EDC Science Weekly, Aug. 29 – Sept. 4, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Sept. 10 webinar: The Experiences of PFAS Contamination in Impacted Communities [Mass. Breast Cancer Coalition]

Sept. 12 symposium: Highlighting Duke’s environmental health community [hybrid] [Duke Integrated Toxicology and Environmental Health Program]

Sept. 15: ECHO symposium: translating science to action [hybrid] [NIH Environmental Influences on Child Health Outcomes (ECHO)]

Sept. 15 Grand Rounds: PCBs: A legacy pollutant [on zoom] [Region 1 PEHSU and Boston Children’s Hospital; CE credits available]

Sept. 17 webinar: The Health Effects of Chemicals used in Food Packaging [Alliance of Nurses for Healthy Environments]

Sept. 22: Plastics, Human Health, and Solutions Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards (CIEH)]

Sept. 29 conference: REACH revision 2025: simpler, faster, bolder, in Brussels [HEAL and CHEM Trust]

Oct. 14 webinar: ToxicDocs: A database of once-secret chemical industry documents [CHE]

Oct. 8 – Nov. 19 class: Plastics, Microplastics, and Human Health [Physician and Scientist Network Addressing Plastics and Health (P-SNAP)]

Jan. 11-14: International Conference on Microplastics [in person in Santa Fe; abstracts due Oct. 1]

Note: HEEDS is now accepting applications for the Lou Guillette, Jr. Outstanding Young Investigator Award, due Sept. 30.

More events

Regulations/Policy

Defining pesticide water quality standards for multi-use water resources to protect human health.

Global Plastic Industry Transition Addressing Key Drivers of the Triple Planetary Crisis.

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Methods/Tools/Screening

AOP report: Adverse Outcome Pathway Network for Developmental Androgen Signalling-Inhibition Leading to Short Anogenital Distance in Male Offspring.

Smaller scale, same impact: replicating high-throughput phenotypic profiling in a medium-throughput lab for use in chemical risk assessment.

Construction of testicular organoids and their applications in the field of toxicology.

Factors influencing chemical relative potency in mixture toxicity risk assessment

Refinement of a workflow for human relevance assessment of adverse outcome pathways and associated new approach methodologies.

Revolutionizing toxicological risk assessment: integrative advances in new approach methodologies (NAMs) and precision toxicology.

In Silico Frontiers Shaping the Next Generation of Transformation Product Prediction and Toxicological Assessment.

Commentaries

A Call for a Unified Database to Address Exposure Disparities in the United States.

Why internists should be concerned about glyphosate.

Ultraprocessed Food on an Ultrafast Track

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The Effects of Maternal Endocrinopathies and Exposure to Endocrine Disruptors During Pregnancy on the Fetus and Newborn.

Exogenous Estrogens as Breast Cancer Risk Factors: A Perspective.

Metabolome informs about the chemical exposome and links to brain health.

Environmental and occupational risks to reproductive health in women service members and veterans.

Endocrine Disrupting Chemicals and Female Sexual Health: An Emerging Research Priority.

Chemical Interference: A Review on Endocrine Disruptors and Reproductive Communication in Amphibians.

Chemically-induced histopathological progression in the polycystic ovary syndrome (PCOS)- A review.

The Impact of Endocrine Disruptors on the Female Genital Tract Microbiome: A Narrative Review

Mitochondria: Key Mediator for Environmental Toxicant-Induced Neurodegeneration.

Phthalates

Differential life cycle toxic effects and molecular mechanisms of Di(2-ethylhexyl) phthalate (DEHP) exposure on the female reproductive system.

PFAS

Visceral, Neural, and Immunotoxicity of Per- and Polyfluoroalkyl Substances: A Mini Review.

Per- and Polyfluoroalkyl Substances (PFAS) Contamination in Agriculture and Its Potential Conflict with Circular Economy.

Pesticides

Pre and postnatal exposure to glyphosate-based herbicides and potential neurodevelopmental outcomes: a systematic review of animal and epidemiological studies.

Chlorpyrifos and neuroendocrine function: Concerns for research with free-living mammal populations.

Metals/Metalloids

Neurodevelopmental Outcomes Associated with Early-Life Exposure to Heavy Metals: A Systematic Review

Toxins to treatments: Impact of environmental pollutants, gut microbiota, and natural compounds on non-alcoholic fatty liver disease progression.

Microplastics/Nanomaterials

Microplastics and human fertility: A comprehensive review of their presence in human samples and reproductive implication.

Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.

Effects of Microplastics and Nanoplastics Exposure on Neurogenesis: Are Thymidine Analogs a Good Option to Study Such Effects?

Micro- and Nanoplastics as Emerging Threats to Both Terrestrial and Aquatic Animals: A Comprehensive Review.

How microplastics influence the health and microbiota of aquatic invertebrates: A review.

The Opportunities and Challenges of Biobased Packaging Solutions.

Air Pollution

Wildland firefighter exposure and female cancer risk: currently available evidence

Human Health Studies

Numerous Chemicals/Mixtures

Combined Effect of per- and Polyfluoroalkyl Substances, Toxic Metals, and Essential Elements on Chronic Kidney Disease.

Nanoplastics from single-use polyethylene terephthalate bottles impair the functionality of human gut-dwelling Lactobacillus rhamnosus and induce toxicity in human cells. [PFAS and metals]

Influences of Chemical and Nonchemical Stressors on Health and Quality of Life in Fenceline Communities: A Community-Based Participatory Research Survey in Southeastern Pennsylvania.

BPA/Phthalates

Testing the Development of a Diet-Based Bisphenol a Score to Facilitate Studies on Child Neurodevelopment: A Pilot Project

Association between bisphenol A exposure and dental caries in U.S. population: insights from the NHANES survey.

Associations between environmental phthalates exposure and maternal thyroid hormone levels during pregnancy.

Association of urinary phthalate metabolites and polycystic ovary syndrome in women undergoing in vitro fertilization.

The mediating role of maternal inflammation on associations between first-trimester plasticizer exposure and personal-social and language in infants.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Associations of plasma persistent organic pollutants with brain atrophy, cognitive decline and risk of dementia in older adults.

PFAS

Exposure to per- and polyfluoroalkyl substances during fetal development and risk of testicular germ cell cancer in adulthood.

Socioeconomic Disparities and Risk of Papillary Thyroid Cancer Associated with Environmental Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in Florida

Association Between Serum per- and Polyfluoroalkyl Substances and Iron Status Biomarkers in a Representative Sample of U.S. Adults: NHANES 2013-2018

Metals/Metalloids

Prenatal exposure to metals and metal mixtures influences birth weight in affected populations in the Republic of Suriname, South America.

Heavy metals exposure and HPG-axis related hormones in women across the lifespan: An integrative epidemiological and bioinformatic perspective.

The associations between prenatal rare earth elements exposure and preterm birth: integrate insights from birth cohort and in vitro study.

Microplastics/Nanomaterials

Microplastic contamination in kidney transplant donor tissues and its association with early post-transplant blood pressure changes in recipients: A multi-modal analytical study.

Air Pollution

Association between fine particulate matter (PM_2.5) air pollution and sex ratio at birth in Taiwan.

Laboratory Studies

Numerous Chemicals/Mixtures

Co-exposure to Bisphenol A and Arsenic Enhance Hepatotoxicity in Zebrafish by Targeting the Hypothalamic-Pituitary-Thyroid Axis and PPAR Pathway.

Environmental exposure to endocrine disruptors induces insulin resistance and hepatic inflammation in adult male rats, with partial transmission across subsequent generations.

Influence of perinatal exposure to an endocrine disruptor mixture on the renal microenvironment of aged male rat offspring: histopathological aspects.

Bisphenol A and Di-n-butyl phthalate disrupt bone homeostasis bidirectionally via CD36-mediated BMSCs autophagy inhibition and exosome-promoted osteoclastogenesis.

BPA/Phenols

Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro

Bisphenol A exposure and its impact on childhood obesity: a molecular and genetic perspective.

Bisphenol A increases fat mass in adipose tissue by disturbing gut microbiota-dependent bile acid metabolism and TGR5/UCP1 signaling pathways in CD-1 mice.

The Detrimental Impact of Bisphenol S (BPS) on Trophoblastic Cells and the Ishikawa Cell Lines: An In Vitro Model of Cytotoxic Effect and Molecular Interactions

A novel bisphenol A alternative, DD-70, may negatively affect haemostasis through cyclooxygenase 1 inhibition.

Reproductive Risk Assessment of Bisphenol A and Its Substitutes on Estrogen Receptors (ERs) in Bivalves

Phthalates

Exposure to phthalate mixtures impairs mouse preimplantation embryonic development in an in vitro model.

Exposure to diethyl phthalates impairs ovarian reserve and oocyte maturation in female mice.

Investigating the Mechanism of Phthalates in Breast Cancer Using Molecular Docking and Network Toxicology.

Chronic DBP exposure may cause reduced fertility in female mice by interfering with the HPO axis.

A Transcriptomics-Based Analysis Provides Insights into the Sex-Dependent Reproductive Toxicity of DEHP in Zebrafish (Danio rerio).

Network toxicological insights into DEHP exposure and thyroid cancer development and progression.

Investigation of protective effects of rutin\cyclodextrin inclusion complex against testicular damage caused by diisononyl phthalate in rats.

Attenuation of MEHP-induced hepatotoxicity and gut microbiota dysbiosis by Lactobacillus brevis Lb-0401 in Carassius auratus.

Parabens/Triclosan/Antimicrobials

Intrauterine Triclosan Exposure Disrupts Hypothalamus-Pituitary-Thyroid Axis Function in Offspring Rats.

Protective role of baicalin against methylparaben-induced reproductive toxicity: Insights into hormonal and enzymatic regulation.

PFAS

Effect of the perfluorooctane sulfonamide on glucose and lipid metabolism in 3T3-L1 adipocytes and zebrafish larvae.

Gestational and Lactation Exposure to Perfluorohexanoic Acid Results in Sex-Specific Changes in the Cerebellum in Mice.

Effects of Per- and polyfluoroalkyl substances on atherosclerosis: an evidence-based risk assessment in the context of the TRAEC strategy.

PFBS Disrupts Lipid Metabolism and Mitochondrial Function in Human Trophoblast Cells.

In Vitro Assessment of Dermal Penetration and Skin Barrier Impairment by Per- and Polyfluoroalkyl Substances (PFASs) from Consumer Products.

Hepatotoxicity of 8:2 Polyfluoroalkyl Phosphate Diesters Exposure via JAK2/STAT3 Pathway Activation and M1 Macrophage Polarization in Mice.

Perfluorodecanoic Acid (PFDA) Disrupts Immune Regulation via the Toll-like Receptor Signaling Pathway in Zebrafish.

Flame Retardants

Tetrabromophthalate bis(2-ethylhexyl) ester (TBPH) exposure induces renal inflammation injury by activating MAVS-IRF3 signaling pathway in vitro and in vivo models.

Transcriptomic profiling reveals tetrabromobisphenol A-induced dysregulation of hepatic lipid homeostasis in common carp (Cyprinus carpio).

Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells.

Pesticides

Love in the Time of Pyrethroids: Mating Behavior of Sitophilus zeamais Is Influenced by Sublethal Concentrations of λ-Cyhalothrin and Lateralization.

Abamectin Disrupts Sperm Function Through the Alteration of, PKA Activity and Tyrosine Phosphorylation in Boar Spermatozoa.

Insights into the chronic toxicity and mechanisms of fluorine-containing pesticides on earthworms.Chronic DBP exposure may cause reduced fertility in female mice by interfering with the HPO axis.

Effects of glyphosate-based herbicide on oxidative stress and neurotoxicity parameters in newt (Triturus ivanbureschi) larvae under temperature changes predicted by future climate scenarios.

Sex-specific hepatotoxicity in zebrafish (Danio rerio) induced by Roundup WG® exposure.

Neurotoxicity mechanisms of pyrethroids studied by network toxicology and molecular docking.

Dietary Exposure to Imidacloprid at Environmental Doses Induces Renal Injury in Mice via P-AMPK Inhibition and Subsequent Purine Metabolism Dysregulation.

Glufosinate-P Herbicide Disrupts Gut Microbiota and Metabolism, Driving Osmia excavata Population Decline.

Metals/Metalloids

Stronger prooxidative effects of chromium(VI) comparing to chromium(III) in endocrine and non-endocrine tissues with the thyroid being completely resistant to antioxidant protection.

Microplastics/Nanomaterials

Developmental toxicity of microplastics in human stem cells using adverse outcome pathway based Integrated Approaches to Testing and Assessment approach.

Nanoplastics from single-use polyethylene terephthalate bottles impair the functionality of human gut-dwelling Lactobacillus rhamnosus and induce toxicity in human cells.

Oral exposure to polystyrene nanoplastics induces anxiety-like behavior and cognitive deficit accompanied with alteration of neuroimmune markers in rats.

In-depth comparative immunotoxicity assessment of pristine and aged PLA microplastics in zebrafish larvae: Bioaccumulation and NF-κB signaling insights.

Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis.

Pharmaceuticals/Personal Care Products

The classic Azole Antifungal Drugs affect steroidogenic activity in a human term placenta model.

Miscellaneous

Novel Graph Neural Network Reveals Binding Mechanisms and Environmental Risks of PAHs Interaction with Estrogen Receptor B.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Environmental Chemical Exposures in Boxer Dogs With Multicentric Lymphoma.

Parabens/Triclosan/Antimicrobials

Preliminary safety risk assessment of parabens in children’s cosmetics sold in China.

Occurrence, Maternal Transfer, and Risk Implications of Parabens in Humpback Dolphins from the South China Sea.

PFAS

Participant Experiences with Human Biomonitoring in Communities Affected by Chronic PFAS Environmental Contamination in the Veneto Region (Italy)

Impact of per- and polyfluoroalkyl substances (PFAS) in wild plants, soil and water in two Austrian national parks.

PFOA and a dash of aluminum: The perfect recipe for growing drug-resistant biofilms in urban water supply.

A geospatial dataset of PFOS and PFOA occurrence records in China’s multi-media environments (2021-2024).

Flame Retardants

Scaling up dissolution-based recycling to eliminate brominated flame retardants from WEEE plastics.

From contamination to remediation: Understanding the toxicity, risk assessment, and degradation pathways of triphenyl phosphate and related organophosphate flame retardants in water and soil.

Pesticides

Pyrethroid-driven toxicity and its relationships with urban land use: Findings from 15 years of statewide monitoring in California watersheds.

Honey bee hives as biomonitors of pesticide environmental pollution. The INSIGNIA-EU monitoring action.

Metals/Metalloids

Fluoride intake during pregnancy: calculation of realistic exposure scenarios for individual risk assessment.

Heavy metal accumulation in non-human primates: a global systematic review.

Pharmaceuticals/Personal Care Products

Exploring the barriers and facilitators to safer hair product purchasing and use among Black women in the greater Boston area through photovoice in the RESTYLE study.

Safety assessment of commercial sanitary pads: Cytotoxicity, volatile organic compounds, and microplastics release.

Pharmaceuticals in soil and groundwater: Analytical methods, sources, and mitigation techniques.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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