EDC Science Weekly, Aug. 25 – 31, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Past, Present, and Possible Future Policies on Plastic Use in the USA, Particularly Microplastics and Nanoplastics: A Review.

Methods/Tools/Screening

A Population-Based Human In Vitro Approach to Quantify Inter-Individual Variability in Responses to Chemical Mixtures.

Characterization of Potential Adverse Outcome Pathways Related to Metabolic Outcomes and Exposure to Per- and Polyfluoroalkyl Substances Using Artificial Intelligence.

A Permutation Test-Based Approach to Strengthening Inference on the Effects of Environmental Mixtures: Comparison between Single-Index Analytic Methods.

Sensory-Motor Perturbations in Larval Zebrafish (Danio rerio) Induced by Exposure to Low Levels of Neuroactive Micropollutants during Development.

Development of physiologically-based toxicokinetic-toxicodynamic (PBTK-TD) model for 4-nonylphenol (4-NP) reflecting physiological changes according to age in males: Application as a new risk assessment tool with a focus on toxicodynamics.

High-throughput identification of oxidative stress-inducing environmental chemicals in the C. elegans system.

On the meta-analysis of hormetic effects.

A scheme to evaluate structural alerts to predict toxicity – Assessing confidence by characterising uncertainties.

Commentaries

Editorial: Obesogens in the XXI century: Emerging health challenges. [intro to a research topic in Frontiers in Endocrinology]

Editorial: Zebrafish as a model for pharmacological and toxicological research. [intro to a research topic in Frontiers in Pharmacology]

Health Effects Associated with Exposures to Endocrine Disrupting Chemicals. [intro to a special issue in Toxics]

Reducing disease and death from Artisanal and Small-Scale Mining (ASM) – the urgent need for responsible mining in the context of growing global demand for minerals and metals for climate change mitigation.

Advanced Studies on Toxic Chemicals: Properties and Characteristics.

Developmental exposure to thyroid disruptors: misprogramming of the brain’s stem cells in later life?

Reviews

Numerous Chemicals/Mixtures

Effect of exposure to endocrine disrupting chemicals in obesity and neurodevelopment: The genetic and microbiota link.

Adverse perinatal conditions and the developmental origins of thyroid dysfunction-Lessons from Animal Models.

Environmental disruptors and testicular cancer.

Exposome, Molecular Pathways and One Health: The Invertebrate Caenorhabditis elegans.

BPA/Phthalates/Parabens

Adverse Effects of Bisphenol A on the Liver and Its Underlying Mechanisms: Evidence from In Vivo and In Vitro Studies.

From Oxidative Stress to Male Infertility: Review of the Associations of Endocrine-Disrupting Chemicals (Bisphenols, Phthalates, and Parabens) with Human Semen Quality.

Perfluoroalkyl Substances

Strategies for the Biodegradation of Polyfluorinated Compounds.

Pesticides

Exposure to organophosphates in association with the development of insulin resistance: Evidence from in vitro, in vivo, and clinical studies.

Glyphosate disturbs various epigenetic processes in vitro and in vivo – A mini review.

Neurotoxicity of pesticides – A link to neurodegeneration.

Molecular Mechanisms of Acute Organophosphate Nephrotoxicity.

Metals/Metalloids

Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium.

Microplastics/Nanomaterials

Effects of Selected Metal Nanoparticles (Ag, ZnO, TiO₂) on the Structure and Function of Reproductive Organs.

Air Pollution

Air Pollution-Related Neurotoxicity Across the Life Span.

Health Outcomes in Children Associated with Prenatal and Early-Life Exposures to Air Pollution: A Narrative Review.

Industrial Air Pollution Leads to Adverse Birth Outcomes: A Systematized Review of Different Exposure Metrics and Health Effects in Newborns.

Long-Term Exposure to Fine Particulate Matter and the Risk of Chronic Liver Diseases: A Meta-Analysis of Observational Studies.

Miscellaneous

The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review.

A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review.

Human Health Studies

Numerous Chemicals/Mixtures

Association between trimester-specific exposure to thirteen endocrine disrupting chemicals and preterm birth: Comparison of three statistical models.

Mixed exposure to phenol, parabens, pesticides, and phthalates and insulin resistance in NHANES: A mixture approach.

Benchmark dose in the presence of coexposure to melamine and diethylhexyl phthalate and urinary renal injury markers in pregnant women.

Phthalates

Sex Differences between Urinary Phthalate Metabolites and Metabolic Syndrome in Adults: A Cross-Sectional Taiwan Biobank Study.

Microbiome alterations associated with phthalate exposures in a US-based sample of Latino workers.

Trimester-specific phthalate exposures in pregnancy are associated with circulating metabolites in children.

Parabens/Triclosan/Antimicrobials

Human serum paraben levels and their associations with rheumatoid arthritis: a case-control study from Hangzhou, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

NMR-based metabolomic analysis of human plasma to examine the effect of exposure to persistent organic pollutants.

Elevated exposures to persistent endocrine disrupting compounds impact the sperm methylome in regions associated with autism spectrum disorder.

Birth outcomes associated with paternal polybrominated and polychlorinated biphenyl exposure.

Perfluoroalkyl Substances

Perfluorooctanesulfonate Can Cause Negative Bias in Creatinine Measurement in Hemodialysis Patients Using Polysulfone Dialysis Membranes.

Prenatal exposure to per- and polyfluoroalkyl substances and childhood adiposity at 7 years of age.

Effect of perfluoroalkyl exposure in pregnancy and infancy on intrauterine and childhood growth and anthropometry. Sub study from COPSAC2010 birth cohort.

Flame Retardants

Early life organophosphate ester exposures and bone health at age 12 years: The Health Outcomes and Measures of the Environment (HOME) study.

Pesticides

Association between serum pyrethroid insecticide levels and incident type 2 diabetes risk: a nested case-control study in Dongfeng-Tongji cohort.

Maternal urinary organophosphate ester metabolite concentrations and glucose tolerance during pregnancy: The HOME Study.

Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study. [chlorothalonil]

Prenatal ambient pesticide exposure and childhood retinoblastoma.

Metals/Metalloids

Prenatal Exposure to Mercury, Manganese, and Lead and Adverse Birth Outcomes in Suriname: A Population-Based Birth Cohort Study.

Associations of Heavy Metals with Activities of Daily Living Disability: An Epigenome-Wide View of DNA Methylation and Mediation Analysis.

Health and economic gain attributable to the introduction of the World Health Organization’s drinking water standard on arsenic level in Hungary: A nationwide retrospective study on cancer occurrence and ischemic heart disease mortality.

Air Pollution

Portable HEPA filter air cleaner use during pregnancy and children’s autistic behaviors at four years of age: The UGAAR randomized controlled trial.

Novel control strategies for the endocrine-disrupting effect of PAEs to pregnant women in traffic system.

Miscellaneous

A case of peripheral precocious puberty may be caused by a diet containing phytosterols in a 20-month-old boy.

Laboratory Studies

Numerous Chemicals/Mixtures

Impact of “chemical cocktails” exposure in shaping mice gut microbiota and the role of selenium supplementation combining metallomics, metabolomics, and metataxonomics.

Morin attenuates neurobehavioural deficits, hippocampal oxidative stress, inflammation, and apoptosis in rats co-exposed to bisphenol S and diethyl phthalate.

BPA/Phenols

Uncovering the functions of plasma proteins in ulcerative colitis and identifying biomarkers for BPA-induced severe ulcerative colitis: A plasma proteome analysis.

Mechanism of action and neurotoxic effects of chronic exposure to bisphenol F in adult zebrafish.

Bisphenol S Impairs Oestradiol Secretion during In Vitro Basal Folliculogenesis in a Mono-Ovulatory Species Model.

Bisphenol A exposure causes testicular toxicity by targeting DPY30-mediated post-translational modification of PI3K/AKT signaling in mice.

Bisphenols A and S Alter the Bioenergetics and Behaviours of Normal Urothelial and Bladder Cancer Cells.

Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups.

Phthalates

Di(2-ethylhexyl) phthalate induced thyroid toxicity via endoplasmic reticulum stress: In vivo and in vitro study.

Exposure to dibutyl phthalate adsorbed to multi-walled carbon nanotubes causes neurotoxicity in mice by inducing the release of BDNF.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Recombinant FGF21 Attenuates Polychlorinated Biphenyl-Induced NAFLD/NASH by Modulating Hepatic Lipocalin-2 Expression.

Perfluoroalkyl Substances

Comparative toxicokinetics and toxicity of PFOA and its replacement GenX in the early stages of zebrafish.

The Role of Ferroptosis in the Damage of Human Proximal Tubule Epithelial Cells Caused by Perfluorooctane Sulfonate.

Early-life perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) exposure cause obesity by disrupting fatty acids metabolism and enhancing triglyceride synthesis in Caenorhabditis elegans.

Preclinical insights into fucoidan as a nutraceutical compound against perfluorooctanoic acid-associated obesity via targeting endoplasmic reticulum stress.

Raman imaging for the identification of Teflon microplastics and nanoplastics released from non-stick cookware.

Assessing the hepatotoxicity of PFOA, PFOS, and 6:2 Cl-PFESA in black-spotted frogs (Rana nigromaculata) and elucidating potential association with gut microbiota.

Uptake, distribution, and depuration of emerging per- and polyfluoroalkyl substances in mice: Role of gut microbiota.

Perfluorooctanoic acid exposure in vivo perturbs mitochondrial metabolic during oocyte maturation.

Perfluorooctanoic acid-induced developmental cardiotoxicity in chicken embryo: Roles of miR-490-5p.

Hepatic metabolism gene expression and gut microbes in offspring, subjected to in-utero PFOS exposure and postnatal diet challenges.

Flame Retardants

Low-dose exposure to PBDE disrupts genomic integrity and innate immunity in mammary tissue.

Organotins

A new perspective on endocrine disrupting effects of triphenyltin on marine medaka: Frombrain transcriptome, gut content metabolome and behavior.

Pesticides

Long-Term Exposure to Neonicotinoid Insecticide Acetamiprid at Environmentally Relevant Concentrations Impairs Endocrine Functions in Zebrafish: Bioaccumulation, Feminization, and Transgenerational Effects.

The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the liver-gut axis in mice.

Gene expression study alerted to possible impairment in Daphnia magna individuals as a consequence of exposure to sublethal concentrations of prochloraz.

Efficiency of Several Cytochrome P450 Biomarkers in Highlighting the Exposure of Daphnia magna to an Organophosphate Pesticide.

Transcriptomics and metabolomics revealed the molecular mechanism of the toxic effect of mancozeb on liver of mice.

Quercetin-3-O-β-D-Glucopyranoside-Rich Fraction from Spondias mombin Leaves Halted Responses from Oxidative Stress, Neuroinflammation, Apoptosis, and Lipid Peroxidation in the Brain of Dichlorvos-Treated Wistar Rats.

Neurotoxicity Assessment of Four Different Pesticides Using In Vitro Enzymatic Inhibition Assays.

Characterization of glyphosate-induced cardiovascular toxicity and apoptosis in zebrafish.

The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay.

Metals/Metalloids

Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.

Microplastics/Nanomaterials

Extrapolating Contaminant Effects from Individuals to Populations: A Case Study on Nanoparticle Toxicity to Daphnia Fed Environmentally Relevant Food Levels.

Polystyrene microplastics induce apoptosis in chicken testis via crosstalk between NF-κB and Nrf2 pathways.

Di-(2-Ethylhexyl) Phthalate and Microplastics Induced Neuronal Apoptosis through the PI3K/AKT Pathway and Mitochondrial Dysfunction.

Ecotoxicity of Polyvinylidene Difluoride (PVDF) and Polylactic Acid (PLA) Microplastics in Marine Zooplankton.

Metabolomics Reveal Nanoplastic-Induced Mitochondrial Damage in Human Liver and Lung Cells.

Induction of transgenerational toxicity is associated with the activated germline insulin signals in nematodes exposed to nanoplastic at predicted environmental concentrations.

Pharmaceuticals/Personal Care Products

Octocrylene: From Sunscreens to the Degradation Pathway during Chlorination Processes: Formation of Byproducts and Their Ecotoxicity Assessment.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Relationships between House Characteristics and Exposures to Metal(loid)s and Synthetic Organic Contaminants Evaluated Using Settled Indoor Dust.

Overview of African water resources contamination by contaminants of emerging concern.

Potential health effects of contaminant mixtures from point and nonpoint sources on fish and frogs in the New Jersey Pinelands.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Residues of polychlorinated biphenyls (PCBs) in a wild predatory fish from an e-waste site in South China between 2009 and 2016.

Spatial distribution and ecological risks of polychlorinated biphenyls in a river basin affected by traditional and emerging electronic waste recycling in South China.

Environmental release of non-Aroclor polychlorinated biphenyls by a silicone rubber production site did not lead to elevated plasma levels in the nearby population.

Perfluoroalkyl Substances

Host-Gut Microbiome Metabolic Interactions in PFAS-Impacted Freshwater Turtles (Emydura macquarii macquarii).

Perfluoroalkylated compounds in the eggs and feathers of resident and migratory seabirds from the Antarctic Peninsula.

Flame Retardants

Profiling of multiple classes of flame retardants in house dust in China: Pattern analysis and human exposure assessment.

Organotins

Organotin contamination in seafood from the Yucatán Peninsula, Mexico: Is there a potential risk for the health of consumers?

Organotins Remain a Serious Threat to the Indo-Pacific Humpback Dolphins in the Pearl River Estuary.

Pesticides

The Assessment of Organophosphate Pesticide Exposure among School Children in Four Regions of Thailand: Analysis of Dialkyl Phosphate Metabolites in Students’ Urine and Organophosphate Pesticide Residues in Vegetables for School Lunch.

Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children.

A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data.

Bird Species Potentially Exposed to Pesticide-treated Corn Seeds in the Continental United States.

Metals/Metalloids

Methylmercury Risk Assessment Based on European Human Biomonitoring Data.

The effect of residential proximity to brownfields, highways, and heavy traffic on serum metal levels in the Detroit Neighborhood Health Study.

Concentrations of Pb and Other Associated Elements in Soil Dust 15 Years after the Introduction of Unleaded Fuel and the Human Health Implications in Pretoria, South Africa.

Microplastics/Nanomaterials

No evidence of microplastic ingestion in emperor penguin chicks (Aptenodytes forsteri) from the Atka Bay colony (Dronning Maud Land, Antarctica).

Pharmaceuticals/Personal Care Products

Antidepressants as emerging contaminants: Occurrence in wastewater treatment plants and surface waters in Hangzhou, China.

Occurrence and risk assessment of pharmaceuticals in surface waters of the Middle East and North Africa: A review.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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