EDC Science Weekly, Aug. 12 – 18, 2020

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Regulations/Policy

Application of GUTS models for regulatory aquatic pesticide risk assessment illustrated with an example for the insecticide chlorpyrifos.

Methods/Tools/Screening

An analysis of the limitations and uncertainties of in vivo developmental neurotoxicity testing and assessment to identify the potential for alternative approaches.

Structures of endocrine-disrupting chemicals determine binding to and activation of the oestrogen receptor α (ERα) and androgen receptor (AR).

Structure-based virtual screening of perfluoroalkyl and polyfluoroalkyl substances (PFASs) as endocrine disruptors of androgen receptor activity using molecular docking and machine learning.

Commentaries

EHP Science Selection:

Bisphenol A and Puberty Onset in Female Mice: Developmental Effects of Low-Dose Exposure.

Is the Observed Decrease in Body Temperature During Industrialization Due to Thyroid Hormone-Dependent Thermoregulation Disruption? Comment on

Decreasing human body temperature in the United States since the industrial revolution

Reviews

BPA/Phenols

Potential Mechanisms of Bisphenol A (BPA) Contributing to Human Disease.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The ever-expanding limits of enzyme catalysis and biodegradation: polyaromatic, polychlorinated, polyfluorinated, and polymeric compounds.

Microplastics

Plastics and microplastics, effects on marine coastal areas: a review.

Air Pollution

Environment and COVID-19: Pollutants, impacts, dissemination, management and recommendations for facing future epidemic threats.

Miscellaneous

The association between prenatal exposure to polycyclic aromatic hydrocarbons and birth weight: A meta-analysis.

DNA methylation in human sperm: a systematic review.

Human Health Studies

Numerous Chemicals

Association of placental concentrations of phenolic endocrine disrupting chemicals with cognitive functioning in preschool children from the Environment and Childhood (INMA) Project. [BPA, parabens, benzophenones]

Phthalates

Determinants of Citation in Epidemiological Studies on Phthalates: A Citation Analysis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Influence of KRAS mutations, persistent organic pollutants, and trace elements on survival from pancreatic ductal adenocarcinoma.

Perfluoroalkyl Substances

Exposure to per- and polyfluoroalkyl substances (PFASs) in serum versus semen and their association with male reproductive hormones.

Pesticides

Exposure to pyrethroid pesticides and ovarian reserve.

Potentially Toxic Elements

Metabolomic Signatures of Lead Exposure in the VA Normative Aging Study.

Urinary Arsenic is Associated with Wasting and Underweight Status in Young Children in Rural Bangladesh.

Air Pollution

Cooking, smoking, and stunting: Effect of household air pollution sources on childhood growth in India.

Associations of smoking and air pollution with peripheral blood RNA N⁶-methyladenosine in the Beijing truck driver air pollution study.

Prenatal Fine Particulate Matter (PM_2.5) Exposure and Pregnancy Outcomes-Analysis of Term Pregnancies in Poland.

Laboratory Studies

BPA/Phenols

Antifibrotic effect of curcumin, n-acetyl cysteine and propolis against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment.

Phthalates

Exposure evaluation of diisononyl phthalate in the adults of Drosophila melanogaster: Potential risks in fertility, lifespan, behavior, and modes of action.

Dibutyl phthalate rapidly alters calcium homeostasis in the gills of Danio rerio.

Monobutyl phthalate (MBP) induces energy metabolism disturbances in the gills of adult zebrafish (Danio rerio).

The dynamic assessment of toxicity and pathological process of DEHP in germ cells of male Sprague Dawley rats

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Single nuclei RNA sequencing assessment of the hepatic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Exposure to prenatal PCBs shifts the timing of neurogenesis in the hypothalamus of developing rats.

Perfluoroalkyl Substances

Binary exposure to hypoxia and perfluorobutane sulfonate disturbs sensory perception and chromatin topography in marine medaka embryos.

An assessment of serum-dependent impacts on intracellular accumulation and genomic response of per- and polyfluoroalkyl substances in a placental trophoblast model.

Orally Administered 6:2 Chlorinated Polyfluorinated Ether Sulfonate (F-53B) Causes Thyroid Dysfunction in Rats.

Flame Retardants

Tris(1,3-dichloro-2-propyl) Phosphate reduces lifespan via activation of an unconventional Insulin/Insulin-like Growth Factor-1 Signaling Pathway.

Organotins

Short term chronic toxicity of tributyltin on the testes of adult albino rats and the possible protective role of omega-3.

Pesticides

Can parasites adapt to pollutants? A multigenerational experiment with a Daphnia × Metschnikowia model system exposed to the fungicide tebuconazole.

Sublethal concentrations of dichlorvos and paraquat induce genotoxic and histological effects in the Clarias gariepinus.

Diazinon impairs bioenergetics and induces membrane permeability transition on mitochondria isolated from rat liver.

Potentially Toxic Elements

Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement.

The mechanisms of arsenic-induced ovotoxicity, ultrastructural alterations, and autophagic related paths: An enduring developmental study in folliculogenesis of mice.

Pb exposure triggers MAPK-dependent inflammation by activating oxidative stress and miRNA-155 expression in carp head kidney.

Long-term exposure of high concentration heavy metals induced toxicity, fatality, and gut microbial dysbiosis in common carp, Cyprinus carpio.

Pollutants and nutrition: Are methylmercury effects on blood pressure and lipoprotein profile comparable to high-fat diet in mice?

Microplastics

Differential modulation of oxidative stress, antioxidant defense, histomorphology, ion-regulation and growth marker gene expression in goldfish (Carassius auratus) following exposure to different dose of virgin microplastics.

Rapid Production of Micro- and Nanoplastics by Fragmentation of Expanded Polystyrene Exposed to Sunlight

Microplastics Reduce Lipid Digestion in Simulated Human Gastrointestinal System.

Effects of MP Polyethylene Microparticles on Microbiome and Inflammatory Response of Larval Zebrafish.

Waterborne exposure of gilthead seabream (Sparus aurata) to polymethylmethacrylate nanoplastics causes effects at cellular and molecular levels.

Air Pollution

Metabolic effects of air pollution exposure and reversibility.

Pharmaceuticals

Novel disinfection byproducts formed from the pharmaceutical gemfibrozil are bioaccumulative and elicit increased toxicity relative to the parent compound in marine polychaetes (Neanthes arenaceodentata).

Potential environmental toxicity of sewage effluent with pharmaceuticals.

Mixtures

Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A systems-biological Understanding of Synergism between TDCPP and TPP.

Exposure to pollutants altered glucocorticoid signaling and clock gene expression in female mice. Evidence of tissue- and sex-specificity.

Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system.

Miscellaneous

Release of Melamine and Formaldehyde from Melamine-Formaldehyde Plastic Kitchenware

Integrated Hypoxia Signaling and Oxidative Stress in Developmental Neurotoxicity of Benzo[a]Pyrene in Zebrafish Embryos.

Exposure/Environment Studies

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Mother to fetus transfer of hydroxylated polychlorinated biphenyl congeners (OH-PCBs) in the Japanese macaque (Macaca fuscata): Extrapolation of Exposure Scenarios to Humans.

Occupational exposure to polychlorinated biphenyls (PCBs) in workers at companies in the Colombian electricity sector.

A global, cross-system meta-analysis of polychlorinated biphenyl biomagnification

Modelling scenarios of environmental recovery after implementation of controls on emissions of persistent organic pollutants.

Flame Retardants

Determination of organophosphate ester flame retardants and plasticisers in fish samples by QuEChERs followed by gas chromatography-tandem mass spectrometry. Exposure and risk assessment through fish consumption.

Pesticides

Organic diet intervention significantly reduces urinary glyphosate levels in U.S. children and adults.

Effect of Environmental Temperature and Humidity on Permethrin Biomarkers of Exposure in U.S. Soldiers Wearing Permethrin-Treated Uniforms.

The dilemma of pesticide residues in fruits and vegetables in the Eastern Mediterranean Region.

Potentially Toxic Elements

Assessment of 12 Essential and Toxic Elements in Whole Blood of Pregnant and Non-pregnant Women Living in Wuhan of China.

Microplastics

Airborne emissions of microplastic fibres from domestic laundry dryers.

Microplastic and tire wear particle occurrence in fishes from an urban estuary: Influence of feeding characteristics on exposure risk.

Consumer-based actions to reduce plastic pollution in rivers: A multi-criteria decision analysis approach.

Occurrence, distribution and provenance of micro plastics: A large scale quantitative analysis of beach sediments from southeastern coast of South Africa.

Air Pollution

Tris(2,4-di- tert-butylphenyl) phosphate: an unexpected abundant toxic pollutant found in PM 2.5

Understanding global PM2.5 concentrations and their drivers in recent decades (1998-2016).

Pharmaceuticals

Occurrence of the main metabolites of pharmaceuticals and personal care products in sludge stabilization treatments.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sarah@healthandenvironment.org and ask to join the group EDC_research@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.