EDC Science Weekly, Dec. 22 – Jan. 2, 2020 – HEEDS

EDC Science Weekly, Dec. 22 – Jan. 2, 2020

Post author:HEEDS
Post published:January 3, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed in the past 2 weeks.

Contents:Regulations/Policy, Methods/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies.

Regulations/Policy

Researcher engagement in policy deemed societally beneficial yet unrewarded.

Methods/Screening

Generalized Read-Across (GenRA): A workflow implemented into the EPA CompTox Chemicals Dashboard.

Concentration-dependent transcriptome of zebrafish embryo for environmental chemical assessment.

Estimate ecotoxicity characterization factors for chemicals in life cycle assessment using machine learning models.

Reviews

Commentaries/Conference Summaries

Perspective: Cell Danger Response Biology-The New Science that Connects Environmental Health with Mitochondria and the Rising Tide of Chronic Illness.

Post Dioxin Period for Feed: Cocktail Effects of Emerging POPs and Analogues.

Lessons from the 2018 International Symposium on Alternatives Assessment: Advances and Reflections on Practice and Ongoing Needs to Build the Field.

2019 environment, epigenetics and reproduction. [On the fourth biannual Kenya Africa Conference ‘Environment, Epigenetics and Reproduction’]

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Growing evidence links air pollution exposure to risk of Alzheimer’s disease and related dementia.

No clear way ahead: smog in northern India.

BPA/Phenols

Bisphenols and Thyroid Hormone.

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability.

Perfluoroalkyl Substances

Adverse effects of perfluoroalkyl acids on fish and other aquatic organisms: A review.

Pesticides

The Potential Effects of Recall Bias and Selection Bias on the Epidemiological Evidence for the Carcinogenicity of Glyphosate.

Thrombotic thrombocytopenic purpura associated with pesticides: A report of 4 cases and literature review.

A Systematic Review of Organic Versus Conventional Food Consumption: Is There a Measurable Benefit on Human Health?

Pesticide exposure and lung function: a systematic review and meta-analysis.

Potentially Toxic Elements

Environmental archives of atmospheric Hg deposition – A review.

Toxicity of mercury: Molecular evidence.

Bioavailability Assessment of Metals in Freshwater Environments: A Historical Review.

Community Water Fluoridation Exposure: A Review of Neurological and Cognitive Effects

Fluorosis and cognitive development among children (6-14 years of age) in the endemic areas of the world: a review and critical analysis.

Environmental exposure of arsenic and fluoride and their combined toxicity: A recent update.

A Synthesis of Maternal Transfer of Mercury in Birds: Implications for Altered Toxicity Risk.

A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer’s Disease.

Microplastics

Micro- and nanoplastic toxicity on aquatic life: Determining factors.

Interaction of chemical contaminants with microplastics: Principles and perspectives.

Air Pollution

Association between air pollutants and development of chronic kidney disease: A systematic review and meta-analysis.

Deciphering the Code between Air Pollution and Disease: The Effect of Particulate Matter on Cancer Hallmarks.

All roads lead to inflammation: Is maternal immune activation a common culprit behind environmental factors impacting offspring neural control of breathing?

Numerous articles in the Annals of Global Health:

The Human Right to Breathe Clean Air.

Academies’ Call to Action: Air Pollution Threatens Global Health.

Global Statement on Air Pollution and Health: Opportunities for Africa.

Air Pollution and Health: A Science-Policy Initiative of National Academies.

Addressing the Complex and Pressing Societal Issue of Air Pollution and Health.

Air Pollution and Human Health: A Comment from the World Health Organization.

Air Pollution and Health – A Science-Policy Initiative.

Miscellaneous

Perturbation of Nuclear Hormone Receptors by Endocrine Disrupting Chemicals: Mechanisms and Pathological Consequences of Exposure.

The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects.

Metabolome response to anthropogenic contamination on microalgae: a review.

A State-of-the-Art Review of Indigenous Peoples and Environmental Pollution.

Human Health Studies

BPA/Phenols

Bisphenol analogue concentrations in human breast milk and their associations with postnatal infant growth.

Maternal bisphenol and phthalate urine concentrations and weight gain during pregnancy.

Phthalates

Perinatal phthalates exposure decreases fine-motor functions in 11-year-old girls: Results from weighted Quantile sum regression.

Prenatal exposure to di-(2-ethylhexyl) phthalate and decreased skeletal muscle mass in 6-year-old children: A prospective birth cohort study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association of Maternal Exposure to Persistent Organic Pollutants in Early Pregnancy With Fetal Growth.

Persistent Organic Pollutants in Human Breast Milk and Associations with Maternal Thyroid Hormone Homeostasis.

Exposure to organochlorine pesticides and the risk of type 2 diabetes in the population of East China.

Simultaneous exploration of nutrients and pollutants in human milk and their impact on preterm infant growth: An integrative cross-platform approach.

Perfluoroalkyl Substances

Association Between Perfluoroalkyl Substance Exposure and Renal Function in Children With CKD Enrolled in H3Africa Kidney Disease Research Network.

The association between total serum isomers of per- and polyfluoroalkyl substances, lipid profiles, and the DNA oxidative/nitrative stress biomarkers in middle-aged Taiwanese adults.

Dynamic growth metrics for examining prenatal exposure impacts on child growth trajectories: Application to perfluorooctanoic acid (PFOA) and postnatal weight gain.

Quantitative bias analysis of the association between subclinical thyroid disease and two perfluoroalkyl substances in a single study.

Pesticides

Association Between Exposure to Pyrethroid Insecticides and Risk of All-Cause and Cause-Specific Mortality in the General US Adult Population. [related: Pyrethroid Insecticides-Time for a Closer Look.]

Susceptibility to organophosphates pesticides and the development of infectious-contagious respiratory diseases.

Variability in urinary neonicotinoid concentrations in single-spot and first-morning void and its association with oxidative stress markers.

Assessment of DNA damage and cholinesterase activity in soybean farmers in southern Brazil: High versus low pesticide exposure.

Potentially Toxic Elements

Exposure to Heavy Metals in Soot Samples and Cancer Risk Assessment in Port Harcourt, Nigeria.

Thallium exposure at low concentration leads to early damage on multiple organs in children: A case study followed-up for four years.

Intelligence gain and social cost savings attributable to environmental lead exposure reduction strategies since the year 2000 in Flanders, Belgium.

Domain- and sex-specific effects of prenatal exposure to low levels of arsenic on children’s development at 6 months of age: Findings from the Ma’anshan birth cohort study in China.

The relationship between lead and cadmium levels and functional dependence among elderly participants.

Insecticide and metal exposures are associated with a surrogate biomarker for non-alcoholic fatty liver disease in the National Health and Nutrition Examination Survey 2003-2004.

Association of adverse birth outcomes with prenatal uranium exposure: A population-based cohort study.

Exposure to arsenic and lead in children from Salamanca México, effects on telomeric lengthening and mitochondrial DNA.

Exposure to multiple metals in early pregnancy and gestational diabetes mellitus: A prospective cohort study.

Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan.

Air Pollution

Exercise-Induced Bronchoconstriction in Iraq and Afghanistan Veterans With Deployment-Related Exposures.

Ambient particulate matter pollution and adult hospital admissions for pneumonia in urban China: A national time series analysis for 2014 through 2017.

Short-term effects of air pollution on blood pressure.

Identifying critical windows of prenatal particulate matter (PM2.5) exposure and early childhood blood pressure.

Long term exposure to ambient fine particulate matter and incidence of stroke: prospective cohort study from the China-PAR project.

Association between ambient fine particulate pollution and hospital admissions for cause specific cardiovascular disease: time series study in 184 major Chinese cities.

Diesel exhaust and bladder cancer risk by pathologic stage and grade subtypes.

Atrial fibrillation hospitalization is associated with exposure to fine particulate air pollutants.

Age- and season-specific effects of ambient particles (PM1, PM2.5, and PM10) on daily emergency department visits among two Chinese metropolitan populations.

The contribution of improved air quality to reduced cardiovascular mortality: Declines in socioeconomic differences over time.

Health effects of PM2.5 sources on children’s allergic and respiratory symptoms in Fukuoka, Japan.

Ambient air pollution and markers of fetal growth: A retrospective population-based cohort study of 2.57 million term singleton births in China.

Exposure to fine particulate matter and temporal dynamics of episodic memory and depressive symptoms in older women.

Household air pollution and arthritis in low-and middle-income countries: Cross-sectional evidence from the World Health Organization’s study on Global Ageing and Adult Health.

Long-Term Exposure to Ambient Fine Particulate Matter (PM2.5) and Lung Function in Children, Adolescents, and Young Adults: A Longitudinal Cohort Study

The acute effects of fine particulate matter constituents on circulating inflammatory biomarkers in healthy adults.

Exposure to household air pollution during first 3 years of life and IQ level among 6-8-year-old children in India – A cross-sectional study.

Mixtures

Influence of the Urban Exposome on Birth Weight.

Miscellaneous

Paternal occupational exposure to chemicals and secondary sex ratio: results from the Japan Environment and Children’s Study.

Laboratory Studies

BPA/Phenols

In quest of effect directed analysis in the smart laboratory: Automated system for flow-through evaluation of membranotropic effects of emerging contaminants.

Transcriptomic responses of Bisphenol S predict involvement of immune function in the cardiotoxicity of early life stage zebrafish (Danio rerio).

Genetic evidence for estrogenicity of bisphenol A in zebrafish gonadal differentiation and its signalling mechanism.

Changes in lipid profiles induced by bisphenol A (BPA) in zebrafish eleutheroembryos during the yolk sac absorption stage.

In Vivo Evaluation of Histopathological Alterations and Trace Metals Estimation of the Small Intestine in Bisphenol A-Intoxicated Rats.

Acute low-dose bisphenol S exposure affects mouse oocyte quality.

Endocrine-independent Cytotoxicity of Bisphenol A is Mediated by Increased Levels of Reactive Oxygen Species and Affects Cell Cycle Progression.

A New LC-MS/MS Method for Simultaneous and Quantitative Detection of Bisphenol-A and Steroids in Target Tissues: A Power Tool to Characterize the Interference of Bisphenol-A Exposure on Steroid Levels.

Bisphenol AF: Halogen bonding effect is a major driving force for the dual ERα-agonist and ERβ-antagonist activities.

In vitro impact of bisphenol A on maturation and function of monocyte-derived dendritic cells in patients with primary Sjögren’s syndrome.

The effects of different bisphenol derivatives on oxidative stress, DNA damage and DNA repair in RWPE-1 cells: A comparative study.

In vitro estrogenic activity of binary and multicomponent mixtures with bisphenol A.

Neonatal Exposure to Agonists and Antagonists of Sex Steroid Receptors Affects AMH and FSH Plasma Level and Their Receptors Expression in the Adult Pig Ovary.

Phthalates

The effects of a phthalate metabolite mixture on antral follicle growth and sex steroid synthesis in mice.

Di-(2-ethyl hexyl) phthalate induces necroptosis in chicken cardiomyocytes by triggering calcium overload.

Mono-(2-ethylhexyl)phthalate regulates cholesterol efflux via microRNAs regulated m6A RNA methylation.

Exposure of DBP in gestation induces inflammation of testicular Sertoli cells in progeny by activating NLRP3 inflammasomes.

Probing the molecular toxic mechanism of di-(2-ethylhexyl) phthalate with glutathione transferase Phi8 from Arabidopsis thaliana.

Parabens/Triclosan/Antimicrobials

Identification of a novel target for the action of endocrine disrupting chemicals: inhibitory effect of methylparaben on human neutrophil functions.

Sublethal exposure to propylparaben leads to lipid metabolism impairment in zebrafish early-life stages.

In utero and lactational exposure to triclocarban: reproductive effects on female rat offspring.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Disruption of 17β-estradiol secretion by persistent organic pollutants present in human follicular fluid is dependent on the potential of ovarian granulosa tumor cell lines to metabolize estrogen.

Organochlorine pesticides induce inflammation, ROS production, and DNA damage in human epithelial ovary cells: An in vitro study.

TCDD inhibited the osteogenic differentiation of human fetal palatal mesenchymal cells through AhR and BMP-2/TGF-β/Smad signaling.

Regulation of aryl hydrocarbon receptor signaling pathway and dioxin toxicity by novel agonists and antagonists.

Polychlorinated biphenyls in a grassland food network: Concentrations, biomagnification, and transmission of toxicity.

Transplacental transfer mechanism of organochlorine pesticides: An in vitro transcellular transport study.

Metatranscriptomic Analysis of the Mouse Gut Microbiome Response to the Persistent Organic Pollutant 2,3,7,8-Tetrachlorodibenzofuran.

Perfluoroalkyl Substances

Probing the Cell Apoptosis Pathway Induced by Perfluorooctanoic Acid and Perfluorooctane Sulfonate at the Subcellular and Molecular Levels.

Green tea polyphenols and epigallocatechin-3-gallate protect against perfluorodecanoic acid induced liver damage and inflammation in mice by inhibiting NLRP3 inflammasome activation.

Behavioural effects and bioconcentration of per- and polyfluoroalkyl substances (PFASs) in zebrafish (Danio rerio) embryos.

Developmental exposure to a mixture of perfluoroalkyl acids (PFAAs) affects the thyroid hormone system and the bursa of Fabricius in the chicken.

Flame Retardants

Comparison of tris(2-ethylhexyl) phosphate and di(2-ethylhexyl) phosphoric acid toxicities in a rat 28-day oral exposure study.

Exposure to HBCD promotes adipogenesis both in vitro and in vivo by interfering with Wnt6 expression.

Cytotoxic and genotoxic effects of the flame retardants (PBDE-47, PBDE-99 and PBDE-209) in human bronchial epithelial cells.

Organotins

Autophagy is Activated In Vivo during Trimethyltin-Induced Apoptotic Neurodegeneration: A Study in the Rat Hippocampus.

Pesticides

Protective effects of fennel essential oil against oxidative stress and genotoxicity induced by the insecticide triflumuron in human colon carcinoma cells.

A computational insight into the molecular interactions of chlorpyrifos and its degradation products with the human progesterone receptor leading to endocrine disruption.

Chlorpyrifos levels within permitted limits induce nuclear abnormalities and DNA damage in the erythrocytes of the common carp.

Photolysis induced neurotoxicity enhancement of Chlorpyrifos in aquatic system: a case investigation on Caenorhabditis elegans.

Neonicotinoid insecticides exposure cause amino acid metabolism disorders, lipid accumulation and oxidative stress in ICR mice.

Colibri® insecticide induces male reproductive toxicity: alleviating effects of Lannea acida (Anacardiaceae) in rats.

Sub-lethal effect of synthetic pyrethroid pesticide on metabolic enzymes and protein profile of non-target Zebra fish, Danio rerio.

Cypermethrin exposure during perinatal period affects fetal development and impairs reproductive functions of F1 female rats.

Effects of chlorothalonil on the antioxidant defense system of mussels Perna perna.

Oxidative stress, hematological and biochemical alterations induced by sub-acute exposure to fipronil (COACH®) in albino mice and ameliorative effect of selenium plus vitamin E.

Synergistic antioxidant effects of resveratrol and curcumin against fipronil-triggered oxidative damage in male albino rats.

Transcriptomic modifications of the thyroid gland upon exposure to phytosanitary-grade fipronil: Evidence for the activation of compensatory pathways.

Impact of chronic exposure to trichlorfon on intestinal barrier, oxidative stress, inflammatory response and intestinal microbiome in common carp (Cyprinus carpio L.).

Effects of trichlorfon on oxidative stress, neurotoxicity, and cortisol levels in common carp, Cyprinus carpio L., at different temperatures.

Nephroprotective Role of Beta vulgaris L. Root Extract against Chlorpyrifos-Induced Renal Injury in Rats.

Interference of goethite in the effects of glyphosate and Roundup® on ZFL cell line.

Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling pathways.

Toxicological evaluation of the herbicide Palace® in Drosophila melanogaster.

Profiling epigenetic changes in human cell line induced by atrazine exposure.

Soybean isoflavones prevent atrazine-induced neurodegenerative damage by inducing autophagy.

Transgenerational disrupting impacts of atrazine in zebrafish: Beneficial effects of dietary spirulina.

Consequences of a short time exposure to a sublethal dose of Flupyradifurone (Sivanto) pesticide early in life on survival and immunity in the honeybee (Apis mellifera).

Enrichment of imidacloprid and its metabolites in lizards and its toxic effects on gonads.

Unraveling the toxic effects of neonicotinoid insecticides on the thyroid endocrine system of lizards.

Bendiocarb-induced nephrotoxicity in rats and the protective role of vitamins C and E.

A metabolomic study on the gender-dependent effects of maternal exposure to fenvalerate on neurodevelopment in offspring mice.

Impact of chronic low dose exposure of monocrotophos in rat brain: Oxidative/ nitrosative stress, neuronal changes and cholinesterase activity.

Flumethrin at honey-relevant levels induces physiological stresses to honey bee larvae (Apis mellifera L.) in vitro.

Life cycle exposure to propiconazole reduces fecundity by disrupting the steroidogenic pathway and altering DNA methylation in zebrafish (Danio rerio).

Acephate interferes with androgen synthesis in rat immature Leydig cells.

Potentially Toxic Elements

Mercury and Alzheimer’s Disease: Hg(II) Ions Display Specific Binding to the Amyloid-β Peptide and Hinder Its Fibrillization.

The influence of long-term cadmium exposure on the male advertisement call of Xenopus laevis.

Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats.

Subacute Testicular Toxicity to Cadmium Exposure Intraperitoneally and Orally.

Deleterious effects of chronic mercury exposure on in vitro LTP, memory process, and oxidative stress.

Changes in Ovarian and Uterine Morphology and Estrous Cycle in CD-1 Mice After Vanadium Inhalation.

The impact of mercury on the genome-wide transcription profile of zebrafish intestine.

Cadmium Induces Acute Liver Injury by Inhibiting Nrf2 and the Role of NF-κB, NLRP3, and MAPKs Signaling Pathway.

Antagonistic Efficacy of Luteolin against Lead Acetate Exposure-Associated with Hepatotoxicity is Mediated via Antioxidant, Anti-Inflammatory, and Anti-Apoptotic Activities.

Serum Proteomic Profiling Analysis of Rats Chronically Exposed to Arsenic.

Microplastics

Ingestion of polyethylene microbeads affects the growth and reproduction of medaka, Oryzias latipes.

Hazard evaluation of polystyrene nanoplastic with nine bioassays did not show particle-specific acute toxicity.

Polystyrene Nanoplastics (20 nm) are able to bioaccumulate and cause oxidative DNA damages in the brain tissue of zebrafish embryo (Danio rerio).

Air Pollution

PM2.5 exposure induces age-dependent hepatic lipid metabolism disorder in female mice.

Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling in Rat Lung, Blood, and Serum for Assessment of Laser Printer-Emitted Nanoparticle Inhalation Exposure-Induced Disease Risks.

Fine Particulate Matter Leads to Unfolded Protein Response and Shortened Lifespan by Inducing Oxidative Stress in C. elegans.

Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts.

PM2.5 Exposure in the Respiratory System Induces Distinct Inflammatory Signaling in the Lung and the Liver of Mice.

Pharmaceuticals

Fluoxetine exposure disrupts food intake and energy storage in the cichlid fish Cichlasoma dimerus (Teleostei, Cichliformes).

Aripiprazole prevents stress-induced anxiety and social impairment, but impairs antipredatory behavior in zebrafish.

Effects of 17β-trenbolone exposure on sex hormone synthesis and social behaviours in adolescent mice.

Developmental programming: Adipose depot-specific changes and thermogenic adipocyte distribution in the female sheep.

Mixtures

Environmental co-exposure to TBT and Cd caused neurotoxicity and thyroid endocrine disruption in zebrafish, a three-generation study in a simulated environment.

Immunotoxicity of microplastics and two persistent organic pollutants alone or in combination to a bivalve species.

Toxicity assessment of municipal sewage treatment plant effluent by an integrated biomarker response in the liver of crucian carp (Carassius auratus).

Accumulation, morpho-physiological and oxidative stress induction by single and binary treatments of fluoride and low molecular weight phthalates in Spirodela polyrhiza L. Schleiden.

Comparative examination on synergistic toxicities of chlorpyrifos, acephate, or tetraconazole mixed with pyrethroid insecticides to honey bees (Apis mellifera L.).

A mixture of fipronil and fungicides induces alterations on behavioral and oxidative stress parameters in zebrafish.

Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae).

Interaction patterns and combined toxic effects of acetamiprid in combination with seven pesticides on honey bee (Apis mellifera L.).

Mixture toxicity of the combinations of silver nanoparticles and environmental pollutants.

Miscellaneous

Toxicological study of metal and metal oxide nanoparticles in zebrafish.

Differences in biomarker and behavioral responses to native and chemically dispersed crude and refined fossil oils in zebrafish early life stages.

Fetal androgen exposure is a determinant of adult male metabolic health.

Exposure/Environment Studies

BPA/Phenols

The EuroMix human biomonitoring study: Source-to-dose modeling of cumulative and aggregate exposure for the bisphenols BPA, BPS, and BPF and comparison with measured urinary levels.

Serum concentration of bisphenol analogues in pregnant women in China.

Phthalates

Ecotoxicological risk evaluation and regulatory compliance of endocrine disruptor phthalates in a sustainable wastewater treatment scheme.

Phthalate Esters and Their Potential Risk in PET Bottled Water Stored under Common Conditions.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Is dietary macronutrient intake associated with serum concentrations of organochlorine pesticides in humans?

Occurrence of Selected Organic Contaminants in Edible Insects and Assessment of Their Chemical Safety. [POPs, plasticizers, flame retardants]

Polychlorinated biphenyl (PCB) contamination of subsistence species on Unalaska Island in the Aleutian Archipelago.

Historical record of polychlorinated biphenyls (PCBs) in the continental shelf of the Korea Strait.

Organochlorine pesticides in the surrounding soils of POPs destruction facility: source fingerprinting, human health, and ecological risks assessment.

Chlordecone and organochlorine compound levels in the French West Indies population in 2013-2014.

Database of persistent organic pollutants in umbilical cord blood: Concentration of organochlorine pesticides, PCBs, BDEs and polycyclic aromatic hydrocarbons.

Health Risk Modifiers of Exposure to Persistent Pollutants among Indigenous Peoples of Chukotka.

Levels of persistent organic pollutants (POPs) in foods from the first regional Sub-Saharan Africa Total Diet Study.

Screening of human health risk to infants associated with the polychlorinated biphenyl (PCB) levels in human milk from Punjab Province, Pakistan.

Biomarker Responses in the Freshwater Shrimp Caridina nilotica as Indicators of Persistent Pollutant Exposure.

North Pacific Baleen Whales as a Potential Source of Persistent Organic Pollutants (POPs) in the Diet of the Indigenous Peoples of the Eastern Arctic Coasts. [review]

Organochlorine pesticides in feathers of three raptor species in southern Brazil.

Bioaccumulation of POPs in human breast milk from south of the Russian Far East and exposure risk to breastfed infants.

Perfluoroalkyl Substances

Concentrations of perfluoroalkyl substances in human milk from Ireland: Implications for adult and nursing infant exposure.

Tissue distribution and bioaccumulation of a novel polyfluoroalkyl benzenesulfonate in crucian carp.

Legacy per- and polyfluoroalkyl substances (PFASs) and alternatives (short-chain analogues, F-53B, GenX and FC-98) in residential soils of China: Present implications of replacing legacy PFASs.

Flame Retardants

Knowledge and attitudes regarding exposure to brominated flame retardants: a survey of Croatian health care providers.

Alternative halogenated flame retardants (AHFRs) in green mussels from the south China sea.

Occurrence and ecological implications of organophosphate triesters and diester degradation products in wastewater, river water, and tap water.

Polybrominated diphenyl ethers and organophosphate esters flame retardants in play mats from China and the exposure risks for children.

Investigation of the heterogeneity of bromine in plastic components as an indicator for brominated flame retardants in waste electrical and electronic equipment with regard to recyclability.

Changes in plasma biochemistry in breeding ring-billed gulls: Effects of anthropogenic habitat use and contaminant exposure.

Leaching behavior of Sb and Br from E-waste flame retardant plastics.

Prenatal exposure levels of polybrominated diphenyl ethers in mother-infant pairs and their transplacental transfer characteristics in Uganda (East Africa).

Pesticides

Temporal variation of pesticide mixtures in rivers of three agricultural watersheds during a major drought in the Western Cape, South Africa.

Distribution of residual agricultural pesticides and their impact assessment on the survival of an endangered species.

Dietary exposure to neonicotinoid insecticides and health risks in the Chinese general population through two consecutive total diet studies.

Neonicotinoid insecticides in the drinking water system – Fate, transportation, and their contributions to the overall dietary risks.

Potentially Toxic Elements

Mercury increase in Lake Champlain fish: links to fishery dynamics and extreme climatic events.

Health Risk Assessment of Heavy Metal Pollution in Groundwater Around an Exposed Dumpsite in Southwestern Nigeria.

Bioaccumulation Factor of Selected Heavy Metals in Zea mays. [review]

Nonlinear patterns in mercury bioaccumulation in American alligators are a function of predicted age.

Pre-pregnancy dietary arsenic consumption among women in the United States.

Deterministic and probabilistic health risk assessment techniques to evaluate non-carcinogenic human health risk (NHHR) due to fluoride and nitrate in groundwater of Panipat, Haryana, India.

Biomonitoring of Metal Exposure During Additive Manufacturing (3D Printing).

Evaluation of heavy metal concentration in imported black tea in Iran and consumer risk assessments.

An integrative approach to identify the impacts of multiple metal contamination sources on the Eastern Andean foothills of the Ecuadorian Amazonia.

Influence of late-Holocene climate change on the solid-phase speciation and long-term stability of arsenic in sub-Arctic lake sediments.

Arsenic and arsenic speciation in mushrooms from China: A review.

Anthropogenic mercury contamination in sediments of Krka River estuary (Croatia).

Risk assessment of trace elements pollution of Manaus urban rivers.

Dragonfly larvae as biosentinels of Hg bioaccumulation in Northeastern and Adirondack lakes: relationships to abiotic factors.

Concentration of metals and trace elements in the normal human and rat thyroid: comparison with muscle and adipose tissue and volcanic versus control areas.

Bioaccumulation of mercury in a terrestrial carnivore, American marten (Martes Americana)

Evaluation of Total Mercury in Sediments of the Descoberto River Environmental Protection Area-Brazil.

Tracking mercury in the southwestern Atlantic Ocean: the use of tuna and tuna-like species as indicators of bioavailability.

Concentration of trace elements in long-finned pilot whales stranded in northern Patagonia, Chile.

Long-term effect of E-waste dismantling activities on the heavy metals pollution in paddy soils of southeastern China.

Methylmercury and inorganic mercury in Chinese commercial rice: Implications for overestimated human exposure and health risk.

Wild edible mushrooms from Mediterranean region: Metal concentrations and health risk assessment.

Microplastics

Freshwater microplastics pollution: Detecting and visualizing emerging trends based on Citespace II.

Identification of microplastics in surface water and Australian freshwater shrimp Paratya australiensis in Victoria, Australia.

Atmospheric microplastic deposition in an urban environment and an evaluation of transport.

Factors controlling the distribution of microplastic particles in benthic sediment of the Thames River, Canada.

Paddle surfing for science on microplastic pollution.

Occurrence of microplastics in gastrointestinal tracts and gills of fish from Beibu Gulf, South China Sea.

Fate of microplastics in wastewater treatment plants and their environmental dispersion with effluent and sludge.

Effects of spatial and seasonal factors on the characteristics and carbonyl index of (micro)plastics in a sandy beach in Aveiro, Portugal.

Occurrence of microplastics in gastrointestinal tracts and gills of fish from Beibu Gulf, South China Sea.

Atmospheric microplastic over the South China Sea and East Indian Ocean: abundance, distribution and source.

Sorption of PAHs to microplastic and their bioavailability and toxicity to marine copepods under co-exposure conditions.

Size-dependent effects of polystyrene plastic particles on the nematode Caenorhabditis elegans as related to soil physicochemical properties.

A close relationship between microplastic contamination and coastal area use pattern.

Initial Survey of Microplastics in Bottom Sediments from United States Waterways.

Analysis of microbeads in cosmetic products in the United Arab Emirates.

Distribution and Characterization of Microplastics in Surface Waters and the Southern Caspian Sea Coasts Sediments.

Paradise Trashed: Sources and solutions to marine litter in a small island developing state.

In search for the sources of plastic marine litter that contaminates the Easter Island Ecoregion.

Data on microplastic contamination of the Baltic Sea bottom sediment samples in 2015-2016.

Occurrence of organic pollutants in plastics on beach: Stranded foams can be sources of pollutants in islands.

Air Pollution

The effects of transboundary air pollution from China on ambient air quality in South Korea.

Youth Engaged Participatory Air Monitoring: A ‘Day in the Life’ in Urban Environmental Justice Communities.

Pharmaceuticals/PCPs

Anthropogenic impacts on the contamination of pharmaceuticals and personal care products (PPCPs) in the coastal environments of the Yellow and Bohai seas.

Occurrence and human health risk assessment of pharmaceuticals and personal care products in real agricultural systems with long-term reclaimed wastewater irrigation in Beijing, China.

Occurrence of quinotone antibiotics and their impacts on aquatic environment in typical river-estuary system of Jiaozhou Bay, China.

Mixtures

Assessing the endocrine disrupting potentials and genotoxicity in environmental samples from Taiwanese rivers.

Estrogens in municipal wastewater and receiving waters in the Beijing-Tianjin-Hebei region, China: Occurrence and risk assessment of mixtures.

Effects of treated wastewater on the ecotoxicity of small streams – Unravelling the contribution of chemicals causing effects.

Oxidative Potential of Chemical Mixtures Extracted from Contaminated Galveston Bay, TX Seafood Using a Human Cell Co-culture Model.

Field survey of environmental estrogen pollution in the coastal area of Tokyo Bay and Nagasaki City using the Japanese common goby Acanthogobius flavimanus.

PAHs

Insights into biomonitoring of human exposure to polycyclic aromatic hydrocarbons with hair analysis: A case study in e-waste recycling area.

Polycyclic aromatic hydrocarbons in soils and sediments in Southwest Nigeria.

Analysis of urinary metabolites of polycyclic aromatic hydrocarbons and cotinine in pooled urine samples to determine the exposure to PAHs in an Australian population.

Miscellaneous

Migration studies and toxicity evaluation of cyclic polyesters oligomers from food packaging adhesives.

Influence of hydrologic and anthropogenic drivers on emerging organic contaminants in drinking water sources in the Susquehanna River Basin.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

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Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

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Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.