EDC Science Weekly, Dec. 16 – 22, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Next week we will take a break but we’ll be back in January! If you appreciate these weekly summaries, please feel free to make a donation! Thank you and happy holidays to all! We hope you are safe and doing well, and hope for a better 2021.

Contents: Events,Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar: An introduction to the “essential use” concept and its application to PFAS, Jan. 13.

Methods/Tools/Screening

Assessing environmental epidemiology questions in practice with a causal inference pipeline: An investigation of the air pollution-multiple sclerosis relapses relationship.

Case study in 21^st century ecotoxicology: using in vitro aromatase inhibition data to predict short term in vivo responses in adult female fish.

High-Throughput Screening to Identify Chemical Cardiotoxic Potential.

Commentaries

Methylmercury Impact on Adult Neurogenesis: Is the Worst Yet to Come From Recent Brazilian Environmental Disasters?

Targeted eco-pharmacovigilance as an optimized management strategy for adverse effects of pharmaceuticals in the environment.

Reviews

Numerous EDCs

Differential susceptibility to endocrine disruptor-induced epimutagenesis.

Adipose Tissue and Endocrine-Disrupting Chemicals: Does Sex Matter?

Endobolome, a New Concept for Determining the Influence of Microbiota Disrupting Chemicals (MDC) in Relation to Specific Endocrine Pathogenesis.

The insulin-like growth factor system: A target for endocrine disruptors?

BPA/Phenols

Bisphenols and Risk of Breast Cancer: A Narrative Review of the Impact of Diet and Bioactive Food Components.

Potentially Toxic Elements

Environmental heavy metals and cardiovascular diseases: Status and future direction.

Microplastics

Current understanding and challenges for aquatic primary producers in a world with rising micro- and nano-plastic levels.

The occurrence and transport of microplastics: The state of the science.

From nanoplastic to microplastic: A bibliometric analysis on the presence of plastic particles in the environment.

Air Pollution

Emerging role of mitochondria in airborne particulate matter-induced immunotoxicity.

The Effects of Air Pollution on COVID-19 Infection and Mortality-A Review on Recent Evidence.

Ambient Air Pollution and Atherosclerosis: Insights Into Dose, Time, and Mechanisms.

A critical review of the epidemiological evidence of effects of air pollution on dementia, cognitive function and cognitive decline in adult population

Human Health Studies

Phthalates

Exposure to phthalates is associated with grip strength in US adults.

Associations of dermal diethyl phthalate level with changes in lung function test value mediated by absolute eosinophil count: a panel study of adults in southern Taiwan.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Cancer- and noncancer-specific cumulative incidence of death after exposure to polychlorinated biphenyls and dioxins: A competing risk analysis among Yusho patients.

Perfluoroalkyl Substances

The Impact of Smoking on the Association between Perfluoroalkyl Acids (PFAS) and Thyroid Hormones: A National Health and Nutrition Examination Survey Analysis.

Flame Retardants

Polybrominated diphenyl ethers in serum from residents living in a brominated flame retardant production area: Occurrence, influencing factors, and relationships with thyroid and liver function.

Pesticides

Organophosphate pesticide exposure among farm women and children: Status of micronutrients, acetylcholinesterase activity, and oxidative stress.

Chromosomal abnormalities and dysregulated DNA repair gene expression in farmers exposed to pesticides.

Occupational exposure to pesticides and health symptoms among family farmers in Brazil.

Ambient Pyrethroid Pesticide Exposures in Adult Life and Depression in Older Residents of California’s Central Valley.

Urinary 3-phenoxybenzoic acid (3-PBA) concentration and pulmonary function in children: A National Health and Nutrition Examination Survey (NHANES) 2007-2012 analysis.

Potentially Toxic Elements

Association of biomarkers of exposure to metals and metalloids with maternal hormones in pregnant women from Puerto Rico.

Environmental Cadmium and Mortality from Influenza and Pneumonia in U.S. Adults.

Prenatal lead exposure and cord blood DNA methylation in PROGRESS: an epigenome-wide association study.

Urinary Arsenic and Cadmium Associations with Findings from Cranial MRI in American Indians: Data from the Strong Heart Study.

Selenium modifies associations between multiple metals and neurologic symptoms in Gulf states residents.

Associations of prenatal methylmercury exposure and maternal polyunsaturated fatty acid status with neurodevelopmental outcomes at 7 years of age: results from the Seychelles Child Development Study Nutrition Cohort 2.

Prenatal methylmercury exposure and DNA methylation in seven-year-old children in the Seychelles Child Development Study

Sex-specific associations of plasma metals and metal mixtures with glucose metabolism: An occupational population-based study in China.

Association between the polymorphism of three genes involved in the methylation and efflux of arsenic (As3MT, MRP1, and P-gp) with lung cancer in a Mexican cohort

Air Pollution

Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study.

Prenatal exposure to air pollutants and early childhood growth trajectories: A population-based prospective birth cohort study.

Prenatal fine particulate matter exposure, placental DNA methylation changes, and fetal growth.

Effect of environmental pollutants PM-2.5, carbon monoxide, and ozone on the incidence and mortality of SARS-COV-2 infection in ten wildfire affected counties in California.

Exposure to O₃ during pregnancy and offspring asthma induced by OVA: Sensitive window identification.

Folic Acid Supplementation and the Association between Maternal Airborne Particulate Matter Exposure and Preterm Delivery: A National Birth Cohort Study in China.

Association of short-term exposure to ambient PM_2.5 with hospital admissions and 30-day readmissions in end-stage renal disease patients: population-based retrospective cohort study.

The effect of weather, air pollution and seasonality on the number of patient visits for epileptic seizures: A population-based time-series study.

Short-Term Effects of Atmospheric Pollution on Daily Mortality and Their Modification by Increased Temperatures Associated with a Climatic Change Scenario in Northern Mexico.

Education Differences in the Adverse Impact of PM2.5 on Incident Cognitive Impairment Among U.S. Older Adults.

Low socioeconomic status aggravated associations of exposure to mixture of air pollutants with obesity in rural Chinese adults: A cross-sectional study.

Associations of ambient particulate matter with homocysteine metabolism markers and effect modification by B vitamins and MTHFR C677T gene polymorphism.

Associations of long-term exposure to traffic-related air pollution with risk of valvular heart disease based on a cross-sectional study.

Short-term exposure to ambient air pollution in association with COVID-19 in two clusters in South Korea.

Air Pollution Is Associated with COVID-19 Incidence and Mortality in Vienna, Austria.

Associations between COVID-19 Incidence Rates and the Exposure to PM2.5 and NO₂: A Nationwide Observational Study in Italy.

Laboratory Studies

BPA/Phenols

Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet.

Bisphenol A interferes with first shell formation and development of the serotoninergic system in early larval stages of Mytilus galloprovincialis.

Deposition, depletion, and potential bioaccumulation of bisphenol F in eggs of laying hens after consumption of contaminated feed.

Phthalates

Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus).

Ginsenoside Rg1 ameliorates reproductive function injury in C57BL/6J mice induced by di-N-butyl-phthalate.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organ-specific effects on glycolysis by the dioxin-activated aryl hydrocarbon receptor.

Exposure to human relevant mixtures of halogenated persistent organic pollutants (POPs) alters neurodevelopmental processes in human neural stem cells undergoing differentiation.

Flame Retardants

Organophosphorus-based chemical additives induced behavioral changes in zebrafish (Danio rerio): Swimming activity is a sensitive stress indicator.

Pesticides

Epigenome-wide association study for atrazine induced transgenerational DNA methylation and histone retention sperm epigenetic biomarkers for disease.

Chronic Atrazine Exposure Beginning Prenatally Impacts Liver Function and Sperm Concentration With Multi-Generational Consequences in Mice.

Translational outcomes relevant to neurodevelopmental disorders following early life exposure of rats to chlorpyrifos.

Combined endocrine disruptive toxicity of malathion and cypermethrin to gene transcription and hormones of the HPG axis of male zebrafish (Danio rerio).

Dermal fungicide exposure at realistic field rates induces lethal and sublethal effects on juvenile European common frogs (Rana temporaria).

Acetylcholinesterase (AChE) monoclonal antibody generation and validation for use as a biomarker of glyphosate-based herbicide exposure in commercial freshwater fish.

Roundup causes embryonic development failure and alters metabolic pathways and gut microbiota functionality in non-target species.

Potentially Toxic Elements

Cell Viability and Immune Response to Low Concentrations of Nickel and Cadmium: An In Vitro Model.

Understanding the effects of metal pre-exposure on the sensitivity of zebrafish larvae to metal toxicity: A toxicokinetics-toxicodynamics approach.

Cognitive decline prevention in offspring of Pb⁺² exposed mice by maternal aerobic training and Cur/CaCO₃@Cur supplementations: In vitro and in vivo studies.

Environmental cadmium exposure induces fetal growth restriction via triggering PERK-regulated mitophagy in placental trophoblasts.

Microplastics

The effects of high-density polyethylene and polypropylene microplastics on the soil and earthworm Metaphire guillelmi gut microbiota.

Effect of chronic exposure to microplastic fibre ingestion in the sea cucumber Apostichopus japonicus.

Impacts of polyethylene microplastics on bioavailability and toxicity of metals in soil.

Air Pollution

Particulate Matter Exposure During Oocyte Maturation: Cell Cycle Arrest, ROS Generation, and Early Apoptosis in Mice.

Developmental exposure to diesel exhaust upregulates transcription factor expression, decreases hippocampal neurogenesis, and alters cortical lamina organization: relevance to neurodevelopmental disorders.

Mixtures

Combining in vivo pathohistological and redox status analysis with in silico toxicogenomic study to explore the phthalates and bisphenol A mixture-induced testicular toxicity.

Fluoride and endosulfan together potentiate cytogenetic effects in Swiss albino mice bone marrow cells.

Reproductive toxicity in male juvenile rats: Antagonistic effects between isolated agrochemicals and in binary or ternary combinations.

Neural stem cell-based in vitro bioassay for the assessment of neurotoxic potential of water samples

Evaluating the estrogenicity of an effluent-dominated river in California, USA: Comparisons of in vitro and in vivo bioassays.

Miscellaneous

Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects.

Toxicogenomic fin(ger)prints for thyroid disruption AOP refinement and biomarker identification in zebrafish embryos.

Exposure/Environment Studies

BPA/Phenols

Young children’s exposure to phenols in the home: Associations between house dust, hand wipes, silicone wristbands, and urinary biomarkers.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Levels of dioxins and dioxin-like polychlorinated biphenyls in seawater from the Hornsund fjord (SW Svalbard).

Occurrence, distribution and pollution pattern of legacy and emerging organic pollutants in surface water of the Kongsfjorden (Svalbard, Norway): Environmental contamination, seasonal trend and climate change.

Levels of omega 3 fatty acids, vitamin D, dioxins and dioxin-like PCBs in oily fish; a new perspective on the reporting of nutrient and contaminant data for risk-benefit assessments of oily seafood.

Non-Dioxin-Like Polychlorinated Biphenyl Neurotoxic Equivalents Found in Environmental and Human Samples.

Perfluoroalkyl Substances

Prenatal exposure and transplacental transfer of perfluoroalkyl substance isomers in participants from the upper and lower reaches of the Yangtze River.

Flame Retardants

Assessing decontamination and laundering processes for the removal of polycyclic aromatic hydrocarbons and flame retardants from firefighting uniforms.

Pesticides

Human exposure to organochlorine, pyrethroid and neonicotinoid pesticides: Comparison between urban and semi-urban regions of India.

Urinary concentrations of 2,4-D in repeated samples from 0-7 year old healthy children in central and south China.

Determination of Neonicotinoids in Honey Samples Originated from Poland and Other World Countries.

Glyphosate and aminomethylphosphonic acid (AMPA) residues in Brazilian honey.

Pesticides and Environmental Contaminants in Organic Honeys According to Their Different Productive Areas toward Food Safety Protection.

Human Health Risk Evaluation of Organophosphate Insecticide Residues in Post-Harvest Cowpea in Gwagwalada, Abuja, Nigeria.

Effects of early-life exposure to sublethal levels of a common neonicotinoid insecticide on the orientation and migration of monarch butterflies (Danaus plexippus).

The carcinogenicity of pesticides used in New Zealand.

Estimating Exposure to Three Commonly Used, Potentially Carcinogenic Pesticides (Chlorolathonil, 2,4-D, and Glyphosate) Among Agricultural Workers in Canada.

Pesticide active substances that do not require a review of the existing maximum residue levels under Article 12 of Regulation (EC) No 396/2005.

Peer review of the pesticide risk assessment of the active substance mancozeb.

Potentially Toxic Elements

Predictors of Plasma Fluoride Concentrations in Children and Adolescents.

Development of a new framework to estimate the environmental risk of heavy metal(loid)s focusing on the spatial heterogeneity of the industrial layout.

Assessment of a Screening Questionnaire to Identify Exposure to Lead in Pregnant Women.

Mercury Exposure in Artisanal and Small-Scale Gold Mining Communities in Sukabumi, Indonesia.

Concentration and Potential Human Health Hazards of Heavy Metals in Periwinkle (Tympanotonus fuscatus) Purchased from Major Markets in Calabar, Nigeria.

Preliminary Study of Heavy Metals in Low-Cost Jewelry Items Available in Nigerian Markets.

Risk of Mercury Ingestion from Canned Fish in Poland.

Content and Dietary Exposure Assessment of Toxic Elements in Infant Formulas from the Chinese Market.

Urinary Mercury Levels and Predictors of Exposure among a Group of Italian Children.

Microplastics

Currently monitored microplastics pose negligible ecological risk to the global ocean.

Evidence of Marine Microplastics in Commercially Harvested Seafood.

How do microplastics affect the marine microbial loop? Predation of microplastics by microzooplankton.

Quantification of different microplastic fibres discharged from textiles in machine wash and tumble drying.

Air Pollution

Community-Based Measurements Reveal Unseen Differences during Air Pollution Episodes.

Comparative Analysis of Indoor and Outdoor Particulate Matter Concentrations and Air Quality in Ogbomoso, Nigeria.

Urinary carboxylic acid metabolites as possible novel biomarkers of exposures to alkylated polycyclic aromatic hydrocarbons

Pharmaceuticals/Personal Care Products

Multiresidue Analysis of Organic UV Filters and UV Stabilizers in Fish of Common Consumption.

Mixtures

Evidence that watershed nutrient management practices effectively reduce estrogens in environmental waters.

Is Food Irrigated with Oilfield-Produced Water in the California Central Valley Safe to Eat? A Probabilistic Human Health Risk Assessment Evaluating Trace Metals Exposure.

Miscellaneous

Rochester’s rivers, lake, and waste: teaching local environmental history using water case studies.

Data Mining Approaches for Assessing Chemical Coexposures Using Consumer Product Purchase Data.

Prioritization of contaminants and biological process targets in the North Sea using toxicity data from ToxCast.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.