EDC Science Weekly, Aug. 11 – 17, 2022 – HEEDS

EDC Science Weekly, Aug. 11 – 17, 2022

Post author:HEEDS
Post published:August 17, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots.

Development, Validation, and Application of a Human Reproductive Toxicity Prediction Model Based on Adverse Outcome Pathway.

The Long Goodbye: Finally Moving on from the Relative Potency Approach to a Mixtures Approach for Polycyclic Aromatic Hydrocarbons (PAHs).

Predictive and explanatory themes of NOAEL through a systematic comparison of different machine learning methods and descriptors.

Commentaries

Artificial Intelligence Meets Toxicology.

Letter to the editors regarding “The conundrum of the PFOA human half-life, an international collaboration.” and the Response.

Reviews

Numerous Chemicals/Mixtures

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.

Health impacts of artificial turf: Toxicity studies, challenges, and future directions.

Review of the toxicity and potential molecular mechanisms of parental or successive exposure to environmental pollutants in the model organism Caenorhabditis elegans.

Perfluoroalkyl Substances

Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis.

Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies.

Sources, occurrence, and treatment techniques of per- and polyfluoroalkyl substances in aqueous matrices: A comprehensive review.

Pesticides

Toxicological effects, environmental behaviors and remediation technologies of herbicide atrazine in soil and sediment: A comprehensive review.

Potentially Toxic Elements

Biomonitoring of inorganic arsenic species in pregnancy.

Natural Dietary Compounds in the Treatment of Arsenic Toxicity.

Microplastics/Nanomaterials

Effects of aging on environmental behavior of plastic additives: Migration, leaching, and ecotoxicity.

The ecotoxicological consequences of microplastics and co-contaminants in aquatic organisms: a mini-review.

Miscellaneous

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.

Human Health Studies

Numerous Chemicals/Mixtures

Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia.

Analysis of environmental chemical mixtures and nonalcoholic fatty liver disease: NHANES 1999-2014.

BPA/Phenols

Association of environmental phenols with endometriosis and uterine leiomyoma: an analysis of NHANES, 2003-2006.

Association between phenols and thyroid hormones: The role of iodothyronine deiodinase genes.

Phthalates

Associations between gastrointestinal infection and urinary phthalate metabolite concentrations in US children and adolescents from NHANES 2005-2016.

Parabens/Triclosan/Antimicrobials

Maternal diet quality moderates associations between parabens and birth outcomes.

Perfluoroalkyl Substances

Determination of Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid Levels with Different Stages of Chronic Kidney Disease.

Flame Retardants

Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and blood lipids in women of Shantou, China.

Potentially Toxic Elements

Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.

Lead exposure and impaired glucose homeostasis in Chinese adults: A repeated measures study with 5 years of follow-up.

Low-level environmental mercury exposure and thyroid cancer risk among residents living near national industrial complexes in South Korea: A population-based cohort study.

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children’s study using the ASQ-3 questionnaire: A prospective birth cohort.

Mercury may reduce the protective effect of sea fish consumption on serum triglycerides levels in Chinese adults: Evidence from China national human biomonitoring.

Laboratory Studies

Numerous Chemicals/Mixtures

Reproductive toxicity of maternal exposure to di-(2-ethilexyl)phthalate and butyl paraben (alone or in association) on both male and female wistar offspring.

BPA/Phenols

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition.

Bisphenol F induces liver-gut alteration in zebrafish.

Iridoid glycoside Aucubin protects against nonylphenol-induced testicular damage in male rats via modulation of steroidogenic and apoptotic signaling.

Adult Exposure to Di-N-Butyl Phthalate (DBP) Induces Persistent Effects on Testicular Cell Markers and Testosterone Biosynthesis in Mice.

Multiple circRNAs regulated by QKI5 conjointly spongemiR-214-3p to antagonize Bisphenol A-induced spermatocyte toxicity.

Phthalates

Di(2-ethylhexyl) Phthalate Disturbs Cholesterol Metabolism Through Oxidative Stress In Rat Liver.

Adult Exposure to Di-N-Butyl Phthalate (DBP) Induces Persistent Effects on Testicular Cell Markers and Testosterone Biosynthesis in Mice.

Parabens/Triclosan/Antimicrobials

Effect of triclosan exposure on ovarian hormones, trace elements and growth in female rats.

Toxicity mechanisms regulating bone differentiation and development defects following abnormal expressions of miR-30c targeted by triclosan in zebrafish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer’s Disease Risk. [see related Invited Perspective: Long-Lasting Legacy of Banned Contaminants in Alzheimer’s Disease Etiology-Convergence of Epidemiological and Toxicological Findings.]

Prenatal Environmental Exposure to Persistent Organic Pollutants and Reproductive Hormone Profile and Pubertal Development in Dutch Adolescents.

Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites.

Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study.

Perfluoroalkyl Substances

Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis.

In vivo relative bioavailability of perfluorooctanoic acid (PFOA) and its alternative hexafluoropropylene oxide trimer acid (HFPO-TA): Influence of food and mechanisms exploration.

Flame Retardants

Insights into the Atmospheric Persistence, Transformation, and Health Implications of Organophosphate Esters in Urban Ambient Air.

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice.

The disruption on gut microbiome of Decabromodiphenyl ethane exposure in the simulator of the human intestinal microbial ecosystem (SHIME).

Pesticides

Glyphosate differentially affects the allergic immune response across generations in mice.

Unveiling the nexus between parental exposure to toxicants and heritable spermiotoxicity – is life history a shield or a shadow?

Bromuconazole fungicide induces cell cycle arrest and apoptotic cell death in cultured human colon carcinoma cells (HCT116) via oxidative stress process.

Developmental and reproduction toxicity of Piperonyl Butoxide Part 3 Two Generation (Two Litter) Reproduction Study of Piperonyl Butoxide Administered in the Diet to CD ® (Sprague Dawley) Rats.

Thiobencarb induces phenotypic abnormalities, apoptosis, and cardiovascular toxicity in zebrafish embryos through oxidative stress and inflammation.

Potentially Toxic Elements

HPLC Analysis and the Antioxidant and Preventive Actions of Opuntia stricta Juice Extract against Hepato-Nephrotoxicity and Testicular Injury Induced by Cadmium Exposure.

Arsenic exposure increases susceptibility to Ptpn11-induced malignancy in mouse embryonic fibroblasts through mitochondrial hypermetabolism.

A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis.

Microplastics/Nanomaterials

Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks.

The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro.

Exposure to zinc oxide nanoparticles affects testicular structure, reproductive development and spermatogenesis in parental and offspring male rats.

Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells.

Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis.

Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds.

Incineration-Generated Polyethylene Micro-Nanoplastics Increase Triglyceride Lipolysis and Absorption in an In Vitro Small Intestinal Epithelium Model.

Miscellaneous

Transcriptional networks underlying a primary ovarian insufficiency disorder in alligators naturally exposed to EDCs.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Development and validation of a method for determination of 17 endocrine disrupting chemicals in milk, water, blood serum and feed by UHPLC-MS/MS.

High Prevalence of Chemical and Microbiological Drinking Water Contaminants in Households with Infants Enrolled in a Birth Cohort-Piura, Peru, 2016.

BPA/Phenols

Detection of Bisphenol A and Four Analogues in Atmospheric Emissions in Petrochemical Complexes Producing Polypropylene in South America.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides in the urban, suburban, agricultural, and industrial soil in South Korea after three decades of ban: Spatial distribution, sources, time trend, and implicated risks.

Highly contaminated river otters (Lontra canadensis) are effective biomonitors of environmental pollutant exposure.

The Kuroshio Regulates the Air-Sea Exchange of PCBs in the Northwestern Pacific Ocean.

Perfluoroalkyl Substances

The Association of Per- and Polyfluoroalkyl Substances Serum Levels and Allostatic Load by Country of Birth and the Length of Time in the United States.

Food grown on fire stations as a potential pathway for firefighters’ exposure to per- and poly-fluoroalkyl substances (PFAS).

Are cosmetics a significant source of PFAS in Europe? product inventories, chemical characterization and emission estimates.

Global patterns and temporal trends of perfluoroalkyl substances in municipal wastewater: A meta-analysis.

Flame Retardants

Percutaneous absorption and exposure risk assessment of organophosphate esters in children’s toys.

Occurrence, spatial variation, seasonal difference, and ecological risk assessment of organophosphate esters in the Yangtze River, China: From upper to lower reaches.

Pesticides

Exposure to organophosphorus compounds of Japanese children and the indoor air quality in their residences.

Cumulative dietary risk assessment of pesticides in food for the Danish population for the period 2012-2017.

Potentially Toxic Elements

Evaluation of some toxic metals in breast milk samples with dietary and sociodemographic characteristics: a case study of Kermanshah, Western Iran.

Using community science for detailed pollution research: a case-study approach in Indianapolis, IN, USA. [lead]

Microplastics/Nanomaterials

Assessing microplastic ingestion and occurrence of bisphenols and phthalates in bivalves, fish and holothurians from a mediterranean marine protected area.

Towards a North Pacific long-term monitoring program for ocean plastic pollution: A systematic review and recommendations for shorelines.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.