EDC Science Weekly, Aug. 19 – 25, 2021

Post author:HEEDS
Post published:August 25, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Continuing Animal Tests on Cosmetic Ingredients for REACH in the EU.

An overview of current practices for regulatory risk assessment with lessons learnt from cosmetics in the European Union.

Methods/Tools/Screening

Safer chemicals using less animals: kick-off of the European ONTOX project.

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities.

Large-Scale Implementation and Flaw Investigation of Human Serum Suspect Screening Analysis for Industrial Chemicals.

COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals.

Predicting the Estrogen Receptor Activity of Environmental Chemicals by Single-Cell Image Analysis and Data-driven Modeling.

Screening for androgen agonists using autonomously bioluminescent HEK293 reporter cells.

Accelerating the pace of ecotoxicological assessment using artificial intelligence.

A new approach method for characterizing inter-species toxicodynamic variability.

Integrated Risk Information System (IRIS) response to “Assessing risk of bias in human environmental epidemiology studies using three tools: different conclusions from different tools”

Commentaries/Conference Summaries

The heritable legacy of Diethylstilbestrol: A bellwether for endocrine disruption in humans.

Air Pollution’s Effects on Newborns’ Thyroid Hormones.

Plastic pollution: When do we know enough?

Environmental injustice: Fracking.

Mycotoxins as Emerging Contaminants. Introduction to the Special Issue “Rapid Detection of Mycotoxin Contamination”.

A cocktail of pesticides, parasites and hunger leaves bees down and out.

The Dilemma of Perfluorooctanoate (PFOA) Human Half-life.

A New View of the Things We Use: Using Purchasing Data to Predict Common Mixture Exposures. [Science Selection in EHP]

Reviews

Numerous EDCs

Xenoestrogen Effects on the Gut Microbiome.

Endocrine-disrupting chemicals and obesity risk: A review of recommendations for obesity prevention policies.

Disruption by stealth – Interference of endocrine disrupting chemicals on hormonal crosstalk with thyroid axis function in humans and other animals.

Developmental origins and transgenerational inheritance of polycystic ovary syndrome.

The effect of endocrine disruptors on the reproductive system – current knowledge.

The Adipose Tissue at the Crosstalk Between EDCs and Cancer Development.

Role of endocrine disrupting chemicals in children’s neurodevelopment.

BPA/Phenols

Bisphenol a Exposure and Kidney Diseases: Systematic Review, Meta-Analysis, and NHANES 03-16 Study.

Phthalates

Comprehensive Insight from Phthalates Occurrence: From Health Outcomes to Emerging Analytical Approaches.

Phthalic Acid Esters: Natural Sources and Biological Activities.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Exposure to persistent organic pollutants and thyroid cancer risk: a study protocol of systematic review and meta-analysis.

Pesticides

The relationship between pesticide exposure during critical neurodevelopment and autism spectrum disorder: A narrative review.

Occupational pesticide exposure, cancer and chronic neurological disorders: A systematic review of epidemiological studies in greenspace workers.

Do environmental and occupational exposure to pyrethroids and organophosphates affect human semen parameters? Results of a systematic review and meta-analysis.

Seed Treatment With Systemic Fungicides: Time for Review.

Potentially Toxic Elements

The association of arsenic exposure with hypertension and blood pressure: A systematic review and dose-response meta-analysis.

Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management.

Effects of Cadmium Exposure on the Immune System and Immunoregulation.

Microplastics

Biodegradation of microplastics: Better late than never.

Genotoxic effect of microplastics and COVID-19: The hidden threat.

Microplastics and environmental pollutants: Key interaction and toxicology in aquatic and soil environments.

Air Pollution

Chemosensory Dysfunction Induced by Environmental Pollutants and Its Potential As a Novel Neurotoxicological Indicator: A Review.

PM_2.5, NO₂, wildfires, and other environmental exposures are linked to higher Covid 19 incidence, severity, and death rates.

Ambient Air Pollution and Atherosclerosis: Recent Updates.

Pharmaceuticals/Personal Care Products

Environmental Distribution of Personal Care Products and Their Effects on Human Health.

Aquatic ecotoxicology of anticancer drugs: A systematic review.

The Biological Effects of Pharmaceuticals in the Marine Environment.

Miscellaneous

Toxicity risks of occupational exposure in 3D printing and bioprinting industries: A systematic review.

A Potential Role and Contribution of Androgens in Placental Development and Pregnancy.

Promising effects of gingerol against toxins: A review article.

Occurrence, environmental fate, ecological issues, and redefining of endocrine disruptive estrogens in water resources.

Human Health Studies

Numerous Chemicals/Mixtures

Exposure to endocrine disrupting chemicals (EDCs) and cardiometabolic indices during pregnancy: The HOME Study [BPA, PBDEs, PFAS, and phthalates]

Prenatal exposure to consumer product chemical mixtures and size for gestational age at delivery.

Prenatal exposure to mixtures of persistent endocrine disrupting chemicals and postnatal body size in British girls.

BPA/Phenols

Maternal bisphenol urine concentrations, fetal growth and adverse birth outcomes: A population-based prospective cohort.

Bisphenol-A exposure and risk of breast and prostate cancer in the Spanish European Prospective Investigation into Cancer and Nutrition study.

Apoptotic microparticles mediate the association between bisphenol A and subclinical atherosclerosis in a young population: A population-based study.

Urinary bisphenol A and its interaction with CYP17A1 rs743572 are associated with breast cancer risk.

Phthalates

Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.

Associations of serum phthalate metabolites with thyroid hormones in GraMo cohort, Southern Spain.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Intakes of Fish and Long-chain n-3 Polyunsaturated Fatty Acid Supplements During Pregnancy and Subsequent Risk of Type 2 Diabetes in a Large Prospective Cohort Study of Norwegian Women.

Maternal exposure to airborne polychlorinated biphenyls (PCBs) and risk of adverse birth outcomes.

Persistent organic pollutants and risk of cutaneous malignant melanoma among women.

Perfluoroalkyl Substances

Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort.

Flame Retardants

Methylation biomarkers of polybrominated diphenyl ethers (PBDEs) and association with breast cancer risk at the time of menopause.

Pesticides

Interactions of agricultural pesticide use near home during pregnancy and adverse childhood experiences on adolescent neurobehavioral development in the CHAMACOS study.

Associations of neonicotinoids with insulin and glucose homeostasis parameters in US adults: NHANES 2015-2016.

Potentially Toxic Elements

Lead, mercury, and cadmium exposures are associated with obesity but not with diabetes mellitus: Korean National Environmental Health Survey (KoNEHS) 2015-2017.

Assessment of hypertension association with arsenic exposure from food and drinking water in Bihar, India.

Association of urinary arsenic and sleep disorder in the US population: NHANES 2015-2016.

Associations of total blood mercury and blood methylmercury concentrations with diabetes in adults: An exposure-response analysis of 2005-2018 NHANES.

Air Pollution

Associations between wildfire smoke exposure during pregnancy and risk of preterm birth in California.

Estimating Short- and Long-Term Associations Between Air Quality Index and COVID-19 Transmission: Evidence From 257 Chinese Cities

Comparison of positive SARS-Cov-2 incidence rate with environmental and socioeconomic factors in northern Illinois.

PAHs

Interactions between exposure to polycyclic aromatic hydrocarbons and xenobiotic metabolism genes, and risk of breast cancer.

Occupational exposure to polycyclic aromatic hydrocarbons and risk of prostate cancer.

The associations of nitrated polycyclic aromatic hydrocarbon exposures with plasma glucose and amino acids.

Laboratory Studies

Numerous Chemicals/Mixtures

Reproducibility of Adipogenic Responses to Metabolism Disrupting Chemicals in the 3T3-L1 Pre-adipocyte Model System: An Interlaboratory Study. [BPA, TBT]

Inflammatory state and autism-like behavioral phenotype of offspring induced by maternal exposure to low-dose chemical mixtures during pregnancy in mice.

miR-122-5p regulates hepatocytes damage caused by BaP and DBP co-exposure through SOCS1/STAT3 signaling in vitro.

BPA/Phenols

Bisphenol A-induced DNA damages promote to lymphoma progression in human lymphoblastoid cells through aberrant CTNNB1 signaling pathway.

Suppression of bisphenol A-induced oxidative stress by taurine promotes neuroprotection and restores altered neurobehavioral response in zebrafish (Danio rerio).

Acute Exposure to Bisphenol A Causes Oxidative Stress Induction with Mitochondrial Origin in Saccharomyces cerevisiae Cells.

Adverse effects of bisphenol B exposure on the thyroid and nervous system in early life stages of zebrafish.

Cardiac toxicity from bisphenol A exposure in human-induced pluripotent stem cell-derived cardiomyocytes.

Biomarker responses induced by bisphenol A on spermatogenesis in a Neotropical teleost fish are temperature-dependent.

Gestational exposure to high fat diets and bisphenol A alters metabolic outcomes in dams and offspring, but produces hepatic steatosis only in dams.

Phthalates

Peritubular Macrophages Are Recruited to the Testis of Peripubertal Rats After Mono-(2-Ethylhexyl) Phthalate Exposure and Is Associated With Increases in the Numbers of Spermatogonia.

Maternal high-fat diet during pregnancy with concurrent phthalate exposure leads to abnormal placentation.

Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development.

Di-(2-ethylhexyl) phthalate enhances cytokine release from group 2 innate lymphoid cells in the presence of interleukin-33.

Early postnatal exposure to di(2-ethylhexyl) phthalate causes sex-specific disruption of gonadal development in pigs.

Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring.

Parabens/Triclosan/Antimicrobials

Triclosan-induced glycolysis drives inflammatory activation in microglia via the Akt/mTOR/HIF 1α signaling pathway.

Potential long-term developmental toxicity of in utero and lactational exposure to Triclocarban (TCC) in hampering ovarian folliculogenesis in rat offspring.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

β-Endosulfan-mediated induction of pro-fibrotic markers in renal (HK-2) cells in vitro: A new insight in the pathogenesis of chronic kidney disease of unknown etiology.

Role of Persistent Organic Pollutants in Breast Cancer Progression and Identification of Estrogen Receptor Alpha Inhibitors Using In-Silico Mining and Drug-Drug Interaction Network Approaches.

Perfluoroalkyl Substances

Exposure to hexafluoropropylene oxide dimer acid (HFPO-DA) disturbs the gut barrier function and gut microbiota in mice.

Sorption and desorption kinetics of PFOS to pristine microplastic.

Probiotics inhibit the stunted growth defect of perfluorobutanesulfonate via stress and thyroid axes in zebrafish larvae.

Exposure to GenX and Its Novel Analogs Disrupts Hepatic Bile Acid Metabolism in Male Mice.

Flame Retardants

ERK/p38/ROS burst responses to environmentally relevant concentrations of diphenyl phosphate-evoked neutrophil extracellular traps formation: Assessing the role of autophagy.

Bioaccumulation of BDE47 in testes by TiO₂ nanoparticles aggravates the reproductive impairment of male zebrafish by disrupting intercellular junctions.

Polybrominated Diphenyl Ether Quinone Exposure Induces Atherosclerosis Progression via CD36-Mediated Lipid Accumulation, NLRP3 Inflammasome Activation, and Pyroptosis.

Bioaccumulation, elimination and metabolism in earthworms and microbial indices responses after exposure to decabromodiphenyl ethane in a soil-earthworm-microbe system.

Organotins

Effects of chronic exposure to environmental levels of tributyltin on the lined seahorse (Hippocampus erectus) liver: Analysis of bioaccumulation, antioxidant defense, and immune gene expression.

Pesticides

Study of muscle fibers of the extensor digitorium longus and soleus muscles of C57BL/6 females exposed to glyphosate during pregnancy and lactation.

Insights into the effects of difenoconazole on the livers in male mice at the biochemical and transcriptomic levels.

Generational effects of a chronic exposure to a low environmentally relevant concentration of glyphosate on rainbow trout, Oncorhynchus mykiss.

Multiple Level Effects of Imazethapyr on Leptodactylus latinasus (Anura) Adult Frogs.

Diazinon toxicity in hepatic and spleen mononuclear cells is associated to early induction of oxidative stress.

Mechanistic revealing of reproductive behavior impairment in male guppy (Poecilia reticulata) induced by environmentally realistic 2,2′-dithiobis-pyridine exposure.

The potential risks of herbicide butachlor to immunotoxicity via induction of autophagy and apoptosis in the spleen.

Toxicological Effects of Roundup^® on Drosophila melanogaster Reproduction.

Paternal Fenitrothion Exposures in Rats Causes Sperm DNA Fragmentation in F0 and Histomorphometric Changes in Selected Organs of F1 Generation.

Fipronil induced oxidative stress in neural tissue of albino rat with subsequent apoptosis and tissue reactivity.

Neonicotinoids can cause arrested pupal ecdysis in Lepidoptera.

3,5,6-trichloro-2-pyridinol intensifies the effect of chlorpyrifos on the paracrine function of Sertoli cells by preventing binding of testosterone and the androgen receptor.

High-fat diet-induced aggravation of cardiovascular impairment in permethrin-treated Wistar rats.

Effects of sublethal concentration of metamifop on hepatic lipid metabolism in adult zebrafish (Danio rerio).

Testicular deficiency associated with exposure to cypermethrin, imidacloprid, and chlorpyrifos in adult rats.

Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver.

First evaluation of the periphyton recovery after glyphosate exposure.

Potentially Toxic Elements

Astaxanthin Induces the Expression of CatSper1 Gene and Protects Sperms in Toxicity Induced by Cadmium in Mice.

Low concentrations of lead disturb phenotypical markers of the inflammatory and the anti-inflammatory profile of bone marrow-derived macrophages from BALB/c mice.

Prepubertal arsenic exposure alters phosphoproteins profile, quality, and fertility of epididymal spermatozoa in sexually mature rats.

Chronic Manganese Exposure and the Enteric Nervous System: An in Vitro and Mouse in Vivo Study.

Gestational cadmium exposure impairs placental angiogenesis via activating GC/GR signaling.

Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis.

Time-dependent Genomic Response in Primary Human Uroepithelial Cells Exposed to Arsenite for up to 60 Days.

Microplastics

Are your shoes safe for the environment? – Toxicity screening of leachates from microplastic fragments of shoe soles using freshwater organisms.

Polystyrene nanoparticles induced neurodevelopmental toxicity in Caenorhabditis elegans through regulation of dpy-5 and rol-6.

The effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels.

Unique metalloid uptake on microplastics: The interaction between boron and microplastics in aquatic environment.

Pharmaceuticals/Personal Care Products

A critical assessment of the estrogenic potency of benzyl salicylate.

Investigation of the in vivo estrogenicity of the UV-filters 4-methylbenzylidene camphor and octyl methoxy cinnamate in rainbow trout (Oncorhynchus mykiss).

Near future ocean acidification modulates the physiological impact of fluoxetine at environmental concentration on larval urchins.

Miscellaneous

Deoxynivalenol interferes with intestinal motility via injuring the contractility of enteric smooth muscle cells: A novel hazard to the gastrointestinal tract by environmental toxins. [a mycotoxin]

Exposure/Environment Studies

Phthalates

Face mask-A potential source of phthalate exposure for human.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Chlorinated Paraffin Levels in Relation to Other Persistent Organic Pollutants Found in Pooled Human Milk Samples from Primiparous Mothers in 53 Countries.

Risk of dietary intake of organochlorine pesticides among the childbearing-age women: A multiple follow-up study in North China.

Analysis of persistent organochlorine pesticides in shellfish and their risk assessment from aquafarms in Taiwan.

Occurrence and risks of PCDD/Fs and PCBs in three raptors from North China.

Organochlorine pesticides, polycyclic aromatic hydrocarbons, metals and metalloids in microplastics found in regurgitated pellets of black vulture from Campeche, Mexico.

Evaluation of PCDD/Fs, PCBs and PBDEs in two penguin species from Antarctica.

Perfluoroalkyl Substances

Correlates of plasma concentrations of per- and poly-fluoroalkyl substances among reproductive-aged Black women.

Placental Transfer and Composition of Perfluoroalkyl Substances (PFASs): A Korean Birth Panel of Parent-Infant Triads.

External and internal human exposure to PFOA and HFPOs around a mega fluorochemical industrial park, China: Differences and implications.

Perfluorinated compounds (PFCs) in regional industrial rivers: Interactions between pollution flux and eukaryotic community phylosymbiosis.

Ineffectiveness of ultrasound at low frequency for treating per- and polyfluoroalkyl substances in sewage sludge.

Microextraction and Determination of Poly- and Perfluoroalkyl Substances, Challenges, and Future Trends.

The occurrence of per- and polyfluoroalkyl substances (PFASs) in fluoropolymer raw materials and products made in China.

Flame Retardants

Emerging Brominated Flame Retardants 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (EHTBB) and Bis(2-ethylhexyl)-tetrabromophthalate (BEH-TEBP) in Chinese Food and Their Health Implications.

Temperature-dependent profiles of dioxin-like toxicants from combustion of brominated flame retardants.

Modeling of Flame Retardants in Typical Urban Indoor Environments in China during 2010-2030: Influence of Policy and Decoration and Implications for Human Exposure.

Ensuring the reliability of brominated flame retardant data on food and feed occurrence through harmonised analytical criteria and proficiency testing.

Pesticides

Biomonitoring of glyphosate and AMPA in the urine of Spanish lactating mothers.

Use of Plant Protection Products in Lombardy, Italy and the Health Risk for the Ingestion of Contaminated Water.

Uncertainty of pesticides in foodstuffs, associated environmental and health risks to humans-a critical case of Bangladesh with respect to global food policy.

Mason Bees (Hymenoptera: Megachilidae) Exhibit No Avoidance of Imidacloprid-Treated Soils.

Potentially Toxic Elements

Distribution and health-ecological risk assessment of heavy metals: an endemic disease case study in southwestern China.

Assessment of heavy metals concentration in soils and plants from electronic waste dumpsites in Lagos metropolis.

Environmental assessment of pediatric Lead exposure in Tehran; a prospective cross-sectional study.

Biomonitoring of arsenic, cadmium and lead in two artisanal and small-scale gold mining areas in Zimbabwe.

Mercury accumulation response of rice plant (Oryza sativa L.) to elevated atmospheric mercury and carbon dioxide.

High lead level in the Alps in XIXth century, learning from the analysis of 138 historical hair stands.

Microplastics

Treading Water: Tire Wear Particle Leachate Recreates an Urban Runoff Mortality Syndrome in Coho but Not Chum Salmon.

Overview on the occurrence of microplastics in air and implications from the use of face masks during the COVID-19 pandemic.

Microplastics in an agricultural soil following repeated application of three types of sewage sludge: A field study.

Air Pollution

Current practices of waste management in teaching hospitals and presence of incinerators in densely populated areas.

Pharmaceuticals/Personal Care Products

Dosing the Coast: Leaking Sewage Infrastructure Delivers Large Annual Doses and Dynamic Mixtures of Pharmaceuticals to Urban Rivers.

Occurrence of synthetic polycyclic and nitro musk compounds in sewage sludge from municipal wastewater treatment plants.

Miscellaneous

Human health risks estimations from polycyclic aromatic hydrocarbons in serum and their hydroxylated metabolites in paired urine samples.

Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Feel free to forward. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.