EDC Science Weekly, Dec. 22, 2023 – Jan. 4, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed the past two weeks. It’s a little longer due to the 2 week timeframe.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Non-targeted analysis in the prenatal exposome; prenatal exposure to PFAS and vaccine antibodies; EDCs in beverage packaging; the urban environment as an endocrine disruptor; micro/nanoplastics released from PVC infusion tubes.

More science highlights

Events

Course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) This two-week course in May at Woods Hole is accepting applications, due Jan. 15. Financial aid is available.

Webinar Jan. 9: Food Contact Materials: A Road Map to Improved Safety Testing [EDC Strategies Partnership]

Webinar Jan. 10: Meet the Editors [of EHP, JHP, and JESEE; sponsored by NIEHS Partnerships for Environmental Public Health (PEHP)]

Symposium Jan. 22-24: USA Exposome Symposium: Children’s Health, Environmental Justice, and the Exposome [Mt Sinai and Meharry Medical College]

Webinar Jan. 25: CHE Café: Multisolving for climate, chemicals & health [CHE and the New School at Commonweal]

Conference Mar. 11-14: 10th Copenhagen Workshop on Endocrine Disruptors – COW2024. Abstracts are due Feb. 1.

More events

Regulations/Policy

The last resort requirement under REACH: From principle to practice.

Glyphosate and neurotoxicity – a call for scientific renewal.

Breaking the cycle: Reforming pesticide regulation to protect pollinators.

Harmonizing pesticides environmental quality standards: A fate-pathway perspective.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Ten Years of Using Key Characteristics of Human Carcinogens to Organize and Evaluate Mechanistic Evidence in IARC Monographs on the Identification of Carcinogenic Hazards to Humans: Patterns and Associations.

Leveraging Implementation Science to Advance Environmental Justice Research and Achieve Health Equity through Neighborhood and Policy Interventions.

Where developmental toxicity meets explainable artificial intelligence: state-of-the-art and perspectives.

Ligand Modification-Free Methods for the Profiling of Protein-Environmental Chemical Interactions.

Enabling novel paradigms: A biological questions-based approach to human chemical hazard and drug safety assessment.

Quantitative Integration of Mode of Action Information in Dose-Response Modeling and POD Estimation for Nonmutagenic Carcinogens: A Case Study of TCDD. [see related Invited Perspective: Reference Values à la Mode of Action.]

Cheminformatics Analysis of the Multitarget Structure-Activity Landscape of Environmental Chemicals Binding to Human Endocrine Receptors.

Interpretable attention-based multi-encoder transformer based QSPR model for assessing toxicity and environmental impact of chemicals.

Screening

Orthogonal Assay and QSAR Modelling of Tox21 PPARγ Antagonist In Vitro High-Throughput Screening Assay.

Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay.

Analysis of vascular disruption in zebrafish embryos as an endpoint to predict developmental toxicity.

Screening for endocrine disrupting chemicals inhibiting monocarboxylate 8 (MCT8) transporter facilitated thyroid hormone transport using a modified nonradioactive assay.

Elucidating Key Characteristics of PFAS Binding to Human Peroxisome Proliferator-Activated Receptor Alpha: An Explainable Machine Learning Approach.

A novel ERβ high throughput microscopy platform for testing endocrine disrupting chemicals.

StackER: a novel SMILES-based stacked approach for the accelerated and efficient discovery of ERα and ERβ antagonists. [for drugs]

Exploring the hidden chemical landscape: Non-target and suspect screening analysis for investigating solid waste-associated environments.

Bioaccumulative chemicals are either too hard or too soft: Conceptual density functional theory as a screening tool for emerging pollutants.

More tools, reports, and resources

Commentaries

Endocrine-disrupting chemicals and neurodevelopment in children.

A (not) new Rx: Quality improvement for NAM.

A Thorny Problem: Glyphosate and 2,4-D Associated with Neurobehavioral Effects for Ecuadorian Adolescents.

Pesticides and endometriosis: Silent links in our everyday environment.

Editorial: Chemical sensing and emerging analysis of environmental contaminants. [intro to a research topic in Frontiers in Chemistry]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis.

Pressures of the urban environment on the endocrine system: Adverse effects and adaptation. [EDCs plus other aspects of urban living]

A review of cumulative toxic effects of environmental endocrine disruptors on the zebrafish immune system: Characterization methods, toxic effects and mechanisms.

Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma.

Water, Water Everywhere, but Every Drop Unique: Challenges in the Science to Understand the Role of Contaminants of Emerging Concern in the Management of Drinking Water Supplies.

Enantioselectivity in ecotoxicity of pharmaceuticals, illicit drugs, and industrial persistent pollutants in aquatic and terrestrial environments: A review.

BPA/Phenols

Invisible Hand behind Female Reproductive Disorders: Bisphenols, Recent Evidence and Future Perspectives.

Environmental Toxicology of Bisphenol A: Mechanistic Insights and Clinical Implications on the Neuroendocrine System.

Bisphenol A (BPA) and Cardiovascular or Cardiometabolic Diseases.

Phenolic compounds in water: Review of occurrence, risk, and retention by membrane technology.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Occurrence, physicochemical properties and environmental behavior of polychlorinated dibenzothiophenes: A comprehensive review and future perspectives.

PFAS

Early-Life Exposure to Perfluoroalkyl Substances (PFAS) and Child Language and Communication Development: A Systematic Review.

The untold story of PFAS alternatives: Insights into the occurrence, ecotoxicological impacts, and removal strategies in the aquatic environment.

Photocatalytic degradation of perfluorooctanoic acid (PFOA) from water: A mini review.

Distribution characteristics and transformation mechanism of per- and polyfluoroalkyl substances in drinking water sources: A review.

Flame Retardants

Critical review on organophosphate esters in water environment: Occurrence, health hazards and removal technologies.

A critical review on organophosphate esters in drinking water: Analysis, occurrence, sources, and human health risk assessment.

A critical review on BDE-209: Source, distribution, influencing factors, toxicity, and degradation.

Pesticides

Status and Perspective on Green Pesticide Utilizations and Food Security.

Pesticides vs. Biopesticides: From Pest Management to Toxicity and Impacts on the Environment and Human Health.

Metals/Metalloids

Cadmium exposure and thyroid hormone disruption: a systematic review and meta-analysis.

Maternal Exposure to Arsenic and Its Impact on Maternal and Fetal Health: A Review.

Arsenic and adipose tissue: an unexplored pathway for toxicity and metabolic dysfunction.

Mercury and Autism Spectrum Disorder: Exploring the Link through Comprehensive Review and Meta-Analysis.

Metal-induced autoimmunity in neurological disorders: A review of current understanding and future directions.

Microplastics/Nanomaterials

Micro/nanoplastics: Critical review of their impacts on plants, interactions with other contaminants (antibiotics, heavy metals, and polycyclic aromatic hydrocarbons), and management strategies.

A review on toxicity of nanomaterials in agriculture: Current scenario and future prospects.

Microplastics as carriers of toxic pollutants: Source, transport, and toxicological effects.

Microplastics and associated chemicals in drinking water: A review of their occurrence and human health implications.

Unraveling the threat: Microplastics and nano-plastics’ impact on reproductive viability across ecosystems.

A global review on the abundance and threats of microplastics in soils to terrestrial ecosystem and human health.

Critical review on airborne microplastics: An indoor air contaminant of emerging concern.

A meta-analysis-based adverse outcome pathway for the male reproductive toxicity induced by microplastics and nanoplastics in mammals.

Air Pollution

World Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence.

Pharmaceuticals/Personal Care Products

Effects associated with exposure to the emerging contaminant octyl-methoxycinnamate (a UV-B filter) in the aquatic environment: a review.

A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters.

Miscellaneous

Environmental and Genetic Traffic in the Journey from Sperm to Offspring.

Nanozyme as detector and remediator to environmental pollutants: between current situation and future prospective.

β-cyclodextrin polymer composites for the removal of pharmaceutical substances, endocrine disruptor chemicals, and dyes from aqueous solution- A review of recent trends.

Human Health Studies

Numerous Chemicals/Mixtures

Risk Factors for Young-Onset Dementia in the UK Biobank.

Association of Combined Metals and PFAS with Cardiovascular Disease Risk.

Screening of environmental chemicals to characterize exposures in participants with Systemic Lupus Erythematosus. [phthalates, PFAS, etc.]

Development of interpretable machine learning models associated with environmental chemicals to predict all-cause and specific-cause mortality：A longitudinal study based on NHANES.

Association of co-exposure to polycyclic aromatic hydrocarbons and phthalates with oxidative stress and inflammation.

A genome-wide association study of 24-hour urinary excretion of endocrine disrupting chemicals.

Phthalates

Associations of Plastic Bottle Exposure with Infant Growth, Fecal Microbiota, and Short-Chain Fatty Acids. [phthalates/plasticizers]

Racial disparities affect the association between gestational urinary phthalate mixtures and infant genital measures.

Associations between Phthalate Metabolite Concentrations in Follicular Fluid and Reproductive Outcomes among Women Undergoing in Vitro Fertilization/Intracytoplasmic Sperm Injection Treatment.

Association of phthalate exposure with all-cause mortality across renal function status: The U.S. National Health and Nutrition Examination Survey, 2005-2018.

Parabens/Triclosan/Antimicrobials

Relationship between exposure to parabens and benzophenones and prostate cancer risk in the EPIC-Spain cohort.

Paternal and maternal preconception and maternal pregnancy urinary concentrations of parabens in relation to child behavior.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region.

Exposure to organochlorine pesticides and polychlorinated biphenyls, adherence to an ideal cardiovascular health, and arterial stiffness among Chinese adults.

Dioxin(-like)-Related Biological Effects through Integrated Chemical-wide and Metabolome-wide Analyses.

PFAS

Prenatal Exposure to Poly- and Perfluoroalkyl Substances (2009-2014) and Vaccine Antibody Titers of Measles, Mumps, Rubella, and Varicella in Children Four to Eight Years Old from the Healthy Start Cohort.

The Association of Perfluoroalkyl Substance Exposure and a Serum Liver Function Marker in Korean Adults.

Per- and poly-fluoroalkyl substances (PFAS) exposure is associated with later occurrence of inflammatory bowel disease.

Overall and individual associations between per- and polyfluoroalkyl substances and liver function indices and the metabolic mechanism.

Prenatal per- and polyfluoroalkyl substances exposure and gut microbiota of infants: A prospective cohort study.

Investigating the progression of preeclampsia through a comprehensive analysis of genes associated with per- and polyfluoroalkyl substances.

Binding of Per- and Polyfluoroalkyl Substances (PFAS) to Serum Proteins: Implications for Toxicokinetics in Humans.

Pesticides

Urinary biomarkers of exposure to organophosphate, pyrethroid, neonicotinoid insecticides and oxidative stress: A repeated measurement analysis among pregnant women.

Association between 2,4-dichlorophenoxyacetic acid and cognitive impairment in older adults: a cross-sectional study from NHANES 2001-2002 and 2011-2014.

Association Between Urinary Glyphosate Exposure and Cognitive Impairment in Older Adults from NHANES 2013-2014.

Thyroid cancer incidence in the population of Ukraine and its epidemiological determinants: Ionizing radiation and endocrine disruptors

Indicators of occupational pesticide exposure are associated with psychiatric symptoms.

Metals/Metalloids

Arsenic Exposure and Epigenetic Aging: The Association with Cardiovascular Disease and All-Cause Mortality in the Strong Heart Study.

Longitudinal associations between early-life fluoride exposures and cardiometabolic outcomes in school-aged children.

Epigenome-wide perspective of cadmium-associated DNA methylation and its mediation role in the associations of cadmium with lipid levels and dyslipidemia risk.

Combined exposure to multiple essential elements and cadmium at early pregnancy on gestational diabetes mellitus: a prospective cohort study.

Serum albumin mediates the associations between heavy metals and two novel systemic inflammation indexes among U.S. adults.

Association of blood metal exposure with age at menarche in Korean women: KNHANES (2008-2017).

Early exposure to mercury and cardiovascular function of seven-year old children in Guadeloupe (French West Indies).

Exposure to cadmium and lead is associated with diabetic kidney disease in diabetic patients.

Quantitative association between lead exposure and amyotrophic lateral sclerosis: a Bayesian network-based predictive study.

Air Pollution

Ambient PM_2.5-bound polycyclic aromatic hydrocarbons (PAHs) associated with pro-thrombotic biomarkers among young healthy adults: A 16 times repeated measurements panel study.

Associations of exposure to ambient fine particulate matter constituents from different pollution sources with semen quality: Evidence from a prospective cohort.

Association of residential greenness, air pollution with adverse birth outcomes: Results from 61,762 mother‑neonatal pairs in project ELEFANT (2011-2021).

Fine Particulate Matter and Diabetes Prevalence in Okayama, Japan.

Ambient air pollution and rate of spontaneous abortion.

Pharmaceuticals/Personal Care Products

Maternal use of hormonal contraception and risk of childhood autism spectrum disorders: A Parental Exposures and Child Health (PECH) cohort study

PAHs

Personal Exposure to Source-Specific Particulate Polycyclic Aromatic Hydrocarbons and Systemic Inflammation: A Cross-Sectional Study of Urban-Dwelling Older Adults in China.

Association of urinary polycyclic aromatic hydrocarbons metabolites with gestational diabetes mellitus and gestational hypertension among pregnant women in Southwest China: A cross-sectional study.

Association between polycyclic aromatic hydrocarbons exposure with red cell width distribution and ischemic heart disease: insights from a population-based study.

Laboratory Studies

Numerous Chemicals/Mixtures

Multiple generation distinct toxicant exposures induce epigenetic transgenerational inheritance of enhanced pathology and obesity.

Exploring applications of non-targeted analysis in the characterization of the prenatal exposome.

Hazard assessment of complex legacy-contaminated groundwater mixtures using a novel approach method in adult fathead minnows.

Prediction and assessment of xenoestrogens mixture effects using the in vitro ERα-CALUX assay.

Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner.

BPA/Phenols

Mixture Effects of Bisphenol A and Its Structural Analogs on Estrogen Receptor Transcriptional Activation.

The probiotic SLAB51 as agent to counteract BPA toxicity on zebrafish gut microbiota -liver-brain axis.

Enhanced inhibition of human and rat aromatase activity by benzene ring substitutions in bisphenol A: QSAR structure-activity relationship and in silico docking analysis.

Cloning and Characterization of Yak DHODH Gene and Its Functional Studies in a Bisphenol S-Induced Ferroptosis Model of Fetal Fibroblasts.

Potential impacts of bisphenols on prostate cells: An overview of cytotoxicity, proliferation, oxidative stress, apoptosis, and ER-stress response activation.

Flexible molecularly imprinted fiber library for the metabolic analysis of bisphenol F and ecological risk evaluation.

Potential involvement of ferroptosis in BPA-induced neurotoxicity: An in vitro study.

Bisphenol A Analogues Induce Neuroendocrine Disruption via Gut-Brain Regulation in Zebrafish.

Neurodevelopment effects of early life bisphenol-A exposure on visual memory: insights into recovery dynamics.

Interacting with luteinizing hormone receptor provides a new elucidation of the mechanism of anti-androgenicity of bisphenol S.

Bisphenol S moderately decreases the expression of syncytiotrophoblast marker genes and induces apoptosis in human trophoblast lineages.

Phthalates

The role of the aryl hydrocarbon receptor in mediating the effects of mono(2-ethylhexyl) phthalate in mouse ovarian antral follicles.

Di-(2-ethylhexyl) phthalate exacerbates abnormalities of testicular development in F1 males via inhibition the Wnt/β-catenin signaling pathway.

Novel insights into DEHP-induced zebrafish spleen damage: Cellular apoptosis, mitochondrial dysfunction, and innate immunity.

Parabens/Triclosan/Antimicrobials

Triclosan and its alternatives, especially chlorhexidine, modulate macrophage immune response with distinct modes of action.

Isothiazolinone Disrupts Reproductive Endocrinology by Targeting the G-Protein-Coupled Receptor Signaling.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Upregulated LncRNA-Meg3 modulates the proliferation and survival of MEPM cells via interacting with Smad signaling in TCDD-induced cleft palate.

Mechanisms and targeted reversion/prevention of hepatic fibrosis caused by the non-hereditary toxicity of benzo(a)pyrene.

Structural insights into the activation of human aryl hydrocarbon receptor by the environmental contaminant benzo[a]pyrene and structurally related compounds.

Dietary Exposure to Environmentally Relevant Levels of Chemical Contaminants Reduces Growth and Survival in Juvenile Chinook Salmon.

PFAS

Hepatic Transcriptome Comparative In Silico Analysis Reveals Similar Pathways and Targets Altered by Legacy and Alternative Per- and Polyfluoroalkyl Substances in Mice.

Dose Response, Dosimetric, and Metabolic Evaluations of Replacement PFAS Perfluoro-(2,5,8-trimethyl-3,6,9-trioxadodecanoic) Acid (HFPO-TeA).

Comparing Ocular Toxicity of Legacy and Alternative Per- and Polyfluoroalkyl Substances in Zebrafish Larvae.

Prenatal exposure to hexafluoropropylene oxide trimer acid (HFPO-TA) disrupts the maternal gut microbiome and fecal metabolome homeostasis.

Perfluorooctanoic acid suppresses sperm functions via abnormal Protein Kinase B activation during capacitation.

GenX Disturbs the Indicators of Hepatic Lipid Metabolism Even at Environmental Concentration in Drinking Water via PPARα Signaling Pathways.

PFOS impacts complex behaviors in larval zebrafish.

Maternal and Neonatal Effects of Maternal Oral Exposure to Perfluoro-2-methoxyacetic Acid (PFMOAA) during Pregnancy and Early Lactation in the Sprague-Dawley Rat.

Transcriptomic and metabolomic profile changes in the liver of Sprague Dawley rat offspring after maternal PFOS exposure during gestation and lactation.

Understanding the effects of per- and polyfluoroalkyl substances on early skin development: Role of ciliogenesis inhibition and altered microtubule dynamics.

PFOS exposure destroys the integrity of the blood-testis barrier (BTB) through PI3K/AKT/mTOR-mediated autophagy.

Flame Retardants

IL-10-TG/TPO-T4 axis, the target of bis (2-ethylhexyl) tetrabromophthalate on thyroid function imbalance.

Changes in the Bacterial Communities of Biocomposites with Different Flame Retardants.

Transcriptome-based approach to identify mechanisms underlying locomotor abnormality induced by decabromodiphenyl ethane in zebrafish larvae.

Endoplasmic reticulum stress participates in apoptosis of HeLa cells exposed to TPHP and OH-TPHP via the eIF2α-ATF4/ATF3-CHOP-DR5/P53 signaling pathway.

Exposure of male adult zebrafish (Danio rerio) to triphenyl phosphate (TPhP) induces eye development disorders and disrupts neurotransmitter system-mediated abnormal locomotor behavior in larval offspring.

First insights into the bioaccumulation, biotransformation and trophic transfer of typical tetrabromobisphenol A (TBBPA) analogues along a simulated aquatic food chain.

The impact of tetrachlorobisphenol A exposure during puberty: Altered Leydig cell development and induced endoplasmic reticulum stress in male mice.

Pesticides

The Developmental Toxicity and Endocrine-Disrupting Effects of Fenpropathrin on Gobiocypris rarus during the Early Life Stage.

Effects of Neonicotinoid Pesticide Metabolic Compounds on Medaka (Oryzias latipes) Embryo Development.

Bifidobacterium mediate gut microbiota-remedied intestinal barrier damage caused by cyproconazole in zebrafish (Danio rerio).

From dysbiosis to neuropathologies: Toxic effects of glyphosate in zebrafish.

Insights into spirotetramat-induced thyroid disruption during zebrafish (Danio rerio) larval development: An integrated approach with in vivo, in vitro, and in silico analyses.

Impaired spermatogenesis and associated endocrine effects of azole fungicides in peripubertal Xenopus tropicalis.

Effects of exposure to the neonicotinoid pesticide clothianidin on mouse intestinal microbiota under unpredictable environmental stress.

Metabolomic analysis of the serum and urine of rats exposed to diazinon, dimethoate, and cypermethrin alone or in combination.

Metals/Metalloids

Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. and related Invited Perspective: Humanized Mice for Arsenic Metabolism-A Better Model for Investigating Arsenic-Induced Diseases?

Lactobacillus strains reduce the toxic effects of a subchronic exposure to arsenite through drinking water.

Subchronic Arsenic Exposure Induces Behavioral Impairments and Hippocampal Damage in Rats.

The Influence of Arsenic Co-Exposure in a Model of Alcohol-Induced Neurodegeneration in C57BL/6J Mice.

Arsenic Exposure Induces Neuro-immune Toxicity in the Cerebral Cortex and the Hippocampus via Neuroglia and NLRP3 Inflammasome Activation in C57BL/6 Mice.

Specific dietary fibers prevent heavy metal disruption of the human gut microbiota in vitro.

Microplastics/Nanomaterials

Endoplasmic reticulum stress exacerbates microplastics-induced toxicity in animal cells.

Photoaging enhances combined toxicity of microplastics and tetrabromobisphenol A by inducing intestinal damage and oxidative stress in Caenorhabditis elegans.

Co-exposure of nanoplastics and arsenic causes neurotoxicity in zebrafish (Danio rerio) through disrupting homeostasis of microbiota-intestine-brain axis.

Nanopolystyrene size effect and its combined acute toxicity with halogenated PAHs on Daphnia magna.

Size-dependent toxicity of polystyrene microplastics on the gastrointestinal tract: Oxidative stress related-DNA damage and potential carcinogenicity.

Seawater Accelerated the Aging of Polystyrene and Enhanced Its Toxic Effects on Caenorhabditis elegans.

Nano-plastics and gastric health: Decoding the cytotoxic mechanisms of polystyrene nano-plastics size.

Microbiota-mediated metabolic perturbations in the gut and brain of mice after microplastic exposure.

Polystyrene nanoplastics exposure causes inflammation and death of esophageal cell.

Gut microbiota and liver metabolomics reveal the potential mechanism of Lactobacillus rhamnosus GG modulating the liver toxicity caused by polystyrene microplastics in mice.

Molecular effects of polystyrene nanoplastics on human neural stem cells.

Air Pollution

Maternal urban particulate matter (SRM 1648a) exposure disrupted the cellular immune homeostasis during early life: The potential attribution of altered placental transcriptome profile.

Exercise ameliorates fine particulate matter-induced metabolic damage through the SIRT1/AMPKα/PGC1-α/NRF1 signaling pathway.

Pharmaceuticals/Personal Care Products

Assessment of developmental toxicity and the potential mode of action underlying single and binary exposure to estrogenic endocrine disrupting chemicals in zebrafish (Danio rerio). [DES and zearalenone]

Comparison of the Glucocorticoid Receptor Binding and Agonist Activities of Typical Glucocorticoids: Insights into Their Endocrine Disrupting Effects.

Prioritisation of data-poor pharmaceuticals for empirical testing and environmental risk assessment.

Evaluation of the anti-androgenic and cytotoxic effects of benzophenone-3 in male Sprague-Dawley rats.

Miscellaneous

6PPD-quinone exposure induces neuronal mitochondrial dysfunction to exacerbate Lewy neurites formation induced by α-synuclein preformed fibrils seeding.

Transformation of 6PPDQ during disinfection: Kinetics, products, and eco-toxicity assessment.

Immunotoxicity Evaluation of Trihalophenolic Disinfection By-Products in Mouse and Human Mononuclear Macrophage Systems: The Role of RNA Epitranscriptomic Modification in Mammalian Immunity.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Exposure to endocrine disrupting chemicals from beverage packaging materials and risk assessment for consumers.

Pesticides and PPCPs in aquatic ecosystems of the andean central region: Occurrence and ecological risk assessment in the Uco valley.

Toxicity and chemical characterization of shale gas wastewater discharged to the receiving water: Evidence from toxicity identification evaluation.

Occurrence and environmental risk assessment of 4 estrogenic compounds in surface water in Belgium in the frame of the EU Watch List.

BPA/Phenols

Bisphenol A and chlorinated derivatives of bisphenol A assessment in end stage renal disease patients: Impact of dialysis therapy.

Relationship between Eating Habits and 4-Nonylphenol Concentration in Breast Milk of Women in Slovakia.

Phthalates

Multi-source exposure and health risks of phthalates among university students in Northeastern China.

Evaluating the risk of phthalate and non-phthalate plasticizers in dust samples from 100 Japanese houses.

A novel method for assessing indoor di 2-ethylhexyl phthalate (DEHP) contamination and exposure based on dust-phase concentration.

Phthalate contamination in marine mammals off the Norwegian coast.

Parabens/Triclosan/Antimicrobials

Determination of parabens in breast milk using stir bar sorptive extraction coupled with UHPLC-UV.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Apparent Khat chewers exposure to DDT in Ethiopia and its potential toxic effects: A scoping review.

Levels, patterns and risk assessment of PCDD/Fs and dl-PCBs through dietary exposure in the Valencian Region (Spain).

Hexachlorobenzene and omega-3 fatty acid intake from traditional foods in the northern Yukon: A risk and benefit analysis.

Assessment of persistent organic pollutants in killer whales (Orcinus orca) of the Canadian Arctic: Implications for subsistence consumption and conservation strategies.

Air monitoring of organochlorine pesticides (OCPs) in Bursa Türkiye: Levels, temporal trends and risk assessment.

PFAS

Occurrence of Major Perfluorinated Alkylate Substances in Human Blood and Target Organs.

Screening Novel Per- and Polyfluoroalkyl Substances in Human Blood Based on Nontarget Analysis and Underestimated Potential Health Risks.

Occurrence of perfluoroalkyl substances in cow’s, goat’s and sheep’s milk – dietary intake and risk assessment.

Emerging and legacy per- and polyfluoroalkyl substances in Daling River and its estuary, Northern China.

Assessment of perfluoroalkyl substances concentration levels in wild bat guano samples.

Spatial distribution, isomer signature and air-soil exchange of legacy and emerging poly- and perfluoroalkyl substances.

Occurrence, mass loading, and post-control temporal trend of legacy perfluoroalkyl substances (PFASs) in the middle and lower Yangtze River.

Multi-media distribution and risk assessment of per- and polyfluoroalkyl substances in the Huai River Basin, China.

Impact of phosphate addition on PFAS treatment performance for drinking water.

A targeted and non-targeted discovery screening approach for poly-and per-fluoroalkyl substances in model environmental biota samples.

Occurrence and pattern of legacy and emerging per- and Poly-FluoroAlkyl substances (PFAS) in eggs of loggerhead turtle Caretta caretta from western Mediterranean.

Removal of PFAS from water by aquatic plants.

Evaluation of fatty acids and carnitine as biomarkers of PFOS exposure in biota (fish and dolphin) from Galveston Bay and the northwestern Gulf of Mexico.

Flame Retardants

Novel halogenated flame retardants in Canadian human milk from the MIREC study (2008-2011).

Pesticides

Characterizing the cumulative health risks of 19 kinds of pesticides in Chinese food from the cancer and non-cancer perspective.

Organophosphorus pesticide contaminants in fruits and vegetables: A meta-analysis.

Exposure of pregnant women and their children to pyrethroid insecticides in Rio de Janeiro, Brazil.

Microplastics/Nanomaterials

Quantitative analysis of microplastics and nanoplastics released from disposable PVC infusion tubes.

Microplastics and other anthropogenic fibres in large apex shark species: Abundance, characteristics, and recommendations for future research.

High microplastic and anthropogenic particle contamination in the gastrointestinal tracts of tiger sharks (Galeocerdo cuvier) caught in the western North Atlantic Ocean.

Pharmaceuticals/Personal Care Products

An optimized methodology for the determination of multiclass organic ultraviolet sunscreens and metabolites in human milk through chromatographic and chemometric resolution.

Comprehensive evaluation of antibiotics pollution the Yangtze River basin, China: Emission, multimedia fate and risk assessment.

Understanding Skincare Preservatives: From Parabens to Essential Oils, Miss Jennifer Doyle Explores The Commonly Used Preservatives in Skincare, Along with Their Evidence for Safety.

Miscellaneous

Public perception on human exposure risk: A case study on endocrine disrupting compounds in the environment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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