EDC Science Weekly, Aug. 11 – 17, 2022 – HEEDS

EDC Science Weekly, Aug. 11 – 17, 2022

Post author:HEEDS
Post published:August 17, 2022
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Methods/Tools/Screening

A state-of-the-science review and guide for measuring environmental exposure biomarkers in dried blood spots.

Development, Validation, and Application of a Human Reproductive Toxicity Prediction Model Based on Adverse Outcome Pathway.

The Long Goodbye: Finally Moving on from the Relative Potency Approach to a Mixtures Approach for Polycyclic Aromatic Hydrocarbons (PAHs).

Predictive and explanatory themes of NOAEL through a systematic comparison of different machine learning methods and descriptors.

Commentaries

Artificial Intelligence Meets Toxicology.

Letter to the editors regarding “The conundrum of the PFOA human half-life, an international collaboration.” and the Response.

Reviews

Numerous Chemicals/Mixtures

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors.

Health impacts of artificial turf: Toxicity studies, challenges, and future directions.

Review of the toxicity and potential molecular mechanisms of parental or successive exposure to environmental pollutants in the model organism Caenorhabditis elegans.

Perfluoroalkyl Substances

Association between per- and polyfluoroalkyl substances exposure and risk of diabetes: a systematic review and meta-analysis.

Perfluoroalkyl substances and lipid concentrations in the blood: A systematic review of epidemiological studies.

Sources, occurrence, and treatment techniques of per- and polyfluoroalkyl substances in aqueous matrices: A comprehensive review.

Pesticides

Toxicological effects, environmental behaviors and remediation technologies of herbicide atrazine in soil and sediment: A comprehensive review.

Potentially Toxic Elements

Biomonitoring of inorganic arsenic species in pregnancy.

Natural Dietary Compounds in the Treatment of Arsenic Toxicity.

Microplastics/Nanomaterials

Effects of aging on environmental behavior of plastic additives: Migration, leaching, and ecotoxicity.

The ecotoxicological consequences of microplastics and co-contaminants in aquatic organisms: a mini-review.

Miscellaneous

Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework.

Human Health Studies

Numerous Chemicals/Mixtures

Integrative exposomic, transcriptomic, epigenomic analyses of human placental samples links understudied chemicals to preeclampsia.

Analysis of environmental chemical mixtures and nonalcoholic fatty liver disease: NHANES 1999-2014.

BPA/Phenols

Association of environmental phenols with endometriosis and uterine leiomyoma: an analysis of NHANES, 2003-2006.

Association between phenols and thyroid hormones: The role of iodothyronine deiodinase genes.

Phthalates

Associations between gastrointestinal infection and urinary phthalate metabolite concentrations in US children and adolescents from NHANES 2005-2016.

Parabens/Triclosan/Antimicrobials

Maternal diet quality moderates associations between parabens and birth outcomes.

Perfluoroalkyl Substances

Determination of Serum Perfluorooctanoic Acid and Perfluorooctanesulfonic Acid Levels with Different Stages of Chronic Kidney Disease.

Flame Retardants

Associations between polybrominated diphenyl ethers (PBDEs) levels in adipose tissues and blood lipids in women of Shantou, China.

Potentially Toxic Elements

Associations of maternal urinary arsenic concentrations during pregnancy with childhood cognitive abilities: The HOME study.

Lead exposure and impaired glucose homeostasis in Chinese adults: A repeated measures study with 5 years of follow-up.

Low-level environmental mercury exposure and thyroid cancer risk among residents living near national industrial complexes in South Korea: A population-based cohort study.

Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children’s study using the ASQ-3 questionnaire: A prospective birth cohort.

Mercury may reduce the protective effect of sea fish consumption on serum triglycerides levels in Chinese adults: Evidence from China national human biomonitoring.

Laboratory Studies

Numerous Chemicals/Mixtures

Reproductive toxicity of maternal exposure to di-(2-ethilexyl)phthalate and butyl paraben (alone or in association) on both male and female wistar offspring.

BPA/Phenols

BPA Decreases PDCD4 in Bovine Granulosa Cells Independently of miR-21 Inhibition.

Bisphenol F induces liver-gut alteration in zebrafish.

Iridoid glycoside Aucubin protects against nonylphenol-induced testicular damage in male rats via modulation of steroidogenic and apoptotic signaling.

Adult Exposure to Di-N-Butyl Phthalate (DBP) Induces Persistent Effects on Testicular Cell Markers and Testosterone Biosynthesis in Mice.

Multiple circRNAs regulated by QKI5 conjointly spongemiR-214-3p to antagonize Bisphenol A-induced spermatocyte toxicity.

Phthalates

Di(2-ethylhexyl) Phthalate Disturbs Cholesterol Metabolism Through Oxidative Stress In Rat Liver.

Adult Exposure to Di-N-Butyl Phthalate (DBP) Induces Persistent Effects on Testicular Cell Markers and Testosterone Biosynthesis in Mice.

Parabens/Triclosan/Antimicrobials

Effect of triclosan exposure on ovarian hormones, trace elements and growth in female rats.

Toxicity mechanisms regulating bone differentiation and development defects following abnormal expressions of miR-30c targeted by triclosan in zebrafish.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer’s Disease Risk. [see related Invited Perspective: Long-Lasting Legacy of Banned Contaminants in Alzheimer’s Disease Etiology-Convergence of Epidemiological and Toxicological Findings.]

Prenatal Environmental Exposure to Persistent Organic Pollutants and Reproductive Hormone Profile and Pubertal Development in Dutch Adolescents.

Binding and Activation of Estrogen-Related Receptor γ: A Novel Molecular Mechanism for the Estrogenic Disruption Effects of DDT and Its Metabolites.

Organochlorine pesticides induce epithelial as well as inflammatory mediators following exposure to human ovarian surface epithelial cells: An in vitro study.

Perfluoroalkyl Substances

Broad toxicological effects of Per-/Poly- fluoroalkyl substances (PFAS) on the unicellular eukaryote, Tetrahymena pyriformis.

In vivo relative bioavailability of perfluorooctanoic acid (PFOA) and its alternative hexafluoropropylene oxide trimer acid (HFPO-TA): Influence of food and mechanisms exploration.

Flame Retardants

Insights into the Atmospheric Persistence, Transformation, and Health Implications of Organophosphate Esters in Urban Ambient Air.

Comparative Effects of Brominated Flame Retardants BDE-209, TBBPA, and HBCD on Neurotoxicity in Mice.

The disruption on gut microbiome of Decabromodiphenyl ethane exposure in the simulator of the human intestinal microbial ecosystem (SHIME).

Pesticides

Glyphosate differentially affects the allergic immune response across generations in mice.

Unveiling the nexus between parental exposure to toxicants and heritable spermiotoxicity – is life history a shield or a shadow?

Bromuconazole fungicide induces cell cycle arrest and apoptotic cell death in cultured human colon carcinoma cells (HCT116) via oxidative stress process.

Developmental and reproduction toxicity of Piperonyl Butoxide Part 3 Two Generation (Two Litter) Reproduction Study of Piperonyl Butoxide Administered in the Diet to CD ® (Sprague Dawley) Rats.

Thiobencarb induces phenotypic abnormalities, apoptosis, and cardiovascular toxicity in zebrafish embryos through oxidative stress and inflammation.

Potentially Toxic Elements

HPLC Analysis and the Antioxidant and Preventive Actions of Opuntia stricta Juice Extract against Hepato-Nephrotoxicity and Testicular Injury Induced by Cadmium Exposure.

Arsenic exposure increases susceptibility to Ptpn11-induced malignancy in mouse embryonic fibroblasts through mitochondrial hypermetabolism.

A Comprehensive Transcriptomic Analysis of Arsenic-Induced Bladder Carcinogenesis.

Microplastics/Nanomaterials

Microplastics-sorbed phenanthrene and its derivatives are highly bioaccessible and may induce human cancer risks.

The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro.

Exposure to zinc oxide nanoparticles affects testicular structure, reproductive development and spermatogenesis in parental and offspring male rats.

Environmental microplastics (EMPs) exposure alter the differentiation potential of mesenchymal stromal cells.

Effect of polystyrene nanoplastics on cell apoptosis, glucose metabolism, and antibacterial immunity of Eriocheir sinensis.

Endoplasmic reticulum stress-controlled autophagic pathway promotes polystyrene microplastics-induced myocardial dysplasia in birds.

Incineration-Generated Polyethylene Micro-Nanoplastics Increase Triglyceride Lipolysis and Absorption in an In Vitro Small Intestinal Epithelium Model.

Miscellaneous

Transcriptional networks underlying a primary ovarian insufficiency disorder in alligators naturally exposed to EDCs.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Development and validation of a method for determination of 17 endocrine disrupting chemicals in milk, water, blood serum and feed by UHPLC-MS/MS.

High Prevalence of Chemical and Microbiological Drinking Water Contaminants in Households with Infants Enrolled in a Birth Cohort-Piura, Peru, 2016.

BPA/Phenols

Detection of Bisphenol A and Four Analogues in Atmospheric Emissions in Petrochemical Complexes Producing Polypropylene in South America.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides in the urban, suburban, agricultural, and industrial soil in South Korea after three decades of ban: Spatial distribution, sources, time trend, and implicated risks.

Highly contaminated river otters (Lontra canadensis) are effective biomonitors of environmental pollutant exposure.

The Kuroshio Regulates the Air-Sea Exchange of PCBs in the Northwestern Pacific Ocean.

Perfluoroalkyl Substances

The Association of Per- and Polyfluoroalkyl Substances Serum Levels and Allostatic Load by Country of Birth and the Length of Time in the United States.

Food grown on fire stations as a potential pathway for firefighters’ exposure to per- and poly-fluoroalkyl substances (PFAS).

Are cosmetics a significant source of PFAS in Europe? product inventories, chemical characterization and emission estimates.

Global patterns and temporal trends of perfluoroalkyl substances in municipal wastewater: A meta-analysis.

Flame Retardants

Percutaneous absorption and exposure risk assessment of organophosphate esters in children’s toys.

Occurrence, spatial variation, seasonal difference, and ecological risk assessment of organophosphate esters in the Yangtze River, China: From upper to lower reaches.

Pesticides

Exposure to organophosphorus compounds of Japanese children and the indoor air quality in their residences.

Cumulative dietary risk assessment of pesticides in food for the Danish population for the period 2012-2017.

Potentially Toxic Elements

Evaluation of some toxic metals in breast milk samples with dietary and sociodemographic characteristics: a case study of Kermanshah, Western Iran.

Using community science for detailed pollution research: a case-study approach in Indianapolis, IN, USA. [lead]

Microplastics/Nanomaterials

Assessing microplastic ingestion and occurrence of bisphenols and phthalates in bivalves, fish and holothurians from a mediterranean marine protected area.

Towards a North Pacific long-term monitoring program for ocean plastic pollution: A systematic review and recommendations for shorelines.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sarhow@gmail.com and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard, Diabetes and Environment and HEEDS, a program of Environmental Health Sciences.

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EHN EHN

Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Lou Guillette Jr. Memorial Symposium
by Sarah Howard on October 22, 2024 at 1:30 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Webinar: The overturning of Chevron deference: impacts on environmental health decision making
by Sarah Howard on October 17, 2024 at 4:21 pm
In this Nov. 13 webinar, legal experts will discuss the implications of the overturning of Chevron deference and its profound impact on science, public health and decision-making. Sponsored by CHE and UCSF's EaRTH Center.

EHN EHN

Ultra-processed foods and plastic packaging make for the ultimate toxic pair, scientists say
by Katherine McMahon,Sarah Howard on October 25, 2024 at 10:37 am
A recent paper published in Globalization and Health explores the relationship between ultra-processed foods (UPFs), plastic packaging, and their combined threat to public health. “Consumers do not have the power to solve a problem of this scale, and thus it is the responsibility of policymakers to ensure that transitions away from unhealthy, unsustainable foods are accompanied by structural measures that support demand and access to healthy foods.”
Microplastic exposure linked to reduced sperm quality in humans
by Katherine McMahon,Sarah Howard on October 23, 2024 at 4:29 pm
Exposure to microplastics is associated with a decrease in sperm concentration, motility, and shape, according to a new study published in The Lancet. “The identification of non-stick pan coating material PTFE as a particularly hazardous microplastic for male fertility underscores the importance of targeted interventions to reduce exposure to this and similar substances.”
Exposure to PFAS in ski wax may be linked to high cholesterol
by Katherine McMahon,Sarah Howard on October 16, 2024 at 7:42 pm
According to a new study published in Environmental Research, skiers and snowboarders may face health risks from their exposure to PFAS via ski wax, which can contain up to 100% PFAS by mass. “Interventions to remove PFAS from fluorinated wax could decrease direct exposure to skiers and reduce PFAS release into the environment.”

EHN EHN

Stricter toxic chemical rules reduce Californians’ exposures
by Kristina Marusic on October 31, 2024 at 11:25 am
Californians have lower levels of toxic chemicals linked to cancer, birth defects and reproductive harm in their bodies than people in the rest of the country, according to a new study. The study, published in Environmental Health Perspectives and conducted by researchers at Silent Spring Institute, a nonprofit scientific research organization, and the University of California at Berkeley (UC Berkeley), looked at nationwide data on the levels of 37 toxic chemicals in people’s blood before and after California introduced its stringent regulations. It found that for 18 of these chemicals, Californians have lower levels in their bodies than the rest of the country.
EPA dismissed data on the neurotoxicity of common insecticides
by Katherine McMahon,Sarah Howard on October 30, 2024 at 5:56 pm
A recent paper in Frontiers in Toxicology examined research submitted by industry to the U.S. Environmental Protection Agency (EPA) on the neurotoxicity of neonicotinoids - the most widely used class of insecticides in the U.S. and worldwide - and found that the data was evaluated improperly by the agency. Why this matters: Neonicotinoids are widely used not only for commercial agriculture but also for more personal uses like home gardens and in some flea and tick treatments for pets. Humans are regularly exposed to neonicotinoids – which are structurally similar to nicotine – through the environment, food and water. Neonicotinoids’ popularity partly comes from the belief that their harmful effects are mostly limited to insects, but studies like this one demonstrate that mammals may also be harmed by the chemicals, and highlight the urgent need for stronger regulations around their use.
Pesticide regulations ignore critical threats to insect health and ecosystems
by EHN Curators on October 30, 2024 at 10:26 am
In a study revealing regulatory gaps, researchers found that pesticides impact insect behavior and survival at non-lethal doses, especially in warmer temperatures, calling into question the effectiveness of current pesticide safety protocols. Dave Goulson writes for The Conversation.