardiovascular health outcomes.

Association between long-term exposure to ambient air pollution and obesity in a Chinese rural population: The Henan Rural Cohort Study.

The relationship between long-term exposure to PM2.5 and fasting plasma glucose levels in Chinese children and adolescents aged 6-17 years: A national cross-sectional study.

Association between long-term exposure to ambient air pollutants and excessive daytime sleepiness in Chinese rural population: The Henan Rural Cohort Study.

The association between wildfire smoke exposure and asthma-specific medical care utilization in Oregon during the 2013 wildfire season.

Effects of PM10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status.

The association between long-term fine particulate air pollution and life expectancy in China, 2013 to 2017 .

Mixtures

Combined exposure to phthalate esters and phosphate flame retardants and plasticizers and their associations with wheeze and allergy symptoms among school children.

Joint and independent neurotoxic effects of early life exposures to a chemical mixture: A multi-pollutant approach combining ensemble learning and g-computation. [PFAS, PCBs, mercury]

Laboratory Studies

BPA/Phenols

Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish.

Long-term exposure of zebrafish to bisphenol S impairs stress function of hypothalamic-pituitary-interrenal axis and causes anxiety-like behavioral responses to novelty.

Discrepant dose responses of bisphenol A on oxidative stress and DNA methylation in grass carp ovary cells.

Bisphenol A (BPA)-Induced Changes in the Number of Serotonin-Positive Cells in the Mucosal Layer of Porcine Small Intestine-the Preliminary Studies.

Bisphenol A-Induced Cell Proliferation and Mitochondrial Oxidative Stress Are Diminished via Modulation of TRPV1 Channel in Estrogen Positive Breast Cancer Cell by Selenium Treatment.

Sperm quality and oxidative stress in chub Squalius orientalis and Padanian barbel Barbus plebejus (Teleostei: Cyprinidae) after in vitro exposure to low doses of bisphenol A.

Boswellic acid protects against Bisphenol-A and gamma radiation induced hepatic steatosis and cardiac remodelling in rats: role of hepatic PPAR-α/P38 and cardiac Calcineurin-A/NFATc1/P38 pathways.

Phthalates

Aberrations of miR-126-3p, miR-181a and Sirtuin1 Network Mediate Di-(2-ethylhexyl) phthalate-induced Testicular Damage in Rats: The Protective Role of Hesperidin.

Transient exposure to environmentally realistic concentrations of di-(2-ethylhexyl)-phthalate during sensitive windows of development impaired larval survival and reproduction success in Japanese medaka.

Genotoxic, metabolic, and biological responses of Chironomus sancticaroli Strixino & Strixino, 1981 (Diptera: Chironomidae) after exposure to BBP.

Cytotoxic and genotoxic effects of e-liquids and their potential associations with nicotine, menthol and phthalate esters.

Triclosan

A multi-biomarker approach using integrated biomarker response to assess the effect of pH on triclosan toxicity in Pangasianodon hypophthalmus (Sauvage, 1878).

Risk Assessment of Cosmetics Using Triclosan on Future Generation’s Germ Cell Maturation via Lactating Mother Rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays.

New insight into the mechanism of POP-induced obesity: Evidence from DDE-altered microbiota.

Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes.

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on spontaneous movement of human neuroblastoma cells.

Alterations in macrophage phagocytosis and inflammatory tone following exposure to the organochlorine compounds oxychlordane and trans-nonachlor.

Flame Retardants

2,2′,4,4′-tetrabromodipheny ether (BDE-47) disrupts gonadal development of the Africa clawed frog (Xenopus laevis).

Pesticides

Chlorpyrifos induces redox imbalance-dependent inflammation in common carp lymphocyte through dysfunction of T-cell receptor γ.

Glyphosate exposure induces inflammatory responses in the small intestine and alters gut microbial composition in rats.

Modification of the head proteome of nurse honeybees (Apis mellifera) exposed to field-relevant doses of pesticides.

An evaluation of the human relevance of the liver tumors observed in female mice treated with permethrin based on mode of action.

Toxicity of thifluzamide in earthworm (Eisenia fetida).

Nephroprotective effects of curcumin loaded chitosan nanoparticles in cypermethrin induced renal toxicity in rabbits.

Sublethal neurotoxicity of organophosphate insecticides to juvenile coho salmon.

Effects of two little-studied environmental pollutants on early development in anurans. [a pesticide and a pharmaceutical]

Potentially Toxic Elements

Chronic Arsenic Exposure Impairs Adaptive Thermogenesis in Male C57BL/6J Mice.

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1-Vps34/PI3K complex in MLTC-1 cells.

Biotransformation of dietary inorganic arsenic in a freshwater fish Carassius auratus and the unique association between arsenic dimethylation and oxidative damage.

Community recovery dynamics in yellow perch microbiome after gradual and constant metallic perturbations.

Pre- and Neonatal Exposure to Lead (Pb) Induces Neuroinflammation in the Forebrain Cortex, Hippocampus and Cerebellum of Rat Pups.

Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice.

Determination of heavy metals in cancerous and healthy colon tissues using laser induced breakdown spectroscopy and its cross-validation with ICP-AES method.

Microplastics

Antioxidants and molecular damage in Nile Tilapia (Oreochromis niloticus) after exposure to microplastics.

Can short exposure to polyethylene microplastics change tadpoles’ behavior? A study conducted with neotropical tadpole species belonging to order anura (Physalaemus cuvieri).

Lipid metabolic response to polystyrene particles in nematode Caenorhabditis elegans.

In vitro avian bioaccessibility of metals adsorbed to microplastic pellets.

Air Pollution

Changes in extrapulmonary organs and serum enzyme biomarkers after chronic exposure to Buenos Aires air pollution.

Pharmaceuticals

Developmental Programming: Prenatal Testosterone Excess on Ovarian SF1/DAX1/FOXO3.

Mixtures

Combined toxic effects of fludioxonil and triadimefon on embryonic development of zebrafish (Danio rerio).

Enhanced adsorption of tetrabromobisphenol a (TBBPA) on cosmetic-derived plastic microbeads and combined effects on zebrafish.

Effects of combined stressors to cadmium and high temperature on antioxidant defense, apoptotic cell death, and DNA methylation in zebrafish (Danio rerio) embryos.

Joint effect of nanoplastics and humic acid on the uptake of PAHs for Daphnia magna: A model study.

Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate.

Miscellaneous

Reproductive toxicity and estrogen activity in Japanese medaka (Oryzias latipes) exposed to environmentally relevant concentrations of octocrylene. [a sunscreen ingredient]

Exposure/Wildlife Studies

Note: I am going to shorten this section by limiting the environment studies from specific areas, as there are so many of them. I’ll still try to include the human exposure studies, wildlife studies, and studies of more general interest.

BPA/Phenols

Determination of alkylphenols, phenylphenols, bisphenol A, parabens, organophosphorus pesticides and triclosan in different cereal-based foodstuffs by gas chromatography-mass spectrometry.

Phthalates

Phthalate metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014-2017.

Parabens/Triclosan/Antimicrobials/UV Filters

Urinary paraben concentrations and their implications for human exposure in Iranian pregnant women.

UV filters in matched seminal fluid-, urine-, and serum samples from young men.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Dioxin-like polybrominated biphenyls (PBBs) and ortho-substituted PBBs in edible cod (Gadus morhua) liver oils and canned cod livers.

Compositional profiles, persistency and toxicity of polychlorinated naphthalene (PCN) congeners in edible cod liver products from 1972 to 2017.

Freshwater seal as a source of direct and indirect increased human exposure to persistent organic pollutants in a background area.

Trophic magnification of legacy persistent organic pollutants in an urban terrestrial food web.

Males Exceeding Females in Whole-Fish PCB Concentration Mainly Due to Higher Energy Expenditure Rate.

Evaluation of dioxin-like polychlorinated biphenyls in fish of the Caspian Sea.

Long-range transport of legacy organic pollutants affects alpine fish eaten by ospreys in western Canada.

Multi-year assessment (2006-2015) of persistent organic pollutant concentrations in blubber and muscle from Western Arctic bowhead whales (Balaena mysticetus), North Slope, Alaska.

PCBs and PBDEs in microplastic particles and zooplankton in open water in the Pacific Ocean and around the coast of Japan.

Perfluoroalkyl Substances

Determinants of serum concentrations of perfluoroalkyl acids (PFAAs) in school children and the contribution of low-level PFAA-contaminated drinking water.

Elevated levels of per- and polyfluoroalkyl substances in Cape Fear River Striped Bass (Morone saxatilis) are associated with biomarkers of altered immune and liver function.

Pesticides

Changes of various insecticides during in vitro human digestion.

Potentially Toxic Elements

Mercury Poisoning From Skin Cream.

Lead exposures in older children (males and females 7-17 years), women of childbearing age (females 16-49 years) and adults (males and females 18+ years): FDA total diet study 2014-16.

Characterization of trace elements exposure in pregnant women in the United States, NHANES 1999-2016.

Human biomonitoring of metals in workers at the waste-to-energy incinerator of Turin: An Italian longitudinal study.

A comparison of individual-level vs. hypothetically pooled mercury biomonitoring data from the Maternal Organics Monitoring Study (MOMS), Alaska, 1999-2012.

Reference values for heavy metals in the urine and blood of Saudi women derived from two human biomonitoring studies.

Environmental monitoring and exposure science dataset to calculate ingestion and inhalation of metal(loid)s through preschool gardening.

A global perspective on mercury cycling in the ocean.

Mercury Levels in Freshwater Fish: Estimating Concentration with Fish Length to Determine Exposures Through Fish Consumption.

Contrasting temporal patterns of mercury, niche dynamics, and body fat indices of polar bears and ringed seals in a melting icescape.

Mercury exposure in songbird communities within Sphagnum bog and upland forest ecosystems in the Adirondack Park (New York, USA).

Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver.

Early atmospheric contamination on the top of the Himalayas since the onset of the European Industrial Revolution.

Relationship between blood lead levels and physiological stress in mute swans (Cygnus olor) in municipal beaches of the southern Baltic.

Microplastics

Adsorption of three bivalent metals by four chemical distinct microplastics.

Agricultural plastic mulching as a source of microplastics in the terrestrial environment.

Surrounded by microplastic, since when? Testing the feasibility of exploring past levels of plastic microfibre pollution using natural history museum collections.

Air Pollution

Assessment of Ambient Air Toxics and Wood Smoke Pollution among Communities in Sacramento County.

Pharmaceuticals

Sorption of three common nonsteroidal anti-inflammatory drugs (NSAIDs) to microplastics.

Comprehensive insights into the occurrence, distribution, risk assessment and indicator screening of antibiotics in a large drinking reservoir system.

Miscellaneous

Integrated assessment of the environmental and economic effects of “coal-to-gas conversion” project in rural areas of northern China.

Endocrine disruption in western mosquitofish from open and closed aquatic ecosystems polluted by swine farm wastewaters.

Evaluating age and temporal trends of chlorinated paraffins in pooled serum collected from males in Australia between 2004 and 2015.

The impact of population mobility on estimates of environmental exposure effects in a case-control study.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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