EDC Science Weekly: Dec. 9 – 15, 2021

Post author:HEEDS
Post published:December 15, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Starting soon! Webinar Dec. 15: PFAS Exposure and Epigenetics in the Firefighter Cancer Cohort Study (EDC Strategies Partnership)

Webinar Dec. 16: The Challenge of PFAS with Dr. Linda S. Birnbaum (CHE-Alaska)

Virtual conference Jan 10-13: PPTOX VII: International Conference on Prenatal Programming and Toxicity

Virtual meeting Jan 20-21: EURION Cluster Annual Meeting (the European Cluster to Improve Identification of Endocrine Disruptors)

In-person course: May 25-June 9: Endocrine-Disrupting Chemicals: Hazards and Opportunities (Marine Biological Laboratory at Woods Hole)

In-person Gordon Research Conference and Seminar June 18-24: EDCs and the Environment and Harnessing Interdisciplinary Evidence for Endocrine Disruption to Improve Public Health

Regulations/Policy

Balancing Bees and Pest Management: Projected Costs of Proposed Bee-Protective Neonicotinoid Regulation in California.

Methods/Tools/Screening

Identification of an Analytical Method Interference for Perfluorobutanoic Acid in Biological Samples

Mortality Risk from PM2.5: A Comparison of Modeling Approaches to Identify Disparities across Racial/Ethnic Groups in Policy Outcomes.

Development and Evaluation of a Holistic and Mechanistic Modeling Framework for Chemical Emissions, Fate, Exposure, and Risk.

New methods of top-to-down mixture toxicity prediction: A case study of eliminating of the effects of cosolvent from binary mixtures.

Potential of concentration-response data to broaden regulatory application of in vitro test guidelines.

Allosteric binding on nuclear receptors: Insights on screening of non-competitive endocrine-disrupting chemicals.

Using metabolomic profiling to inform use of surrogate species in ecological risk assessment practices.

Improving QSAR Modeling for Predictive Toxicology using Publicly Aggregated Semantic Graph Data and Graph Neural Networks.

A hierarchical integrative group least absolute shrinkage and selection operator for analyzing environmental mixtures.

Uncertainty-Informed Deep Transfer Learning of Perfluoroalkyl and Polyfluoroalkyl Substance Toxicity.

A Systematic Review of Published Physiologically-based Kinetic Models and an Assessment of their Chemical Space Coverage.

New Models to Predict the Acute and Chronic Toxicities of Representative Species of the Main Trophic Levels of Aquatic Environments.

Commentaries/Conference Summaries

Editorial: Presence and Daily Exposure to Endocrine Disruptors: How Can Human Life Change?

New Evidence of Renal and Cardiovascular Alterations Promoted by Bisphenol A.

Expanding the liver exposome: should hepatologists care about air pollution?

Reviews

Numerous Chemicals/Mixtures

The exposome and toxicology: a win-win collaboration.

Obesogens: How They Are Identified and Molecular Mechanisms Underlying Their Action.

Health consequences of exposure to e-waste: an updated systematic review.

BPA/Phenols

[Impacts of Bisphenol A exposure on spermatogenesis in men: Advances in studies]. [in Chinese]

Perfluoroalkyl Substances

Understanding the dynamics of physiological changes, protein expression, and PFAS in wildlife.

Per- and Polyfluoroalkyl Substances (PFAS) in Integrated Crop-Livestock Systems: Environmental Exposure and Human Health Risks.

Flame Retardants

A review on environmental occurrence, toxic effects and transformation of man-made bromophenols.

Pesticides

Epigenetics in neurodegenerative disorders induced by pesticides.

Organophosphate pesticides and new-onset diabetes mellitus: From molecular mechanisms to a possible therapeutic perspective.

Effects on Puberty of Nutrition-Mediated Endocrine Disruptors Employed in Agriculture.

Potentially Toxic Elements

Developmental exposure to methylmercury and ADHD, a literature review of epigenetic studies.

Methylmercury plus Ethanol Exposure: How Much Does This Combination Affect Emotionality?

Human Body Burden of Heavy Metals and Health Consequences of Pb Exposure in Guiyu, an E-Waste Recycling Town in China.

Microplastics

Microplastics altered contaminant behavior and toxicity in natural waters.

Microplastics in Asian freshwater ecosystems: Current knowledge and perspectives.

Synthetic microfibers and tyre wear particles pollution in aquatic systems: Relevance and mitigation strategies.

Nanoplastic Impact on the Gut-Brain Axis: Current Knowledge and Future Directions.

Adsorption of environmental contaminants on micro- and nano-scale plastic polymers and the influence of weathering processes on their adsorptive attributes.

Micro- and nanoplastic transfer, accumulation, and toxicity in humans.

Quantifying the importance of plastic pollution for the dissemination of human pathogens: The challenges of choosing an appropriate ‘control’ material.

Pharmaceuticals/Personal Care Products

The beauty of biocatalysis: sustainable synthesis of ingredients in cosmetics.

When pharmaceutical drugs become environmental pollutants: Potential neural effects and underlying mechanisms.

Miscellaneous

A mechanistic evaluation of the potential for octamethylcyclotetrasiloxane to produce effects via endocrine modes of action.

Evidence-to-decision frameworks: a review and analysis to inform decision-making for environmental health interventions.

Molecular mechanisms regulating spermatogenesis in vertebrates: Environmental, metabolic, and epigenetic factor effects.

Impact of intra-uterine life on future health.

Human Health Studies

Numerous Chemicals/Mixtures

Prenatal Exposure to Nonpersistent Chemical Mixtures and Offspring IQ and Emotional and Behavioral Problems.

Prenatal exposure to mixtures of persistent environmental chemicals and fetal growth outcomes in Western Australia.

Environmental pollutant exposure associated with altered early-life gut microbiome: Results from a birth cohort study. [metals, PFAS, pesticides]

Associations between residential proximity to oil and gas extraction and hypertensive conditions during pregnancy: a difference-in-differences analysis in Texas, 1996-2009.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

High mortality and high PCDD/Fs exposure among residents downwind of municipal solid waste incinerators: A case study in China.

In Utero Chlordecone Exposure and Thyroid, Metabolic, and Sex-Steroid Hormones at the Age of Seven Years: A Study From the TIMOUN Mother-Child Cohort in Guadeloupe.

Perfluoroalkyl Substances

Relationships between maternal perfluoroalkyl substance levels, polymorphisms of receptor genes, and adverse birth outcomes in the Hokkaido birth cohort study, Japan.

Association between maternal serum concentration of perfluoroalkyl substances (PFASs) at delivery and acute infectious diseases in infancy

Flame Retardants

Gestational exposure to polybrominated diphenyl ethers and social skills and problem behaviors in adolescents: The HOME study.

Organophosphate and Organohalogen Flame-Retardant Exposure and Thyroid Hormone Disruption in a Cross-Sectional Study of Female Firefighters and Office Workers from San Francisco.

Pesticides

Glyphosate and AMPA exposure in relation to markers of biological aging in an adult population-based study.

Fipronil and its metabolites in human seminal plasma from Shijiazhuang, north China.

Intake of fruits and vegetables according to pesticide residue status in relation to all-cause and disease-specific mortality: Results from three prospective cohort studies.

Potentially Toxic Elements

The association of arsenic exposure and arsenic metabolism with all-cause, cardiovascular and cancer mortality in the Strong Heart Study.

High Lead Exposure Associated With Higher Blood Pressure in Haiti: a Warning Sign for Low-Income Countries.

The combined effects of nucleotide-binding domain-like receptor protein 3 polymorphisms and levels of blood lead on developmental delays in preschool children.

Lead exposure and serum metabolite profiles in pregnant women in Mexico City.

Association Between Cadmium Exposure and Liver Function in Adults in the United States: A Cross-sectional Study.

The Risk Factors of Blood Cadmium Elevation in Chronic Kidney Disease.

Status of metals in serum and urine samples of chronic kidney disease patients in a rural area of Bangladesh: An observational study.

Toxic Metals and Subclinical Atherosclerosis in Carotid, Femoral, and Coronary Vascular Territories: The Aragon Workers Health Study.

Urinary element profiles and associations with cardiometabolic diseases: A cross-sectional study across ten areas in China.

Pharmaceuticals/Personal Care Products

Analgesic use and circulating estrogens, androgens, and their metabolites in the Women’s Health Initiative Observational Study.

Laboratory Studies

Numerous Chemicals/Mixtures

Environmental dose of 16 priority-controlled PAHs mixture induce damages of vascular endothelial cells involved in oxidative stress and inflammation.

BPA/Phenols

A comparative in vitro study on monomer release from bisphenol A-free and conventional temporary crown and bridge materials.

Alteration of Extracellular Matrix Components in the Anterior Pituitary Gland of Neonatal Rats Induced by a Maternal Bisphenol A Diet during Pregnancy.

Protective role of resveratrol and apigenin against toxic effects of bisphenol a in rat salivary gland.

Disposition of Bisphenol S metabolites in Sprague-Dawley rats.

Teratogenicity and toxicity of the new BPA alternative TMBPF, and BPA, BPS, and BPAF in chick embryonic development.

Gestational and lactational xenoestrogen exposure disrupts morphology and inflammatory aspects in mammary gland of gerbil mothers during involution.

Phthalates

Integration of data from the in vitro long-term exposure study on human endothelial cells and the in silico analysis: A case of dibutyl phthalate-induced vascular dysfunction.

Accumulation, detoxification, and toxicity of dibutyl phthalate in the swimming crab.

Parabens/Triclosan/Antimicrobials

Oxidative stress responses after exposure to triclosan sublethal concentrations: an integrated biomarker approach with a native (Corydoras paleatus) and a model fish species (Danio rerio).

Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Sensitivity of a Model Reptile, the Common Snapping Turtle (Chelydra serpentina), to In Ovo Exposure to TCDD and Other Dioxin-Like Chemicals.

Effects of different DDE exposure paradigms on testicular steroid hormone secretion and hepatic oxidative stress in male Long-Evans rats.

Perfluoroalkyl Substances

Comparative chronic toxicities of PFOS and its novel alternatives on the immune system associated with intestinal microbiota dysbiosis in adult zebrafish.

The comprehensive analysis based study of perfluorinated compounds-Environmental explanation of bladder cancer progression.

Immunotoxicity of PFOA to the Marine Bivalve Species Ruditapes philippinarum.

Flame Retardants

Prenatal exposure to environmentally relevant levels of PBDE-99 leads to testicular dysgenesis with steroidogenesis disorders.

Bis (2-ethylhexyl)-2,3,4,5-tetrabromophthalate showed poor penetrability but increased the permeability of blood brain barrier: Evidences from in vitro and in vivo studies.

Liver-Based Probabilistic Risk Assessment of Exposure to Organophosphate Esters via Dust Ingestion Using a Physiologically Based Toxicokinetic (PBTK) Model.

Effects of tris(1,3-dichloro-2-propyl) phosphate on epididymal sperm parameters in adult male rats.

Organotins

Transient developmental exposure to tributyltin reduces optomotor responses in larval zebrafish (Danio rerio).

Evaluation of the effects produced by subacute tributyltin administration on vascular reactivity of male wistar rats.

Pesticides

Cis-bifenthrin inhibits cortisol and aldosterone biosynthesis in human adrenocortical H295R cells via cAMP signaling cascade.

Effects of trichlorfon organophosphate on the morphology of the gills and liver of Pseudoplatystoma corruscans.

In vitro cytotoxicity and genotoxicity of single and combined pesticides used by Bolivian farmers.

Vitamin C Mitigates Oxidative Stress and Behavioral Impairments Induced by Deltamethrin and Lead Toxicity in Zebrafish.

Sublethal Exposure to Deltamethrin Stimulates Reproduction and Alters Symbiotic Bacteria in Aphis gossypii.

Transgenerational effects on the fecundity and sperm proteome in rats exposed to a mixture of pyrethroids at doses similar to human consumption.

Effects on reproductive, biochemical and genotoxic parameters of herbicides 2,4-D and glyphosate in silver catfish (Rhamdia quelen).

Imidacloprid activates ROS and causes mortality in honey bees (Apis mellifera) by inducing iron overload.

[Atrazine changes meiosis and reduces spermatogenesis in male mice]. [in Chinese]

Potentially Toxic Elements

Early-Life Exposure to Low-Dose Cadmium Accelerates Diethylnitrosamine and Diet-Induced Liver Cancer.

In situ analysis of variations of arsenicals, microbiome and transcriptome profiles along murine intestinal tract.

Biochemical Investigation of Therapeutic Potential of Resveratrol Against Arsenic Intoxication.

Cadmium induced Fak -mediated anoikis activation in kidney via nuclear receptors (AHR/CAR/PXR)-mediated xenobiotic detoxification pathway.

Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice.

Protective Effect of Dictyophora Polysaccharides on Sodium Arsenite-Induced Hepatotoxicity: A Proteomics Study.

Intraperitoneal kisspeptin-10 administration ameliorates sodium arsenite-induced reproductive toxicity in adult male mice.

Gut microbiota-mediated ferroptosis contributes to mercury exposure-induced brain injury in common carp.

Microplastics/Nanomaterials

Titanium dioxide nanoparticles perturb the blood-testis barrier via disruption of actin-based cell adhesive function.

Air Pollution

Toxicity to bronchial cells and endocrine disruptive potentials of indoor air and dust extracts and their association with multiple chemical classes.

Pharmaceuticals/Personal Care Products

Prenatal Octamethylcyclotetrasiloxane Exposure Impaired Proliferation of Neuronal Progenitor, Leading to Motor, Cognition, Social and Behavioral Functions.

Miscellaneous

Experimental data sets on the evaluation of graphene oxide as a thyroid endocrine disruptor and a modulator of gas gland cells in Japanese medaka (Oryzias latipes) larvae at the onset of maturity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Per-and polyfluoroalkyl substances (PFAS) and persistent chemical mixtures in dust from U.S. colleges.

Novel prioritisation strategies for evaluation of temporal trends in archived white-tailed sea eagle muscle tissue in non-target screening.

Pathologic impacts of contaminants in freshwater fish of Cook County IL.

Review of harmful chemical pollutants of environmental origin in honey and bee products.

BPA/Phenols

Bisphenol A-A Dangerous Pollutant Distorting the Biological Properties of Soil.

Phthalates

The concentration of phthalates in toys and children’s care items in Kosovo.

Investigation and risk assessment of dibutyl phthalate in a typical region by a high-throughput dual-signal immunoassay.

Parabens/Triclosan/Antimicrobials

Evaluation of human exposure to parabens in north eastern Poland through hair sample analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent and toxic chemical pollutants in fish consumed by Asians in Chicago, United States.

Level, source, and distribution of organochlorine pesticides (OCPs) in agricultural soils of Tanzania.

Spatial Variation in Contaminant Occurrence in Marine Fishes and Prawns from Coastal Tanzania.

Perfluoroalkyl Substances

Maternal consumption of ultra-processed foods and newborn exposure to perfluoroalkyl substances (PFAS).

Perfluorooctanoic acid triggers oxidative stress in anaerobic digestion of sewage sludge.

Research progress on the pollution, adsorption, and transport of perfluorooctanoic acid (PFOA ) at the sediment-water interface.

Distribution, sources, and dietetic-related health risk assessment of perfluoroalkyl acids (PFAAs) in the agricultural environment of an industrial-agricultural interaction region (IAIR), Changshu, East China.

Per- and Polyfluoroalkyl Substances (PFASs) in Airborne Particulate Matter (PM_2.0) Emitted During Floor Waxing: A Pilot Study.

Extractable organofluorine analysis: A way to screen for elevated per- and polyfluoroalkyl substance contamination in humans?

Developing Innovative Treatment Technologies for PFAS-Containing Wastes.

Flame Retardants

Partial dust removal in vehicles does not mitigate human exposure to organophosphate esters.

Full Characterization of the UV Hydrodebromination Products of the Current-Use Brominated Flame Retardants Hexabromobenzene, Pentabromotoluene, and Pentabromoethylbenzene.

High-Resolution Mass Spectrometry Screening of Emerging Organophosphate Esters (OPEs) in Wild Fish: Occurrence, Species-Specific Difference, and Tissue-Specific Distribution.

Pesticides

Pesticides Burden in Neotropical Rivers: Costa Rica as a Case Study.

Parameterization of a Brazilian scenario in the US-EPA Pesticide in Water Calculator tool to estimate the environmental exposure of pesticide in surface waters.

Potentially Toxic Elements

Monitoring of urinary arsenic (As) and lead (Pb) among a sample of pregnant Iranian women.

Biomonitoring of Exposure to Metals in a Population Residing in an Industrial Area in Brazil: A Feasibility Study.

Potential driving forces and probabilistic health risks of heavy metal accumulation in the soils from an e-waste area, southeast China.

Changes in heavy metal levels, reproductive characteristics, oxidative stress markers and testicular apoptosis in rams raised around thermal power plant.

Mercury spatiality and mobilization in roadside soils adjacent to a savannah ecological reserve.

Ecological risk assessment of heavy metals in the sediments of a Mediterranean lagoon complex.

Substantial accumulation of mercury in the deepest parts of the ocean and implications for the environmental mercury cycle.

Microplastics

Identification of microplastics in conventional drinking water treatment plants in Tehran, Iran.

Ecological risk assessment of marine microplastics using the analytic hierarchy process: A case study in the Yangtze River Estuary and adjacent marine areas.

Microplastics in an anadromous national fish, Hilsa shad Tenualosa ilisha from the Bay of Bengal, Bangladesh.

Microplastic pollution in surface seawater and beach sand from the shore of Rayong province, Thailand: Distribution, characterization, and ecological risk assessment.

Enhanced microbial degradation of PET and PS microplastics under natural conditions in mangrove environment.

Seawater copper content controls biofilm bioaccumulation and microbial community on microplastics.

The occurrence and effect of altitude on microplastics distribution in agricultural soils of Qinghai Province, northwest China.

Gray Water from Ships: A Significant Sea-Based Source of Microplastics?

The deposition of atmospheric microplastics in Jakarta-Indonesia: The coastal urban area.

Pharmaceuticals/Personal Care Products

Animal gut microbiome mediates the effects of antibiotic pollution on an artificial freshwater system.

Target and Suspect Screening of Pharmaceuticals and Their Transformation Products in the Klip River, South Africa Using Ultra High-Performance Liquid Chromatography-Mass Spectrometry.

Monsoon dilutes the concurrence but increases the correlation of viruses and Pharmaceuticals and Personal Care Products (PPCPs) in the Urban Waters of Guwahati, India: The context of pandemic viruses.

Insights into the spatiotemporal occurrence and mixture risk assessment of household and personal care products in the waters from rivers to Laizhou Bay, southern Bohai Sea.

Occurrence of Pharmaceuticals and Endocrine Disrupting Compounds in Brazilian Water and the Risks They May Represent to Human Health.

Miscellaneous

Predictors of urinary polycyclic aromatic hydrocarbon metabolites in girls from the San Francisco Bay Area.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.