EDC Science Weekly: Dec. 2 – 8, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Dec. 8 (today!): Embryonic BPA Exposure Causes Liver Disease in Generations of Fish (EDC Strategies Partnership and Young EDC Scientists Showcase)

Regulations/Policy

Conducting evaluations of evidence that are transparent, timely and can lead to health-protective actions.

Neurodegeneration in a Regulatory Context: The Need for Speed [re pesticides]

Methods/Tools/Screening

Methods

Bayesian Estimation of Human Population Toxicokinetics of PFOA, PFOS, PFHxS, and PFNA from Studies of Contaminated Drinking Water.

Variable selection for discrete survival model with frailty in presence of left truncation and right censoring: Studying association of environmental toxicants on time-to-pregnancy.

Problems, principles and progress in computational annotation of NMR metabolomics data.

Evaluation of strategies for the occupational health risk assessment of chemical toxicants in the workplace based on a quantitative analysis model. also see Occupational health risk assessment methods in China: A scoping review.

Tools

Unveiling toxicity profile for food risk components: A manually curated toxicological databank of food-relevant chemicals.

The Systematic Review Toolbox: keeping up to date with tools to support evidence synthesis.

Development and evaluation of a novel dietary bisphenol A (BPA) exposure risk tool.

Screening

Screening Method for the Identification of Compounds That Activate Pregnane X Receptor.

Machine Learning-Based Models with High Accuracy and Broad Applicability Domains for Screening PMT/vPvM Substances.

Commentaries

Plastic pollution: the science we need for the planet we want. [Intro to a special issue]

Plastic pollution requires an integrative systems approach to understand and mitigate risk.

Reviews

Numerous Chemicals/Mixtures

Endocrine-disrupting chemicals and endocrine neoplasia: A forty-year systematic review.

Genetics, epigenetics and transgenerational transmission of obesity in children.

Select Early-Life Environmental Exposures and DNA Methylation in the Placenta.

Nutritional, pharmacological, and environmental programming of NAFLD in early life.

Heavy Metals, Halogenated Hydrocarbons, Phthalates, Glyphosate, Cordycepin, Alcohol, Drugs, and Herbs, Assessed for Liver Injury and Mechanistic Steps.

Book/special issue of Adv Exp Med Biol: Oxidative Stress and Toxicity in Reproductive Biology and Medicine: A Comprehensive Update on Male Infertility Volume II (which also includes sections on female infertility), includes chapters such as these as well as others listed throughout this email:

BPA/Phenols

Effects of BPA substitutes on the prenatal and cardiovascular systems.

Bisphenol A and Male Infertility: Role of Oxidative Stress.

Flame Retardants

The role of polybrominated diphenyl ethers in the induction of cancer: a systematic review of insight into their mechanisms.

Pesticides

Maternal exposure to pesticides and autism or attention-deficit/hyperactivity disorders in offspring: A meta-analysis.

Pesticide contamination in agro-ecosystems: toxicity, impacts, and bio-based management strategies.

Pesticide Toxicity Associated with Infertility.

Metals/Metalloids

Arsenic-Induced Sex Hormone Disruption: An Insight into Male Infertility.

What happens to gut microorganisms and potential repair mechanisms when meet heavy metal(loid)s.

Microplastics/Nanomaterials

Micro and nano-plastics, a threat to human health?

Micro- and nanoplastics: A new cardiovascular risk factor?

Eco-toxicity of nano-plastics and its implication on human metabolism: Current and future perspective.

A perspective on reproductive toxicity of metallic nanomaterials

Pharmaceuticals/Personal Care Products

Bioaccumulation/bioconcentration of pharmaceutical active compounds in aquatic organisms: Assessment and factors database.

Human Health Studies

Numerous Chemicals/Mixtures

Associations between serum polychlorinated biphenyls, halogen flame retardants, and renal function indexes in residents of an e-waste recycling area.

Urinary phthalates, phenols, and parabens in relation to sleep health markers among a cohort of Mexican adolescents.

BPA/Phenols

Probing Prenatal Bisphenol Exposures and Tissue-specific DNA Methylation Responses in Cord Blood, Cord Tissue, and Placenta.

Exposure to bisphenol A and its analogs and polycystic ovarian syndrome in women of childbearing age: A multicenter case-control study.

Association of urinary bisphenol A with chronic obstructive pulmonary disease-related diseases: evidence from the National Health and Nutrition Examination Survey database (2005-2016).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Do changes in persistent organic pollutants after bariatric surgery cause endocrine disruption?

Perfluoroalkyl Substances

Associations of per- and polyfluoroalkyl substances and their alternatives with bone mineral density levels and osteoporosis prevalence: A community-based population study in Guangzhou, Southern China.

Flame Retardants

Gestational organophosphate ester exposure and preschool attention-deficit/hyperactivity disorder in the Norwegian Mother, Father, and Child cohort study.

Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case-Control Study in Eastern China.

Pesticides

Exposure to organophosphate insecticides, inappropriate personal protective equipment use, and cognitive performance among pesticide applicators.

Metals/Metalloids

Urinary Concentrations of Endocrine-Disrupting Metals and Prevalent Breast Cancer in US Women.

Associations of Prenatal First Trimester Essential and Nonessential Metal Mixtures with Body Size and Adiposity in Childhood.

Association between prenatal metals exposure and blood pressure in 5-6 years children: A birth cohort study.

Serum heavy metals and breast cancer risk: A case-control study nested in the Florence cohort of the EPIC (European Prospective Investigation into Cancer and nutrition) study.

Association between combined exposure to plasma heavy metals and dyslipidemia in a chinese population.

Air Pollution

Effect of air pollution on the human immune system.

Association of urinary and ambient black carbon, and other ambient pollutants with risk of prediabetes and metabolic syndrome in children and adolescents.

Associations between PM_2.5 exposure and Alzheimer’s Disease prevalence Among elderly in eastern China.

Miscellaneous

Exposure to p-dichlorobenzene and serum α-Klotho levels among US participants in their middle and late adulthood.

Associations between concentrations of serum α-klotho and selected urinary monohydroxy metabolites of polycyclic aromatic hydrocarbons: data for US adults aged 40-79 years.

Laboratory Studies

Numerous Chemicals/Mixtures

Mixture and individual effects of benzene, toluene, and formaldehyde in zebrafish (Danio rerio) development: metabolomics, epigenetics, and behavioral approaches.

BPA/Phenols

Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity.

Bisphenol A is a carcinogen that induces lipid accumulation, peroxisome proliferator‑activated receptor‑γ expression and liver disease.

Foetal exposure to the bisphenols BADGE and BPAF impairs meiosis through DNA oxidation in mouse ovaries.

Widespread formation of toxic nitrated bisphenols indoors by heterogeneous reactions with HONO.

An endophytic Schizophyllum commune possessing antioxidant activity exhibits genoprotective and organprotective effects in fresh water fish Channa punctatus exposed to bisphenol A.

Phthalates

Effects of non-phthalate plasticizer bis(2-ethylhexyl) sebacate (DEHS) on the endocrine system in Japanese medaka (Oryzias latipes).

Parabens/Triclosan/Antimicrobials

Endocrine disruption and reproductive impairment of methylparaben in adult zebrafish.

Health safety of parabens evaluated by selected in vitro methods.

Microbiota-mediated reactivation of triclosan oxidative metabolites in colon tissues.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Tris(4-chlorophenyl)methane and tris(4-chlorophenyl)methanol disrupt pancreatic organogenesis and gene expression in zebrafish embryos.

Expression Levels and Network Analysis of inflammamiRs in Peripheral Blood Mononuclear Cells Exposed to DDE “in vitro”.

Probing the Role of CYP2 Enzymes in the Atropselective Metabolism of Polychlorinated Biphenyls Using Liver Microsomes from Transgenic Mouse Models.

Perfluoroalkyl Substances

Maternal exposure to perfluorobutane sulfonate (PFBS) during pregnancy: evidence of adverse maternal and fetoplacental effects in New Zealand White (NZW) rabbits.

Tissue-specific accumulation, depuration, and effects of perfluorooctanoic acid on fish: Influences of aqueous pH and sex.

Acute toxicity and risk assessment of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) in tropical cladocerans Moina micrura.

Toxicity assessment of hexafluoropropylene oxide-dimer acid on morphology, heart physiology, and gene expression during zebrafish (Danio rerio) development.

PFAS-induced lipidomic dysregulations and their associations with developmental toxicity in zebrafish embryos.

Flame Retardants

The potential mechanisms of TBBPA bis(2-hydroxyethyl) ether induced developmental neurotoxicity in juvenile zebrafish (Danio rerio).

Pesticides

In vitro study of glyphosate effects on thyroid cells.

Biochemical, histopathological and untargeted metabolomic analyses reveal hepatotoxic mechanism of acetamiprid to Xenopus laevis.

Atrazine alters early sexual development of the South American silverside, Odontesthes bonariensis.

Immunohistochemical distribution of Bcl-2 and p53 apoptotic markers in acetamiprid-induced nephrotoxicity.

Cellular and Molecular Responses to Ethyl-Parathion in Undifferentiated SH-SY5Y Cells Provide Neurotoxicity Pathway Indicators for Organophosphorus Impacts.

Effects of haloxyfop-p-methyl on the developmental toxicity, neurotoxicity, and immunotoxicity in zebrafish.

Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson’s Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk.

Benomyl-induced development and cardiac toxicity in zebrafish embryos.

Inhibition of human and rat placental 3β-hydroxysteroid dehydrogenase/Δ^5,4-isomerase activities by insecticides and fungicides: Mode action by docking analysis.

Joint toxic effects of thiamethoxam and fluconazole on the adult worker honey bees (Apis mellifera L.).

Metals/Metalloids

Effects of Co-exposure to Fluoride and Arsenic on TRAF-6 Signaling and NF-κB Pathway of Bone Metabolism.

Integrated miRNA-mRNA analysis reveals the dysregulation of lipid metabolism in mouse liver induced by developmental arsenic exposure.

The gut microbiome promotes arsenic metabolism and alleviates the metabolic disorder for their mammal host under arsenic exposure.

Prenatal arsenic exposure stymies gut butyrate production and enhances gut permeability in post natal life even in absence of arsenic deftly through miR122-Occludin pathway.

Oxidative stress in the ovaries of mice chronically exposed to a low lead concentration: A generational approach.

Genetic and epigenetic interplay allows rapid transgenerational adaptation to metal pollution in zebrafish.

Microplastics/Nanomaterials

Insight into the photodegradation and universal interactive products of 2,2′,4,4′-tetrabromodiphenyl ether on three microplastics.

The interaction mechanism of polystyrene microplastics with pharmaceuticals and personal care products.

Reproductive toxicity and cross-generational effect of polyethylene microplastics in Paramisgurnus dabryanus.

Pharmaceuticals/Personal Care Products

Human health risk assessment of cinnamate UV absorbers: In vitro and in silico investigations.

Transformation of macrolide antibiotics during chlorination process: Kinetics, degradation products, and comprehensive toxicity evaluation.

Pharmacological targeting of androgen receptor elicits context-specific effects in estrogen receptor-positive breast cancer.

Dydrogesterone disrupts lipid metabolism in zebrafish brain: A study based on metabolomics and Fourier transform infrared spectroscopy.

Environmental concentrations of benzophenone-3 disturbed lipid metabolism in the liver of clown anemonefish (Amphiprion ocellaris).

Miscellaneous

Effects of benzo[a]pyrene on the reproductive axis: Impairment of kisspeptin signaling in human gonadotropin-releasing hormone primary neurons.

Melatonin attenuates cardiopulmonary toxicity induced by benzo(a)pyrene in mice focusing on apoptosis and autophagy pathways.

Molecular insights of 2,6-dichlorobenzoquinone-induced cytotoxicity in zebrafish embryo: Activation of ROS-mediated cell cycle arrest and apoptosis. [a disinfection byproduct]

Embryo developmental toxicity in marine medaka (Oryzias melastigma) due to parental and embryonic 17α-ethinylestradiol exposure.

Long-term exposure to tire-derived 6-PPD quinone causes intestinal toxicity by affecting functional state of intestinal barrier in Caenorhabditis elegans.

Effects of β-eudesmol and atractylodin on target genes and hormone related to cardiotoxicity, hepatotoxicity, and endocrine disruption in developing zebrafish embryos.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Footprints in compositions, PCDD/Fs and heavy metals in medical waste fly ash: Large-scale evidence from 17 medical waste thermochemical disposal facilities across China.

Phthalates

Phthalates in glass window films are associated with dormitory characteristics, occupancy activities and habits, and environmental factors.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A comparative monitoring of maternal and cord serum polychlorinated biphenyls levels from Iranian pregnant women between industrial and urban areas.

Bioaccumulation of emerging persistent organic pollutants in the deep-sea cold seep ecosystems: Evidence from chlorinated paraffin.

Perfluoroalkyl Substances

Infant formula and baby food as a source of perfluoroalkyl substances for infants.

Occurrence of perfluoroalkyl substances in the environment compartments near a mega fluorochemical industry: Implication of specific behaviors and emission estimation.

Nontargeted screening reveals fluorotelomer ethoxylates in indoor dust and industrial wastewater.

Occurrence and removal of per- and polyfluoroalkyl substances (PFAS) in leachates from incineration plants: A full-scale study.

Suspect Screening and Nontargeted Analysis of Per- and Polyfluoroalkyl Substances in a Lake Ontario Food Web.

Flame Retardants

Discovery of 18 Organophosphate Esters and 3 Organophosphite Antioxidants in Food Contact Materials Using Suspect and Nontarget Screening: Implications for Human Exposure.

Halogenated flame retardant exposure pathways in urban-adapted gulls: Are atmospheric routes underestimated?

Occurrence, spatial distribution, and risk assessment of brominated flame retardants in farmland soils of typical provinces in China.

Pesticides

Honey bee colony loss linked to parasites, pesticides and extreme weather across the United States.

Monarch Butterfly Ecology, Behavior, and Vulnerabilities in North Central United States Agricultural Landscapes.

Ecotoxicological risk assessment of 14 pesticides and corresponding metabolites to groundwater and soil organisms using China-PEARL model and RQ approach.

Risk assessment of persistent pesticide pollution: Development of an indicator integrating site-specific characteristics.

Occurrence, bioaccumulation and trophic transfer of organophosphate esters in marine food webs: Evidence from three bays in Bohai Sea, China.

Metals/Metalloids

Nationwide geospatial analysis of county racial and ethnic composition and public drinking water arsenic and uranium.

Microplastics/Nanomaterials

Characterization of ingested MPs and their relation with growth parameters of endemic and invasive fish from a coastal wetland.

The transport of microplastics by ants cannot be neglected in the soil ecosystem.

Secondary pollution of microplastic hetero-aggregates after chlorination: Released contaminants rarely re-adsorbed by the second-formed hetero-aggregates.

Identification and quantification of additive-derived chemicals in beached micro-mesoplastics and macroplastics.

Air Pollution

Unexpected air pollutants with potential human health hazards: Nitrification inhibitors, biocides, and persistent organic substances.

Disparities in Air Pollutants Across Racial, Ethnic, and Poverty Groups at US Public Schools.

Miscellaneous

Occurrence and ecotoxicological risk assessment of pharmacologically active dyes in the environmental water of Poland.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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