EDC Science Weekly, Dec. 24, 2022 – Jan. 5, 2023

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

A bit longer this week because it covers the past two weeks. Happy New Year!

Regulations/Policy

One Health collaboration with and among EU Agencies – Bridging research and policy.

Critical endpoints of PFOA and PFOS exposure for regulatory risk assessment in drinking water: Parameter choices impacting estimates of safe exposure levels.

Reappraising the public health benefits conferred by environmental policy: Considerations for an aging society.

Current testing programs for pesticides adequately capture endocrine activity and adversity for protection of vertebrate wildlife [by Bayer, BASF, etc.]

Methods/Tools/Screening

Advancing environmental health sciences through implementation science.

“They Kept Going for Answers”: Knowledge, Capacity, and Environmental Health Literacy in Michigan’s PBB Contamination.

Methods

Machine Learning Toxicity Prediction: Latest Advances by Toxicity End Point.

Human biomonitoring guidance values (HBM-GVs) for priority substances under the HBM4EU initiative – New values derivation for deltamethrin and cyfluthrin and overall results.

Use of computational toxicology models to predict toxicological points of departure: A case study with triazine herbicides.

Integrating Physiologically Based Pharmacokinetic Modeling-Based Forward Dosimetry and in Vitro Bioassays to Improve the Risk Assessment of Organophosphate Esters on Human Health.

Tools

Hemocytes: A Useful Tool for Assessing the Toxicity of Microplastics, Heavy Metals, and Pesticides on Aquatic Invertebrates.

Toxicogenomics scoring system: TGSS, a novel integrated risk assessment model for chemical carcinogenicity prediction.

Screening

Chromatin modifiers: a new class of pollutants with potential epigenetic effects revealed by in vitro assays and transcriptomic analyses.

Screening of Potential Plasticizer Alternatives for Their Toxic Effects on Male Germline Stem Cells.

Prediction of the Endocrine disruption profile of fluorinated biphenyls and analogues: An in silico study.

Hormone receptor activities of complex mixtures of known and suspect chemicals in personal silicone wristband samplers worn in office buildings.

XML-CIMT: Explainable Machine Learning (XML) Model for Predicting Chemical-Induced Mitochondrial Toxicity.

Commentaries

Epigenetic Inheritance: Impact for Biology and Society-recent progress, current questions and future challenges. [Meeting report]

Reviews

Numerous Chemicals/Mixtures

The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes.

Chemical Compounds and Ambient Factors Affecting Pancreatic Alpha-Cells Mass and Function: What Evidence?

Endocrine disrupting micropollutants in water and their effects on human fertility and fecundity.

The impact of social and environmental factors on cancer biology in Black Americans.

Thyroid Carcinoma: A Review for 25 Years of Environmental Risk Factors Studies.

Environmental Exposures and Kidney Disease.

Recent Trends in Multiclass Analysis of Emerging Endocrine Disrupting Contaminants (EDCs) in Drinking Water.

Comprehensive Analysis of the Association between Human Diseases and Water Pollutants.

Probiotic cultures as a potential protective strategy against the toxicity of environmentally relevant chemicals: State-of-the-art knowledge.

BPA/Phenols

Hazard characterization of bisphenol A (BPA) based on rodent models – Multilevel meta-analysis and dose-response analysis for reproductive toxicity.

Phthalates

Occurrence, source, ecological risk, and mitigation of phthalates (PAEs) in agricultural soils and the environment: A review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

An exposure to endocrine active persistent pollutants and endometriosis – a review of current epidemiological studies.

A systematic evidence map for the evaluation of noncancer health effects and exposures to polychlorinated biphenyl mixtures.

Environmental exposure and the role of AhR in the tumor microenvironment of breast cancer.

Perfluoroalkyl Substances

Toxicity of Per- and Polyfluoroalkyl Substances to Aquatic Invertebrates, Planktons, and Microorganisms.

A Review of PFAS Destruction Technologies.

Occupational exposure and serum levels of per- and polyfluoroalkyl substances (PFAS): A review.

Phytoremediation of fluoroalkylethers (ether-PFASs): A review on bioaccumulation and ecotoxilogical effects.

A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure.

Pesticides

Carbendazim: Ecological risks, toxicities, degradation pathways and potential risks to human health.

Metals/Metalloids

Association between arsenic exposure and inflammatory cytokines and C-reaction protein: A systematic review and meta-analysis.

Arsenic-induced toxicity and the ameliorative role of antioxidants and natural compounds.

A review of mechanisms underlying the protective effects of natural compounds against arsenic-induced neurotoxicity.

A review on arsenic pollution, toxicity, health risks, and management strategies using nanoremediation approaches.

Cadmium exposure and risk of breast cancer: A meta-analysis.

Chromium as a Risk Factor for Breast Cancer: A Meta-Analysis.

Epigenetic mechanisms in metal carcinogenesis.

Heavy metals as risk factors for human diseases – a Bayesian network approach.

Impacts of heavy metals on early development, growth and reproduction of fish – A review.

Microplastics/Nanomaterials

Combined toxicity of micro/nanoplastics loaded with environmental pollutants to organisms and cells: Role, effects, and mechanism.

Microplastics induce neurotoxicity in aquatic animals at environmentally realistic concentrations: A meta-analysis.

Micro(nano)plastic pollution in terrestrial ecosystem: emphasis on impacts of polystyrene on soil biota, plants, animals, and humans.

Research advances of microplastics and potential health risks of microplastics on terrestrial higher mammals: a bibliometric analysis and literature review.

Pharmaceuticals/Personal Care Products

The Complex Interplay Between Antibiotic Resistance and Pharmaceutical and Personal Care Products in the Environment.

Miscellaneous

Effect of polycyclic aromatic hydrocarbons on immunity.

Exposure to Polycyclic Aromatic Hydrocarbons and adverse reproductive outcomes in women: current status and future perspectives.

Formation of disinfection by-products from microplastics, tire wear particles, and other polymer-based materials.

Human Health Studies

Numerous Chemicals/Mixtures

Assessing the relationship between hypospadias risk and parental occupational exposure to potential endocrine-disrupting chemicals.

BPA/Phenols

Associations between urinary concentrations of bisphenols and serum concentrations of sex hormones among US. Males.

Prenatal exposure to phenols and benzophenones in relation to markers of male reproductive function in adulthood.

Influence of BPA exposure, measured in saliva, on childhood weight.

Serum glycolipids mediate the relationship of urinary bisphenols with NAFLD: analysis of a population-based, cross-sectional study.

Phthalates

Associations between maternal phthalate exposure and neonatal neurobehaviors: The Taiwan maternal and infant cohort study (TMICS).

Screening for phthalates biomarkers and its potential role in infertility outcomes in Jordan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Biomonitoring of organochlorine pesticides and cancer survival: a population-based study.

Prenatal exposure to persistent organic pollutants and changes in infant growth and childhood growth trajectories.

Flame Retardants

Urinary concentrations of organophosphate esters in relation to semen quality: A cross-sectional study.

Independent and combined effects of exposure to organophosphate esters on thyroid hormones in children and adolescents.

Pesticides

Organophosphorus Pesticide Exposure at 17 Weeks’ Gestation and Odds of Offspring Attention-Deficit/Hyperactivity Disorder Diagnosis in the Norwegian Mother, Father, and Child Cohort Study.

Genotoxicity and Reproductive Risk in Workers Exposed to Pesticides in Rural Areas of Curicó, Chile: A Pilot Study.

Effects of urinary of organophosphate metabolites on nerve conduction and neurobehavioral performance among farmers in northern Thailand.

Metals/Metalloids

Altered Metal Homeostasis Associates with Inflammation, Oxidative Stress, Impaired Glucose Metabolism, and Dyslipidemia in the Crosstalk between Childhood Obesity and Insulin Resistance.

Relation between blood levels of heavy metals and some markers of oxidative stress among boys with neuropathic bladder and posterior urethral valve.

The association between serum cadmium and diabetes in the general population: A cross-sectional study from NHANES (1999-2020).

Prenatal exposure to heavy metal mixtures and anthropometric birth outcomes: a cross-sectional study.

Exposure to metals and the disruption of sex hormones in 6-19 years old children: An exploration of mixture effects.

Do trace elements influence the course of newly diagnosed type 1 diabetes mellitus?

Air Pollution

Alzheimer’s disease-like cortical atrophy mediates the effect of air pollution on global cognitive function.

Exposure of ambient PM_2.5 during gametogenesis period affects the birth outcome: Results from the project ELEFANT.

Miscellaneous

Environmental exposure to perchlorate, nitrate and thiocyanate, and thyroid function in Chinese adults: A community-based cross-sectional study.

Effects of perchlorate, nitrate, and thiocyanate exposures on serum total testosterone in children and adolescents.

Urinary polycyclic aromatic hydrocarbon metabolites are positively related to serum testosterone levels of males and serum estradiol levels of females among U.S. adults.

Laboratory Studies

Numerous Chemicals/Mixtures

A human-relevant mixture of endocrine disrupting chemicals induces changes in hippocampal DNA methylation correlating with hyperactive behavior in male mice.

Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner.

Early Exposure to Environmental Pollutants: Imidacloprid Potentiates Cadmium Toxicity on Zebrafish Retinal Cells Death.

Target Organ Toxicity in Rats After Subchronic Oral Exposure to Soil Extracts Containing a Complex Mixture of Contaminants.

A comparative study on endocrine disrupting effects of leachates from virgin and aged plastics under simulated media in marine medaka larvae (Oryzias melastigma).

DBP and BaP co-exposure induces kidney injury via promoting pyroptosis of renal tubular epithelial cells in rats.

BPA/Phenols

Evaluation of toxicological effects of bisphenol S with an in vitro human bone marrow mesenchymal stem cell: Implications for bone health.

Physiologically based modelling of dermal absorption and kinetics of consumer-relevant chemicals: A case study with exposure to bisphenol A from thermal paper.

Impact of Extended and Combined Exposure of Bisphenol Compounds on Their Chromosome-Damaging Effect─Increased Potency and Shifted Mode of Action.

Genome-wide distribution of histone trimethylation reveals a global impact of bisphenol A on telomeric binding proteins and histone acetyltransferase factors: a pilot study with human and in vitro data.

Bisphenol S disrupts opsins gene expression and impairs the light-sensing function via antagonizing TH-TRβ signaling pathway in zebrafish larvae.

To investigate the role of rutin on bisphenol-A induced female infertility in rats.

Bioaccumulation, internal distribution and toxicity of bisphenol S in the earthworm Eisenia fetida.

Adverse (geno)toxic effects of bisphenol A and its analogues in hepatic 3D cell model.

Comparison of toxicokinetic properties of eleven analogues of Bisphenol A in pig after intravenous and oral administrations.

Influence of Bisphenol A and 17β-trenbolone Exposure in Oryzias Congeners.

System-wide health risk prediction for 4-methyl-2,4-bis(4-hydroxyphenyl)pent-1-ene(MBP), a major active metabolite of environmental pollutant and food contaminant – bisphenol A.

Identification of risk for ovarian disease enhanced by BPB or BPAF exposure.

Preconception exposure of adult male rats to bisphenol S impairs insulin sensitivity and glucose tolerance in their male offspring.

Untargeted Lipidomics Revealed the Protective Effects of Cyanidin-3-O-glucoside on Bisphenol A-Induced Liver Lipid Metabolism Disorder in Rats.

Bisphenol A-induced neurobehavioral transformation is associated with augmented monoamine oxidase activity and neurodegeneration in zebrafish brain.

Phthalates

First Identification of a Large Set of Serine Hydrolases by Activity-Based Protein Profiling in Dibutyl Phthalate-Exposed Zebrafish Larvae.

Lycopene Attenuates Di(2-ethylhexyl) Phthalate-Induced Mitochondrial Damage and Inflammation in Kidney via cGAS-STING Signaling.

Di-(2-ethylhexyl) phthalate exposure impairs cortical development in hESC-derived cerebral organoids.

Parabens/Triclosan/Antimicrobials

Redox Status, Estrogen and Progesterone Production by Swine Granulosa Cells Are Impaired by Triclosan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Synergetic effects of concurrent chronic exposure to a mixture of OCPs and high-fat diets on type 2 diabetes and beneficial effects of caloric restriction in female zebrafish.

Perfluoroalkyl Substances

Perfluorooctanoic acid and perfluorooctanesulfonic acid induce immunotoxicity through the NF-κB pathway in black-spotted frog (Rana nigromaculata).

In silico analysis decodes transthyretin (TTR) binding and thyroid disrupting effects of per- and polyfluoroalkyl substances (PFAS).

Effect of pretreatment with a synbiotic on Perfluorooctanoic acid-induced liver damage after sub-acute oral exposure in C57BL/6J mice.

Occurrence of late-apoptotic symptoms in porcine preimplantation embryos upon exposure of oocytes to perfluoroalkyl substances (PFASs) under in vitro meiotic maturation.

Experimental evidence of a limited impact of new-generation perfluoroalkyl substance C6O4 on differentiating human dopaminergic neurons from induced pluripotent stem cells.

Perfluorobutanesulfonate exposure induces metabolic disturbances in different regions of mouse gut.

Vitamin C protects the spleen against PFOA-induced immunotoxicity.

Novel Insight into the Mechanisms of Neurotoxicity Induced by 6:6 PFPiA through Disturbing the Gut-Brain Axis.

Flame Retardants

Maternal Organophosphate Flame Retardant Exposure Alters the Developing Mesencephalic Dopamine System in Fetal Rat.

Gestation and lactation triphenyl phosphate exposure disturbs offspring gut microbiota in a sex-dependent pathway.

Reproductive and developmental toxicity following exposure to organophosphate ester flame retardants and plasticizers, triphenyl phosphate and isopropylated phenyl phosphate, in Sprague Dawley rats.

The brominated flame retardant, 1,2,5,6-tetrabromocyclooctane (TBCO), causes multigenerational effects on reproductive capacity of Japanese medaka (Oryzias latipes).

The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models.

Triphenyl phosphate induced reproductive toxicity through the JNK signaling pathway in Caenorhabditis elegans.

In vitro neurotoxic potential of emerging flame retardants on neuroblastoma cells in an acute exposure scenario.

Tetrabromobisphenol A and hexabromocyclododecane, brominated flame retardants, trigger endoplasmic reticulum stress and activate necroptosis signaling in PC12 cells.

Pesticides

Exposure to dithiocarbamate fungicide maneb in vitro and in vivo: Neuronal apoptosis and underlying mechanisms.

Impact of Glyphosate on the Development of Insulin Resistance in Experimental Diabetic Rats: Role of NFκB Signalling Pathways.

Acute and chronic effects of the organophosphate malathion on the pancreatic α and β cell viability, cell structure, and voltage-gated K⁺ currents.

Declines in Reproductive Condition of Male Largemouth Bass (Micropterus salmoides) Following Seasonal Exposure to Estrogenic Endocrine-Disrupting Compounds. [atrazine]

Transcriptome analysis reveals the mechanisms of hepatic injury caused by long-term environmental exposure to atrazine in juvenile common carp (Cyprinus carpio L.).

Evaluation of acute toxicity and histology effect on liver of glyphosate and atrazine in the African catfish Clarias gariepinus (Burchell 1822).

Effects of imidacloprid-contaminated feed exposure on spermatogenic cells and Leydig cells in testes of adult male rabbits (Oryctolagus cuniculus).

Chitosan oligosaccharide alleviates and removes the toxicological effects of organophosphorus pesticide chlorpyrifos residues.

The role of the gut microbiota in depressive-like behavior induced by chlorpyrifos in mice.

Screening potential toxicity of currently used herbicides in the freshwater amphipod Gammarus fossarum based on multi-level biomarker responses to field-realistic exposures.

Effects of maternal exposure to procymidone on hepatic metabolism in the offspring of mice.

Metals/Metalloids

Fluoride exposure causes behavioral, molecular and physiological changes in adult zebrafish (Danio rerio) and their offspring.

Joint Action Toxicity of Arsenic (As) and Lead (Pb) Mixtures in Developing Zebrafish.

Arsenic Ingested Early in Life Is More Readily Absorbed: Mechanistic Insights from Gut Microbiota, Gut Metabolites, and Intestinal Morphology and Functions.

Intergenerational Arsenic Exposure on the Mouse Epigenome and Metabolic Physiology.

Inorganic arsenic alters the development of dopaminergic neurons but not serotonergic neurons and induces motor neuron development via Sonic hedgehog pathway in zebrafish.

Chronic environmental inorganic arsenic exposure causes social behavioral changes in juvenile zebrafish (Danio rerio).

Microplastics/Nanomaterials

Male reproductive toxicity of polystyrene microplastics: Study on the endoplasmic reticulum stress signaling pathway.

The toxicity of nano polyethylene terephthalate to mice: Intestinal obstruction, growth retardant, gut microbiota dysbiosis and lipid metabolism disorders.

Endocrine disrupting effect and reproductive toxicity of the separate exposure and co-exposure of nano-polystyrene and diethylstilbestrol to zebrafish.

Accumulation and ecotoxicological effects induced by combined exposure of different sized polyethylene microplastics and oxytetracycline in zebrafish.

Microplastics exacerbate virus-mediated mortality in fish.

Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri.

Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice.

Pharmaceuticals/Personal Care Products

Are Fish Populations at Risk? Metformin Disrupts Zebrafish Development and Reproductive Processes at Chronic Environmentally Relevant Concentrations.

Use of all-male triploid population of zebrafish (Danio rerio) for evaluation of 17α-ethinylestradiol effects.

Miscellaneous

Toxicological signature for thyroid endocrine disruption of dichlorooctylisothiazolinone in zebrafish larvae.

Chronic estrone exposure affects spermatogenesis and sperm quality in zebrafish (Danio rerio).

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Characterization and quantification of endocrine disruptors in female menstrual blood samples.

Does Using Corsi-Rosenthal Boxes to Mitigate COVID-19 Transmission Also Reduce Indoor Air Concentrations of PFAS and Phthalates?

BPA/Phthalates

The effect of training about environmental toxicant Bisphenol-A exposure in pregnancy on maternal urine Bisphenol-A level.

Exposure to Endocrine Disruptors (Di(2-Ethylhexyl)phthalate (DEHP) and Bisphenol A (BPA)) in Women from Different Residing Areas in Italy: Data from the LIFE PERSUADED Project.

Predictors of urinary biomarker concentrations of phthalates and some of their replacements in children in the Project Viva cohort.

Estimated exposure to bisphenol A in breastfed and breastfed plus formula-fed infants in Turkey: a comparison study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Elimination of PBB-153; findings from a cohort of Michigan adults.

Investigation of dichlorodiphenyltrichloroethane (DDT) on xenobiotic enzyme disruption and metabolomic bile acid biosynthesis in DDT-sprayed areas using wild rats.

Perfluoroalkyl Substances

Sampling of freely dissolved per- and polyfluoroalkyl substances (PFAS) in surface water and groundwater using a newly developed passive sampler.

Is PFAS from land applied municipal biosolids a significant source of human exposure via groundwater?

Concentrations of Per- and Polyfluoroalkyl Substances in Paired Maternal Plasma and Human Milk in the New Hampshire Birth Cohort.

Isomer-specific perfluoroalkyl acids accumulation, excretion and maternal transfer to eggs in chickens around a fluorochemical manufactory in China.

Exposure and Health Risk Assessment of Per- and Polyfluoroalkyl Substances in Crayfish from the Middle and Lower Reaches of the Yangtze River.

Analytical method interferences for perfluoropentanoic acid (PFPeA) and perfluorobutanoic acid (PFBA) in biological and environmental samples.

Trace Analysis Method Based on UPLC-MS/MS for the Determination of (C2-C18) Per-and Polyfluoroalkyl Substances and Its Application to Tap Water and Bottled Water.

Flame Retardants

Distribution and pollution characteristics of organophosphate esters: reflected by tree rings of arbor species.

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure.

Legacy and novel brominated flame retardants in agricultural soils of eastern China (2011-2021): Concentration level, temporal trend, and health risk assessment.

Pesticides

Predictors of pesticide levels in carpet dust collected from child care centers in Northern California, USA.

Assessment of exposure to pesticide mixtures in five European countries by a harmonized urinary suspect screening approach.

Pesticide Prioritization by Potential Biological Effects in Tributaries of the Laurentian Great Lakes.

Metals/Metalloids

Concentrations and predictors of aluminum, antimony, and lithium in breast milk: A repeated-measures study of donors.

Microplastics/Nanomaterials

Occurrence of microplastics in tap and bottled water, and food packaging: A narrative review on current knowledge.

Pharmaceuticals/Personal Care Products

Lysmeral Exposure in Children and Adolescences Participating in the German Environmental Survey (2012-2015): Integrating Sex/Gender into Analysis.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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