EDC Science Weekly, Dec. 2 – 8, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Dec. 15: PFAS Exposure and Epigenetics in the Firefighter Cancer Cohort Study (EDC Strategies Partnership)

Webinar Dec. 8: Microplastics from Food and Water: State of the Science and Potential Impacts on Human Health (the National Academies)

Virtual workshop Dec. 10: Addressing Racism As a Public Health Issue Through the Lens of Environmental Health Disparities and Environmental Justice (NIEHS)

Virtual seminar Dec. 10: The Multifaceted Challenges with Microplastics and Nanoplastics (University of Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD))

Virtual conference Jan 10-13: PPTOX VII: International Conference on Prenatal Programming and Toxicity

In-person course: May 25-June 9: Endocrine-Disrupting Chemicals: Hazards and Opportunities (Marine Biological Laboratory at Woods Hole)

In-person Gordon Research Conference and Seminar June 18-24: EDCs and the Environment and Harnessing Interdisciplinary Evidence for Endocrine Disruption to Improve Public Health

Regulations/Policy

Precise Yet Uncertain: Broadening Understandings of Uncertainty and Policy in the BPA Controversy.

Towards regulation of Endocrine Disrupting chemicals (EDCs) in water resources using bioassays – A guide to developing a testing strategy.

Chemical risk governance: Exploring stakeholder participation in Canada, the USA, and the EU.

U.S. Federal Agency interests and key considerations for new approach methodologies for nanomaterials.

Methods/Tools/Screening

Structures of Endocrine-Disrupting Chemicals Correlate with the Activation of 12 Classic Nuclear Receptors.

Impact of perinatal environmental health education intervention on exposure to endocrine disruptors during pregnancy-PREVED study: study protocol for a randomized controlled trial.

A plea for the integration of Green Toxicology in sustainable bioeconomy strategies – Biosurfactants and microgel-based pesticide release systems as examples.

Methods, models, mechanisms and metadata: Introducing the Nanotoxicology collection at F1000Research.

Predicting environmentally responsive transgenerational differential DNA methylated regions (epimutations) in the genome using a hybrid deep-machine learning approach.

Integrating toxicokinetics into toxicology studies and the human health risk assessment process for chemicals: Reduced uncertainty, better health protection.

Data mining of natural hazard biomarkers and metabolites with integrated metabolomic tools.

Commentaries/Conference Summaries

Per- and polyfluoroalkyl substances (PFAS)-contaminants of emerging concern.

Safe- and sustainable-by-design: The case of Smart Nanomaterials. A perspective based on a European workshop.

Reviews

Numerous Chemicals/Mixtures

Life-Time Environmental Chemical Exposure and Obesity: Review of Epidemiological Studies Using Human Biomonitoring Methods.

Review of Rodent Models of Attention Deficit Hyperactivity Disorder.

Endocrine Disruptors-‘Food’ for Thought.

Pollution-Induced Food Safety Problem in China: Trends and Policies.

Pollution in the Arctic Ocean: An overview of multiple pressures and implications for ecosystem services.

BPA/Phenols

Perinatal exposure to Bisphenol A and developmental programming of the cardiovascular changes in the offspring.

Perfluoroalkyl Substances

The use of in vitro methods in assessing human health risks associated with short-chain perfluoroalkyl and polyfluoroalkyl substances (PFAS).

The impact of perfluoroalkyl substances on pregnancy, birth outcomes and offspring development: A review of data from mouse models

Organotins

Tributyltin and the female hypothalamic-pituitary-gonadal disruption.

Microplastics

A rapid review and meta-regression analyses of the toxicological impacts of microplastic exposure in human cells.

Potential toxicity of nanoplastics to fish and aquatic invertebrates: Current understanding, mechanistic interpretation, and meta-analysis.

Physical and chemical threats posed by micro(nano)plastic to sea urchins.

Pharmaceuticals/Personal Care Products

Protocol for a systematic review on systemic and skin toxicity of important hazardous hair and nail cosmetic ingredients in hairdressers.

Human Health Studies

BPA/Phenols

Lipidomic biomarkers: Potential mediators of associations between urinary bisphenol A exposure and colorectal cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Analysis of serum levels of organochlorine pesticides and related factors in Parkinson’s disease.

Associations of prenatal exposure to mixtures of organochlorine pesticides and smoking and drinking behaviors in adolescence.

Sex specific associations between in utero exposure to persistent organic pollutants and allergy-related outcomes in childhood: The Rhea Mother-Child Cohort (Crete, Greece).

Pesticides

Association between pesticide exposure and sleep health among a representative sample of US adults: evidence from NHANES 2009-2014.

Effectiveness of a Participatory Program on Pesticide Use Behavior and Blood Cholinesterase Levels in Chiang Mai Province, Northern Thailand.

Potentially Toxic Elements

Association between prenatal metal exposure and adverse respiratory symptoms in childhood.

Gene expression and oxidative stress markers profile associated with toxic metals in patients with renal cell carcinoma.

Associations of blood and urinary heavy metals with rheumatoid arthritis risk among adults in NHANES, 1999-2018.

Urinary cadmium and incident heart failure: A case-cohort analysis among never-smokers in Denmark.

Effect of occupational co-exposure to lead and cadmium on selected immunomodulatory cytokines.

Air Pollution

Exposure to polycyclic aromatic hydrocarbons and volatile organic compounds is associated with a risk of obesity and diabetes mellitus among Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Laboratory Studies

Numerous Chemicals/Mixtures

Converging Effects of Three Different Endocrine Disrupters on Sox and Pou Gene Expression in Developing Rat Hippocampus: Possible Role of microRNA in Sex Differences. [PCBs, BPA, chlorpyrifos]

Gut microbiota disturbance exaggerates battery wastewater-induced hepatotoxicity through a gut-liver axis.

BPA/Phenols

Effects of Bisphenols A, AF, and S on Endochondral Ossification and the Transcriptome of Murine Limb Buds.

Bisphenol A disrupts apolipoprotein E expression through estrogen-related receptor gamma and DNA methlylation in the liver of male rare minnow Gobiocypris rarus.

Different bisphenols induce non-monotonous changes in miRNA expression and LINE-1 methylation in two cell lines.

Phthalates

Effects of Dicyclohexyl Phthalate Exposure on PXR Activation and Lipid Homeostasis in Mice.

mRNA expression and protein-protein interaction (PPI) network analysis of adrenal steroidogenesis in response to exposure to phthalates in rats.

Exposure to a combination of MWCNTs and DBP causes splenic toxicity in Mice. [multi-walled carbon nanotubes and phthalates]

[Disruption of sexual behavior by phthalates in mice: Females are more vulnerable than males]. [in French]

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Endosulfan promotes cell proliferation and extracellular matrix accumulation through TGF-β/Smad signaling pathway in HRMCs.

PCB126 Induced Toxic Actions on Liver Energy Metabolism is Mediated by AhR in Rats.

Perfluoroalkyl Substances

PFOA induces alteration in DNA methylation regulators and SARS-CoV-2 targets Ace2 and Tmprss2 in mouse lung tissues.

Using comprehensive lipid profiling to study effects of PFHxS during different stages of early zebrafish development.

Effects of perfluoroalkyl substances on root and rhizosphere bacteria: Phytotoxicity, phyto-microbial remediation, risk assessment.

Toxicity of perfluorooctanoic acid on zebrafish early embryonic development determined by single-cell RNA sequencing.

Flame Retardants

Impact of brominated flame retardants on lipid metabolism: An in vitro approach.

Pesticides

Sublethal pesticide exposure induces larval removal behavior in honeybees through chemical cues.

The silence of the clams: Forestry registered pesticides as multiple stressors on soft-shell clams. [best title of the week]

The Effects of Benoxacor on the Liver and Gut Microbiome of C57BL/6 Mice. [an “inert” pesticide ingredient]

Low concentrations of glyphosate alone affect the pubertal male rat meiotic step: An in vitro study.

Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats.

Evaluation of acetamiprid and azoxystrobin residues and their hormonal disrupting effects on male rats using liquid chromatography-tandem mass spectrometry.

Elucidation of the species differences of epyrifenacil-induced hepatotoxicity between mice and humans by mass spectrometry imaging analysis in chimeric mice with humanized liver.

Impacts of early-life paraquat exposure on gut microbiota and body weight in adult mice.

Bioaccumulation and toxicity effects of flubendiamide in zebrafish (Danio rerio).

Potentially Toxic Elements

Significance of Inflammation and Apoptosis in Hepatocellular Death in Rat, Co-treated with Arsenic and Fluoride.

Life-long arsenic exposure damages the microstructure of the rat hippocampus.

Heterogeneity effects of nanoplastics and lead on zebrafish intestinal cells identified by single-cell sequencing.

Chlorine disinfection elevates the toxicity of polystyrene microplastics to human cells by inducing mitochondria-dependent apoptosis.

Sex differences in the effects of whole-life, low-dose cadmium exposure on postweaning high-fat diet-induced cardiac pathogeneses.

Modification of the toxic effects of methylmercury and thimerosal by testosterone and estradiol in SH-SY5Y neuroblastoma cell line.

Microplastics

Influence of polystyrene microplastics on the volatilization, photodegradation and photoinduced toxicity of anthracene and pyrene in freshwater and artificial seawater.

Comparing the effects of polystyrene microplastics exposure on reproduction and fertility in male and female mice.

Intergenerational effects of environmentally-aged microplastics on the Crassostrea gigas.

Polystyrene nanoplastics affect digestive function and growth in juvenile groupers.

The synergic toxicity of temperature increases and nanopolystrene on zebrafish brain implies that global warming may worsen the current risk based on plastic debris.

Combined effects of polystyrene microplastics and copper on antioxidant capacity, immune response and intestinal microbiota of Nile tilapia (Oreochromis niloticus).

Shedding light on the impacts of gestational exposure to polystyrene nanoplastics on the reproductive performance of Poecilia reticulata female and on the biochemical response of embryos.

Enhanced microalgal toxicity due to polystyrene nanoplastics and cadmium co-exposure: From the perspective of physiological and metabolomic profiles.

The nephrotoxic potential of polystyrene microplastics at realistic environmental concentrations.

Microplastics hamper the fertilization success of a broadcast spawning bivalve through reducing gamete collision and gamete fusion efficiency.

Effects of pollutants and microplastics ingestion on oxidative stress and monoaminergic activity of seabream brains.

Pharmaceuticals/Personal Care Products

Tissue distribution and endocrine disruption effects of chronic exposure to pharmaceuticals and personal care products mixture at environmentally relevant concentrations in zebrafish.

Long-term exposure to environmental diclofenac concentrations impairs growth and induces molecular changes in Lymnaea stagnalis freshwater snails.

Chronic Exposure to Climbazole Induces Oxidative Stress and Sex Hormone Imbalance in the Testes of Male Zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Relationships between gene transcription and contaminant concentrations in Baltic ringed seals: A comparison between tissue matrices.

Multiple Lines of Evidence for Identifying Potential Hazards to Fish from Contaminants of Emerging Concern in Great Lakes Tributaries.

Reproductive health and endocrine disruption in smallmouth bass (Micropterus dolomieu) from the Lake Erie drainage, Pennsylvania, USA.

Contaminant concentrations and risks associated with the Pacific oyster in the highly urbanized San Diego Bay.

Seasonal variations in air concentrations of 27 organochlorine pesticides (OCPs) and 25 current-use pesticides (CUPs) across three agricultural areas of South Africa.

Trends of banned pesticides and PCBs in different tissues of striped dolphins (Stenella coeruleoalba) stranded in the Northwestern Mediterranean reflect changing contamination patterns.

BPA/Phenols

Biomonitoring of bisphenol A, 4-nonylphenol, and 4-t-octylphenol in Turkish population: exposure and risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organic contaminants in marine sediments and seawater: A review for drawing environmental diagnostics and searching for informative predictors.

In vitro assessment of polychlorinated biphenyl bioaccessibility in meat: Influence of fat content, cooking level and consumer age on consumer uptake.

Perfluoroalkyl Substances

Modeling PFAS Fate and Transport in Groundwater, With and Without Precursor Transformation.

Perfluorinated compounds in a river basin from QingHai-Tibet Plateau: Occurrence, sources and key factors.

Investigation of per- and polyfluoroalkyl substances (PFAS) in soils and sewage sludges by fluorine K-edge XANES spectroscopy and combustion ion chromatography.

A Bad Start in Life? Maternal Transfer of Legacy and Emerging Poly- and Perfluoroalkyl Substances to Eggs in an Arctic Seabird.

Flame Retardants

Identifying dermal exposure as the dominant pathway of children’s exposure to flame retardants in kindergartens.

Tetrabromobisphenol A (TBBPA) biodegradation in acidogenic systems: One step further on where and who.

Pollution characteristics and emissions of typical organophosphate esters of a wastewater treatment plant.

Recycling plastics containing decabromodiphenyl ether into new consumer products including children’s toys purchased in Japan and seventeen other countries.

Pesticides

Suspecting screening “known unknown” pesticides and transformation products in soil at pesticide manufacturing sites.

Holistic evaluation of long-term earthworm field studies with a fungicide.

Occurrence and ecological risk assessment of neonicotinoids and related insecticides in the Bohai Sea and its surrounding rivers, China.

Ecotoxicological and human health risk assessment of selected pesticides in Kurose River, Higashi-Hiroshima City (Japan).

Potentially Toxic Elements

Biological monitoring of exposure to rare earth elements and selected metals in the inuit population of Nunavik, Canada.

Biomonitoring of urinary metals in athletes according to particulate matter air pollution before and after exercise.

Association of selenium, arsenic, and other trace elements in drinking water and urine in residents of the plateau region in China.

Diet-driven mercury contamination is associated with polar bear gut microbiota.

Human Health Risk Assessment of Heavy Metals and Metalloids in Herbal Medicines Used to Treat Anxiety: Monitoring of Safety.

Trace Metal Lead Exposure in Typical Lip Cosmetics From Electronic Commercial Platform: Investigation, Health Risk Assessment and Blood Lead Level Analysis.

Microplastics

A review of plastic pollution in aquatic ecosystems of Turkey.

Plastic ingestion by the Wels catfish (Silurus glanis L.): detailed chemical analysis and degradation state evaluation.

Adsorption of a diverse range of pharmaceuticals to polyethylene microplastics in wastewater and their desorption in environmental matrices.

Pharmaceuticals/Personal Care Products

The potential for adverse effects in fish exposed to antidepressants in the aquatic environment.

Pharmaceuticals in water and sediment of small streams under the pressure of urbanization: Concentrations, interactions, and risks.

Miscellaneous

Assessing potential risks of aquatic polycyclic aromatic compounds via multiple approaches: A case study in Jialing and Yangtze Rivers in downtown Chongqing, China.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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