EDC Science Weekly, Aug. 2-8, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Prenatal BPA and autism.

More science highlights

Events

Aug. 21 webinar: Innovations in Health Assessments: New Approach Methods and EPA’s Transcriptomics Assessment Product [EPA]

Aug. 28 webinar: The CATMoS Model for Acute Oral Toxicity and Evaluation of its Potential Use in a Regulatory Context for Pesticide Hazard and Risk Assessment [EPIC webinar series]

Sept. 18 webinar: Artificial Turf: Research on Plastic Pollution, PFAS, and Health Concerns [CHE]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

More events

Methods/Tools/Screening

The HEALthy Brain and Child Development Study (HBCD): NIH collaboration to understand the impacts of prenatal and early life experiences on brain development.

The HEALthy Brain and Child Development Study (HBCD) experience: Recruiting and retaining diverse families in a longitudinal, multi-method early childhood study.

What Structural Biology Tells Us About the Mode of Action and Detection of Toxicants.

A developmental neurotoxicity adverse outcome pathway (DNT-AOP) with voltage gate sodium channel (VGSC) inhibition as a molecular initiating event (MiE). [EFSA]

Toxicokinetics of a developmental toxicity test in zebrafish embryos and larvae: Relationship with drug exposure in humans and other mammals.

Using machine learning to classify the immunosuppressive activity of per- and polyfluoroalkyl substances.

Application of Machine Learning in Nanotoxicology: A Critical Review and Perspective.

A Multigenerational Model of Environmental Risk for Black, Indigenous, and People of Color (BIPOC) Children and Families.

Endeavours made by trade associations, pharmaceutical companies and regulators in the replacement, reduction and refinement of animal experimentation in safety testing of pharmaceuticals

Honey bee larval toxicity study designs: Applicability of the current study protocols and endpoints as a predictor of pesticide hazard for pollinators.

Commentaries

Potential association between arsenic and vitamin D.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

An overview of environmental risk factors for type 2 diabetes research using network science tools.

BPA/Phenols

Bisphenol A in Water Systems: Risks to Polycystic Ovary Syndrome and Biochar-Based Adsorption Remediation: A Review.

Indian and global scenarios of Bisphenol A distribution and its new analogues: Prevalence & probability exceedance.

Phthalates

Di-(2-ethylhexyl) phthalate and its metabolites research trend: a bibliometric analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between polychlorinated biphenyl (PCB) and dioxin with metabolic syndrome (METS): a systematic review and meta-analysis.

PFAS

An In-depth Examination of Per- and Polyfluoroalkyl (PFAS) Effects on Transporters, with Emphasis on the ABC Superfamily: A Critical Review.

Innovative Techniques for Combating a Common Enemy Forever Chemicals: A Comprehensive Approach to Mitigating Per- and Polyfluoroalkyl Substances (PFAS) Contamination.

Per- and poly-fluoroalkyl substances (PFAS) effects on lung health: a perspective on the current literature and future recommendations.

Organotins

Tributyltin induces apoptosis in mammalian cells in vivo: a scoping review.

Pesticides

Neonicotinoids as emerging contaminants in China’s environment: a review of current data.

Metals/Metalloids

Exploring the link between toxic metal exposure and ADHD: a systematic review of Pb and Hg.

Prenatal heavy metal exposure and pediatric asthma, allergic rhinitis, atopic dermatitis: a systematic review and meta-analysis.

Microplastics/Nanomaterials

A Systematic Review on the Impact of Micro-Nanoplastics on Human Health: Potential Modulation of Epigenetic Mechanisms and Identification of Biomarkers.

The alarming link between environmental microplastics and health hazards with special emphasis on cancer.

Miscellaneous

Generational stability of epigenetic transgenerational inheritance facilitates adaptation and evolution.

Human Health Studies

Numerous Chemicals/Mixtures

Bisphenol mixtures, metal mixtures and type 2 diabetes mellitus: Insights from metabolite profiling.

BPA/Phenols

Male autism spectrum disorder is linked to brain aromatase disruption by prenatal BPA in multimodal investigations and 10HDA ameliorates the related mouse phenotype. [human and lab studies]

Phthalates

Urine Phthalate Metabolites are Elevated in Patients with Esophageal Squamous Cell Carcinoma and Associated with Advanced Cancer Stage and Poor Survival.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effect of bariatric surgery in the body burden of persistent and non-persistent pollutants: longitudinal study in a cohort of morbidly obese patients.

Genetic variants reduced POPs-related colorectal cancer risk via altering miRNA binding affinity and m⁶A modification.

PFAS

Association of per- and polyfluoroalkyl substances with the antioxidant bilirubin across pregnancy.

Biochemical and haematological effects of serum PFOA, ADV and cC₆O₄ in workers of a chemical company producing fluoropolymers, Italy, 2013-2022.

Moderate-intensity physical activity reduces the role of serum PFAS on COPD: A cross-sectional analysis with NHANES data.

Metals/Metalloids

Association of Urinary Metals With Cardiovascular Disease Incidence and All-Cause Mortality in the Multi-Ethnic Study of Atherosclerosis (MESA).

Maternal arsenic exposure modifies associations between arsenic, folate and arsenic metabolism gene variants, and spina bifida risk: A case‒control study in Bangladesh.

Uric acid mediates the relationship between mixed heavy metal exposure and renal function in older adult people.

Association between heavy metals exposure and persistent infections: the mediating role of immune function.

Air Pollution

Exposure to multiple ambient air pollutants changes white matter microstructure during early adolescence with sex-specific differences.

Laboratory Studies

Numerous Chemicals/Mixtures

Cheminformatic Read-Across Approach Revealed Ultraviolet Filter Cinoxate as an Obesogenic Peroxisome Proliferator-Activated Receptor γ Agonist.

Insight into the molecular recognition of human and polar bear pregnane X receptor by three organic pollutants using molecular docking and molecular dynamics simulations.

BPA/Phenols

Adolescent exposure to bisphenol-a antagonizes androgen regulation of social behavior in male mice.

Interaction of Bisphenol A and Its Analogs with Estrogen and Androgen Receptor from Atlantic Cod (Gadus morhua).

Bisphenol P induces increased oxidative stress in renal tissues of C57BL/6 mice and human renal cortical proximal tubular epithelial cells, resulting in kidney injury.

Exploring the mechanism of intestinal injury induced by Bisphenol S in freshwater crayfish (Procambarus clarkii): Molecular and biochemical approaches.

Developmental Exposure to Nonylphenol Leads to Depletion of the Neural Precursor Cell Pool in the Hippocampal Dentate Gyrus.

Phthalates

Quercetin antagonizes apoptosis, autophagy and immune dysfunction induced by di(2-ethylhexyl) phthalate via ROS/ASK1/JNK pathway.

An insight into carcinogenic activity and molecular mechanisms of Bis(2-ethylhexyl) phthalate.

PFAS

Diverse PFAS produce unique transcriptomic changes linked to developmental toxicity in zebrafish.

The long-chain polyfluorinated alkyl substance perfluorohexane sulfonate (PFHxS) promotes bone marrow adipogenesis.

Effects of Perfluorohexane Sulfonate Exposure on Immune Cell Populations in Naive Mice.

Flame Retardants

TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio).

Organotins

Effect of tributyltin exposure on the embryonic development and behavior of a molluscan model species, Lymnaea stagnalis.

Pesticides

Sexual dysfunction in dichlorvos-exposed male Wistar rat is ameliorated by curcumin and associated with the upregulation of testosterone.

Accumulated inflammation and fibrosis participate in atrazine induced ovary toxicity in mice.

Ameliorative effects of gallic acid on tebuconazole-induced adverse effects in the cerebellum of adult albino rats: histopathological and immunohistochemical evidence.

Dopaminergic and anti-estrogenic responses in juvenile steelhead (Oncorhynchus mykiss) exposed to bifenthrin.

Early exposure to glyphosate during larval development induces late behavioural effects on adult honey bees.

Metals/Metalloids

Curcumin Treatment Ameliorates Hepatic Insulin Resistance Induced by Sub-chronic Oral Exposure to Cadmium LOAEL Dose via NF-κB and Nrf2 Pathways.

Prenatal arsenic exposure alters EZH2-H3K27me3 occupancy at TNF-α promoter leading to insulin resistance and metabolic syndrome in a mouse model.

Arsenic-induced transition of thymic inflammation-to-fibrosis involves Stat3-Twist1 interaction: Melatonin to the rescue.

Effects of arsenic exposure on the PI3K/Akt/NF-κB signaling pathway in the hippocampus of offspring mice at different developmental stages.

Microplastics/Nanomaterials

Polystyrene nanoplastics induce apoptosis, autophagy, and steroidogenesis disruption in granulosa cells to reduce oocyte quality and fertility by inhibiting the PI3K/AKT pathway in female mice.

Polystyrene nanoplastics-induced intestinal barrier disruption via inflammation and apoptosis in zebrafish larvae (Danio Rerio).

Polystyrene nano-plastics impede skeletal muscle development and induce lipid accumulation via the PPARγ/LXRβ pathway in vivo and in vitro in mice.

Microplastics exposure disrupts nephrogenesis and induces renal toxicity in human iPSC-derived kidney organoids.

Exposure to polystyrene nanoplastics causes immune damage, oxidative stress and intestinal flora disruption in salamander (Andrias davidianus) larvae.

Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans.

Microplastic-induced hepatic adverse effects evaluated in advanced quadruple cell human primary models following three weeks of repeated exposure.

Miscellaneous

A Quantitative Adverse Outcome Pathway for Embryonic Activation of the Aryl Hydrocarbon Receptor of Fishes by Polycyclic Aromatic Hydrocarbons Leading to Decreased Fecundity at Adulthood.

Assessment of the Aryl Hydrocarbon Receptor-Mediated Effects of Aromatic Sensitizers in Paper Recycling Effluent Employing Zebrafish Embryos and in Silico Docking.

Ancestral lineages of dietary exposure to an endocrine disrupting chemical drive distinct forms of transgenerational subfertility in an insect model.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Public drinking water contaminant estimates for birth cohorts in the Environmental Influences on Child Health Outcomes (ECHO) Cohort.

Comprehensive risk assessment of the inhalation of plasticizers from the use of face masks.

Chemical and toxicological characterization of food contact recycled paperboard extracts.

Hybridization in the Anthropocene – how pollution and climate change disrupt mate selection in freshwater fish.

Phthalates

Phthalate migration potential in vacuum-packed fish.

End-of-life vehicle dismantling activity emits large quantities of phthalates and their alternatives: New insights on environmental sources and co-exposure risks.

PFAS

A data-driven approach to identifying PFAS water sampling priorities in Colorado, United States.

Discovery of perfluoroalkyl sulfonyl quaternary ammonium substances in the environment and their environmental behaviors.

Flame Retardants

Nationwide Investigation on Organophosphate Flame Retardants in Tea from China: Migration from Packaging Materials and Implications for Global Risk Assessment.

Organophosphate Esters in Raw Cow Milk and Cow’s Drinking Water and Feed from China: Occurrence, Regional Distribution, and Dietary Exposure Assessment.

Pesticides

Glyphosate contamination in European rivers not from herbicide application?

Metals/Metalloids

Human Exposure to Heavy Metals over the Last 100 Years.

Microplastics/Nanomaterials

Identification and characterization of microplastics in human nasal samples.

Untargeted metabolomic insights into plastisphere communities in European rivers.

Small microplastics have much higher mass concentrations than large microplastics at the surface of nine major European rivers.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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