EDC Science Weekly, Apr. 7 – 13, 2022

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar April 14: Urgency of Addressing Forever Chemicals: The Scientific Basis for Managing PFAS as a Chemical Class (CHE Alaska)

Webinar April 20: Do chemicals in plastic consumer products contribute to obesity? (EDC Strategies Partnership)

Regulations/Policy

Arsenic in drinking water: An analysis of global drinking water regulations and recommendations for updates to protect public health.

Methods/Tools/Screening

Implementation of Zebrafish Ontologies for Toxicology Screening.

Predicting joint toxicity of chemicals by incorporating a weighted descriptor into a mixture model: Cases for binary antibiotics and binary nanoparticles.

Integration of toxicodynamic and toxicokinetic new approach methods into a weight-of-evidence analysis for pesticide developmental neurotoxicity assessment: A case-study with DL- and L-glufosinate.

Morphological profiling of environmental chemicals enables efficient and untargeted exploration of combination effects.

Next-generation risk assessment of chemicals – Rolling out a human-centric testing strategy to drive 3R implementation: The RISK-HUNT3R project perspective.

A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies.

Commentaries

Invited Perspective: How Relevant Are Mode-of-Action Considerations for the Assessment and Prediction of Mixture Effects? see related article, Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action.

Reviews

Numerous Chemicals/Mixtures

Comprehending The Role of Endocrine Disruptors In Inducing Epigenetic Toxicity.

Endocrine disrupting chemicals impact on ovarian aging: Evidence from epidemiological and experimental evidence.

Effects of exposure to environmental pollutants on mitochondrial DNA copy number: a meta-analysis.

Stress, Thyroid Dysregulation and Thyroid Cancer in Children and Adolescents. Proposed Impending Mechanisms.

BPA/Phenols

The effects of bisphenols on the cardiovascular system.

Perfluoroalkyl Substances

Association Between Exposure to Per- and Polyfluoroalkyl Substances and Birth Outcomes: A Systematic Review and Meta-Analysis.

Pesticides

Daily temperature fluctuations can magnify the toxicity of pesticides.

Microplastics

Leaching of microplastic-associated additives in aquatic environments: A critical review.

Human Health Studies

Numerous Chemicals/Mixtures

Maternal occupational exposures and fetal growth in a Spanish birth cohort.

BPA/Phthalates/Parabens

Associations of Phthalate Metabolites and Bisphenol A Levels with Obesity in Children: The Korean National Environmental Health Survey (KoNEHS) 2015 to 2017.

Association of urine phthalate metabolites, bisphenol A levels and serum electrolytes with 24-h blood pressure profile in adolescents.

Associations of prepubertal urinary phthalate metabolite concentrations with pubertal onset among a longitudinal cohort of boys.

Phthalate biomarkers and associations with respiratory symptoms and healthcare utilization among low-income urban children with asthma.

Environmental Phenol and Paraben Exposure Risks and Their Potential Influence on the Gene Expression Involved in the Prognosis of Prostate Cancer.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Adverse effects of dioxins on cognitive ability and motor performance of 5-year-old children residing in a hotspot of dioxin contamination originating from Agent Orange in Vietnam: A prospective cohort study.

Perfluoroalkyl Substances

Effect of Plasma and Blood Donations on Levels of Perfluoroalkyl and Polyfluoroalkyl Substances in Firefighters in Australia: A Randomized Clinical Trial.

In utero exposure to perfluoroalkyl and polyfluoroalkyl substances and attention and executive function in the offspring: A study in the Danish National Birth Cohort.

Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN).

Perfluoroalkyl substance mixtures and cardio-metabolic outcomes in highly exposed male workers in the Veneto Region: A mixture-based approach.

Pesticides

Prenatal exposure to insecticides and weight trajectories among South African children in the VHEMBE birth cohort.

Maternal pesticides exposure in pregnancy and the risk of wheezing in infancy: A prospective cohort study.

Potentially Toxic Elements

Causal relationships between blood calcium, iron, magnesium, zinc, selenium, phosphorus, copper, and lead levels and multisystem disease outcomes in over 400,000 Caucasian participants.

Association between whole blood metallic elements concentrations and gestational diabetes mellitus in Japanese women: The Japan environment and Children’s study.

Mixture analysis of associations between exposure to low levels of multiple metals and semen quality and sperm DNA integrity.

Exposure to arsenic and level of Vitamin D influence the number of Th17 cells and production of IL-17A in human peripheral blood mononuclear cells in adults.

Association between prenatal cadmium exposure and cord blood DNA methylation.

Prevalence of arterial hypertension and cardiovascular risk factors in a rural population exposed to arsenic in Argentina.

Cancer mortality and chemical exposure in a retrospective zinc and lead smelter cohort: A 48-year follow-up.

Relationship between cumulative exposure to metal mixtures and heart rate among Chinese preschoolers.

Prenatal Exposure to Metals and Neurodevelopment in Infants at Six Months: Rio Birth Cohort Study of Environmental Exposure and Childhood Development (PIPA Project).

Laboratory Studies

Numerous Chemicals/Mixtures

Transcriptomic analysis in zebrafish larvae identifies iron-dependent mitochondrial dysfunction as a possible key event of NAFLD progression induced by benzo[a]pyrene/ethanol co-exposure.

Endocrine-disrupting chemicals affect sertoli TM4 cell functionality through dysregulation of gap junctional intercellular communication in vitro.

Pollution induces epigenetic effects that are stably transmitted across multiple generations.

Histopathological and immunohistochemical evaluation for detecting changes in blood hormone levels caused by endocrine disruptors in a 28-day repeated-dose study in rats.

A Novel Ex Vivo Approach Based on Proteomics and Biomarkers to Evaluate the Effects of Chrysene, MEHP, and PBDE-47 on Loggerhead Sea Turtles (Caretta caretta).

BPA/Phenols

Bisphenol B disrupts testis differentiation partly via the estrogen receptor-mediated pathway and subsequently causes testicular dysgenesis in Xenopus laevis.

Assessing the toxicity of bisphenol A and its six alternatives on zebrafish embryo/larvae.

Bisphenol S promotes the progression of prostate cancer by regulating the expression of COL1A1 and COL1A2.

Bisphenol A Impairs Lipid Remodeling Accompanying Cell Differentiation in the Oligodendroglial Cell Line Oli-Neu.

Phthalates

Di-n-butyl phthalate promotes monocyte recruitment via miR-137-3p-SP1-MCP-1 pathway.

Revealing the effects of maternal di(2-ethylhexyl) phthalate exposure on the progression of early meiosis in female foetal germ cells at single-cell resolution.

Parabens/Triclosan/Antimicrobials

Impairment of the gut health in Danio rerio exposed to triclocarban.

Perfluoroalkyl Substances

Perfluorooctanoic acid alters the developmental trajectory of female germ cells and embryos in rodents and its potential mechanism.

Leydig cell function in adult male rats is disrupted by perfluorotetradecanoic acid through increasing oxidative stress and apoptosis.

Flame Retardants

BDE-99 Disrupts the Photoreceptor Patterning of Zebrafish Larvae via Transcription Factor six7.

Organotins

Toll-like receptors in the mechanism of tributyltin-induced production of pro-inflammatory cytokines, IL-1β and IL-6.

Pesticides

Developmental toxicity of glyphosate on embryo-larval zebrafish (Danio rerio).

The immune modulatory role of marjoram extract on imidacloprid induced toxic effects in thymus and spleen of adult rats.

A retrospective analysis of honey bee (Apis mellifera) pesticide toxicity data.

Glyphosate-based herbicides induces autophagy in IPEC-J2 cells and the intervention of N-acetylcysteine.

Potentially Toxic Elements

Comprehensive insight into the neurotoxic mechanisms of low dose Pb exposure in Wistar rats: Benchmark dose analysis.

Microplastics

Oral exposure to polyethylene microplastics alters gut morphology, immune response, and microbiota composition in mice.

Accumulation of nylon microplastics and polybrominated diphenyl ethers and effects on gut microbial community of Chironomus sancticaroli.

Combined effect of arsenic and polystyrene-nanoplastics at environmentally relevant concentrations in mice liver: Activation of apoptosis, pyroptosis and excessive autophagy.

Pharmaceuticals/Personal Care Products

UV-filter octyl methoxycinnamate causes reproductive toxicity associated with germline apoptosis and vitellogenin decrease in Caenorhabditis elegans.

Inhibitory effects of estrogenic endocrine disrupting chemicals on fin regeneration in zebrafish are dependent on estrogen receptors.

Miscellaneous

Gestational Exposure to Perchlorate in the Rat: Thyroid Hormones in Fetal Thyroid Gland, Serum, and Brain.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Simultaneous determination of poly- and perfluoroalkyl substances and organophosphorus flame retardants in serum by ultra performance liquid chromatography-tandem mass spectrometry.

Dermal Exposure to Hazardous Chemicals in Baby Diapers: A Re-Evaluation of the Quantitative Health Risk Assessment Conducted by The French Agency for Food, Environmental and Occupational Health and Safety (ANSES).

BPA/Phenols

Thermodynamics Affecting Glacier-Released 4-Nonylphenol Deposition in Alaska, USA.

Phthalates

Distribution, source apportionment and health risk assessment of phthalate esters in outdoor dust samples on Tibetan Plateau, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Temporal Trends of Exposure to Organochlorine Pesticides in the United States: A Population Study from 2005 to 2016.

Body burden and influencing factors of polychlorinated dibenzodioxins and dibenzofurans (PCDD/Fs) in male workers from a municipal waste incineration plant in China.

Perfluoroalkyl Substances

Biomonitoring of per- and polyfluoroalkyl substances (PFAS) exposure in firefighters: Study design and lessons learned from stakeholder and participant engagement.

Per- and polyfluoralkyl substances (PFAS) in drinking water system: Target and non-target screening and removal assessment.

Fate of Per- and Polyfluoroalkyl Substances from Durable Water-Repellent Clothing during Use.

Spatiotemporal distribution, ecological risk assessment and source analysis of legacy and emerging per- and Polyfluoroalkyl Substances in the Bohai Bay, China.

Bioaccumulation of per- and polyfluoroalkyl substance in fish from an urban river: Occurrence, patterns and investigation of potential ecological drivers.

Flame Retardants

Elevated concentration and high Diversity of organophosphate esters (OPEs) were Discovered in Sediment from Industrial, and E-Waste Recycling Areas.

Comparison of Dechlorane Plus Concentrations in Sequential Blood Samples of Pregnant Women in Taizhou, China.

Pesticides

Pesticide exposure in New Zealand school-aged children: Urinary concentrations of biomarkers and assessment of determinants.

Potentially Toxic Elements

Sociodemographic inequalities in uranium and other metals in community water systems across the USA, 2006-11: a cross-sectional study.

Air Pollution

Occupational Exposure of Hairdressers to Airborne Hazardous Chemicals: A Scoping Review.

Miscellaneous

Evaluating predictive relationships between wristbands and urine for assessment of personal PAH exposure.

Are fish oil-based dietary supplements a significant source of exposure to chlorinated paraffins?

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me at sar…@gmail.com and ask to join the EDC Science Weekly group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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