EDC Science Weekly, Aug. 16-21, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Sending early this week, as I’ll be on vacation until September.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Zürich II Statement on Per- and Polyfluoroalkyl Substances (PFASs): Scientific and Regulatory Needs.

We are now accepting applications for the Lou Guillette, Jr Outstanding Young Investigator Award, due Sept. 30!

Science summaries and highlights

Events

Aug. 28 webinar: The CATMoS Model for Acute Oral Toxicity and Evaluation of its Potential Use in a Regulatory Context for Pesticide Hazard and Risk Assessment [EPIC webinar series]

Sept. 18 webinar: Artificial Turf: Research on Plastic Pollution, PFAS, and Health Concerns [CHE]

Sept. 23-24: Plastics and Human Health Symposium [NYU Langone Health Center for the Investigation of Environmental Hazards]

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC.

Oct. 28: Swiss Symposium on Endocrine Disrupting Chemicals [Food Packaging Forum and ETH Zurich]

Nov. 5-6 conference: State of the science on development and use of NAMs for chemical safety testing [U.S. EPA]

More events

Regulations/Policy

Zürich II Statement on Per- and Polyfluoroalkyl Substances (PFASs): Scientific and Regulatory Needs.

Use of the Threshold of Toxicological Concern (TTC) Approach as an Alternative Tool for Regulatory Purposes: A Case Study with an Inert Ingredient used in Pesticide Products.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Calculating toxic pressure for mixtures of endocrine disruptors.

Practical Lessons of the 3Rs: Learning from the Past and Looking Toward the Future

High-Throughput Transcriptomics screen of ToxCast chemicals in U-2 OS cells.

Single cell multiomics systems biology for molecular toxicity

Application of Single Cell Methods in Immunometabolism and Immunotoxicology

Artificial intelligence in microplastic detection and pollution control.

Commentaries

Editorial: Insights in developmental endocrinology: 2023. [intro to a research topic in Frontiers in Endocrinology]

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Chemical exposome and children health: identification of dose-response relationships from meta-analyses and epidemiological studies.

Impact of Developmental Exposures to Endocrine Disrupting Chemicals on Pituitary Gland Reproductive Function.

Metals/Metalloids

Vitamin D and Toxic Metals in Pregnancy – a Biological Perspective.

Fluoride-Induced Alterations in the Pancreas of Mammals: A Meta-analysis.

Microplastics/Nanomaterials

The role of gut microbiota in MP/NP-induced toxicity.

Protective effect of curcumin against microplastic and nanoplastics toxicity.

Human Health Studies

Numerous Chemicals/Mixtures

Associations of Urinary Biomarkers of Phthalates, Phenols, Parabens, and Organophosphate Esters with Glycemic Traits in Pregnancy: The Healthy Start Study.

Effect of combined exposure to phthalates and polycyclic aromatic hydrocarbons during early pregnancy on gestational age and neonatal size: A prospective cohort study.

The effect of endocrine-disrupting chemicals in follicular fluid: The insights from oocyte to fertilization.

Exposure-associated DNA methylation among people exposed to multiple industrial pollutants.

BPA/Phenols

Effects of environmental phenols on eGFR: machine learning modeling methods applied to cross-sectional studies.

PFAS

Associations between Per- and polyfluoroalkyl substance exposures and metabolic dysfunction associated steatotic liver disease (MASLD) in adult National Health and Nutrition Examination Survey 2017-2018.

Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial.

Flame Retardants

Associations of prenatal exposure to individual and mixed organophosphate esters with ADHD symptom trajectories in preschool children: The modifying effects of maternal Vitamin D.

Metals/Metalloids

Associations of heavy metal exposure with diabetic retinopathy in the U.S. diabetic population: a cross-sectional study.

Trajectory model to analyse the effect of multi-metal exposures on sperm parameters and sex hormones of the MARHCS cohort in China.

Air Pollution

Disturbed glucose homeostasis and its increased allostatic load in response to individual, joint and fluctuating air pollutants exposure: Evidence from a longitudinal study in prediabetes.

Pregnancy complications and birth outcomes following low-level exposure to per- and polyfluoroalkyl substances in the vitamin D antenatal asthma reduction trial.

Estimation of couple fecundity in the general population and the association with monthly time-varying ambient particulate matter exposure in low- and middle-income countries: A population-based multi-center epidemiological study.

Association between long-term exposure to environmental fine particulate matter and the prevalence of thyroid disorders: A national cross-sectional study in China.

Laboratory Studies

BPA/Phenols

Co-exposure of bisphenol A and selenium deficiency induces pyroptosis via ROS/NLRP3 pathway in chicken spleen.

DHA-enriched phosphatidylserine alleviates bisphenol A-induced liver injury through regulating glycerophospholipid metabolism and the SIRT1-AMPK pathway.

Elucidation and active ingredient identification of aqueous extract of Ficus exasperata Vahl leaf against bisphenol A-induced toxicity through in vivo and in silico assessments.

Effect of thyroid disruption on ovarian development following maternal exposure to Bisphenol S.

Prenatal exposure to bisphenol AF causes toxicities in liver, spleen, and kidney tissues of SD rats.

Bisphenol AF Caused Reproductive Toxicity in Rats and Cineole Co-Treatment Exhibited Protective Effect.

Phthalates

Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells.

Di(2-ethylexyl) phthalate and chromosomal damage: Insight on aneugenicity from the cytochalasin-block micronucleus assay.

Prenatal exposure to dibutyl phthalate contributes to erectile dysfunction in offspring male rats by activating the RhoA/ROCK signalling pathway.

Investigating the modulation of the endocannabinoid system by probiotic Lactiplantibacillus plantarum IMC513 in a zebrafish model of di-n-hexyl phthalate exposure.

PFAS

Perfluorohexanesulfonic Acid (PFHxS) Impairs Lipid Homeostasis in Zebrafish Larvae through Activation of PPARα.

Perfluoroalkyl substances and immunotoxicity: an in vitro structure-activity relationship study in THP-1-derived monocytes and macrophages.

A novel molecular pathway of lipid accumulation in human hepatocytes caused by PFOA and PFOS.

Adolescent F-53B exposure induces ovarian toxicity in rats: Autophagy-apoptosis interplay.

SAP130 mediates crosstalk between hepatocyte ferroptosis and M1 macrophage polarization in PFOS-induced hepatotoxicity.

Unbound Fractions of PFAS in Human and Rodent Tissues: Rat Liver a Suitable Proxy for Evaluating Emerging PFAS?

Flame Retardants

TDMPP activation of estrogen receptor 2a regulates smc2 and p53 signaling to interfere with liver development in zebrafish (Danio rerio).

Organotins

Tributyltin-induced visceral adiposity is associated with impaired redox balance in white adipose tissue of male rats.

Pesticides

Chlorpyrifos induces cytotoxicity via oxidative stress and mitochondrial dysfunction in HepG2 cells.

Liver damage and lipid metabolic dysregulation in adult zebrafish (Danio rerio) induced by spirotetramat.

The zebrafish embryo as a model for chemically-induced steatosis: a case study with three pesticides.

Impacts of tolylfluanid on implantation and placental development: Disruption of mitochondrial function and implantation-related gene expression in vitro and in vivo.

Pesticide-induced transgenerational alterations of genome-wide DNA methylation patterns in the pancreas of Xenopus tropicalis correlate with metabolic phenotypes.

Hypoactivity and neurochemical alterations in the basal ganglia of female Sprague-Dawley rats after repeated exposure to atrazine.

Metals/Metalloids

Different Short-Chain Fatty Acids Unequally Modulate Intestinal Homeostasis and Reverse Obesity-Related Symptoms in Lead-Exposed High-Fat Diet Mice.

Screening of differentially expressed RNAs and identifying a ceRNA axis during cadmium-induced oxidative damage in pancreatic β cells.

Sirt1 m6A modification-evoked Leydig cell senescence promotes Cd-induced testosterone decline.

Microplastics/Nanomaterials

Tris(1-chloro-2-propyl) phosphate enhances the adverse effects of biodegradable polylactic acid microplastics on the mussel Mytilus coruscus.

Polystyrene nanoplastics induced learning and memory impairments in mice by damaging the glymphatic system.

Fragile Guts Make Fragile Brains: Intestinal Epithelial Nrf2 Deficiency Exacerbates Neurotoxicity Induced by Polystyrene Nanoplastics.

Microplastics at an environmentally relevant dose enhance mercury toxicity in a marine copepod under multigenerational exposure: Multi-omics perspective.

Negligible additive effect of environmental concentrations of fragmented polyethylene terephthalate microplastics on the growth and reproductive performance of Java medaka exposed to 17β-estradiol and bisphenol A.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Legacy and novel contaminants in surface sediments of Admiralty Bay, Antarctica Peninsula.

Phthalates

Phthalate content in toy samples available on the market of the Republic of Serbia.

Mono-n-hexyl phthalate: exposure estimation and assessment of health risks based on levels found in human urine samples.

Exploring noninvasive matrices for assessing long-term exposure to phthalates: a scoping review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The Commerson’s dolphin as Subantarctic sentinel of POPs: insights into the pollutant status in one of the southernmost coastal areas of the globe.

PFAS

Occurrence of perfluoroalkyl compounds in commercially available baby food produced in different European countries – levels, dietary intake, and exposure assessment.

Temporal Trends of Per- and Polyfluoroalkyl Substances Concentrations Insights from Australian Human Biomonitoring 2002-2021 and the U.S. NHANES Programs 2003-2018.

First report of accumulation of perfluorooctane sulfonate (PFOS) in platypuses (Ornithorhynchus anatinus) in New South Wales, Australia.

Targeted quantification of per- and polyfluoroalkyl substances (PFASs) in livestock serum by liquid chromatography-high-resolution mass spectrometry.

Spatial heterogeneity of per- and polyfluoroalkyl substances caused by glacial melting in Tibetan Lake Nam Co due to global warming.

Flame Retardants

Organophosphate esters in terrestrial environments of Fildes Peninsula, Antarctica: Occurrence, potential sources, and bioaccumulation.

Metals/Metalloids

A multi-year heavy metal analysis of 72 dark chocolate and cocoa products in the USA.

Microplastics/Nanomaterials

The difference between tire wear particles and polyethylene microplastics in stormwater filtration systems: Perspectives from aging process, conventional pollutants removal and microbial communities.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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