EDC Science Weekly, Aug. 4 – 10, 2022 – HEEDS

EDC Science Weekly, Aug. 4 – 10, 2022

Post author:HEEDS
Post published:August 10, 2022
Post category:EDC Science Weekly

Contents: Regulations/Policy, Methods/Tools/Screening, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Health, Pesticide Adjuvants, and Inert Ingredients: California Case Study Illustrates Need for Data Access. and related Invited Perspective: Pesticide Adjuvants and Inert Ingredients – A Missing Piece of the Puzzle.

Linear non-threshold (LNT) fails numerous toxicological stress tests: Implications for continued policy use.

Strategic science translation in emerging science: genetically modified crops and Bisphenol A in two cases of contested animal toxicity studies.

Methods/Tools/Screening

Assembly and Curation of Lists of Per- and Polyfluoroalkyl Substances (PFAS) to Support Environmental Science Research.

Development of an adverse outcome pathway network for breast cancer: a comprehensive representation of the pathogenesis, complexity and diversity of the disease.

Application of ToxCast/Tox21 data for toxicity mechanism-based evaluation and prioritization of environmental chemicals: Perspective and limitations.

High-throughput screening paradigms in ecotoxicity testing: Emerging prospects and ongoing challenges.

Reference Chemical Potency List (RCPL): A new tool for evaluating the accuracy of skin sensitisation potency measurements by New Approach Methodologies (NAMs).

Reviews

Numerous Chemicals/Mixtures

Sex specific effects of endocrine-disrupting chemicals on brain monoamines and cognitive behavior.

Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Legacy and emerging pollutants in Latin America: A critical review of occurrence and levels in environmental and food samples.

Perfluoroalkyl Substances

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes.

Flame Retardants

An overview of organophosphate esters and their metabolites in humans: Analytical methods, occurrence, and biomonitoring.

Microplastics/Nanomaterials

Microplastic pollution in soils, plants, and animals: A review of distributions, effects and potential mechanisms.

Coronas of micro/nano plastics: a key determinant in their risk assessments.

Towards a North Pacific Ocean long-term monitoring program for plastic pollution: A review and recommendations for plastic ingestion bioindicators.

Pharmaceuticals/Personal Care Products

Global groundwater vulnerability for Pharmaceutical and Personal care products (PPCPs): The scenario of second decade of 21st century.

Human Health Studies

Numerous Chemicals/Mixtures

Association between exposure to a mixture of metals, parabens, and phthalates and fractional exhaled nitric oxide: A population-based study in US adults.

BPA/Phenols

Effect of Bisphenol A-Mediated RBP-4 on Pregnancy Outcomes in Nonobese Pregnant Female with Subclinical Hypothyroidism.

Bisphenol A analogues in associations with serum hormone levels among reproductive-aged Chinese men.

Phthalates

Application of growth modeling to assess the impact of hospital-based phthalate exposure on preterm infant growth parameters during the neonatal intensive care unit hospitalization.

Flame Retardants

Association between organophosphorus flame retardants exposure and cognitive impairment among elderly population in southern China.

Pesticides

The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013-2014.

Potential Mechanisms Involved in Chronic Kidney Disease of Unclear Etiology.

Effects of prenatal and infant daily exposure to pyrethroid pesticides on the language development of 2-year-old toddlers: a prospective cohort study in rural Yunnan, China.

Potentially Toxic Elements

Exposure to multiple toxic metals and polycystic ovary syndrome risk: Endocrine disrupting effect from As, Pb and Ba.

Miscellaneous

Urinary polycyclic aromatic hydrocarbon excretion and regional body fat distribution: evidence from the U.S. National Health and Nutrition Examination Survey 2001-2016.

Laboratory Studies

Numerous Chemicals/Mixtures

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males.

Amphibian Metamorphosis Assay: Investigation of the potential effects of five chemicals on the hypothalamic-pituitary thyroid axis of Xenopus laevis. [phthalates, nonylphenol, etc.]

BPA/Phenols

New insights into the effect of bisphenol AF exposure on maternal mammary glands at various stages of gestation in mice.

Bisphenols A, F, S and AF trigger apoptosis and/or endoplasmic reticulum stress in human endometrial stromal cells.

Perinatal exposure to environmental endocrine disruptor bisphenol A aggravates the onset of non-alcoholic fatty liver disease (NAFLD) in weanling F1 offspring of obese rats.

Phthalates

Di-n-butyl Phthalate Regulates Vascular Smooth Muscle Cells Phenotypic Switching by MiR-139-5p-MYOCD Pathways.

Multi-omics profiling and biochemical assays reveal the acute toxicity of environmental related concentrations of Di-(2-ethylhexyl) phthalate (DEHP) on the gill of crucian carp (Carassius auratus).

Development of ecological risk assessment for Diisobutyl phthalate and di-n-octyl phthalate in surface water of China based on species sensitivity distribution model.

Physiologically-based toxicokinetic modeling of human dermal exposure to diethyl phthalate: Application to health risk assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Inadvertently Generated PCBs in Consumer Products: Concentrations, Fate and Transport, and Preliminary Exposure Assessment.

Perfluoroalkyl Substances

Identification of molecular initiating events and key events leading to endocrine disrupting effects of PFOA: Integrated molecular dynamic, transcriptomic, and proteomic analyses.

Internal extractive electrospray ionization mass spectrometry for investigating the phospholipid dysregulation induced by perfluorooctanoic acid in Nile tilapia.

Comparative cytotoxicity of seven per- and polyfluoroalkyl substances (PFAS) in six human cell lines.

Oxidative stress and Cx43-mediated apoptosis are involved in PFOS-induced nephrotoxicity.

Flame Retardants

Bidirectional regulation of BDE-47 on 3T3-L1 cell differentiation based on a restricted cubic spline model.

Melatonin administration alleviates 2,2,4,4-tetra-brominated diphenyl ether (PBDE-47)-induced necroptosis and secretion of inflammatory factors via miR-140-5p/TLR4/NF-κB axis in fish kidney cells.

Polybrominated diphenyl ether quinone exposure leads to ROS-driven lysosomal damage, mitochondrial dysfunction and NLRP3 inflammasome activation.

Pesticides

Developmental and reproduction toxicity of Piperonyl Butoxide Part 1 Developmental Safety of Piperonyl Butoxide in the CD® (Sprague Dawley) Rat.

Exposure to iprodione induces ROS production and mitochondrial dysfunction in porcine trophectoderm and uterine luminal epithelial cells, leading to implantation defects during early pregnancy.

Integrated Strategy of Network Pharmacology and in vitro Screening to Identify Mechanism of Diazinon-induced Hippocampal Neurotoxicity.

Integrated biomarker approach strongly explaining in vivo sub-lethal acute toxicity of butachlor on Labeo rohita.

Microplastics/Nanomaterials

Investigation of Microplastics in Digestion System: Effect on Surface Microstructures and Probiotics.

Adsorption of di (2-ethylhexyl) phthalate (DEHP) to microplastics in seawater: a comparison between pristine and aged particles.

Comparison of the combined toxicity of polystyrene microplastics and different concentrations of cadmium in zebrafish.

The combined toxic effects of polyvinyl chloride microplastics and di(2-ethylhexyl) phthalate on the juvenile zebrafish (Danio rerio).

Developmental polyethylene microplastic fiber exposure entails subtle reproductive impacts in juvenile Japanese Medaka (Oryzias latipes).

Toxicological impact of environmental microplastics and benzo[a]pyrene in the seaworm Hediste diversicolor under environmentally relevant exposure conditions.

Miscellaneous

Use of biomarker data and metabolite relative potencies to support derivation of noncancer reference values based on the reproductive and developmental toxicity effects of 1,3-butadiene.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Long-term stability of several endocrine disruptors in the first morning urine samples and their associations with lifestyle characteristics.

BPA/Phenols

Hair Sample Analysis of Residents from Olsztyn, Northeastern Poland, to Evaluate Levels of Bisphenol S and Bisphenol A: A Pilot Study.

Human body burden of bisphenol A: a case study of lactating mothers in Florianopolis, Brazil.

Nonylphenol (NP) exposure in Germany between 1991 and 2021: Urinary biomarker analyses in the German Environmental Specimen Bank (ESB).

Phthalates

Phthalic acid esters in grains, vegetables, and fruits: concentration, distribution, composition, bio-accessibility, and dietary exposure.

Wide occurrence of seven phthalate plasticizers and two typical microplastics in pig feed.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Characteristics and health impacts of PM_2.5-bound PCDD/Fs in three Asian countries.

Silicone wristbands as personal passive samplers of exposure to polychlorinated biphenyls in contaminated buildings.

Organochlorine contaminants in Rio skate (Rioraja agassizii), an endangered batoid species, from southeastern coast of Brazil.

Perfluoroalkyl Substances

Do PFAS changes in landfill leachate treatment systems correlate with changes in physical chemical parameters?

Perfluoroalkyl substances in freshwater and marine fish from northern Vietnam: Accumulation levels, profiles, and implications for human consumption.

Flame Retardants

Occurrence, emission sources, and risk assessment of polybrominated diphenyl ethers and current-use brominated flame retardants in settled dust from end-of-life vehicle processing, urban, and rural areas, northern Vietnam.

Pollution level, spatial distribution, and congener fractionation characteristics of low-brominated polybrominated diphenyl ethers (PBDEs) in sediments around Chaohu Lake, China.

Pesticides

Pesticide exposure among Czech adults and children from the CELSPAC-SPECIMEn cohort: Urinary biomarker levels and associated health risks.

Miscellaneous

Integration of probabilistic exposure assessment and risk characterization for perchlorate in infant formula and supplementary food.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.