EDC Science Weekly, Apr. 4-10, 2025

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Methods/Tools/Screening, Commentaries/Policy, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Science summaries and highlights

Events

Apr. 15 webinar: Children’s Health: Assessing impacts of the exposome [EDC Strategies Partnership]

Apr. 16 webinar: This is Your Brain on Plastic: What You Need to Know About Plastics & Health [Plastic Pollution Coalition]

Apr. 15-16: Iowa PFAS Conference, in person in Iowa City [Iowa College of Engineering]

Apr. 17 webinar: Scientific Principles to Protect Public Health [PRHE’s Science Action Network]

Apr. 18 webinar: Perspectives on the Plastics Lifecycle: Plastic Pollution and Fate [National Academies]

Apr. 24 webinar: Childhood cancer and the environment: Prevention opportunities [CHE-Alaska]

CANCELLED: Apr. 25: HEEDS EDC-North Carolina group 5th Annual Meeting [HEEDS]

Apr. 27-29 conference: Break the Cycle of Children’s Environmental Health Disparities

May 8 webinar: Changes at NIH: What do they mean for environmental health? [EDC Strategies Partnership]

May 10-13: EDC sessions at European endocrinology society meeting [European Society for Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE)]

May 14: Minimising the impact of endocrine disrupting chemicals on health and environment [a scientific update following the Joint Congress of ESPE and ESE, sponsored by ESE]

May 15 webinar: Microplastics’ Impact on the Brain & Heart [Beyond Plastics, PSR NY, Environmental Advocates]

June 16-17 workshop: Roadmap to phase out animal testing for chemical safety assessments [The European Chemicals Agency (ECHA)]

July 30 – Aug. 1 conference: U.S. Developmental Origins of Health and Disease (DOHaD) Society Annual Meeting

More events

Methods/Tools/Screening

Report of the European Commission Workshop on “The Roadmap Towards Phasing Out Animal Testing for Chemical Safety Assessments”, Brussels, 11-12 December 2023.

Look What You Made Me Do: Discerning Feature for Classification of Endocrine-Disrupting Chemical Binding to Steroid Hormone Receptors.

Combining Molecular Docking and Pharmacophore Models Predicts Ligand Binding of Endocrine-Disrupting Chemicals to Nuclear Receptors.

The use of canonical dose-response models for benchmark dose analysis of continuous toxicological data.

Commentaries/Policy

Apolitical Science

More EDC policy, FPF’s regulations open for comment, Science’s Trump-Tracker, and links to preserved resources removed from U.S. federal websites

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The impact of environmental pollution on metabolic health and the risk of non-communicable chronic metabolic diseases in humans.

Environmental exposure to selected non-persistent endocrine disrupting chemicals and polycystic ovary syndrome: a systematic review.

Endocrine disrupters affect the immune system of fish: the example of the European seabass.

BPA/Phenols

Interlinkage between inflammation, oxidative stress, and endoplasmic reticulum stress in bisphenols-induced testicular steroidogenesis disturbance: A mini review.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticides: occurrence and spatial distribution of residues, toxicity, and toxic mechanisms.

PFAS

Systematic review and meta-analysis of epidemiologic data on infectious disease in relation to exposure to twelve perfluoroalkyl substances (PFAS).

PFAS regulations and economic impact: A review of U.S. pulp & paper and textiles industries.

Pesticides

The neurotoxicity of pesticides: Implications for Parkinson’s disease.

Microplastics/Nanomaterials/Plastics

Microplastic pollution: Critical analysis of global hotspots and their impact on health and ecosystems.

Synthetic biology strategies for sustainable bioplastic production by yeasts. [also see Ecotoxicity of Biodegradable Microplastics and Bio-based Microplastics: A Review of in vitro and in vivo Studies]

Air Pollution

Airborne culprits: A comprehensive review of PM, silica, and TCDD in autoimmune diseases.

Pharmaceuticals/Personal Care Products

In utero exposure to synthetic sex hormones and their multigenerational impact on neurodevelopmental disorders: Endocrine disruptors as neuroendocrine disruptors. [DES etc.]

The impact of early-life and prolonged antibiotics exposure on 78 common diseases: Evidence from epidemiology.

Miscellaneous

Rethinking Chlorine: Essential Chemical or Replaceable Risk?

Human Health Studies

BPA/Phenols

Bisphenol analogs exposure in 4-year-old children and their intelligence quotient at 6 years: A prospective cohort study.

Phthalates

Associations between urinary phthalate metabolites and reproductive, adrenal, and gonadotropic hormones in peripubertal children: the Hokkaido study.

Association of Phthalate Exposure with Respiratory and Allergic Symptoms and Type 2 and Non-Type 2 Inflammation: The Hokkaido Study.

Exploring the relationships between prenatal phthalate exposure and neonatal thyroid function: A prospective cohort study.

Prenatal and childhood phthalate mixtures and adolescent sleep health in The HOME Study.

Exploring the link between Di-2-ethylhexyl phthalate (DEHP) exposure and muscle mass: A systematic investigation utilizing NHANES data analysis, network toxicology and molecular docking approaches.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Organochlorine pesticide use and mosaic loss of chromosome Y in a study of male farmers.

PFAS

Per- and polyfluoroalkyl substances (PFAS) in drinking water, gestational diabetes mellitus, hypertension and preeclampsia: A nation-wide register-based study on PFAS in drinking water.

Flame Retardants

Associations between brominated flame retardants, including polybrominated diphenyl ethers, and immune responses among women in the California Teachers Study.

Association between organophosphate esters exposure and the prevalence of hyperuricemia in US adults from NHANES 2011-2016.

Associations between organophosphate flame retardants metabolites in follicular fluid and reproductive outcomes among women undergoing IVF/ICSI treatment in Southwest China.

Pesticides

Exposure to Polyoxyethylene Tallow Amines (POEAs), Glyphosate Co-Formulation Surfactants, in a US Pregnant Population and their Potential Endocrine Disrupting Effects.

The effect of fiber intake on the association of pesticide exposure and hypertension: a population-level study.

Associations between urinary glyphosate and arthritis: an US NHANES analysis.

Metals/Metalloids

Association of Metal Mixtures during the Second Trimester with Gestational Hypothyroidism and its Mediation by Metabolites.

Associations of non-essential metal/metalloids and their mixture with liver function in Chinese older adults: the mediating roles of lipid profiles.

Association between urinary arsenic and the prevalence of endometriosis in women in the United States.

Microplastics/Nanomaterials

Urinary microplastic contaminants in primary school children: Associations with behavioral development.

Association between microplastics exposure and depressive symptoms in college students.

Air Pollution

Neighborhood Deprivation and Iodine Levels Influence Air Pollution Effects on Maternal Thyroid Function in Early Pregnancy.

Association of long-term ozone exposure with the incidence and progression of hypertension, diabetes, and chronic kidney disease: A national retrospective cohort study.

Association between long-term exposure to PM_2.5 and thyroid nodules in school-aged children and adolescents: a cross-sectional study in Eastern China.

Laboratory Studies

Numerous Chemicals/Mixtures

Prioritizing endocrine-disrupting chemicals targeting systemic lupus erythematosus genes via Mendelian randomization and colocalization analyses.

Identification of Endocrine Disrupting Chemicals Targeting NTD-related Hub Genes During Pregnancy via In Silico Analysis.

Bioinformatics analysis to identify environmental endocrine chemicals that target endometriosis genes.

BPA/Phenols

BPS causes abnormal blastocyst development by inhibiting cell proliferation.

Inhibition of CCN5 Protects Against Apoptosis and Endoplasmic Reticulum Stress in Bisphenol A-Induced Sertoli Cells via p38/JNK MAPK Signaling Pathway.

The combined damage of bisphenol A and high fat diet to learning and memory in young male mice: the regulatory effect of BDNF/TrkB/PI3K/AKT pathway on autophagy.

Multi-Omics Analysis Reveals BPF Exposure Causes Hepatic Glucose and Lipid Metabolism Disorder in Rats by Disrupting Energy Homeostasis.

Network Toxicology and Molecular Docking Strategy for Analyzing the Toxicity and Mechanisms of Bisphenol A in Alzheimer’s Disease.

Bisphenol S exposure and MASLD: a mechanistic study in mice.

Phthalates

Gestational and lactational exposure to DEHP triggers ACSL4/TFR-mediated hippocampal neuronal ferroptosis via YAP activation: Implication for the neurocognitive disorders in male offspring.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Regulation of in vitro human hematopoietic differentiation by dioxin-like compounds.

Polychlorinated biphenyls induce immunometabolic switch of antiinflammatory macrophages toward an inflammatory phenotype.

PFAS

Multiomic Landscape of Primary Hypothyroidism Induced by Subchronic Exposure to Low-Dose Novel PFOS Substitute OBS in Human and Murine Models.

High-Throughput Single-Cell Mass Spectrometry Reveals Sex-Specific Metabolic Responses to 6:2 Chlorinated Polyfluoroalkyl Ether Sulfonate in Zebrafish Liver Cells.

PFOS Exposure Impairs Porcine Oocyte Maturation and Embryo Development via Mitochondria-Dependent Ferroptosis.

Exposure to long- and short-chain per- and polyfluoroalkyl substances in mice and ovarian-related outcomes: an in vivo and in vitro study.

Integrative transcriptomics analysis reveals convergent toxicological effects of perfluorooctanoic acid and perfluorooctane sulfonate on human liver: Evidence from multiple models.

Flame Retardants

2-Ethylhexyl Diphenyl Phosphate Affects Steroidogenesis and Lipidome Profile in Human Adrenal (H295R) Cells.

Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway.

Organotins

Transgenerational Effects of the Obesogen Tributyltin on Metabolic Health in Mice: Interactions with a Western Diet.

Memantine Exacerbates Trimethyltin-Induced Neurodegeneration and Delays Cognitive Impairment Recovery.

Pesticides

Lipidomics Atlas Tracks Alterations Associated with Deltamethrin-Induced Developmental Neurotoxicity in Embryonic Zebrafish.

Environmental concentrations of glyphosate through direct or parental exposure alter nervous system development and reduce the fertility rate in zebrafish.

The multi-level effect of chlorpyrifos during clownfish metamorphosis.

Combined exposure to ecologically relevant concentrations of atrazine and microcystin causes morphological changes in the hepatopancreas of crayfish.

Identification of Molecular Signatures for Azole Fungicides Toxicity in Zebrafish Embryos by Integrating Transcriptomics and Gene Network Analysis.

Atrazine Exposure Induces TDP-43 Protein Translocation: A Potential Mechanism for Prefrontal Cortical Neurodegeneration Induced by Environmental Pollutants.

Glyphosate exposure impairs glucose and lipid metabolism by disturbing the circadian clock system in mice liver.Phenyltins may pose a higher health risk to Indo-Pacific finless porpoises than butyltins.

Metals/Metalloids

Novel native probiotics with protective effects against nickel-induced kidney injury: a strategy for heavy metal toxicity.

Chronic Arsenic Exposure Causes Alzheimer’s Disease Characteristic Effects and the Intervention of Fecal Microbiota Transplantation in Rats.

Molecular Changes Associated with Inflammation and Reproduction in Cadmium-Induced Testicular Toxicity: Mitigating Effect of Lactobacillus plantarum.

Early developmental exposure to lead (Pb) as a risk factor for stress-related disorders investigated in larval zebrafish (Danio rerio).

Microplastics/Nanomaterials

Perinatal exposure to polystyrene nanoplastics alters socioemotional behaviors via the microbiota-gut-brain axis in adult offspring mice.

Effects of polystyrene microparticles exposures on spermatogenic cell differentiation and reproductive endpoints in male mice.

Aged microplastics-induced growth inhibition via DNA damage, GH/IGF-1 and HPT axes disruption in zebrafish larvae.

Plastic chemicals disrupt molecular circadian rhythms via adenosine 1 receptor in vitro.

Swim in Plastics: Clean Nanoplastics Cause Minimal Mortality but Alter Neurobehavioral and Molecular Rhythms in Fish.

Size-Dependent Pulmonary Toxicity and Whole-Body Distribution of Inhaled Micro/Nanoplastic Particles in Male Mice from Chronic Exposure.

Comparative Analysis of Metabolic Dysfunctions Associated with Pristine and Aged Polyethylene Microplastic Exposure via the Liver-Gut Axis in Mice.

Long-Term Exposure to Environmentally Realistic Doses of Starch-Based Microplastics Suggests Widespread Health Effects.

Revealing the neurodevelopmental toxicity of face mask-derived microplastics to humans based on neural organoids.

PVC nanoplastics impair cardiac function via lysosomal and mitochondrial dysfunction.

Distinct Effects between Polystyrene Micro- and Nanoplastics: Exacerbation of Adverse Outcomes in Inflammatory Bowel Disease-like Zebrafish and Mice.

Pharmaceuticals/Personal Care Products

Are environmental levels of gabapentin (GBP) a cause for concern? Chronic reproductive effects of GBP in zebrafish.

Miscellaneous

6PPD impairs immune responses and fin regeneration in zebrafish.

Impact of the Environmental Endocrine Disruptor 4-Octylphenol on Reproductive Function in Pubertal Male Mice.

Long-term exposure to 2,4-di-tert-butylphenol impairs zebrafish fecundity and affects offspring development.

Therapeutic Potential of Cucurbita maxima Duch. Seed Extract in Ameliorating Nonylphenol-Induced Reproductive Toxicity in Male Mice: In-vivo and In-silico approaches.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Simultaneous determination of multiple endocrine disrupting chemicals in human amniotic fluid samples by solid phase extraction coupled with liquid chromatography tandem mass spectrometry (LC-MS/MS).

Tracking Toxic Chemical Exposure in Uganda: Insights from Silicone Wristbands.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of multiple annual biosolids applications on the soil concentrations of metals, organochlorine pesticides and polychlorinated biphenyls in a field trial in Victoria, Australia.

PFAS

Per- and polyfluoroalkyl substances (PFAS) in paired tap water and house dust from United States homes.

Fate of per- and polyfluoroalkyl substances through commercial composting facilities.

Machine learning for monitoring per- and polyfluoroalkyl substance (PFAS) in California’s wastewater treatment plants: An assessment of occurrence and fate.

Flame Retardants

Do urinary metabolites reflect occupational exposure to organophosphate flame retardants? A case study in electronic waste recycling workers.

Organotins

Phenyltins may pose a higher health risk to Indo-Pacific finless porpoises than butyltins.

Pesticides

New Sources of Very Persistent and Very Mobile (vPvM) Substances: A Case Study of the Fluorinated Herbicide Pyroxasulfone.

Pesticide Contamination in Indoor Home Dust: A Pilot Study of Non-Occupational Exposure in Argentina.

Metals/Metalloids

Metal and metalloid content in real urban synthetic surfaces made of recycled tire crumb rubber including playgrounds and football fields.

Microplastics/Nanomaterials

Airborne microplastics enter plant leaves and end up in our food re Leaf absorption contributes to accumulation of microplastics in plants

Microplastics accumulate in all major organs of the mediterranean loggerhead sea turtle (Caretta caretta).

Pharmaceuticals/Personal Care Products

State of microbeads in facial scrubs: persistence and the need for broader regulation.

Presence of antibiotics in children’s urine: a silent risk beyond drinking water.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Industry-funded articles are included without notation. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. There are searchable archives. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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