EDC Science Weekly, Dec. 13-19, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

We won’t be publishing next week due to the holidays. See you in January and happy holidays!

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Jan. 15: Strategies for Change: Turning Your Science into Action [PRHE’s Science Action Network]

Jan. 22 webinar: Gamechanger: California sues ExxonMobil over plastic recycling lies [Beyond Plastics]

Jan. 30 and Feb. 13 webinars: EDC exposure and gonadal function: consequences and interventions [Endocrine Society EDC Special Interest Group]

Mar. 14-15: Lou Guillette Jr. Symposium, in person at the University of Florida in Gainesville [HEEDS]

Apr. 27-29, 2025 conference: Break the Cycle of Children’s Environmental Health Disparities

May 21 – June 4, 2025 course: Endocrine-Disrupting Chemicals: Hazards and Opportunities (ECHO) [applications due Jan 10, financial aid is available]

More events

Regulations/Policy

The Normative Role of the Circular Plastics Alliance in the EU’s Transition towards a European Circular Economy for Plastics.

Conceptual basis for the development of guidance for the use of biomarkers of effect in regulatory risk assessment of chemicals.

More EDC policy and regulations open for comment

Methods/Tools/Screening

PFAS (per- and polyfluorinated alkyl substances) as EDCs (endocrine-disrupting chemicals) – Identification of compounds with high potential to bind to selected terpenoids NHRs (nuclear hormone receptors).

Report of the First ONTOX Hackathon: Hack to Save Lives and Avoid Animal Suffering. The Use of Artificial Intelligence in Toxicology – A Potential Driver for Reducing/Replacing Laboratory Animals in the Future.

Increasing the utility of epidemiologic studies as key evidence in chemical risk assessment.

A critical review on the toxicological and epidemiological evidence integration for assessing human health risks to environmental chemical exposures.

State of the science on assessing developmental neurotoxicity using new approach methods.

Commentaries

Editorial: Environmental threats to human reproduction. [intro to a research topic in Frontiers in Endocrinology]

Here’s the Rub: Skin Care Products and Children’s Phthalate Exposures. [Science Selection in EHP]

A Wide Reach: California’s Prop 65 and Reduced Chemical Exposures Across the United States. [Science Selection in EHP]

Health impacts of microplastic exposure.

Editorial: Spotlight on North America – chemical sciences. [Intro to a research topic in Frontiers in Chemistry]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Seafood toxicant exposure during pregnancy, lactation, and childhood and child outcomes: A scoping review.

Impact of Endocrine-Disrupting Chemicals, Climate, and Air Pollution on Pregnancy Outcomes: A Scoping Review.

Molecular Mechanism of Action of Endocrine-Disrupting Chemicals on the Respiratory System.

POPs and PFAS

Early-life exposure to PCBs and PFAS exerts negative effects on the developing central nervous system.

Exposure to Per- and Poly-fluoroalkyl Substances and Lung, Head and Neck, and Thyroid Cancer: A Systematic Review and Meta-Analysis.

Exposure to Poly- and Perfluoroalkyl Substances During Pregnancy and Asthma in Childhood: A Systematic Review.

Pesticides

Implication of Pyrethroid Neurotoxicity for Human Health: A Lesson from Animal Models.

The impact of neonicotinoid insecticides on amphibians: A comprehensive review and future research challenges.

A review of the influence of pH on toxicity testing of acidic environmental chemical pollutants in aquatic systems using zebrafish (Danio rerio) and glyphosate toxicity as a case study.

Metals/Metalloids

Host-microbiota interplay in arsenic metabolism: Implications on host glucose homeostasis.

Association Between Serum Concentrations of (Certain) Metals and Type 2 Diabetes Mellitus.

Microplastics/Nanomaterials

Effects of Microplastic Exposure on Human Digestive, Reproductive, and Respiratory Health: A Rapid Systematic Review.

Microplastic exposure is associated with male reproductive health.

Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks.

A review of the influence mechanisms of climate-induced events on groundwater microplastic contamination: A focus on aquifer vulnerabilities and mitigation strategies.

Uncovering layer by layer the risk of nanoplastics to the environment and human health.

Impact of micro-nano plastics in daily life on human health: toxicological evaluation from the perspective of normal tissue cells and organoids.

Miscellaneous

Melamine regulatory assessment for endocrine disruption.

Food packaging solutions in the post-per- and polyfluoroalkyl substances (PFAS) and microplastics era: A review of functions, materials, and bio-based alternatives.

Human Health Studies

Numerous Chemicals/Mixtures

The benefits of removing toxic chemicals from plastics.

Early-life exposures to phenols, parabens and phthalates and fat mass at 3 years of age in the SEPAGES cohort.

Increased health risk from co-exposure to polycyclic aromatic hydrocarbons, phthalates, and per- and polyfluoroalkyl substances: Epidemiological insight from e-waste workers in Hong Kong.

Impact of metabolism-disrupting chemicals and folic acid supplementation on liver injury and steatosis in mother-child pairs.

BPA/Phenols

A pilot study: relationship between Bisphenol A, Bisphenol-glucuronide and total 25 hydroxy vitamin D in maternal-child pairs in a South African population.

Correlation of bisphenol A and bisphenol S exposure with the metabolic parameters on FDG PET/CT image.

The correlation of bisphenol A exposure on inflammatory cytokines in preschool children.

Urinary concentrations of eighteen environmental phenols and the associations with feeding pattern in infants in the first 6 months of life.

Phthalates

Prenatal exposure to phthalates and phthalate replacements in relation to chorionic plate surface vasculature at delivery.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

A new approach to study stochastic epigenetic mutations in sperm methylome of Vietnam war veterans directly exposed to Agent Orange.

Association between mixed exposure to dioxins and dioxin-like polychlorinated biphenyls and obesity among U.S. adults.

PFAS

Maternal concentrations of perfluoroalkyl sulfonates and alterations in white matter microstructure in the developing brains of young children.

Associations of PFAS concentrations during pregnancy and midlife with bone health in midlife: Cross-sectional and prospective findings from Project Viva.

Individual and joint associations of exposure to per- and polyfluoroalkyl substances with children’s mitochondrial DNA copy number, and modified by estimated glomerular filtration rate.

Associations between prenatal exposure to PFAS and cardiometabolic health in preadolescents.

Serum metabolome associated with novel and legacy per- and polyfluoroalkyl substances exposure and thyroid cancer risk: A multi-module integrated analysis based on machine learning.

Pesticides

Prenatal Exposure of Pesticide Mixtures and the Placental Transcriptome: Insights from Trimester-specific, Sex-Specific and Metabolite-Scaled Analyses in the SAWASDEE Cohort.

Multiple pesticide exposure and impaired glucose regulation in US non-diabetic population.

Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults.

Urinary Neonicotinoid Exposure and Its Association with Hypertension and Dyslipidemia Among the Elderly: A Cross-Sectional Study in Shenzhen, China.

Metals/Metalloids

Association between urinary cadmium levels and prevalence of coronary artery disease: NHANES cross-sectional study (2009-2018).

Association of low-level heavy metal exposure with risk of chronic kidney disease and long-term mortality.

Urinary arsenic species and birth outcomes in Tacna, Peru, 2019: a prospective cohort study.

Deciphering the impact of heavy metal mixed exposure on lipid metabolism using three statistical models.

Air Pollution

Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study.

Laboratory Studies

Numerous Chemicals/Mixtures

An estrogenic municipal effluent decreased fathead minnow reproduction to a near stop.

Plastic additives affect estrogenic pathways and lipid metabolism in precision – cut – liver slices in Atlantic cod (Gadus morhua).

BPA/Phenols

Reproductive toxicity of bisphenol A and nitro-bisphenol A in male zebrafish at environmentally relevant concentrations.

Comparative study of cytotoxic Signaling pathways in H1299 cells exposed to alternative Bisphenols: BPA, BPF, and BPS.

Protective Effects of Adipose Mesenchymal Stem Cell Secretome On Oxidative Stress-Induced Bisphenol-A in Isolated Rat Testes Mitochondria and Sperm Quality.

Long-term exposure to bisphenol-A causes oxidative stress-related alterations at the genetic and cellular levels in the mature ovary of adult zebrafish.

Phthalates

Myricetin alleviates the mechanism of IL-1β production caused by the endocrine-disrupting chemical Di(2-ethylhexyl) phthalate in RAW 264.7 cells.

DINCH Exposure Triggers Inflammatory, Oxidative, and Apoptotic Pathways in the Liver of Long-Evans Lactating Rats and Their Offspring.

Parabens/Triclosan/Antimicrobials

Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to PCB52 (2,2′,5,5′-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose.

PFAS

Perfluorohexanesulfonic Acid (PFHxS) Induces Hepatotoxicity through the PPAR Signaling Pathway in Larval Zebrafish (Danio rerio).

Increased perfluorooctanoic acid accumulation facilitates the migration and invasion of lung cancer cells via remodeling cell mechanics.

Predicting the molecular mechanisms of cardiovascular toxicity induced by per- and polyfluoroalkyl substances: an In Silico network toxicology perspective.

Perfluorooctane sulfonate (PFOS) induced bone loss by inhibiting FoxO1-mediated defense against oxidative stress in osteoblast.

Melatonin Attenuates PFOS-Induced Reproductive Toxicity of Pregnant Mice due to Placental Damage Via Antioxidant, Anti-Aging and Anti-Inflammatory Pathways.

Flame Retardants

Polybrominated diphenyl ether flame retardants inhibit growth factor-induced activation of EGFR by binding to its extracellular domain.

Prenatal Triphenyl Phosphate Exposure and Hyperlipidemia in Offspring: Role of Trophoblast-Derived Extracellular Vesicle PPARγ.

Tributyl phosphate inhibits neurogenesis and motor functions during embryonic development in zebrafish.

Exposure to triphenyl phosphate during pregnancy: The role of gut-bile acids-liver axis on lipid metabolism in male offspring.

Uncovering toxin production and molecular-level responses in Microcystis aeruginosa exposed to the flame retardant Tetrabromobisphenol A.

Pesticides

Effects of Chlorpyrifos on gut dysbiosis and barriers integrity in women with a focus on pregnancy and prebiotic intervention: insights from advanced in vitro human models.

A New Insight into the Mechanism of Atrazine-Induced Neurotoxicity: Triggering Neural Stem Cell Senescence by Activating the Integrated Stress Response Pathway.

Melatonin protects spermatogenic cells against DNA damage and necroptosis induced by atrazine.

Chronic chlorpyrifos exposure induces oxidative stress, neurological damage, and hepatopancreas enrichment in Chinese mitten crab (Eriocheir sinensis).

Metals/Metalloids

Arsenic exposure accelerates type 1 diabetes mellitus progression via pyroptosis pathway in mice.

Arsenic inducible islet β-cell dysfunction and ferroptosis through m⁶A-YTHDF2-dependent CHAC1 enhancement.

Helicobacter pylori promotes intestinal flora imbalance and hepatic metabolic disorders under arsenic stress.

Consuming probiotics protects against cadmium exposure from rice consumption while promotes gut health: An assessment based on a mouse model.

Microplastics/Nanomaterials

Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction.

Assessing the chemical interactions and biological effects of a petrochemical and bio-based plastic with a common plastic flame retardant and solvent.

Polypropylene microplastics triggered mouse kidney lipidome reprogramming combined with ROS stress as revealed by lipidomics and Raman biospectra.

Polystyrene microplastics exacerbate acetochlor-induced reproductive toxicity and transgenerational effects in zebrafish.

Invisible but Insidious Effects of Microplastics.

Resveratrol Butyrate Esters Reduce Hypertension in a Juvenile Rat Model of Chronic Kidney Disease Exacerbated by Microplastics.

Effects of Combined Exposure to 17α-Methyltestosterone and Polystyrene Microplastics on Lipid Metabolism and the Nervous System in Danio rerio.

Miscellaneous

6-PPD quinone causes lipid accumulation across multiple generations differentially affected by metabolic sensors and components of COMPASS complex in Caenorhabditis elegans.

6PPD induces cerebrovascular defects by triggering oxidative stress and ferroptosis in zebrafish.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Plasticizer exposure in Germany from 1988 to 2022: Human biomonitoring data of 20 plasticizers from the German Environmental Specimen Bank.

BPA/Phenols

Development of the Bisphenol A exposure scale in adults.

Phthalates

Impacts of COVID-19 Pandemic: Phthalate Esters Released from Face Masks and its Associated Exposure Risk.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated biphenyls and polybrominated diphenyl ethers in infant food: Occurrence and exposure assessment.

PFAS

Sensitive and accurate determination of 32 PFAS in human serum using online SPE-UHPLC-HRMS.

Temporal and spatial distribution of inorganic fluoride, total adsorbable organofluorine, PFOA and PFOS concentrations in the Hungarian section of the Danube River.

Perfluoroalkyl substances (PFASs) in groundwater and surface water in the Turin metropolitan area (Italy): An attempt to unravel potential point sources and compliance with environmental/drinking water quality standards.

Characterization of PFAS Residuals: A Case Study on PFAS Content in a Firefighting Foam Delivery System of an Aircraft Rescue and Firefighting Vehicle.

Assessing PFAS in Drinking Water: Insights from the Czech Republic’s Risk-Based Monitoring Approach.

Flame Retardants

Organophosphate flame retardants and their metabolites in paired dog food and urine: Pet exposure through food consumption.

Metals/Metalloids

Biomonitoring of toxic metal exposure in New Jersey adults in 2015-2018.

Microplastics/Nanomaterials

Determination of additives as markers of microplastic contamination in the environment.

Characteristics of heavy metal migration from virgin PET and recycled PET plastic bottles in beverage products.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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