EDC Science Weekly, Aug. 5 – 11, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Aug 13, Dr. Leo Trasande will discuss his new paper recently published in The Lancet Diabetes and Endocrinology: “Endocrine-disrupting chemicals: implications for human health”

Regulations/Policy

Can direct environmental regulation promote green technology innovation in heavily polluting industries? Evidence from Chinese listed companies.

Towards a tiered test strategy for plant protection products to address mixture toxicity by alternative approaches in human health assessment

Methods/Tools/Screening

Chemical Screening of Nuclear Receptor Modulators. [review]

Assessing species-specific differences for nuclear receptor activation for environmental water extracts.

Predictive modeling of estrogen receptor agonism, antagonism, and binding activities using machine- and deep-learning approaches

Is there an optimal sampling time and number of samples for assessing exposure to fast elimination endocrine disruptors with urinary biomarkers? [10 to 31 samples were necessary to correctly classify most subjects into quartiles according to their level of exposure]

Commentaries/Conference Summaries

Special Issue “Health Effects of Agrochemicals as Endocrine Disruptors” [in Mol Cell Endocrinol, see collection here]

Impacts of environmental issues on health and well-being: a global pollution challenge [re the International Caparica Conference on Pollution Metal Ions and Molecules (PTIM)]

Reviews

Numerous EDCs

How microplastic components influence the immune system and impact on children health: Focus on cancer. [BPA and phthalates]

Effects of endocrine disruptors on fetal testis development, male puberty, and transition age.

Mitochondrial epigenetics and environmental health: making a case for endocrine disrupting chemicals

Epigenetic Modifications due to Environment, Ageing, Nutrition, and Endocrine Disrupting Chemicals and Their Effects on the Endocrine System

BPA/Phenols

Biomass-derived chemical substitutes for bisphenol A: recent advancements in catalytic synthesis.

Phthalates

Mechanism of phthalate esters in the progression and development of breast cancer.

Critical Review on the Presence of Phthalates in Food and Evidence of Their Biological Impact

Parabens

Using assessment criteria for pesticides to evaluate the endocrine disrupting potential of non-pesticide chemicals: Case butylparaben

Perfluoroalkyl Substances

Per- and polyfluoroalkyl substances and male reproductive health: a systematic review of the epidemiological evidence.

U.S. Department of Defense-Funded Research on Treatment of Per- and Polyfluoroalkyl Substance-Laden Materials.

Exposure characteristics for congeners, isomers, and enantiomers of perfluoroalkyl substances in mothers and infants

Flame Retardants

Tris(2-chloroethyl) phosphate, a pervasive flame retardant: critical perspective on its emissions into the environment and human toxicity.

Release kinetics as a key linkage between the occurrence of flame retardants in microplastics and their risk to the environment and ecosystem: A critical review

Pesticides

Harnessing microbial volatiles to replace pesticides and fertilizers.

Analytical Methods to Analyze Pesticides and Herbicides.

Herbicides based on 2,4-D: its behavior in agricultural environments and microbial biodegradation aspects. A review

Potentially Toxic Elements

Arsenic and Obesity: a Review of Causation and Interaction.

Effect of fluoride on endocrine tissues and their secretory functions — review.

Arsenic and Other Geogenic Contaminants in Groundwater – A Global Challenge

Microplastics/Nanoplastics

Bibliometric Profile of Global Microplastics Research from 2004 to 2019.

Environmental fate, toxicity and risk management strategies of nanoplastics in the environment: Current status and future perspectives.

The Toxicity Phenomenon and the Related Occurrence in Metal and Metal Oxide Nanoparticles: A Brief Review From the Biomedical Perspective.

Toxicity of engineered nanomaterials to aquatic and land snails: A scientometric and systematic review.

A critical review of harm associated with plastic ingestion on vertebrates.

The detrimental effect of microplastics on critical periods of development in the neuroendocrine system

Air Pollution

Air Pollution and Alzheimer’s Disease: A Systematic Review and Meta-Analysis.

Early-life exposure to air pollution and childhood allergic diseases: An update on the link and its implications.

Potential link between compromised air quality and transmission of the novel corona virus (SARS-CoV-2) in affected areas.

Effects of particulate matter on atherosclerosis: a link via high-density lipoprotein (HDL) functionality?

The association between air pollution and cancers: controversial evidence of a systematic review.

Maternal exposure to air pollution and the risk of low birth weight: a meta-analysis of cohort studies

The association between traffic-related air pollution and obstructive sleep apnea: A systematic review.

Air Pollution and Adverse Pregnancy and Birth Outcomes: Mediation Analysis Using Metabolomic Profiles

Miscellaneous

The estrogenic activity of resveratrol: a comprehensive review of in vitro and in vivo evidence and the potential for endocrine disruption.

Early life risk and resiliency factors and their influences on developmental outcomes and disease pathways: a rapid evidence review of systematic reviews and meta-analyses.

Environmental Impact on Male (In)Fertility via Epigenetic Route.

Early life exposure to nicotine: Postnatal metabolic, neurobehavioral and metabolic outcomes and the development of childhood cancers.

The effects of exposure to crude oil or PAHs on fish swim bladder development and function

Human Health Studies

Numerous Chemicals

Pooled analysis of genotoxicity markers in relation to exposure in the Flemish Environment and Health Studies (FLEHS) between 1999 and 2018.

The Association between Seafood Intake and Fecundability: Analysis from Two Prospective Studies.

Levels of endocrine disrupting chemicals associated with the peri-pubertal epigenome.

Mixtures

The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma.

Exposure to environmental chemical mixtures is associated with nasal colonization by Staphylococcus aureus: NHANES 2001-2004

BPA/Phthalates

Association between prenatal bisphenol A exposure and promoter hypermethylation of CAPS2, TNFRSF25, and HKR1 genes in cord blood

Exposures to phthalates and bisphenols in pregnancy and postpartum weight gain in a population-based longitudinal birth cohort.

Decreased levels of urinary di-2-ethylhexyl phthalate (DEHP) metabolites and biomarkers of oxidative stress in children exposed to DEHP-tainted foods in Taiwan in 2011: A 44-month follow-up.

A combined cohort analysis of prenatal exposure to phthalate mixtures and childhood asthma

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors

Perfluoroalkyl Substances

Per- and poly-fluoroalkyl substances (PFASs) in follicular fluid from women experiencing infertility in Australia.

Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children

Pesticides

Organophosphate Pesticides Exposure during Fetal Development and IQ Scores in 3 and 4-Year Old Canadian Children

Ambient Exposure to Agricultural Pesticides during Pregnancy and Risk of Cerebral Palsy: A Population-Based Study in California.

Association between pesticide usage during pregnancy and neonatal hyperbilirubinemia requiring treatment: the Japan Environment and Children’s Study.

Potentially Toxic Elements

Urinary metals and incident diabetes in midlife women: Study of Women’s Health Across the Nation (SWAN).

Alterations in Th17 and Treg Lymphocyte Subset in Workers Occupationally Exposed to Lead.

Study of occupational exposure to brick kiln emissions on heavy metal burden, biochemical profile, cortisol level and reproductive health risks among female workers at Rawat, Pakistan.

Blood lead levels among the occupationally exposed workers and its effect on calcium and vitamin D metabolism: A case-control study.

Prenatal toxic metal mixture exposure and newborn telomere length: modification by maternal antioxidant intake

Association of blood cadmium levels in pregnant women with infant birth size and small for gestational age infants: The Japan Environment and Children’s Study

Air Pollution

Particle air pollution and gestational diabetes mellitus in Houston, Texas.

Association between prenatal exposure to PM 2.5 and the increased risk of specified infant mortality in South Korea

Early life exposure to air pollution, green spaces and built environment, and body mass index growth trajectories during the first 5 years of life: A large longitudinal study.

Examining the relationship between ambient carbon monoxide, nitrogen dioxide, and mental health-related emergency department visits in California, USA.

Evidence-Based Considerations Exploring Relations between SARS-CoV-2 Pandemic and Air Pollution: Involvement of PM2.5-Mediated Up-Regulation of the Viral Receptor ACE-2.

Satellite-detected tropospheric nitrogen dioxide and spread of SARS-CoV-2 infection in Northern Italy.

Is obesity the missing link between COVID-19 severity and air pollution?

COVID-WAREHOUSE: A Data Warehouse of Italian COVID-19, Pollution, and Climate Data.

Region-specific air pollutants and meteorological parameters influence COVID-19: A study from mainland China

Ambient air pollution and cause-specific risk of hospital admission in China: A nationwide time-series study.

The association between ambient air pollution concentrations and psychological distress.

Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry).

Concomitant exposure to area-level poverty, ambient air volatile organic compounds, and cardiometabolic dysfunction: a cross-sectional study of U.S. adolescents

Association between fine Particulate Matter and Fatal Hemorrhagic Stroke Incidence: A Time Stratified Case-crossover Study in Shanghai, China

Short-Term Air Pollution as a Risk for Stroke Admission: A Time-Series Analysis

Miscellaneous

Chronic respiratory morbidity in the Bhopal gas disaster cohorts: a time-trend analysis of cross-sectional data (1986-2016).

Laboratory Studies

BPA/Phenols

Identification of receptors for eight endocrine disrupting chemicals and their underlying mechanisms using zebrafish as a model organism. [BPA, triclosan, and more]

In vitro effects of emerging bisphenols on myocyte differentiation and insulin responsiveness.

Impacts of bisphenol A analogues on zebrafish post-embryonic brain.

Bisphenol-A analogue (bisphenol-S) exposure alters female reproductive tract and apoptosis/oxidative gene expression in blastocyst-derived cells.

The prostaglandin synthases, COX-2 and L-PGDS, mediate prostate hyperplasia induced by low-dose bisphenol A.

In vitro evaluation of the hepatic lipid accumulation of bisphenol analogs: A high-content screening assay.

Paternal Exposure to Bisphenol-A Transgenerationally Impairs Testis Morphology, Germ Cell Associations, and Stemness Properties of Mouse Spermatogonial Stem Cells.

Bisphenol A in utero exposure induces ovary dysfunction in mice offspring and the ameliorating effects of Cuscuta chinensis flavonoids

Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca 2+ Signals in Boar Sperm Cells

Chronic exposure of BPA impairs male germ cell proliferation and induces lower sperm quality in male mice

Pistacia integerrima alleviated Bisphenol A induced toxicity through Ubc13/p53 signalling

Phthalates

Ascorbic acid ameliorates dysregulated folliculogenesis induced by mono-(2-ethylhexyl)phthalate in neonatal mouse ovaries via reducing ovarian oxidative stress.

Development of a physiologically based pharmacokinetic model of diisononyl phthalate (DiNP) in pregnant rat and human

Parabens/Personal Care Products

Effects of methylparaben on in vitro maturation of porcine oocytes.

Acute and chronic exposure of the holometabolous life cycle of Aedes aegypti L. to emerging contaminants naproxen and propylparaben

Toxicological responses of Carassius auratus induced by benzophenone-3 exposure and the association with alteration of gut microbiota

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Changes in Histophysiology of the Adrenal Medulla in Rats after Prenatal and Postnatal Exposure to Endocrine Disruptor DDT.

Targeting on Gut Microbiota-Derived Metabolite Trimethylamine to Protect Adult Male Rat Offspring against Hypertension Programmed by Combined Maternal High-Fructose Intake and Dioxin Exposure.

Protocatechuic acid modulates reproductive dysfunction linked to furan exposure in rats.

Emerging contaminant 1,3,6,8-tetrabromocarbazole induces oxidative damage and apoptosis during the embryonic development of zebrafish (Danio rerio).

Effects of 2,3′,4,4′,5-pentachlorobiphenyl exposure during pregnancy on DNA methylation in the testis of offspring in the mouse

Comparison of the biological behaviors of palatal mesenchymal and epithelial cells induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vitro

Perfluoroalkyl Substances

Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled estrogen receptor: spectroscopic analyses and computational simulations.

Concentration- and nutrient-dependent cellular responses of microalgae Chlorella pyrenoidosa to perfluorooctanoic acid

[Effects of PFOS on inflammatory factors in human placental trophoblast cells]. [in Chinese]

Flame Retardants

Cytotoxicity of hexabromocyclododecane, 1,2-dibromo-4-(1,2-dibromoethyl) cyclohexane and 1,2,5,6-tetrabromocyclooctane in human SH-SY5Y neuroblastoma cells.

Pesticides

Effects of the chorion on the developmental toxicity of organophosphate esters in zebrafish embryos.

Perinatal exposure to a dietary pesticide cocktail does not increase susceptibility to high-fat diet-induced metabolic perturbations at adulthood but modifies urinary and fecal metabolic fingerprints in C57Bl6/J mice.

Evaluation of the anti-oxidant effect of ascorbic acid on apoptosis and proliferation of germinal epithelium cells of rat testis following malathion-induced toxicity.

Ecotoxicological evaluation of fungicides used in viticulture in non-target organisms.

Quantitative T₂ MRI is predictive of neurodegeneration following organophosphate exposure in a rat model.

Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor.

DNA damage, immunotoxicity, and neurotoxicity induced by deltamethrin on the freshwater crayfish, Procambarus clarkii.

Impact of herbicide pretilachlor on reproductive physiology of walking catfish, Clarias batrachus (Linnaeus)

Glyphosate-based herbicides influence antioxidants, reproductive hormones and gut microbiome but not reproduction: A long-term experiment in an avian model

Effect of age on insecticide susceptibility and enzymatic activities of three detoxification enzymes and one invertase in honey bee workers (Apis mellifera)

The protective effects of melatonin on survival, immune response, digestive enzymes activities and intestinal microbiota diversity in Chinese mitten crab (Eriocheir sinensis) exposed to glyphosate

Genetic Variation Influences Tolerance to a Neonicotinoid Insecticide in Three Butterfly Species

Dietary quercetin impacts the concentration of pesticides in honey bees

Potentially Toxic Elements

Environmental exposure to cadmium impairs fetal growth and placental angiogenesis via GCN-2-mediated mitochondrial stress

Chronic arsenic exposure induces the time-dependent modulation of inflammation and immunosuppression in spleen.

Microplastics/Nanoparticles

Long-term exposure to microplastics induces oxidative stress and a pro-inflammatory response in the gut of Sparus aurata Linnaeus, 1758.

Toxicity of iron nanoparticles towards primary cultures of human bronchial epithelial cells.

Bioaccumulation and reproductive effects of fluorescent microplastics in medaka fish.

Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae

Air Pollution

Thymoquinone ameliorates the PM2.5-induced lung injury in rats.

Intermittent fasting ameliorates PM_2.5 exposure-induced abnormalities in glycaemic control.

Embryonic gene expression altered by maternal exposure to air pollution in rats

Particulate matter (PM10) enhances RNA virus infection through modulation of innate immune responses

Pharmaceuticals

Prenatal diclofenac exposure delays pubertal development and induces behavioral changes in rats

Mixtures

Combined effects of mulch film-derived microplastics and atrazine on oxidative stress and gene expression in earthworm (Eisenia fetida).

A polycyclic aromatic hydrocarbon-enriched environmental chemical mixture enhances AhR, antiapoptotic signaling and a proliferative phenotype in breast cancer cells.

Integrated ecotoxicological assessment of the complex interactions between chlorpyrifos and glyphosate on a non-target species Cnesterodon decemmaculatus (Jenyns, 1842).

Bioassay guided analysis coupled with non-target chemical screening in polyethylene plastic shopping bag fragments after exposure to simulated gastric juice of Fish. [phenols, phthalates, etc.]

The individual and combined effects of cadmium, polyvinyl chloride (PVC) microplastics and their polyalkylamines modified forms on meiobenthic features in a microcosm

Toxicological effects of microplastics and heavy metals on the Daphnia magna

Miscellaneous

Sensitivity of a PER.C6® Cell Line to bis(2,4-di-tert-butylphenyl)phosphate (bDtBPP) and Evaluation of a New, Biocompatible Single-Use Film.

Exposure to benzo[a]pyrene triggers distinct patterns of microRNA transcriptional profiles in aquatic firefly Aquatica wuhana (Coleoptera: Lampyridae).

Exposure/Environment Studies

Phenols

Nonylphenol ethoxylates biodegradation increases estrogenicity of textile wastewater in biological treatment systems.

Phthalates

Estimation of Dietary Exposure to Contaminants Transferred from the Packaging in Fatty Dry Foods Based on Cereals.

Assessing the potential risk and relationship between microplastics and phthalates in surface seawater of a heavily human-impacted metropolitan bay in northern China.

Skin transferability of phthalic acid ester plasticizers and other plasticizers using model polyvinyl chloride sheets.

Prevalent phthalates in air-soil-vegetable systems of plastic greenhouses in a subtropical city and health risk assessments.

Parabens/Personal Care Products

Metabolites of the fragrance 2-(4-tert-butylbenzyl)propionaldehyde (lysmeral) in urine of children and adolescents in Germany – Human biomonitoring results of the German Environmental Survey 2014-2017 (GerES V).

Parabens in stretch mark creams: A source of exposure in pregnant and lactating women.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Concentration of polychlorinated biphenyls in serum from New Jersey biomonitoring study: 2016-2018

Blood mercury and plasma polychlorinated biphenyls concentrations in pregnant Inuit women from Nunavik: Temporal trends, 1992-2017.

Investigating the presence of emerging and legacy POPs in European domestic air.

Congener patterns of polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls as a useful aid to source identification during a contamination incident in the food chain.

Coastal biomonitoring survey on persistent organic pollutants using oysters (Saccostrea mordax) from Okinawa, Japan: Geographical distribution and polystyrene foam as a potential source of hexabromocyclododecanes.

Persistent organic pollutants in Kemp’s Ridley sea turtle Lepidochelys kempii in Playa Rancho Nuevo Sanctuary, Tamaulipas, Mexico.

Characterization of mono- to deca-chlorinated biphenyls in a well-preserved sediment core from Beppu Bay, Southwestern Japan: Historical profiles, emission sources, and inventory.

Bioaccumulation of persistent organic pollutants in the gonads of Barbus barbus (Linnaeus, 1758)

Yellow-legged gull eggs (Larus michahellis) as persistent organic pollutants and trace metal bioindicator for two nearby areas with different human impact

Perfluoroalkyl Substances

Impact of the Sediment Organic vs. Mineral Content on Distribution of the Per- and Polyfluoroalkyl Substances (PFAS) in Lake Sediment

Flame Retardants

Occurrence and risk assessment of organophosphate esters in urban rivers from Piracicaba watershed (Brazil).

Analysis of polybrominated diphenyl ethers, hexabromocyclododecanes, and legacy and emerging phosphorus flame retardants in human hair

Legacy and emerging flame retardants (FRs) in the urban atmosphere of Pakistan: Diurnal variations, gas-particle partitioning and human health exposure.

Polybrominated diphenyl ethers in plastic waste of electrical and electronic equipment: a case study in Belarus

Young infants’ exposure to organophosphate esters: Breast milk as a potential source of exposure

Organotins

Tissue distribution of triphenyltin compounds in marine teleost fishes.

Pesticides

Exposure and cumulative risk assessment to non-persistent pesticides in Spanish children using biomonitoring.

Health risk assessment of 42 pesticide residues in Tieguanyin tea from Fujian, China.

Glyphosate in Portuguese Adults – A Pilot Study.

A three-year large scale study on the risk of honey bee colony exposure to blooming sunflowers grown from seeds treated with thiamethoxam and clothianidin neonicotinoids

Potentially Toxic Elements

Exposure to uranium and co-occurring metals among pregnant Navajo women.

Human biomonitoring of metals in sub-Arctic Dene Communities of the Northwest Territories, Canada

Low mercury, cadmium and lead concentrations in tuna products from the eastern Pacific.

Multi-pathway mercury health risk assessment, categorization and prioritization in an abandoned mercury mining area: A pilot study for implementation of the Minamata Convention.

Response of male reproductive function to environmental heavy metal pollution in a free-living passerine bird, Passer montanus

Microplastics/Nanoplastics

A survey on knowledge and awareness on the issue “microplastics”: a pilot study on a sample of future public health professionals.

The long-term legacy of plastic mass production.

Is incineration the terminator of plastics and microplastics?

Microbial carbon metabolic functions of biofilms on plastic debris influenced by the substrate types and environmental factors.

Nanoplastics affect moulting and faecal pellet sinking in Antarctic krill (Euphausia superba) juveniles.

Analysis of microplastics in a remote region of the Tibetan Plateau: Implications for natural environmental response to human activities.

An examination of the occurrence and potential risks of microplastics across various shellfish.

Contamination of stream fish by plastic waste in the Brazilian Amazon.

Air Pollution

Metals and Particulates Exposure from a Mobile E-Waste Shredding Truck: A Pilot Study.

Implications for air quality management of changes in air quality during lockdown in Auckland (New Zealand) in response to the 2020 SARS-CoV-2 epidemic.

Reductions in traffic-related black carbon and ultrafine particle number concentrations in an urban neighborhood during the COVID-19 pandemic.

Response of major air pollutants to COVID-19 lockdowns in China.

Biomonitoring of Polycyclic Aromatic Hydrocarbon Deposition in Greenland Using Historical Moss Herbarium Specimens Shows a Decrease in Pollution During the 20^th Century.

Effects of China’s current Air Pollution Prevention and Control Action Plan on air pollution patterns, health risks and mortalities in Beijing 2014-2018

Cross-validation of biomonitoring methods for polycyclic aromatic hydrocarbon metabolites in human urine: Results from the formative phase of the Household Air Pollution Intervention Network (HAPIN) trial in India.

A field-based quantitative analysis of sublethal effects of air pollution on pollinators

Pharmaceuticals

Occurrence and ecological risks of pharmaceuticals in a Mediterranean river in Eastern Spain.

Assessment of Sucralose, Caffeine and Acetaminophen as Anthropogenic Tracers in Aquatic Systems Across Florida.

Toxicity prediction and effect characterization of 90 pharmaceuticals and illicit drugs measured in plasma of fish from a major European river (Sava, Croatia)

Occurrence and ecological risk assessment of pharmaceuticals and cocaine in a beach area of Guarujá, São Paulo State, Brazil, under the influence of urban surface runoff

Mixtures/Numerous EDCs

Occurrence and risk assessment of emerging contaminants in a water reclamation and ecological reuse project.

Occurrence of regulated pollutants in populated Mediterranean basins: Ecotoxicological risk and effects on biological quality

Miscellaneous

Framing Effects in Risk Communication Messages – Hazard Identification vs. Risk Assessment.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.