EDC Science Weekly, Dec. 6-12, 2024 – HEEDS

EDC Science Weekly, Dec. 6-12, 2024

Post author:HEEDS
Post published:December 12, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Special series on Impact of Real-Life Environmental Exposures on Reproduction.
Chemical exposomics in biobanked plasma samples and associations with breast cancer risk factors.
PFOS and its alternative, 6:2 Cl-PFESA, induce multidrug resistance in pancreatic cancer.
POPs in the milk of individuals living near municipal waste incinerators in the UK

Science summaries and highlights

Methods/Tools/Screening

A Cheminformatics Workflow to Select Representative TSCA Chemicals for New Approach Methodology (NAM) Screening.

The Environmental Neuroactive Chemicals List of Prioritized Substances for Human Biomonitoring and Neurotoxicity Testing: A Database and High-Throughput Toxicokinetics Approach.

Comprehensive analysis of the toxicity-related findings from repeated-dose subacute toxicity studies of industrial chemicals in male rats.

Commentaries

A roadmap to better health in the USA [also see related articles in this issue of The Lancet, e.g., Ten Americas: a systematic analysis of life expectancy disparities in the USA ]

Special series on Impact of Real-Life Environmental Exposures on Reproduction.

Editorial: Environmental factors, epigenetics, and reproductive health. [intro to a Research topic in Frontiers in Endocrinology]

Environmental Determinants of Health—Time to Redefine the Social History?

PFOA affects androgen metabolism.

The legacy of DDT lives on in the Southern California Bight.‘

Arsenic Exposure in Celiac Disease: The Hidden Cost of a Gluten-Free Diet.

More retractions in Sci Total Environ on microplastics.

Reviews/Meta-Analyses

BPA/Phenols

Bisphenols in Indoor Dust: A Comprehensive Review of Global Distribution, Exposure Risks, Transformation, and Biomonitoring.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biological concentrations of DDT metabolites and breast cancer risk: an updated systematic review and meta-analysis.

PFAS

Examining the relationship between per-and polyfluoroalkyl substances and breast, colorectal, prostate, and ovarian cancers: a meta-analysis.

Per- and poly-fluoroalkyl substances exposure and risk of gastrointestinal cancers: a systematic review and meta-analysis.

PFAS-Free Energy Storage: Investigating Alternatives for Lithium-Ion Batteries.

Poly- and per-fluoroalkyl substances (PFAS) in the African environments: progress, challenges, and future perspectives.

Confronting PFAS persistence: enzymes catalyzing C-F bond cleavage.

Pesticides

Evaluating the Impact of Neonicotinoids on Aquatic Non-target Species: A comprehensive Review.

Microplastics/Nanomaterials

A systematic review of the effects of airborne microplastic contamination on human lungs.

Microplastics/nanoplastics and Neurological Health: An Overview of Neurological Defects and Mechanisms.

The Emerging Threat of Micro- and Nanoplastics on the Maturation and Activity of Immune Cells.

A Critical Review of an Environmental Risk Substance Induced by Aging Microplastics: Insights into Environmentally Persistent Free Radicals.

Air Pollution

Mechanistic insights regarding neuropsychiatric and neuropathologic impacts of air pollution.

Pharmaceuticals/Personal Care Products

Interference Mechanisms of Endocrine System and Other Systems of Endocrine-Disrupting Chemicals in Cosmetics-In Vitro Studies.

Human Health Studies

Numerous Chemicals/Mixtures

Chemical exposomics in biobanked plasma samples and associations with breast cancer risk factors.

BPA/Phenols/Parabens

Effect of exposure to environmental phenols and parabens on folate concentrations among 3-19 years old children and adolescents: A cross-sectional study in NHANES 2005-2016.

Phthalates

Phthalates exposure, biological aging, and increased risks of insulin resistance, prediabetes, and diabetes in adults with metabolic dysfunction-associated steatotic liver disease.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Investigating the impact of dioxins, furans, and coplanar polychlorinated biphenyls on mortality, inflammatory states, and chronic diseases: An integrative epidemiological analysis.

PFAS

Per- and polyfluoroalkyl substances, apolipoproteins and the risk of coronary heart disease in US men and women.

Triglycerides mediate the relationships of per- and poly-fluoroalkyl substance (PFAS) exposure with nonalcoholic fatty liver disease (NAFLD) risk in US participants.

Associations between Per- and Polyfluoroalkyl Substances (PFAS) and Female Sexual Function in a Preconception Cohort.

Flame Retardants

Prenatal and Postnatal Exposure to Organophosphate Esters and Replacement Flame Retardant Mixtures and Childhood Respiratory Outcomes.

Pesticides

Association of maternal pyrethroid pesticides exposure during the whole pregnancy with neonate lipid metabolism: A prospective birth cohort, Yunnan, China.

Geographical disparities in cancer and occupational exposure to pesticides in a French-West Indies territory (2006-2019).

Metals/Metalloids

Associations Between Heavy Metal Exposure from Milk and Steroid Hormones in Mothers.

Microplastics/Nanomaterials

Microplastic particles in human blood and their association with coagulation markers.

Miscellaneous

The association of prenatal volatile organic compounds exposure and newborn anthropometrics: A cross-sectional study.

Association of mixed polycyclic aromatic hydrocarbons exposure with cardiovascular disease and the mediating role of inflammatory indices in US adults.

Laboratory Studies

BPA/Phenols

Enriched environment rescues bisphenol A induced anxiety-like behavior and cognitive impairment by modulating synaptic plasticity.

BPA Exacerbates Zinc Deficiency-Induced Testicular Tissue Inflammation in Male Mice Through the TNF-α/NF-κB/Caspase8 Signaling Pathway.

Maternal bisphenol A (BPA) exposure induces placental dysfunction and health risk in adult female offspring: Insights from a mouse model.

m6A RNA methylation modulates autophagy by targeting Map1lc3b in bisphenol A induced Leydig cell dysfunction.

2,4-bisphenol S triggers physiological changes, oxidative stress and lipidome alterations in Gram-positive Enterococcus faecalis at environmental concentrations.

Zinc Attenuates Bisphenol A-Induced Reproductive Toxicity in Male Mice by Inhibiting Ferroptosis and Apoptosis Through Improving Zinc Homeostasis.

Analyzing the potential targets and mechanisms of chronic kidney disease induced by common synthetic Endocrine Disrupting Compounds (EDCs) in Chinese surface water environment using network toxicology and molecular docking techniques. [Nonylphenol and Octylphenol]

Phthalates

Female rat liver after sub-acute dibutyl phthalate treatment: Histological, stereological, biochemical, and global gene expression study.

The mechanism of DEHP-induced lipid accumulation in liver of female zebrafish.

ROS-mediated M1 polarization-necroptosis crosstalk involved in Di-(2-ethylhexyl) phthalate-induced chicken liver injury.

Species-specific responses to di (2-ethylhexyl) phthalate reveal activation of defense signaling pathways in California sea lion but not in human skeletal muscle cells in primary culture.

Toxic effects of dibutyl phthalate on trophoblast through mitochondria mediated cellular dysfunction.

Phthalates esters disrupt demersal fish behavior: Unveiling the brain-gut axis impact.

DEHP impairs the oxidative stress response and disrupts trace element and mineral metabolism within the mitochondria of detoxification organs.

DEHP-mediated oxidative stress leads to impaired testosterone synthesis in Leydig cells through the cAMP/PKA/SF-1/StAR pathway.

DEHP and Its Metabolite MEHP Alter the Insr and Glut4 Gene Expression by Blunting the Interaction of Transcription Factors in L6 Myotubes.

Green tea polyphenols alleviate di (2-ethylhexyl) phthalate-induced testicular injury in mice via lncRNA-miRNA-mRNA axis.

Exposure to environmentally relevant concentrations of di-(2-ethylhexyl) phthalate (DEHP) induced reproductive toxicity in female koi carp (Cyprinus carpio).

Parabens/Triclosan/Antimicrobials

Human cardiac organoid model reveals antibacterial triclocarban promotes myocardial hypertrophy by interfering with endothelial cell metabolism.

Effects of long-term treatment with low concentration butylparaben on prostate organoids.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Neuroendocrine and Developmental Impacts of Early Life Exposure to EDCs. [PCBs]

PFAS

PFOS and Its Commercial Alternative, 6:2 Cl-PFESA, Induce Multidrug Resistance in Pancreatic Cancer.

Are HFPO-TA and HFPO-DA safe substitutes for PFOA? A comprehensive toxicity study using zebrafish (Danio rerio) embryos and adults.

Transcriptome-based analysis reveals the toxic effects of perfluorononanoic acid by affecting the development of the cardiovascular system and lipid metabolism in zebrafish.

An oat fiber intervention for reducing PFAS body burden: A pilot study in male C57Bl/6 J mice.

Embryonic exposure to 6:2 fluorotelomer alcohol mediates autism spectrum disorder-like behavior by dysfunctional microbe-gut-brain axis in mice.

Applying newly suggested simultaneous analysis of metabolomics and lipidomics into perfluorooctanesulfonate-derived neurotoxicity mechanism in zebrafish embryos.

Sub-acute exposure of sea urchin (Strongylocentrotus intermedius) to environmentally relevant concentrations of PFOA and GenX influences gonadal development.

Hepatic injury and metabolic perturbations in mice exposed to perfluorodecanoic acid revealed by metabolomics and lipidomics.

Perfluorooctane sulfonate causes DNA damage and apoptosis via oxidative stress in umbilical cord fibroblast cells of Yangtze finless porpoise.

Flame Retardants

Impact of Exposure to a Mixture of Organophosphate Esters on the Adrenal Glands of Sprague Dawley Rats.

Pesticides

Glyphosate exposure exacerbates neuroinflammation and Alzheimer’s disease-like pathology despite a 6-month recovery period in mice.

A Shotgun Proteomic-Based Approach with a Q-Exactive Hybrid Quadrupole-Orbitrap High-Resolution Mass Spectrometer for the Assessment of Pesticide Mixture-Induced Neurotoxicity on a 3D-Developed Neurospheroid Model from Human Brain Meningiomas: Identification of Trityl-Post-Translational Modification.

Mechanistic insight into the neurodevelopmental toxicity of the novel pesticide pyrifluquinazon (PFQ) and its major metabolite in early-life stage zebrafish.

Insecticide chlorfenapyr confers induced toxicity in human cells through mitochondria-dependent pathways of apoptosis.

Effects of Flurochloridone on the Developmental Toxicity in Zebrafish (Danio rerio) Embryo.

Metals/Metalloids

Molecular disturbances and thyroid gland dysfunction in rats chronically exposed to a high dose of NaAsO₂: Insights from proteomic and phosphoproteomic analyses.

Gestational exposure to arsenic reduces female offspring fertility by impairing the repair of DNA double-strand breaks and synapsis formation in oocytes.

NLRP3 inflammasome activation and disruption of IRS-1/PI3K/AKT signaling: Potential mechanisms of arsenic-induced pancreatic beta cells dysfunction in rats.

Microplastics/Nanomaterials

Polystyrene microplastics exposition on human placental explants induces time-dependent cytotoxicity, oxidative stress and metabolic alterations.

Reversibility of polystyrene nanoplastics-induced disruption of testosterone biosynthesis in mice: The role of histone modifications.

Polystyrene microplastic exposure modulates gut microbiota and gut-liver axis in gilthead seabream (Sparus aurata).

Maternal exposure to polystyrene nanoplastics induces sex-specific cardiotoxicity in offspring mice.

Prenatal exposure on nanoplastics: a study of spatial transcriptomics in hippocampal offspring.

Exploring the Biological Effects of Polystyrene Nanoplastics on Spermatogenesis: Insights From Transcriptomic Analysis in Mouse Spermatocytes.

Polystyrene nanoplastics sequester the toxicity mitigating potential of probiotics by altering gut microbiota in grass carp (Ctenopharyngodon idella).

Chronic Exposure of Adult Zebrafish to Polyethylene and Polyester-based Microplastics: Metabolomic and Gut Microbiome Alterations Reflecting Dysbiosis and Resilience.

Polystyrene nanoplastics promote the blood-brain barrier dysfunction through autophagy pathway and excessive erythrophagocytosis.

Comparative Toxicity of Microplastics Obtained from Human Consumer Products on Human Cell-Based Models.

Miscellaneous

6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway.

In silico and in vitro evaluation of potential agonistic and antagonistic estrogenic and androgenic activities of pure cyanotoxins, microcystin-LR and cylindrospermopsin.

Quaternary Ammonium Compound Exposure Causes Infertility by Altering Endocrine Signaling and Gametogenesis.

Effective analysis of thyroid toxicity and mechanisms of acetyltributyl citrate using network toxicology, molecular docking and machine learning strategies.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Characteristics, sources, and concentration prediction of endocrine disruptors in a large reservoir driven by hydrological rhythms: A case study of the Danjiangkou Reservoir.

Phthalates

Phthalate esters in dusts from different indoor and outdoor microenvironment and potential human health risk: A case study in Beijing.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated dibenzo-dioxin/furan and polychlorinated biphenyl concentrations in the human milk of individuals living near municipal waste incinerators in the UK: Findings from the Breast milk, Environment, Early-life, and Development (BEED) human biomonitoring study.

PFAS

Understanding prenatal household exposures to per- and polyfluorylalkyl substances using paired Biological and dust measurements with sociodemographic and housing variables.

Toxic layering and compound extremes: Per- and polyfluoroalkyl substances (PFAS) exposure in rural, environmental justice copper mining communities.

Per- and polyfluoroalkyl substances in paired serum and breastmilk samples among pregnant farmworkers in Thailand.

Spatial and seasonal distribution, sources, and health risks of PM_2.5 loaded per- and polyfluoroalkyl substances (PFASs) in a typical megacity.

Fate and Transformation of 15 Classes of Per- and Polyfluoroalkyl Substances in Aqueous Film-Forming Foam (AFFF)-Amended Soil Microcosms.

Flame Retardants

Evaluating the Impact of Dermal Absorption on Internal Doses of Dechlorane Plus in Chinese E-waste Recycling Employees.

Occupational exposure to traditional and emerging organophosphate esters: A comparison of levels across different sources and blood distribution.

Metals/Metalloids

Lactational exposure of human infants to metal(loid)s in Sub-Saharan Africa and Mediterranean Europe: A systematic review and meta-analysis.

Making waves: Public health risks from arsenic in Mexico’s water extraction practices.

Risk assessment of complex organoarsenic species in food.

Microplastics/Nanomaterials

Disinfection inducing release of contaminants from baby play mats: microplastics and volatile organic compounds.

Occurrence and risk of microplastics and hexabromocyclododecane in urban drinking water systems: From source water to tap water.

Assessing occupational styrene exposure in the European and US Glass Reinforced Plastics Industry for the period between 1947 and 2020.

Plastic pollution in a special protected area for migratory birds.

Miscellaneous

Environmental and dietary factors associated with urinary OH-PAHs in mid-pregnancy in a large multi-site study.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.