EDC Science Weekly, Aug. 25-31, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Toward Property-Based Regulation

Synergistic effects of chemical mixtures: how frequent is rare?

Underestimation of glyphosate intake by the methods currently used by regulatory agencies.

How Federal and State Regulatory Systems Perpetuate Environmental Injustice in the United States: Industrial Ethylene Oxide Emissions as a Case Study.

Exposure considerations in human safety assessment: Report from an EPAA Partners’ Forum.

International regulatory uses of acute systemic toxicity data and integration of new approach methodologies.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Translating community-based participatory research into broadscale sociopolitical change: insights from a coalition of women firefighters, scientists, and environmental health advocates.

Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in CLARITY-BPA.

Basic concepts of mixture toxicity and relevance for risk evaluation and regulation.

A latent functional approach for modeling the effects of multidimensional exposures on disease risk.

Screening for chemicals with thyroid hormone-disrupting effects using zebrafish embryo.

Machine Learning Methods for Endocrine Disrupting Potential Identification Based on Single-Cell Data.

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines.

Network Toxicology and Molecular Docking to Investigate the Non-AChE Mechanisms of Organophosphate-Induced Neurodevelopmental Toxicity.

The Effect of Plastic-Related Compounds on Transcriptome-Wide Gene Expression on CYP2C19-Overexpressing HepG2 Cells.

Perspectives on the Drosophila melanogaster Model for Advances in Toxicological Science.

A Mode of Action-Based Probabilistic Framework of Dose-Response Assessment for Non-mutagenic Liver Carcinogens: A Case Study of PCB-126.

DeepAmes: A deep learning-powered Ames test predictive model with potential for regulatory application

More tools, reports, and resources

Commentaries

Neurotoxicity and Outcomes from Developmental Lead Exposure: Persistent or Permanent? and related Invited Perspective: Challenging the Dogma of Lead Neurotoxicity.

Editorial: Endocrine-active substances in food: identification, evaluation, and control. [intro to a research topic in Frontiers in Nutrition]

Editorial: Environmental effect on neuroinflammation and neurodegeneration, volume II. [intro to a research topic in Frontiers in Cellular Neuroscience]

The Microbiomes of Wildlife and Chemical Pollution – Status, Knowledge Gaps and Challenges

Reviews

Phthalates

Characterizing the Contribution of Indoor Residential Phthalate and Phthalate Alternative Dust Concentrations to Internal Dose in the US General Population: An Updated Systematic Review and Meta-Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants exposure and risk of autism spectrum disorders: A systematic review and meta-analysis.

Exposure to Organochlorine Pesticides and Female Breast Cancer Risk According to Molecular Receptors Expression: a Systematic Review and Meta-analysis of Epidemiological Evidence.

A data-driven analysis of global research trends on dirty-dozen persistent organic pollutants.

Organotins

Environmental Health and Toxicology: Immunomodulation Promoted by Endocrine-Disrupting Chemical Tributyltin.

Pesticides

Linking environmental risk factors with epigenetic mechanisms in Parkinson’s disease.

Epidemiologic studies of glyphosate and non-Hodgkin’s lymphoma: A review with consideration of exposure frequency, systemic dose, and study quality.

Research on knowledge construction and analysis of pesticide exposure to children based on bibliometrics.

Hotspots of soil pollution: Possible glyphosate and aminomethylphosphonic acid risks on terrestrial ecosystems and human health.

From EFSA:

Peer review of the pesticide risk assessment of the active substance metconazole.
Peer review of the pesticide risk assessment of the active substance metribuzin.

Metals/Metalloids

Association between Heavy Metals, Metalloids and Metabolic Syndrome: New Insights and Approaches.

Prenatal Exposure to Toxic Metals and Neural Tube Defects: A Systematic Review of the Epidemiologic Evidence.

Microplastics/Nanomaterials

The Microplastics Iceberg: Filling Gaps in Our Understanding.

Nano- and Microplastics Migration from Plastic Food Packaging into Dairy Products: Impact on Nutrient Digestion, Absorption, and Metabolism.

The effects of microplastics on heavy metals bioavailability in soils: a meta-analysis.

Pharmaceuticals/Personal Care Products

Prevalence of PPCPs, microplastics and co-infecting microbes in the post-COVID-19 era and its implications on antimicrobial resistance and potential endocrine disruptive effects.

Microbial approaches for pharmaceutical wastewater recycling and management for sustainable development: A multicomponent approach.

Miscellaneous

Review: Mitigation measures to reduce tire and road wear particles.

Human Health Studies

Numerous Chemicals/Mixtures

PFAS and Phthalate/DINCH Exposure in Association with Age at Menarche in Teenagers of the HBM4EU Aligned Studies.

Midpregnancy Phthalate and Phenol Biomarkers in Relation to Infant Body Composition: The Healthy Start Prospective Cohort.

The association of bisphenol A and paraben exposure with sensorineural hearing loss in children.

BPA/Phenols

Associations of exposure to bisphenol A and its substitutes with neurodevelopmental outcomes among infants at 12 months of age: A cross-sectional study.

Association between Urinary Bisphenols and Body Compositions among American adults: Cross-sectional NHANES Study.

Association of bisphenol A with 25(OH)D, 1,25(OH)₂D levels and 1,25(OH)2D/25(OH)D ratio in cord blood.

Phthalates

Prenatal exposure to common plasticizers: a longitudinal study on phthalates, brain volumetric measures, and IQ in youth.

Monomethyl Phthalate Causes Early Embryo Development Delay, Apoptosis, and Energy Metabolism Disruptions Through Inducing Redox Imbalance.

Association of phthalate exposure with pulmonary function in adults: NHANES 2007-2012.

Parabens/Triclosan/Antimicrobials

Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort.

Perfluoroalkyl Substances

Environmental exposure to per- and perfluoroalkyl substances in early pregnancy and newborn anogenital distance: A prospective cohort study.

Prenatal and Childhood Per- and Polyfluoroalkyl Substance (PFAS) Exposures and Blood Pressure Trajectories From Birth to Late Adolescence in a Prospective US Prebirth Cohort.

Prenatal per- and polyfluoroalkyl substances (PFAS) exposure in relation to preterm birth subtypes and size-for-gestational age in the LIFECODES cohort 2006-2008.

Metabolic characteristics and pathogenesis of precocious puberty in girls: the role of perfluorinated compounds.

Low transplacental transfer of PFASs in the small-for-gestational-age (SGA) new-borns: Evidence from a Chinese birth cohort.

Pesticides

Impact of occupational pesticide exposure on the human gut microbiome.

Metals/Metalloids

Associations between multiple metals during early pregnancy and gestational diabetes mellitus under four statistical models.

Associations between exposure to cadmium, lead, mercury and mixtures and women’s infertility and long-term amenorrhea.

Heavy metal exposure linked to metabolic syndrome in Korean male firefighters: FRESH cohort cross-sectional analysis.

The associations of non-essential metal mixture with fasting plasma glucose among Chinese older adults without diabetes.

Content of selected heavy metals in the umbilical cord blood and anthropometric data of mothers and newborns in Poland: preliminary data.

Air Pollution

Causal relationship between particulate matter 2.5 and diabetes: two sample Mendelian randomization.

Laboratory Studies

Phthalates

DBP exposure induces thyroid inflammatory impairment through activating AKT/NF-κB/NLRP3 signaling.

Parabens/Triclosan/Antimicrobials

Impact of butylparaben on β-cell damage and insulin/PEPCK expression in zebrafish larvae: Protective effects of morin.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Multiomics analyses reveal dose-dependent effects of dicofol exposure on host metabolic homeostasis and the gut microbiota in mice.

Perfluoroalkyl Substances

Effects of Perfluorooctane Sulfonate on Cerebellar Cells via Inhibition of Type 2 Iodothyronine Deiodinase Activity.

The stage-specific toxicity of per- and polyfluoroalkyl substances (PFAS) in nematode Caenorhabditis elegans.

Comparative developmental toxicities of zebrafish towards structurally diverse per- and polyfluoroalkyl substances.

Flame Retardants

Tetrabromobisphenol a and its alternative tetrachlorobisphenol a induce oxidative stress, lipometabolism disturbance, and autophagy in the liver of male Pelophylax nigromaculatus.

Toxicological evaluation of TBBPA by common carp (Cyprinus carpio) about the in vivo/vitro disturbance of the AHR pathway.

TBBPA caused apoptosis in grass carp hepatocytes involving destroyed ER-mitochondrial function.

Inulin alleviates neuroinflammation and oxidative stress induced by perinatal 2-ethylhexyl diphenyl phosphate (EHDPHP) exposure in female mice and offspring.

Effects of tris (2-chloroethyl) phosphate exposure on gut microbiome using the simulator of the human intestinal microbial ecosystem (SHIME).

Pesticides

A mixture of glyphosate and 2,4-D herbicides enhances the deleterious reproductive outcomes induced by Western diet in obese male mice.

Melatonin Supplementation during In Vitro Maturation of Porcine Oocytes Alleviates Oxidative Stress and Endoplasmic Reticulum Stress Induced by Imidacloprid Exposure.

Chlorpyrifos induces placental oxidative stress and barrier dysfunction by mediating mitochondrial apoptosis via the ERK/MAPK signaling pathway: In vitro and in vivo studies.

A New Approach for Detecting Sublethal Effects of Neonicotinoids on Bumblebees Using Optical Sensor Technology.

Machine learning – based q-RASAR modeling to predict acute contact toxicity of binary organic pesticide mixtures in honey bees.

Metals/Metalloids

Sex-specific transgenerational effects of preconception exposure to arsenite: metabolic phenotypes of C57BL/6 offspring.

Subchronic Arsenite Exposure Induced Atrophy and Erythropoietin Sensitivity Reduction in Skeletal Muscle Were Relevant to Declined Serum Melatonin Levels in Middle-Aged Rats.

Chronic Exposure to Drinking Water As, Pb, and Cd at Provisional Guideline Values Reduces Weight Gain in Male Mice via Gut Microflora Alterations and Intestinal Inflammation.

An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats.

Microplastics/Nanomaterials

The crosstalk between M1 macrophage polarization and energy metabolism disorder contributes to polystyrene nanoplastics-triggered testicular inflammation.

Polystyrene microplastics disrupt female reproductive health and fertility via sirt1 modulation in zebrafish (Danio rerio).

Screening for microplastics in drinking water and its toxicity profiling in zebrafish.

Long-term exposure to polystyrene microplastics triggers premature testicular aging.

Pharmaceuticals/Personal Care Products

Postnatal Tamoxifen Exposure Induces Long-Lasting Changes to Adipose Tissue in Adult Mice.

Miscellaneous

Skeletal muscle function is altered in male mice on low dose androgen receptor antagonist or estrogen receptor agonist.

Urine Excretion, Organ Distribution, and Placental Transfer of 6PPD and 6PPD-Quinone in Mice and Potential Developmental Toxicity through Nuclear Receptor Pathways.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Occurrence and dietary intake of dioxins, furans (PCDD/Fs), PCBs, and flame retardants (PBDEs and HBCDDs) in baby food and infant formula.

International Comparison, Risk Assessment, and Prioritisation of 26 Endocrine Disrupting Compounds in Three European River Catchments in the UK, Ireland, and Spain.

BPA/Phenols

Levels of Bisphenol A and its analogs in nails, saliva, and urine of children: a case control study.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mobilization of persistent organic pollutants in humpback whales: Insights from feeding areas in the Antarctic peninsula and Strait of Magellan to migration, breeding, and calving grounds along the Brazilian coast.

Perfluoroalkyl Substances

Toward Advancing Precision Environmental Health: Developing a Customized Exposure Burden Score to PFAS Mixtures to Enable Equitable Comparisons Across Population Subgroups, Using Mixture Item Response Theory.

Per- and polyfluoroalkyl substances (PFAS) in white-tailed sea eagle eggs from Sweden: temporal trends (1969-2021), spatial variations, fluorine mass balance, and suspect screening.

Production of perfluoroalkyl acids (PFAAs) from precursors in contaminated agricultural soils: Batch and leaching experiments.

Novel Per- and Polyfluoroalkyl Substances Discovered in Cattle Exposed to AFFF-Impacted Groundwater.

Fluorine mass balance analysis of PFAS in communal waters at a wastewater plant from Austria.

Flame Retardants

Evaluation of the oral bioaccessibility of legacy and emerging brominated flame retardants in indoor dust.

Organotins

Organotins in fish, shrimp, and cephalopods from the Pearl River Estuary, China: Dietary exposure risk to Indo-Pacific humpback dolphin and human.

Pesticides

High levels of pesticides found in illicit cannabis inflorescence compared to licensed samples in Canadian study using expanded 327 pesticides multiresidue method.

Simultaneous Screening of 322 Residual Pesticides in Fruits and Vegetables Using GC-MS/MS and Deterministic Health Risk Assessments.

Biomonitoring equivalents for glyphosate.

Spatial distribution and seasonal variation of pesticide residues in the sediment, seawater, and edible seaweeds: Environmental and human health risk assessment.

Metals/Metalloids

Maternal blood concentrations of toxic metal(loid)s and trace elements from preconception to pregnancy and transplacental passage to fetuses.

Lead, Mercury, and Cadmium Concentrations in Blood Products Transfused to Neonates: Elimination Not Just Mitigation.

A critical analysis of various post-harvest arsenic removal treatments of rice and their impact on public health due to nutrient loss.

Blood and Urinary Metal Levels among Exclusive Marijuana Users in NHANES (2005-2018).

Geospatial Assessment of Racial/Ethnic Composition, Social Vulnerability, and Lead Water Service Lines in New York City.

Microplastics/Nanomaterials

Occupational exposure to nanomaterials and biomarkers in exhaled air and urine: Insights from the NanoExplore international cohort.

Constructed wetlands as neglected fixed source of microplastics and antibiotic resistance genes in natural water bodies?

Combined Effects of Micro- and Nanoplastics at the Predicted Environmental Concentration on Functional State of Intestinal Barrier in Caenorhabditis elegans.

Miscellaneous

Determination of melamine contamination in milk with various packaging: a risk assessment study.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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