EDC Science Weekly, Dec. 9 – 15, 2022 – HEEDS

EDC Science Weekly, Dec. 9 – 15, 2022

Post author:HEEDS
Post published:December 15, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

Methods

Understanding and overcoming the technical challenges in using in silico predictions in regulatory decisions of complex toxicological endpoints – A pesticide perspective for regulatory toxicologists with a focus on machine learning models.

The importance of integrating morphological attributes of microplastics: a theoretical discussion to assess environmental impacts.

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto-Placental Organ-on-Chip Platform.

The Italian Wall Lizard Podarcis siculus as a Biological Model for Research in Male Reproductive Toxicology.

Prioritization of mixtures of neurotoxic chemicals for biomonitoring using high-throughput toxicokinetics and mixture toxicity modeling.

HBM4EU feasibility studies: Lessons learned in combining health and human biomonitoring studies.

Toxicity prediction: An application of alternative testing and computational toxicology in contaminated groundwater sites in Taiwan.

Tools

HealthcareLCA: an open-access living database of health-care environmental impact assessments.

An algorithm to classify homologous series within compound datasets.

Commentaries

Advancing racial and ethnic equity in health [intro to a special issue in The Lancet on racism and health]

Environmental health justice across the globe

Editorial: Updates on epigenetic regulation of endocrine disorders with polygenic traits: What is new? [intro to a research topic in Frontiers in Endocrinology, which includes some discussion of EDCs]

Editorial: Fetal testicular hormones. [intro to a research topic in Frontiers in Endocrinology on this topic]

Reviews

Numerous Chemicals/Mixtures

Domestic Exposure to Chemicals in Household Products, Building Materials, Decoration, and Pesticides: Guidelines for Interventions During the Perinatal Period from the French National College of Midwives.

Use of Cosmetic Products in Pregnant and Breastfeeding Women and Young Children: Guidelines for Interventions during the Perinatal Period from the French National College of Midwives.

Exposure to endocrine-disrupting chemicals and risk of gestational hypertension and preeclampsia: A systematic review and meta-analysis. [BPA, phthalates, PFAS]

The Impact of Environmental Contaminants on Extracellular Vesicles and their Key Molecular Regulators: A Literature and Database-Driven Review.

A scientometric analysis of research trends on emerging contaminants in the field of cancer in 2012-2021.

BPA/Phenols

The association between bisphenol a exposure and attention deficit hyperactivity disorder in children: a meta-analysis of observational studies.

Exposure to Bisphenol A Substitutes, Bisphenol S and Bisphenol F, and Its Association with Developing Obesity and Diabetes Mellitus: A Narrative Review.

Bisphenol-A and Female Fertility: An Update of Existing Epidemiological Studies.

Phthalates

Do phthalates and their metabolites cause poor semen quality? A systematic review and meta-analysis of epidemiological studies on risk of decline in sperm quality.

Parabens/Triclosan/Antimicrobials

Impact of Paraben Exposure on Adiposity-Related Measures: An Updated Literature Review of Population-Based Studies.

Pesticides

Environmental occurrence, toxicity concerns, and biodegradation of neonicotinoid insecticides.

Metals/Metalloids

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine.

Mercury Contamination in Fish and Its Effects on the Health of Pregnant Women and Their Fetuses, and Guidance for Fish Consumption-A Narrative Review.

Microplastics/Nanomaterials

Recent consequences of micro-nanaoplastics (MNPLs) in subcellular/molecular environmental pollution toxicity on human and animals.

Understanding hazardous concentrations of microplastics in fresh water using non-traditional toxicity data.

Pharmaceuticals/Personal Care Products

Regulatory Risk Assessment of Pharmaceuticals in the Environment – Current Practice and Future Priorities.

Miscellaneous

Secular trends in age at pubertal onset assessed by breast development among Chinese girls: A systematic review.

Human Health Studies

Numerous Chemicals/Mixtures

Association between environmental chemicals co-exposure and peripheral blood immune-inflammatory indicators.

BPA/Phenols

Association between environmental phenols and all-cause and cancer mortality.

Phthalates

Effects of exposure to phthalate during early pregnancy on gestational diabetes mellitus: a nested case-control study with propensity score matching.

The association of phthalate metabolites with childhood waist circumference and abdominal obesity

Associations of phthalates with NAFLD and liver fibrosis: A nationally representative cross-sectional study from NHANES 2017 to 2018.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutant exposure and thyroid function among 12-year-old children.

Perfluoroalkyl Substances

Human serum poly- and perfluoroalkyl substance concentrations and their associations with gestational diabetes mellitus.

Per- and polyfluoroalkyl substances (PFAS) exposure in melanoma patients: a retrospective study on prognosis and histological features.

Association of exposure to perfluoroalkyl substances and risk of the acute coronary syndrome: A case-control study in Shijiazhuang Hebei Province.

Relative rates of cancers and deaths in Australian communities with PFAS environmental contamination associated with firefighting foams: A cohort study using linked data.

Detected prenatal perfluorooctanoic acid (PFOA) exposure is associated with decreased fetal head biometric parameters in participants experiencing higher perceived stress during pregnancy in the MADRES cohort.

Flame Retardants

Gestational exposure to organophosphate esters and adiposity measures of children up to 6 years: Effect modification by breastfeeding.

Pesticides

Associations between residential proximity to agricultural land use as pesticides exposure and birth outcomes.

Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks.

An ecological study regarding the association between paraquat exposure and end stage renal disease.

Metals/Metalloids

Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh.

Metal mixtures modeling identifies birth weight-associated gene networks in the placentas of children born extremely preterm.

Associations of metal mixtures in the meconium with birth outcomes in northern Taiwan.

Race and Gender Differences in the Associations Between Cadmium Exposure and Bone Mineral Density in US Adults.

Air Pollution

Landscape fire smoke enhances the association between fine particulate matter exposure and acute respiratory infection among children under 5 years of age: Findings of a case-crossover study for 48 low- and middle-income countries.

Laboratory Studies

Numerous Chemicals/Mixtures

Chemical nature of attention deficit hyperactivity disorder (ADHD) – related chemical subfamily.

BPA/Phenols

New insight on the mechanism of eating disorder in females based on metabolic differences of bisphenol S in female and male zebrafish.

Developmental and Reproductive Impacts of Four Bisphenols in Daphnia magna.

Effects of BPZ, BPC, BPF, and BPS Exposure on Adult Zebrafish (Danio rerio): Accumulation, Oxidative Stress, and Gene Expression.

Changes in the Enteric Neurons Containing Selected Active Substances in the Porcine Descending Colon after the Administration of Bisphenol A (BPA).

Bisphenol AF Promoted the Growth of Uterus and Activated Estrogen Signaling Related Targets in Various Tissues of Nude Mice with SK-BR-3 Xenograft Tumor.

Bisphenol A modulates proliferation, apoptosis, and wound healing process of normal prostate cells: Involvement of G2/M-phase cell cycle arrest, MAPK signaling, and transcription factor-mediated MMP regulation.

In vitro and in silico assessment of GPER-dependent neurocytotoxicity of emerging bisphenols.

Gestational bisphenol A exposure advances puberty onset in female offspring: Critical time window identification.

Phthalates

Dibutyl phthalate affects insulin synthesis and secretion by regulating the mitochondrial apoptotic pathway and oxidative stress in rat insulinoma cells.

Multi-omics reveals the mechanisms of DEHP driven pulmonary toxicity in ovalbumin-sensitized mice.

Parabens/Triclosan/Antimicrobials

Developmental exposure to triclosan and benzophenone-2 causes morphological alterations in zebrafish (Danio rerio) thyroid follicles and eyes.

Ototoxicity of Triclosan: A Rat Model Study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to endosulfan can cause long term effects on general biology, including the reproductive system of mice.

Perfluoroalkyl Substances

Perfluorooctanoic Acid-Disturbed Serum and Liver Lipidome in C57BL/6 Mice.

F-53B induces hepatotoxic effects and slows self-healing in ulcerative colitis in mice.

Emerging polyfluorinated compound Nafion by-product 2 disturbs intestinal homeostasis in zebrafish (Danio rerio).

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes.

Flame Retardants

Time- and dose-dependent detoxification and reproductive endocrine disruption induced by tetrabromobisphenol A (TBBPA) in mussel Mytilus galloprovincialis.

Tetrabromobisphenol A and Diclazuril Evoke Tissue-Specific Changes of Thyroid Hormone Signaling in Male Thyroid Hormone Action Indicator Mice.

Chlorinated Organophosphate Flame Retardants Impair the Lung Function via the IL-6/JAK/STAT Signaling Pathway.

Histopathological and transcriptomic analyses reveal the reproductive endocrine-disrupting effects of decabromodiphenyl ethane (DBDPE) in mussel Mytilus galloprovincialis.

Tris(1,3-dichloro-2-propyl) phosphate is a metabolism-disrupting chemical in male mice.

BDE-99 (2,2′,4,4′,5 – pentain polybrominated diphenyl ether) induces toxic effects in Oreochromis niloticus after sub-chronic and oral exposure.

Pesticides

The quest for metabolic biomarkers of agrochemicals exposure via in vitro studies and suspect screening.

Untargeted Metabolomics Reveals Lipid Impairment in the Liver of Adult Zebrafish (Danio rerio) Exposed to Carbendazim.

Alterations in the Expression of Antioxidant Enzyme Genes in Response to Pesticide Exposure During Embryonic Development in the Native Reptile Species Caiman latirostris.

Glyphosate-based herbicide (GBH) causes damage in embryo-larval stages of zebrafish (Danio rerio).

Effects of Subtoxic Concentrations of Atrazine, Cypermethrin, and Vinclozolin on microRNA-Mediated PI3K/Akt/mTOR Signaling in SH-SY5Y Cells.

DNA methylation 6 mA and histone methylation involved in multi-/trans-generational reproductive effects in Caenorhabditis elegans induced by Atrazine.

Suspected gut barrier disruptors and development of food allergy: Adjuvant effects and early immune responses. [glyphosate]

Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics. [chlorpyrifos]

Developmental toxicity of chlorpyrifos-methyl and its primary metabolite, 3,5,6-trichloro-2-pyridinol to early life stages of zebrafish (Danio rerio).

A Time-course Transcriptional Kinetics of Genes in Behavior, Cortisol Synthesis and Neurodevelopment in Zebrafish Larvae Exposed to Imidacloprid and Thiamethoxam.

Metals/Metalloids

Cadmium exposure promotes thyroid pyroptosis and endocrine dysfunction by inhibiting Nrf2/Keap1 signaling.

Microplastics/Nanomaterials

Prenatal and postnatal exposure to polystyrene microplastics induces testis developmental disorder and affects male fertility in mice.

Toxicity of polystyrene nanoparticles for mouse ovary and cultured human granulosa cells.

Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.

Exposure of Cyprinus carpio var. larvae to PVC microplastics reveals significant immunological alterations and irreversible histological organ damage.

Polystyrene microplastic particles induce autophagic cell death in BEAS-2B human bronchial epithelial cells.

Polystyrene nanoplastics promote the apoptosis in Caco-2 cells induced by okadaic acid more than microplastics.

Polystyrene nanoplastics affect the human ubiquitin structure and ubiquitination in cells: a high-resolution study.

Polystyrene nanoplastics affect transcriptomic and epigenomic signatures of human fibroblasts and derived induced pluripotent stem cells: Implications for human health.

Cytotoxicity and pro-inflammatory effect of polystyrene nano-plastic and micro-plastic on RAW264.7 cells.

Joint effects of micro-sized polystyrene and chlorpyrifos on zebrafish based on multiple endpoints and gut microbial effects.

Pharmaceuticals/Personal Care Products

Benzophenones alter autophagy and ER stress gene expression in pancreatic beta cells in vitro.

Mouse uterine stem cells are affected by endocrine disruption and initiate uteropathies.

Environmentally relevant concentrations of organic (benzophenone-3) and inorganic (titanium dioxide nanoparticles) UV filters co-exposure induced neurodevelopmental toxicity in zebrafish.

Exposure/Environment Studies

BPA/Phenols

Bisphenol A alternatives continuously contribute to the endocrine disruption in cetaceans.

Quantitative Determination of Bisphenol A and Its Congeners in Plant-Based Beverages by Liquid Chromatography Coupled to Tandem Mass Spectrometry.

Phthalates

Quantitative Measurement of Phthalate Exposure Biomarker Levels in Diaper-Extracted Urine of Japanese Toddlers and Cumulative Risk Assessment: An Adjunct Study of JECS Birth Cohort.

Parabens/Triclosan/Antimicrobials

Within-day variability, predictors, and risk assessments of exposure to parabens among Chinese adult men.

Perfluoroalkyl Substances

Plasma and Skin Per- and Polyfluoroalkyl Substance (PFAS) Levels in Dairy Cattle with Lifetime Exposures to PFAS-Contaminated Drinking Water and Feed.

Uptake and translocation of both legacy and emerging per- and polyfluorinated substances in hydroponic vegetables.

Disclosing the bioaccumulation and biomagnification behaviors of emerging per/polyfluoroalkyl substances in aquatic food web based on field investigation and model simulation.

PFAS levels and exposure determinants in sensitive population groups.

Pesticides

Contributions of nearby agricultural insecticide applications to indoor residential exposures.

Characterization of multiple pesticide exposure in pregnant women in Brittany, France.

Metals/Metalloids

Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico.

Microplastics/Nanomaterials

Potential Adsorption Affinity of Estrogens on LDPE and PET Microplastics Exposed to Wastewater Treatment Plant Effluents.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.