EDC Science Weekly, Apr. 7 – 13, 2021 – HEEDS

EDC Science Weekly, Apr. 7 – 13, 2021

Post author:HEEDS
Post published:April 13, 2021
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

April 14 Webinar: The Monsanto Papers (EDC Strategies Partnership)

April 15 Webinar: Putting the EU Chemicals Strategy for Sustainability into action: Addressing EDCs and mixtures [Food Packaging Forum]

April 14-15: Leveraging Advances in Remote Geospatial Technologies to Inform Precision Environmental Health Decisions – A Workshop [The National Academies]

April 19-20 Conference:16th Annual Break the Cycle of Children’s Environmental Health Disparities [The Southeast PEHSU and Break the Cycle of Health Disparities, Inc.]

April 21 Virtual Town Hall: EPA’s Lead & Copper Rule: What Schools and Child Care Need to Know [Children’s Environmental Health Network]

April 22 Earth Day Symposium: John P. Wyatt, M.D. Environment & Health Symposium [University of Kentucky]

April 28 Webinar: Protecting Your Child’s Health with Dr. Ruth Etzel (CHE-Alaska)

Apr. 28 Webinar: 5th Annual Mind the Store Retailer Report Card (Mind the Store and Toxic Free Future)

Methods/Tools/Screening

Chemical Mixture Calculator – A novel tool for mixture risk assessment.

Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition.

Commentaries

Adopting a “Compound” Exposome Approach in Environmental Aging Biomarker Research: A Call to Action for Advancing Racial Health Equity.

Reviews

Numerous EDCs

Interplay Between Endocrine Disruptors and Immunity: Implications for Diseases of Autoreactive Etiology.

Dysregulations of long non-coding RNAs - The emerging “lnc” in environmental carcinogenesis.

Hypospadias induced by medications and environmental exposures- A scoping review.

Chronic Kidney Disease of Undetermined Etiology around the World.

BPA/Phenols

An overview of the literature on emerging pollutants: Chlorinated derivatives of Bisphenol A (Cl_xBPA).

Endocrine disrupting chemical Bisphenol A and its potential effects on female health.

An integrative review on the toxicity of Bisphenol A (BPA) released from resin composites used in dentistry.

Understanding the Mechanistic Link between Bisphenol A and Cancer Stem Cells: A Cancer Prevention Perspective.

Perfluoroalkyl Substances

Considering Environmental Exposures to Per- and Polyfluoroalkyl Substances (PFAS) as Risk Factors for Hypertensive Disorders of Pregnancy.

Per- and polyfluoroalkyl Substances (PFAS) as Contaminants of Emerging Concern in Asia’s Freshwater Resources.

Pesticides

Chronic oral exposure to pesticides and their consequences on metabolic regulation: role of the microbiota.

Pyrethroid based pesticides – chemical and biological aspects.

Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis.

The Effect of Glyphosate on the Reproduction of Estuarine Crabs: Neohelice granulata as a Study Model.

Potentially Toxic Elements

Lead (Pb) exposure and heart failure risk.

Microplastics

Occurrence, effect, and fate of residual microplastics in anaerobic digestion of waste activated sludge: A state-of-the-art review.

The extraction of microplastics from sediments: An overview of existing methods and the proposal of a new and green alternative.

Air Pollution

Association between ambient particulate matter exposure and metabolic syndrome risk: A systematic review and meta-analysis.

Travelling to Polluted Cities: A Systematic Review on the Harm of Air Pollution on International Travellers’ Health.

Acute and chronic exposure to air pollution in relation with incidence, prevalence, severity and mortality of COVID-19: a rapid systematic review.

Pharmaceuticals/Personal Care Products

Current opinion on risk assessment of cosmetics.

Human Health Studies

Numerous Chemicals

Gaussian graphical modeling of the serum exposome and metabolome reveals interactions between environmental chemicals and endogenous metabolites.

Pregnancy exposure to common-detect organophosphate esters and phthalates and maternal thyroid function.

BPA/Phenols

Exposure of Bisphenol-A in breast cancer patients-quantitatively assessed by a sensitivity-enhanced high performance liquid chromatography coupled with fluorescence detector: A Case-Control Study.

Phthalates

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study.

Effect of prenatal phthalate exposure on the association of maternal hormone levels during early pregnancy and reproductive markers in infants at the age of 3 months.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Persistent organic pollutants in pregnant women potentially affect child development and thyroid hormone status.

Trends in concentrations of selected dioxins and furans across various stages of kidney function for US adults.

Perfluoroalkyl Substances

Joint effects of prenatal exposure to per- and poly-fluoroalkyl substances and psychosocial stressors on corticotropin-releasing hormone during pregnancy.

Perfluorooctane sulfonate alternatives and metabolic syndrome in adults: New evidence from the Isomers of C8 Health Project in China.

Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese Child cohort.

Pesticides

Investigation of the association between pesticide exposure and the prevalence of type 2 diabetes in Shahedieh population in Yazd.

Association between pyrethroid exposure and cardiovascular disease: A national population-based cross-sectional study in the US.

Evaluation of Occupational Pesticide Exposure on Egyptian Male Adolescent Cognitive and Motor Functioning.

Potentially Toxic Elements

Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women.

Metal exposure and bone remodeling during pregnancy: Results from the PROGRESS cohort study.

Rare, Protein-Altering Variants in AS3MT and Arsenic Metabolism Efficiency: A Multi-Population Association Study.

Child marriage, maternal serum metal exposure, and risk of preterm birth in rural Bangladesh: evidence from mediation analysis.

Comprehensive screen the lead and other toxic metals in total environment from a coal-gas industrial city (NW, China): Based on integrated source-specific risks and site-specific blood lead levels of 0-6 aged children.

Relationship between urinary heavy metals with metabolic syndrome and its components in population from Hoveyzeh cohort study: A case-control study in Iran.

Pre and postnatal exposure to mercury and respiratory health in preschool children from the Spanish INMA Birth Cohort Study.

Exposure to multiple metals and the risk of hypertension in adults: A prospective cohort study in a local area on the Yangtze River, China.

T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma.

Air Pollution

Global PM2.5-attributable health burden from 1990 to 2017: estimates from the Global Burden of Disease Study 2017.

Cardiovascular morbidity and mortality associations with biomass- and fossil-fuel-combustion fine-particulate-matter exposures in Dhaka, Bangladesh.

Short-Term Effects of Particle Sizes and Constituents on Blood Biomarkers among Healthy Young Adults in Guangzhou, China.

Association between ambient air pollution and cause-specific mortality in Cape Town, Durban, and Johannesburg, South Africa: any susceptible groups?

Effect of PM_2.5 pollution on perinatal mortality in China.

Ambient air pollutants are associated with morning serum cortisol in overweight and obese Latino youth in Los Angeles.

Maternal exposure to ambient air pollution and congenital heart defects in China.

Acute effect of particulate matter pollution on hospital admissions for stroke among patients with type 2 diabetes in Beijing, China, from 2014 to 2018.

Association between prenatal exposure to air pollutants and newborn thyroxine (T4) levels.

Long-Term Exposure to Fine Particle Elemental Components and Natural and Cause-Specific Mortality-a Pooled Analysis of Eight European Cohorts within the ELAPSE Project.

Air pollution exposure and risk of adverse obstetric and neonatal outcomes among women with type 1 diabetes.

Pharmaceuticals/Personal Care Products

Grandmothers’ endocrine disruption during pregnancy, low birth weight, and preterm birth in third generation. [DES]

Non-Combustible Source Indoor Air Pollutants Concentration in Beauty Salons and Associated Self-Reported Health Problems Among the Beauty Salon Workers.

Miscellaneous

Childhood Overweight and Obesity and Pubertal Onset Among Mexican American Boys and Girls in the CHAMACOS Longitudinal Study.

Grandchild’s IQ is associated with grandparental environments prior to the birth of the parents. [smoking and GDP]

Laboratory Studies

BPA/Phenols

Multigenerational impacts of gestational bisphenol A exposure on the sperm function and fertility of male mice.

Bisphenol A Exposure Disrupts Organelle Distribution and Functions During Mouse Oocyte Maturation.

Molecular mechanisms of vitamin D plus Bisphenol A effects on adipogenesis in human adipose-derived mesenchymal stem cells.

Phthalates

Toxicity Assessment of Transfluthrin, Benzyl Butyl Phthalate, and 17β-Estradiol on the Primary Fibroblast of the Striped Field Mouse, Apodemus agrarius.

Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1.

Parabens/Triclosan/Antimicrobials

Behavioural effects of early-life exposure to parabens in zebrafish larvae.

Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis.

Thirteen-week subcutaneous repeated dose toxicity study of butylparaben and its toxicokinetics in rats.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Susceptibility to DNA Damage Caused by Abrogation of Rad54 homolog B: A Putative Mechanism for Chemically Induced Cleft palate. [TCDD]

Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats.

Perfluoroalkyl Substances

Toxicological Response of Chironomus dilutus in Single Chemical and Binary Mixture Exposure Experiments with Six Perfluoralkyl Substances.

Increased toxicity and retention of Perflourooctane Sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a High-Fat Diet (HFD).

Perfluorooctanesulfonic acid (PFOS) thwarts the beneficial effects of calorie restriction and Metformin.

Flame Retardants

The ecotoxicological contaminant tris(4-chlorophenyl)methanol (TCPMOH) impacts embryonic development in zebrafish (Danio rerio).

Pesticides

Toxicological status changes the susceptibility of the honey bee Apis mellifera to a single fungicidal spray application.

The Reproductive Injury and Oxidative Testicular Toxicity Induced by Chlorpyrifos Can Be Restored by Zinc in Male Rats.

Use of nontarget organism Chironomus sancticaroli to study the toxic effects of nanoatrazine.

The neonicotinoid alternative sulfoxaflor causes chronic toxicity and impairs mitochondrial energy production in Chironomus kiinensis.

Chlorpyrifos pesticide promotes oxidative stress and increases inflammatory states in BV-2 microglial cells: A role in neuroinflammation.

Effects of penconazole enantiomers exposure on hormonal disruption in zebrafish Danio rerio (Hamilton, 1822).

Glyphosate exposure induces synaptic impairment in hippocampal neurons and cognitive deficits in developing rats.

Exposure to environmental concentrations of fipronil induces biochemical changes on a neotropical freshwater fish.

Chronic pesticide exposure induced aberrant Notch signalling along the visual pathway in a murine model.

Biological toxicity assessment of carbamate pesticides using bacterial and plant bioassays: An in-vitro approach.

Pathophysiological Changes in the Enteric Nervous System of Rotenone-Exposed Mice as Early Radiological Markers for Parkinson’s Disease.

Potentially Toxic Elements

Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells.

Coenzyme Q₁₀ protected against arsenite and enhanced the capacity of 2,3-dimercaptosuccinic acid to ameliorate arsenite-induced toxicity in mice.

Microplastics

Effects of polyethylene microplastics on the microbiome and metabolism in larval zebrafish.

Air Pollution

Exposure to PM2.5 aggravates Parkinson’s disease via inhibition of autophagy and mitophagy pathway.

Paternal Exposure to PM_2.5 Programs Offspring’s Energy Homeostasis.

In vitro toxicity of indoor and outdoor PM₁₀ from residential wood combustion.

Pharmaceuticals/Personal Care Products

Acute toxicity and ecological risk assessment of 4,4′-dihydroxybenzophenone, 2,4,4′-trihydroxybenzophenone and 4-MBC in ultraviolet (UV)-filters.

Mixtures

Ancestral plastics exposure induces transgenerational disease-specific sperm epigenome-wide association biomarkers.

Transcriptome-Wide Prediction and Measurement of Combined Effects Induced by Chemical Mixture Exposure in Zebrafish Embryos.

Miscellaneous

PAH-pollution effects on sensitive and resistant embryos: Integrating structure and function with gene expression.

Exposure/Environment Studies

Phthalates

Determinants of phthalate exposure among a U.S.-based group of Latino workers.

Parabens

Occurrence of parabens in outdoor environments: Implications for human exposure assessment.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Are temporal trends of some persistent organochlorine and organobromine compounds in Swedish breast milk slowing down?

Terrestrial inputs govern spatial distribution of polychlorinated biphenyls (PCBs) and hexachlorobenzene (HCB) in an Arctic fjord system (Isfjorden, Svalbard).

Lake Superior Has Lost over 90% of Its Pesticide HCH Load since 1986.

Bioanalytical screening of low levels of dioxins and dioxin-like PCBs in pig meat (pork) for checking compliance with EU maximum and action levels using highly sensitive “third generation” recombinant H4L7.5c2 rat hepatoma cells.

Chemical hazard in glacial melt? The glacial system as a secondary source of POPs (in the Northern Hemisphere). A systematic review.

Population-based biomonitoring of exposure to persistent and non-persistent organic pollutants in the Grand Duchy of Luxembourg: Results from hair analysis.

Perfluoroalkyl Substances

Time trends of perfluoroalkyl substances in blood in 30-year old Norwegian men and women in the period 1986-2007.

Exposure to perfluoroalkyl substances through human milk in preterm infants.

Occurrence of per- and polyfluoroalkyl substances and unidentified organofluorine in leachate from waste-to-energy stockpile – A case study.

Biological and behavioural responses of European honey bee (Apis mellifera) colonies to perfluorooctane sulfonate (PFOS) exposure.

Exploring unknown per- and polyfluoroalkyl substances in the German environment – The total oxidizable precursor assay as helpful tool in research and regulation.

A rapid method for the detection and quantification of legacy and emerging per- and polyfluoroalkyl substances (PFAS) in bird feathers using UPLC-MS/MS.

Flame Retardants

Exposure of children and mothers to organophosphate esters: Prediction by house dust and silicone wristbands.

Levels of polybrominated diphenyl ethers (PBDEs) in water and sediment from open city drains in Makurdi Metropolitan Area, North Central Nigeria.

Contamination status, emission sources, and human health risk of brominated flame retardants in urban indoor dust from Hanoi, Vietnam: the replacement of legacy polybrominated diphenyl ether mixtures by alternative formulations.

Sorption and migration of organophosphate flame retardants between sources and settled dust.

Pesticides

Organophosphate pesticide exposure: Demographic and dietary predictors in an urban pregnancy cohort.

Human Exposures to Neonicotinoids in Kumasi, Ghana.

Experimental field evidence shows milkweed contaminated with a common neonicotinoid decreases larval survival of monarch butterflies.

Pesticides in honey bee colonies: Establishing a baseline for real world exposure over seven years in the USA.

Estimated dietary exposure to pesticide residues based on organic and conventional data in omnivores, pesco-vegetarians, vegetarians and vegans.

Potentially Toxic Elements

Potentially toxic elements concentrations in schoolyard soils in the city of Coronel, Chile.

Human Methylmercury Exposure and Potential Impacts in Central Tibet: Food and Traditional Tibetan Medicine.

Total mercury and methylmercury in human hair and food: Implications for the exposure and health risk to residents in the Three Gorges Reservoir Region, China.

Stress Response, Immunity, and Organ Mass in Toads (Rhinella diptycha) Living in Metal-Contaminated Areas.

Diet influence on mercury bioaccumulation as revealed by polyunsaturated fatty acids in zoobenthos from two contrasting environments: Chinese reservoirs and Swedish lakes.

Microplastics

Microplastic pollution in Southern Atlantic marine waters: Review of current trends, sources, and perspectives.

A roadmap for a Plastisphere.

Microplastics in four bivalve species and basis for using bivalves as bioindicators of microplastic pollution.

Mixtures

Assessment of epigenotoxic profiles of Dongjiang River: A comprehensive of chemical analysis, in vitro bioassay and in silico approach.

A review of the current environmental status and human health implications of one of the most polluted rivers of Mexico: The Atoyac River, Puebla.

Endocrine Disruptor Impacts on Fish From Chile: The Influence of Wastewaters.

Miscellaneous

PAHs and their hydroxylated metabolites in the human fingernails from e-waste dismantlers: Implications for human non-invasive biomonitoring and exposure.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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EHN EHN

Webinar: Fluoride, neurodevelopment, and cognition: a National Toxicology Program monograph
by Sarah Howard on November 19, 2024 at 5:00 pm
This Dec. 3 webinar features Dr. Kyla Taylor of NIEHS who will discuss the results of a National Toxicology Program monograph review that concluded there is "moderate confidence" in the scientific evidence that showed an association between higher levels of fluoride exposure and lower IQ in children.
Webinar: Behind the scenes at EPA: What's gone wrong and what does it mean for our work?
by Sarah Howard on November 19, 2024 at 3:56 pm
This Dec. 9 webinar, Behind the scenes at EPA: what's gone wrong and what does it mean for our work? is part 2 of a series on the future of EPA decision-making. Sponsored by the Collaborative for Health and Environment (CHE), Earthjustice, and UCSF's Earth Center.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on October 31, 2024 at 2:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.

EHN EHN

“We have enough evidence” to act on toxic plastic exposure now
by Katherine McMahon,Sarah Howard on November 22, 2024 at 3:31 pm
In a recent commentary published in The Lancet, Dr. Leonardo Trasande of NYU’s Grossman School of Medicine emphasizes the need to address the well-established health harms from exposure to chemical additives used in plastics. “Only through a serious and concerted effort to turn off the plastic tap will we apply the lessons learned from plastic use… and avoid the invisible chemicals used in plastic materials from becoming visible in the form of a larger global pandemic of chronic disease.”
Kids who adopt a gluten-free diet have increased arsenic levels
by Katherine McMahon,Sarah Howard on November 20, 2024 at 1:32 pm
A recent study published in The American Journal of Gastroenterology found that children who adopted a gluten-free (GF) diet after being diagnosed with celiac disease had significantly increased arsenic exposure after only six months. “More research needs to be done to determine whether there are long-term effects of this bump, but overall, I think it speaks to the importance of diversifying the grains in the gluten-free diet.”
NIEHS publishes new strategic plan
by Sarah Howard on November 19, 2024 at 6:03 pm
The National Institute of Environmental Health Sciences (NIEHS) published a 2025-2029 strategic plan, "Health at the Intersection of People and Their Environments."

EHN EHN

Trump’s second term could mean fewer protections for drinking water
by EHN Curators on November 21, 2024 at 12:30 pm
Donald Trump’s plans for the Environmental Protection Agency may include rolling back protections against PFAS and other drinking water threats, worrying public health advocates. Hiroko Tabuchi reports for The New York Times.
Kennedy’s fluoride policy faces obstacles
by EHN Curators on November 19, 2024 at 8:28 pm
President-elect Trump’s selection of Robert F. Kennedy Jr. to lead the Department of Health and Human Services won’t give him direct control over water fluoridation policies, though his influence could sway public and local debates. Miranda Willson reports for E&E News.
Scientists' Declaration for the Global Plastics Treaty
by Sarah Howard on November 19, 2024 at 5:54 pm
The signatories of this declaration are independent scientists with expertise on plastics, and who are free of conflicts of interest associated with the life cycle of plastics. Read it here and sign it here. Due Nov. 22, 2024.