EDC Science Weekly, Dec. 2 – 8, 2020 – HEEDS

EDC Science Weekly, Dec. 2 – 8, 2020

Post author:HEEDS
Post published:December 8, 2020
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Management of PFAS with the aid of chemical product registries – an indispensable tool for future control of hazardous substances.

Hormone data collection in support of endocrine disruption (ED) assessment for aquatic vertebrates: Pragmatic and animal welfare considerations.

Commentaries/Conference Summaries

25^th anniversary of the Berlin Workshop on Developmental Toxicology: DevTox database update, challenges in risk assessment of developmental neurotoxicity and alternative methodologies in bone development and growth.

Reviews

Numerous EDCs

Female Fertility and Environmental Pollution.

Exposure to Endocrine Disrupting Chemicals and Risk of Breast Cancer.

Environmental Endocrine Disruptors and Endometriosis.

Developmental Origins of Metabolic Disease.

Overview of intentionally used food contact chemicals and their hazards.

Physiological and Behavioral Responses of Land Molluscs as Biomarkers for Pollution Impact Assessment: A Review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

New perspective on the regulation of acetylcholinesterase via the aryl hydrocarbon receptor.

Pesticides

Determinants of non-dietary exposure to agricultural pesticides in populations living close to fields: A systematic review.

Potentially Toxic Elements

Environmental impact of metals resulting from military training activities: A review.

Mercury exposure, cardiovascular disease, and mortality: a systematic review and dose-response meta-analysis.

Microplastics/Nanomaterials

Assessment of Human Health Risks Posed by Nano-and Microplastics Is Currently Not Feasible.

Research progress of nanoplastics in freshwater.

Recent Developments in the Application of Nanomaterials in Agroecosystems.

Air Pollution

In Utero Exposure to Particulate Air Pollution during Pregnancy: Impact on Birth Weight and Health through the Life Course.

Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis.

Indoor Exposure to Selected Air Pollutants in the Home Environment: A Systematic Review.

Pharmaceuticals/Personal Care Products

Synthetic Musk Compounds in Human Biological Matrices: Analytical Methods and Occurrence – a Review.

Miscellaneous

The what, how, why, and when of dendrochemistry: (paleo)environmental information from the chemical analysis of tree rings.

Human Health Studies

Numerous Chemicals

Association of Maternal-Neonatal Steroids with Early Pregnancy Endocrine Disrupting Chemicals and Pregnancy Outcomes.

Phthalates

A pilot investigation of couple-level phthalates exposure and in vitro fertilization (IVF) outcomes.

Parabens/Triclosan/Antimicrobials

Age, gender, and racial/ethnic differences in the association of triclocarban with adulthood obesity using NHANES 2013-2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants and maternal glycemic outcomes in a diverse pregnancy cohort of overweight women.

Perfluoroalkyl Substances

Exposure to Per- and Polyfluoroalkyl Substances and Adiposity at Age 12 Years: Evaluating Periods of Susceptibility.

Parental plasma concentrations of perfluoroalkyl substances and In Vitro fertilization outcomes.

Flame Retardants

Association between urinary organophosphate flame retardant diesters and steroid hormones: A metabolomic study on type 2 diabetes mellitus cases and controls.

Potentially Toxic Elements

The association between prenatal exposure to thallium and shortened telomere length of newborns.

Higher blood cadmium level is associated with greater cognitive decline in rural Chinese adults aged 65 or older.

Exposure to heavy metals modifies optimal gestational weight gain: A large nationally representative cohort of the Japan Environment and Children’s Study.

Linking metal (Pb, Hg, Cd) industrial air pollution risk to blood metal levels and cardiovascular functioning and structure among children in Syracuse, NY.

Mercury in Pancreatic Cells of People with and without Pancreatic Cancer.

Arsenic and selenium measurements in nail and hair show important relationships to Alzheimer’s disease in the elderly.

Air Pollution

Sperm mtDNA copy number, telomere length, and seminal spermatogenic cells in relation to ambient air pollution: Results of a cross-sectional study in Jing-Jin-Ji region of China.

Air pollution, sociodemographic and health conditions effects on COVID-19 mortality in Colombia: An ecological study.

Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort.

Residential Exposure to PM_2.5 Components and Risk of Childhood Non-Hodgkin Lymphoma in Denmark: A Nationwide Register-Based Case-Control Study.

Depression and Anxiety Associated with Exposure to Fine Particulate Matter Constituents: A Cross-Sectional Study in North China.

Short-term personal and outdoor exposure to ultrafine and fine particulate air pollution in association with blood pressure and lung function in healthy adults.

Residential Proximity to Major Roadways and Prevalent Hypertension Among Older Women and Men: Results From the Chinese Longitudinal Healthy Longevity Survey.

Miscellaneous

A Comparative Cancer Risk Evaluation of MTBE and Other Compounds (Including Naturally Occurring Compounds) in Drinking Water in New Hampshire.

Laboratory Studies

BPA/Phenols

Long-term bisphenol A exposure exacerbates diet-induced prediabetes via TLR4-dependent hypothalamic inflammation.

The interference effects of bisphenol A on the synthesis of steroid hormones in human ovarian granulosa cells.

Bisphenol A Deranges the Endocannabinoid System of Primary Sertoli Cells with an Impact on Inhibin B Production.

Oral Bisphenol A Worsens Liver Immune-Metabolic and Mitochondrial Dysfunction Induced by High-Fat Diet in Adult Mice: Cross-Talk between Oxidative Stress and Inflammasome Pathway.

Bisphenol A and rotenone induce S-nitrosylation of protein disulfide isomerase (PDI) and inhibit neurite outgrowth of primary cultured cells of the rat hippocampus and PC12 cells.

Effects of Bisphenol A and Bisphenol S on microRNA expression during bovine (Bos Taurus) oocyte maturation and early embryo development.

Counteracting Environmental Chemicals with Coenzyme Q10: An Educational Primer for Use with “Antioxidant CoQ10 Restores Fertility by Rescuing Bisphenol A-Induced Oxidative DNA Damage in the Caenorhabditis elegans Germline”.

Phthalates

Acute exposure of di(2-ethylhexyl) phthalate (DEHP) induces immune signal regulation and ferroptosis in oryzias melastigma.

Perfluoroalkyl Substances

Effects of In Utero Exposure to Perfluorooctane Sulfonate on Placental Functions.

Plasma, liver, and kidney exposures in rats after oral doses of industrial chemicals predicted using physiologically based pharmacokinetic models: A case study of perﬂuorooctane sulfonic acid.

Perfluorooctanoic acid-induced liver injury is potentially associated with gut microbiota dysbiosis.

Comparison of toxicokinetics and toxic effects of PFOS and its novel alternative OBS in zebrafish larvae.

Sensitivity and Accumulation of Perfluorooctanesulfonate (Pfos) and Perfluorohexanesulfonic Acid (PFHxS) in Fathead Minnows (Pimephales promelas) Exposed Over Critical Life-Stages of Reproduction and Development.

Flame Retardants

Maternal organophosphate flame-retardant exposure alters offspring feeding, locomotor and exploratory behaviors in a sexually-dimorphic manner in mice.

Tris (1-chloro-2-propyl) phosphate exposure to zebrafish causes neurodevelopmental toxicity and abnormal locomotor behavior.

Organotins

Influence of triphenyltin on morphologic abnormalities and the thyroid hormone system in early-stage zebrafish (Danio rerio).

Pesticides

Biochemical and Histopathological Alterations in Different Tissues of Rats Due to Repeated Oral Dose Toxicity of Cymoxanil.

Impact of chronic exposure of rainbow trout, Oncorhynchus mykiss, to low doses of glyphosate or glyphosate-based herbicides.

Protective effects of black seed (Nigella sativa) diet supplementation in common carp (Cyprinus carpio) against immune depression, oxidative stress and metabolism dysfunction induced by glyphosate.

Early embryonic exposure to chlorpyrifos-cypermethrin combination induces pattern deficits in the heart of domestic hen.

Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms.

Chronic effects of a binary insecticide Acer 35 EC on Nile tilapia Oreochromis niloticus through a multi-biomarker approach.

Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson’s disease.

Responses of Aquatic Nontarget Organisms in Experiments Simulating a Scenario of Contamination by Imidacloprid in a Freshwater Environment.

Carbofuran accelerates the cellular senescence and declines the life span of spns1 mutant zebrafish.

Alterations in the non-neuronal cholinergic system induced by in-vitro exposure to diazoxon in spleen mononuclear cells of Nile tilapia (O. niloticus).

Potentially Toxic Elements

Gestational Cd Exposure in the CD-1 Mouse Induces Sex-Specific Hepatic Insulin Insensitivity, Obesity, and Metabolic Syndrome in Adult Female Offspring.

Subacute cadmium exposure disrupts the hypothalamic-pituitary-gonadal axis, leading to polycystic ovarian syndrome and premature ovarian failure features in female rats.

Relationship between osteoid formation and iron deposition induced by chronic cadmium exposure in ovariectomized rats.

Neurobehavioral and immune-toxic impairments induced by organic methyl mercury dietary exposure in Nile tilapia Oreochromis niloticus.

Gestational arsenic exposure induces site-specific DNA hypomethylation in active retrotransposon subfamilies in offspring sperm in mice.

Microplastics/Nanomaterials

Developmental toxicity of plastic leachates on the sea urchin Paracentrotus lividus.

Enhanced hepatic cytotoxicity of chemically transformed polystyrene microplastics by simulated gastric fluid.

Toxicokinetic/toxicodynamic-based risk assessment of freshwater fish health posed by microplastics at environmentally relevant concentrations.

Size-dependent toxic effects of polystyrene microplastic exposure on Microcystis aeruginosa growth and microcystin production.

Uptake, accumulation and associated cellular alterations of environmental samples of microplastics in the seaworm Hediste diversicolor.

The Effects of Gold Nanoparticles on Leydig Cells and Male Reproductive Function in Mice.

Air Pollution

Fine particulate matter PM_2.5 generated by building demolition increases the malignancy of breast cancer MDA-MB-231 cells.

Determining the effects of nanoparticulate air pollution on proteostasis in Caenorhabditis elegans.

Pathological Cardiopulmonary Evaluation of Rats Chronically Exposed to Traffic-Related Air Pollution.

Particulate matter less than 10 μm (PM₁₀) activates cancer related genes in lung epithelial cells.

Pharmaceuticals/Personal Care Products

Development and Molecular Investigation into the Effects of Carbamazepine Exposure in the Zebrafish (Danio rerio).

Mixtures

Development and Validation of a Mixture Toxicity Implementation in DED-IBM: Effects of Copper and Zinc on Daphnia Magna Populations.

Multigenerational toxic effects on Daphnia magna induced by silver nanoparticles and glyphosate mixture.

The joint effect of parental exposure to microcystin-LR and polystyrene nanoplastics on the growth of zebrafish offspring.

Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio).

Miscellaneous

Benzo[a]pyrene exposure and overcrowding stress impacts anxiety-like behavior and impairs learning and memory in adult zebrafish, Danio rerio.

Exposure/Environment Studies

BPA/Phenols

Determination of Free Bisphenol A in Commercially Packaged Ready-to-Consume Carbonated/Non-Carbonated and Non-Alcoholic Beverages with Immunoaffinity Column Purification and UPLC with Fluorescence Detector, First Action 2019.07.

Determinants of exposure levels of bisphenols in Flemish adolescents.

Identification and Quantitation Studies of Migrants from BPA Alternative Food-Contact Metal Can Coatings.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Comprehensive Subchronic Inhalation Toxicity Assessment of an Indoor School Air Mixture of PCBs.

Trends of Polychlorinated Compounds in the Surroundings of a Municipal Solid Waste Incinerator in Mataró (Catalonia, Spain): Assessing Health Risks.

Serum dioxin concentrations in military workers at three dioxin-contaminated airbases in Vietnam.

Perfluoroalkyl Substances

Exploring Community Psychosocial Stress Related to Per- and Poly-Fluoroalkyl Substances (PFAS) Contamination: Lessons Learned from a Qualitative Study.

Correlation Analysis of Perfluoroalkyl Substances in Regional U.S. Precipitation Events.

Enhanced perfluorooctanoic acid (PFOA) accumulation by combination with in-situ formed Mn oxides under drinking water conditions.

Groundwater contamination by fluorinated aromatics: Benzotrifluoride and its derivatives.

Atmospheric diffusion of perfluoroalkyl acids emitted from fluorochemical industry and its associated health risks.

Flame Retardants

Global distribution and trends of polybrominated diphenyl ethers in human blood and breast milk: A quantitative meta-analysis of studies published in the period 2000-2019.

Accumulation and influencing factors of novel brominated flame retardants in soil and vegetation from Fildes Peninsula, Antarctica.

Pesticides

Variability of urinary pyrethroid biomarkers in Chinese young-aged men and women over one year.

A Pesticide Residues Insight on Honeybees, Bumblebees and Olive Oil after Pesticidal Applications against the Olive Fruit Fly Bactrocera oleae (Diptera: Tephritidae).

Pesticide active substances in infant food in Serbia and risk assessment.

Potentially Toxic Elements

Arsenic metabolism differs between child and adult patients during acute arsenic poisoning.

Lead poisoning due to incense burning: an outbreak in a family.

250-year records of mercury and trace element deposition in two lakes from Cajas National Park, SW Ecuadorian Andes.

Heavy Metals and Trace Elements in Whole-Blood Samples of the Fishermen in Turkey: The Fish/Ermen Heavy Metal Study (FHMS).

Microplastics

First insights into plastic and microplastic occurrence in biotic and abiotic compartments, and snow from a high-mountain lake (Carnic Alps).

Air Pollution

Satellite-based estimates of decline and rebound in China’s CO₂ emissions during COVID-19 pandemic.

Health Benefits of Sustained Air Quality Improvements in New York City: A Simulation Based on Air Pollution Levels During the COVID-19 Shutdown.

Measuring The Impact Of Air Pollution On Health Care Costs.

Health Care Pollution And Public Health Damage In The United States: An Update.

Air pollution and critical air pollutant assessment during and after COVID-19 lockdowns: Evidence from pandemic hotspots in China, the Republic of Korea, Japan, and India.

Pharmaceuticals/Personal Care Products

Bioaccumulation of estrogenic hormones and UV-filters in red swamp crayfish (Procambarus clarkii).

Mixtures

Pathway-Based Approaches for Assessing Biological Hazards of Complex Mixtures of Contaminants: A Case Study in the Maumee River.

Miscellaneous

Retrospective analysis of estrogenic endocrine disruption and land-use influences in the Chesapeake Bay watershed.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.