EDC Science Weekly, Apr. 21-27, 2023

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Events

Webinar Apr. 27 (today!): The Perils of PVC Plastic Pipes [Beyond Plastics]

Webinar May 4: Will the Global Plastics Treaty Address Toxic Chemicals? [The Collaborative for Health and Environment]

Webinar May 17: Reducing Breast Cancer Risk by Eliminating Parabens and Phthalates [EDC Strategies Partnership]

For more upcoming events, see the April issue of HEEDS News

Regulations/Policy

What Limits Will the World Health Organization Recommend for PFOA and PFOS in Drinking Water?

Evaluating adverse effects of environmental agents in food: a brief critique of the US FDA’s criteria.

The importance of study design in investigating intrinsic developmental toxic properties of substances in new studies under the REACH and CLP Regulations in the European Union

Statement concerning the testing strategy and timelines proposed by the applicant for the assessment of the endocrine disruption properties of acibenzolar-S-methyl in the context of the review of the approval of the active substance.

Mitigating potential public health risks and challenges from hazardous materials contained in electronic waste items in a developing country setting.

Mercury in the Amazon: The danger of a single story.

Methods/Tools/Screening

National blood bank services as a platform for national human biomonitoring – A proof-of-concept study.

Lessons learned in the practice of community-based participatory research with community partner collaboration in study design and implementation: the community scientist model.

Harnessing modelling for assessing the population relevance of exposure to endocrine active chemicals.

Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays.

The Amphibian Short Term Assay (ASTA): Evaluation of a new ecotoxicological method for amphibians using two organophosphate pesticides commonly found in nature. Assessment of behavioral traits.

Reducing Uncertainties in Quantitative Adverse Outcome Pathways by Analysis of Thyroid Hormone in the Neonatal Rat Brain.

External Quality Assurance Schemes (EQUASs) and Inter-laboratory Comparison Investigations (ICIs) for human biomonitoring of polycyclic aromatic hydrocarbon (PAH) biomarkers in urine as part of the quality assurance programme under HBM4EU.

High-throughput AR dimerization assay identifies androgen disrupting chemicals and metabolites.

Commentaries

Avoiding the Next Silent Spring: Our Chemical Past, Present, and Future.

Editorial: Biodegradation of plastics. [intro to a Research Topic in Frontiers in Bioengineering and Biotechnology]

Making Persistent Plastics Degradable.

Mixed plastics upcycled dynamically. [re Dynamic crosslinking compatibilizes immiscible mixed plastics.]

Failure to Connect: Experimental Evidence that Benzo(a)pyrene Impedes Embryonic Implantation. [Science Selection in EHP]

Reviews

Numerous Chemicals/Mixtures

Global occurrence of synthetic glucocorticoids and glucocorticoid receptor agonistic activity, and aquatic hazards in effluent discharges and freshwater systems.

Environmental factors and their impact on the COVID-19 pandemic.

Phthalates

The safety of phthalate-containing medications used during pregnancy.

Environmental health risks induced by interaction between phthalic acid esters (PAEs) and biological macromolecules: A review.

Perfluoroalkyl Substances

Significance of fluorinated compound chain length, treatment technology and influent composition on PFAS removal in worldwide wastewater treatment plants.

Flame Retardants

Organophosphate Flame Retardants in Pregnant Women: Sources, Occurrence, and Potential Risks to Pregnancy Outcomes.

Metals/Metalloids

Relationship between exposure to heavy metals on the increased health risk and carcinogenicity of urinary tract (kidney and bladder).

Microplastics/Nanomaterials

Adverse multigeneration combined impacts of micro(nano)plastics and emerging pollutants in the aquatic environment.

Potential lifetime effects caused by cellular uptake of nanoplastics: A review.

Microplastics as an emerging menace to environment: Insights into their uptake, prevalence, fate, and sustainable solutions.

Effects of microplastics in aquatic environments on inflammatory bowel disease.

New insights into the migration, distribution and accumulation of micro-plastic in marine environment: A critical mechanism review.

Recent advances in biodegradation of emerging contaminants – microplastics (MPs): Feasibility, mechanism, and future prospects.

Air Pollution

Impact of the exposome on cardiovascular disease.

Human Health Studies

Numerous Chemicals/Mixtures

Mixed and single effects of endocrine disrupting chemicals in follicular fluid on likelihood of diminished ovarian reserve: A case-control study.

Associations between exposure to phthalates, phenols, and parabens with objective and subjective measures of sleep health among Mexican women in midlife: a cross-sectional and retrospective analysis.

Individual and joint association of phenols, parabens, and phthalates with childhood lung function: Exploring the mediating role of peripheral immune responses.

Phthalates

Early pregnancy phthalates and replacements in relation to fetal growth: The human placenta and phthalates study.

JAK3/STAT5b/PPARγ Pathway Mediates the Association between Di(2-ethylhexyl) Phthalate Exposure and Lipid Metabolic Disorder in Chinese Adolescent Students.

Urinary di-(2-ethylhexyl) phthalate metabolites are independently related to serum neurofilament light chain, a biomarker of neurological diseases, in adults: results from NHANES 2013-2014.

Parabens/Triclosan/Antimicrobials

Associations between urinary parabens and lung cancer.

Perfluoroalkyl Substances

Association of perfluoroalkyl and polyfluoroalkyl substances with sex hormones in children and adolescents 6-19 Years of age.

Pesticides

Obesity modifies the association of environmental pyrethroid exposure with glucose homeostasis in the US general adults.

Metals/Metalloids

Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort. [see related Invited Perspective: Toxic Metals and Hypertensive Disorders of Pregnancy.]

Prenatal exposure to metals and concentration thereof in umbilical cord blood in a Mexico City cohort.

Independent and combined associations of multiple-heavy-metal exposure with lung function: a population-based study in US children.

Air Pollution

Association of long-term ambient fine particulate matter (PM_2.5) and incident non-alcoholic fatty liver disease in Chinese adults.

Association of the components of ambient fine particulate matter (PM_2.5) and chronic kidney disease prevalence in China.

Impact of lifetime air pollution exposure patterns on the risk of chronic disease.

Exploring Relevant Time Windows in the Association Between PM2.5 Exposure and Amyotrophic Lateral Sclerosis: A Case-Control Study in Denmark.

Interactions between long-term ambient particle exposures and lifestyle on the prevalence of hypertension and diabetes: insight from a large community-based survey.

Acrolein Exposure Impaired Glucose Homeostasis and Increased Risk of Type 2 Diabetes: An Urban Adult Population-Based Cohort Study with Repeated Measures.

Cross-sectional and longitudinal relationships between ozone exposure and glucose homeostasis: Exploring the role of systemic inflammation and oxidative stress in a general Chinese urban population.

Dietary polyunsaturated fatty acids intake, air pollution, and the risk of lung cancer: A prospective study in UK biobank.

Miscellaneous

Focusing on testosterone levels in male: A half-longitudinal study of polycyclic aromatic hydrocarbon exposure and diastolic blood pressure in coke oven workers.

Testicular toxicity in mice exposed to terephthalic acid in utero and during lactation.

Laboratory Studies

Numerous Chemicals/Mixtures

The mixture effect of propyl paraben and bisphenol A on the uterotrophic response in the ovariectomized rats after oral administration.

BPA/Phenols

BPA exposure enhances the metastatic aggression of ovarian cancer through the ERα/AKT/mTOR/HIF-1α signaling axis.

Realistic concentrations of Bisphenol-A trigger a neurotoxic response in the brain of zebrafish: Oxidative stress, behavioral impairment, acetylcholinesterase inhibition, and gene expression disruption.

Molecular insights underlying the adverse effects of bisphenol A on gonadal somatic cells’ steroidogenic activity.

Prenatal bisphenol S exposure induces hepatic lipid deposition in male mice offspring through downregulation of adipose-derived exosomal miR-29a-3p.

Analogy or fallacy, unsafe chemical alternatives: Mechanistic insights into energy metabolism dysfunction induced by Bisphenol analogs in HepG2 cells.

The bisphenol S contamination level observed in human follicular fluid affects the development of porcine oocytes.

Bisphenol-A (BPA) Impairs Hippocampal Neurogenesis via Inhibiting Regulation of the Ubiquitin Proteasomal System.

Phthalates

Phthalates Promote Dissemination of Antibiotic Resistance Genes: An Overlooked Environmental Risk.

Molecular evaluation of the metabolism of estrogenic di(2-ethylhexyl) phthalate in Mycolicibacterium sp.

Parabens/Triclosan/Antimicrobials

The perturbation of parabens on the neuroendocrine system in zebrafish larvae.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

PCB126 Exposure during Pregnancy Alters Maternal and Fetal Gene Expression.

Exposure to the persistent organic pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, dioxin) disrupts development of the zebrafish inner ear.

Perfluoroalkyl Substances

Early life exposure to low-dose perfluorooctane sulfonate disturbs gut barrier homeostasis and increases the risk of intestinal inflammation in offspring.

Flame Retardants

The crosstalk effects of polybrominated diphenyl ethers on the retinoic acid and thyroid hormone signaling pathway.

Pesticides

Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats.

Effects of Dichlorvos on cardiac cells: Toxicity and molecular mechanism of action.

Concentrations of the glyphosate-based herbicide Roundup® causes developmental defects in Artemia salina.

Paraquat-induced neurogenesis abnormalities via Drp1-mediated mitochondrial fission.

Integrated metabolomics and transcriptomics reveal glyphosate based-herbicide induced reproductive toxicity through disturbing energy and nucleotide metabolism in mice testes.

Insights into enhanced toxic effects by the binary mixture of carbendazim and procymidone on hepatic lipid metabolism in mice.

Glyphosate induces autophagy in hepatic L8824 cell line through NO-mediated activation of RAS/RAF/MEK/ERK signaling pathway and energy metabolism disorders.

Metals/Metalloids

Arsenic interferes with spermatogenesis involving Rictor/mTORC2-mediated blood-testis barrier disruption in mice.

Innovative accumulative risk assessment strategy of co-exposure of As and Pb in medical earthworms based on in vivo-in vitro correlation.

Microplastics/Nanomaterials

Parental exposure to polystyrene nanoplastics and di(2-ethylhexyl) phthalate induces transgenerational growth and reproductive impairments through bioaccumulation in Daphnia magna.

Reproductive toxicity of polystyrene nanoplastics in Drosophila melanogaster under multi-generational exposure.

Combined effects of microplastics and benz[a]anthracene on cardiotoxicity in zebrafish (Danio rerio) larvae: Size matters.

Maternal exposure to nanoplastic induces transgenerational toxicity in the offspring of rotifer Brachionus koreanus.

Single inhalation exposure to polyamide micro and nanoplastic particles impairs vascular dilation without generating pulmonary inflammation in virgin female Sprague Dawley rats.

First report on the toxicity of Sars-Cov-2, alone and in combination with polyethylene microplastics in neotropical fish.

Combined effect of microplastic and triphenyltin: Insights from the gut-brain axis.

Effects of UV-based oxidation processes on the degradation of microplastic: Fragmentation, organic matter release, toxicity and disinfection byproduct formation.

Air Pollution

Maternal exposure to air pollution alters energy balance transiently according to gender and changes gut microbiota.

Modulation of insulin signaling pathway genes by ozone inhalation and the role of glucocorticoids: A multi-tissue analysis.

Xanthine-derived reactive oxygen species exacerbates adipose tissue disorders in male db/db mice induced by real-ambient PM2.5 exposure.

Miscellaneous

Study of DNA methylation of hsd17β, er and reproductive endocrine disrupting effects in female Chlamys farreri under benzo[a]pyrene stress.

Thyroid endocrine disruption induced by [C₈mim]Br: An integrated in vivo, in vitro, and in silico study.

Prenatal benzene exposure in mice alters offspring hypothalamic development predisposing to metabolic disease in later life.

Characterization of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD)-induced cardiotoxicity in larval zebrafish (Danio rerio).

Drinking water disinfection byproduct iodoacetic acid affects thyroid hormone synthesis in Nthy-ori 3-1 cells.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Transfer of polychlorinated, brominated and mixed-halogenated dioxins, furans and biphenyls, polychlorinated naphthalenes and alkanes, polycyclic aromatic hydrocarbons and chlorobenzenes to the milk of dairy cattle from controlled ingestion of industrial and municipal bioresources recycled to agricultural land.

BPA/Phenols

[Determination of 26 bisphenols in dust by ultra performance liquid chromatography-tandem mass spectrometry]. [in Chinese]

Phthalates

Method to analyze phthalate esters from soft toys dissolving into water mimicking infant playing.

Phthalate esters and their metabolites in paired soil-crop systems from farmland in major provinces of eastern China: Pollution characteristics and implications for human exposure.

Occurrence and ecological risk assessment of 16 phthalates in surface water of the mainstream of the Yangtze River, China.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Polychlorinated naphthalenes in milk-based infant and toddler formula sold on the Chinese market.

Organochlorine pesticides and polychlorinated biphenyls in raw bovine milk from various dairy farms in Beja, Tunisia: contamination status, dietary intake, and health risk assessment for the consumers.

First evidence of legacy chlorinated POPs bioaccumulation in Antarctic sponges from the Ross sea and the South Shetland Islands.

Perfluoroalkyl Substances

Novel perfluoroalkyl substances (PFAS) discovered in whole blood using automated non-targeted analysis of dried blood spots.

Trace analysis of per- and polyfluorinated alkyl substances (PFAS) in dried blood spots – Demonstration of reproducibility and comparability to venous blood samples.

Global ocean contamination of per- and polyfluoroalkyl substances: A review of seabird exposure.

Large-scale assessment of exposure to legacy and emerging per- and polyfluoroalkyl substances in China’s shorebirds.

Smouldering to treat PFAS in sewage sludge.

Removal of per- and polyfluoroalkyl substances by nanofiltration: Effect of molecular structure and coexisting natural organic matter.

Formation and Degradability of Per- and Polyfluoroalkyl Substances in River Soils around a Fluoropolymer-Manufacturing Plant in Osaka, Japan.

Flame Retardants

Human exposure to organophosphate esters in water and packed beverages.

Environmental signature and health risk assessment of polybrominated diphenyl ethers (PBDEs) emitted from a landfill fire in Santiago de Chile.

Metals/Metalloids

Prenatal exposure to metals and concentration thereof in umbilical cord blood in a Mexico City cohort.

Human health risk assessment of potentially toxic elements in the breast milk consumed by infants in Western Iran.

Relations between personal exposure to elevated concentrations of arsenic in water and soil and blood arsenic levels amongst people living in rural areas in Limpopo, South Africa.

Microplastics/Nanomaterials

Detection of microplastics and nanoplastics released from a kitchen blender using Raman imaging.

Human occupational exposure to microplastics: A cross-sectional study in a plastic products manufacturing plant.

Microplastics discharged from urban drainage system: Prominent contribution of sewer overflow pollution.

Air Pollution

Do shale oil and gas production activities impact ambient air quality? A comprehensive study of 12 years of chemical concentrations and well production data from the Barnett Shale region of Texas.

Miscellaneous

Solvent-like bis (2-chloro-1-methylethyl) ether occurrence in drinking water: Multidimensional risk assessment integrated health and aesthetic aspects.

Non-carcinogenic and cumulative risk assessment of exposure of kitchen workers in restaurants and local residents in the vicinity of polycyclic aromatic hydrocarbons.

The presence of polycyclic aromatic hydrocarbons in disposable baby diapers: A facile determination method via salting-out assisted liquid-liquid extraction coupled with gas chromatography-mass spectrometry.

Level of BTEX in the Areas of Domestic Waste Incinerators in Northern Vietnam: A Comprehensive Assessment of Contamination, Composition and Human Health Risk.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

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