EDC Science Weekly, Apr. 19-25, 2024

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights: Chemicals in recycled tire rubber/turf; disparities in PFAS levels in NJ drinking water; recommendations on priorities for the IARC Monographs.

More science highlights

Events

Apr. 30 webinar: The True Costs of Artificial Turf: Experts Discuss Cornell University’s New “PFAS-Free” Project [Beyond Plastics]

Apr. 30 and May 7 workshop: Horizon Scanning: Sharing strategies to move from reactive to proactive approaches to identify new environmental concerns [NIEHS]

May 2 webinar: Plastics and your health [Beyond Plastics]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase and EDC Strategies Partnership]

May 8 webinar: Reducing PFAS in products: progress and challenges [EPA]

May 20 symposium: Brain and environment [Univ of Rochester/in Washington DC]

May 21 seminar: Silent Spring 2.0: Adverse impacts of neonicotinoid pesticides on human and wildlife health [CACHET and HEEDS. Virtual and in-person in Chicago. See the ChicAgo Center for Health and EnvironmentT (CACHET) website for additional seminars.]

May 29: Webinaire dédié au rassemblement de la communauté française sur les perturbateurs endocriniens [in French]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

US EPA sets historic new restrictions on toxic PFAS in drinking water.

Advisory Group recommendations on priorities for the IARC Monographs

The 2022 European Union report on pesticide residues in food.

A new regulatory paradigm for pesticide registration in Brazil: Comments on recent legislative amendments (Law 14.785/2023).

More EDC policy and regulations open for comment

Methods/Tools/Screening

New approach methodologies to enhance human health risk assessment of immunotoxic properties of chemicals – a PARC (Partnership for the Assessment of Risk from Chemicals) project.

ProTox 3.0: a webserver for the prediction of toxicity of chemicals.

An artificial intelligence-based model for predicting reproductive toxicity of bisphenol analogues mixtures to the rotifer Brachionus calyciflorus.

Determination of organic fluorinated compounds content in complex samples through combustion ion chromatography methods: a way to define a “Total Per- and Polyfluoroalkyl Substances (PFAS)” parameter?

AhR agonists screening and identification in indoor dust based on non-target chemical analysis by GC-Q-TOFMS and biological effect evaluation referring to ToxCast/Tox21 database.

Comparison of maternal venous blood metabolomics collected as dried blood spots, dried blood microsamplers, and plasma for integrative environmental health research.

Commentaries

Earth Day: time for transformational change.

Environmental chemical obesogens, what can we do?

Link circular economy to waste hierarchy in treaty

Invited Perspective: Per- and Polyfluoroalkyl Substances in Drinking Water-Disparities in Community Exposures Based on Race and Socioeconomic Status [re Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019-2021.]

A toxicological perspective on climate change and the exposome.

ACMT Comment on Recent Guidance on PFAS Laboratory Testing.

Microplastics are everywhere – we need to understand how they affect human health.

Comment on “Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly Available in Vivo, in Vitro, and in Silico Data”.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

The epidemiology of cryptorchidism and potential risk factors, including endocrine disrupting chemicals.

Lipoprotein alterations in endocrine disorders – a review of the recent developments in the field.

Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion.

Contributions of Synthetic Chemicals to Autoimmune Disease Development and Occurrence.

Environmental pollutants and male infertility: Effects on CatSper.

PFAS

Chloroperfluoropolyether carboxylate compounds: a review.

Emerging contaminants in food matrices: An overview of the occurrence, pathways, impacts and detection techniques of per- and polyfluoroalkyl substances.

Per-and polyfluoroalkyl (PFAS) Eternal pollutants: sources, environmental impacts and treatment processes.

Review of per- and poly-fluoroalkyl treatment in combustion-based thermal waste systems in the United States.

Flame Retardants

Exposure to organophosphate esters and maternal-child health.

Metals/Metalloids

Effect of arsenic on the risk of gestational diabetes mellitus: a systematic review and meta-analysis.

Microplastics/Nanomaterials

When antibiotics encounter microplastics in aquatic environments: Interaction, combined toxicity, and risk assessments.

Miscellaneous

Environmental Justice and Health in Nigeria.

Human Health Studies

Numerous Chemicals/Mixtures

Thyroid Cancer and Endocrine Disruptive Chemicals: A Case-Control Study on Per-fluoroalkyl Substances (PFAS) and Other Persistent Organic Pollutants (POPs).

Suspect-Screening Analysis of Environmental Chemicals in Paired Human Cerebrospinal Fluid and Serum Samples.

Exposure to environmental pollutants and genetic variants related to oxidative stress and xenobiotic metabolism – Association with prostate cancer.

BPA/Phenols

Connecting Bisphenol A Exposure to PCOS: Findings from a Case-Control Investigation.

Associations of prenatal exposure to bisphenols with infant anthropometry: A prospective cohort study.

Phthalates

Serum Phthalate Concentrations and Biomarkers of Oxidative Stress in Adipose Tissue in a Spanish Adult Cohort.

Phthalate Exposure and Coronary Heart Disease: Possible Implications of Oxidative Stress and Altered miRNA Expression.

Relationship between phthalates exposures and metabolic dysfunction-associated fatty liver disease in United States adults.

Exposure to DEP Modifies the Human Umbilical Artery Vascular Resistance Contributing to Hypertension in Pregnancy.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Association between exposure to a mixture of organochlorine pesticides and hyperuricemia in U.S. adults: A comparison of four statistical models.

PFAS

Associations of per- and polyfluoroalkyl substances with maternal early second trimester sex-steroid hormones.

Per- and polyfluoroalkyl substances (PFAS), perceived stress, and depressive symptoms in a prospective cohort study of black women.

Association of exposure to multiple perfluoroalkyl and polyfluoroalkyl substances and glucose metabolism in National Health and Nutrition Examination Survey 2017-2018.

Exposure to Per- and Polyfluoroalkyl Substances in Lung Cancer Patients and Their Associations with Clinical Health Indicators.

Kidney function decline mediates the adverse effects of per- and poly-fluoroalkyl substances (PFAS) on uric acid levels and hyperuricemia risk.

Pesticides

Prenatal exposure to pyrethroids and chlorpyrifos and IQ in 7-year-old children from the Odense child cohort.

Chronic exposures to cholinesterase-inhibiting pesticides adversely affects the health of agricultural workers in India.

Metals/Metalloids

Association of Water Arsenic With Incident Diabetes in U.S. Adults: The Multi-Ethnic Study of Atherosclerosis and the Strong Heart Study.

Laboratory Studies

Numerous Chemicals/Mixtures

Synergistic developmental effects of zebrafish exposed to combined perfluorooctanoic acid and atrazine.

Single and mixture effects of bisphenol A and benzophenone-3 on in vitro T helper cell differentiation.

BPA/Phenols

SWATH-MS reveals that Bisphenol A and its analogs regulate pathways leading to disruption in Insulin signaling and fatty acid metabolism.

Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions.

Decreased Treg cells induced by bisphenol A is associated with up-regulation of PI3K/Akt/mTOR signaling pathway and Foxp3 DNA methylation in spleen of adolescent mice.

Low-dose BPA-induced neuronal energy metabolism dysfunction and apoptosis mediated by PINK1/parkin mitophagy pathway in juvenile rats.

Reproductive toxic effects of chronic exposure to bisphenol A and its analogues in marine medaka (Oryzias melastigma).

Effects of salinity on behavior and reproductive toxicity of BPA in adult marine medaka.

Bisphenol S enhances the cell proliferation ability of prostate cancer cells by regulating the expression of SDS.

Lycium barbarum polysaccharides attenuate nonylphenol and octylphenol-induced oxidative stress and neurotransmitter disorders in PC-12 cells.

Long-term 4-nonylphenol exposure drives cervical cell malignancy through MAPK-mediated ferroptosis inhibition.

Phthalates

Systemic investigation of di-isobutyl phthalate (DIBP) exposure in the risk of cardiovascular via influencing the gut microbiota arachidonic acid metabolism in obese mice model.

Modulating responses of indicator genes in cellular homeostasis, immune defense and apoptotic process in the Macrophthalmus japonicus exposed to di(2-ethylhexyl) phthalate as a plastic additive.

Thyroid and sex hormone disrupting effects of DEHTP at different life stages of zebrafish (Danio rerio).

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of an environmentally relevant mixture of organochlorine pesticide compounds on adipogenesis and adipocyte function in an immortalized human adipocyte model.

PFAS

Persistent metabolic toxicities following developmental exposure to hexafluoropropylene oxide trimer acid (HFPO-TA): Roles of peroxisome proliferator activated receptor gamma.

Sex, Age, and Species Differences of Perfluorooctanoic Acid Modeled by Flow- versus Permeability-limited Physiologically-Based Pharmacokinetic Models.

Hexafluoropropylene oxide trimer acid (HFPO-TA) exerts cytotoxic effects on Leydig cells via the ER stress/JNK/β-TrCP/Mcl-1 axis.

In vitro evaluation of the carcinogenic potential of perfluorinated chemicals.

Perfluoroalkyl sulfonate induces cardiomyocyte apoptosis via endoplasmic reticulum stress activation and autophagy flux inhibition.

Flame Retardants

Single cell transcriptomics unveiled that early life BDE-99 exposure reprogrammed the gut-liver axis to promote a pro-inflammatory metabolic signature in male mice at late adulthood.

Pesticides

Lower malathion concentrations reduce testosterone biosynthesis by Leydig TM3 cells in vitro by altering cellular redox profile and inducing oxidative damage.

Potential Common Mechanisms of Cytotoxicity Induced by Organophosphorus Pesticides via NLRP3 Inflammasome Activation.

Metals/Metalloids

Functional Metabolomics Reveals Arsenic-Induced Inhibition of Linoleic Acid Metabolism in Mice Kidney in Drinking Water.

Microplastics/Nanomaterials

Polystyrene nanoplastics with different functional groups and charges have different impacts on type 2 diabetes.

Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish.

Effects on food intake of Gammarus spp. after exposure to PFBA in very low concentrations.

Effect of micro- and nanoplastic particles on human macrophages.

Comparative impact of pristine and aged microplastics with triclosan on lipid metabolism in larval zebrafish: Unveiling the regulatory role of miR-217.

Quantitative assessment and monitoring of microplastics and nanoplastics distributions and lipid metabolism in live zebrafish using hyperspectral stimulated Raman scattering microscopy.

Exploring the impact of polystyrene microplastics on human health: unravelling the health implications of polystyrene microplastics (PS-MPs): a comprehensive study on cytotoxicity, reproductive health, human exposure, and exposure assessment.

Pharmaceuticals/Personal Care Products

Prenatal acetaminophen exposure and the developing ovary: time, dose, and course consequences for fetal mice.

6-PPD

6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes.

Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans.

Acute Toxicity Testing of Pink Salmon (Oncorhynchus gorbuscha) with the Tire Rubber-Derived Chemical 6PPD-Quinone.

Miscellaneous

Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Endocrine disrupting chemicals in children’s and their parents’ urine: Is the exposure related to the Chinese and Western lifestyle?

Recycled tire rubber materials in the spotlight. Determination of hazardous and lethal substances.

BPA/Phenols

Conjugated Bisphenol S Metabolites in Human Serum and Whole Blood.

PFAS

Quantifying Disparities in Per- and Polyfluoroalkyl Substances (PFAS) Levels in Drinking Water from Overburdened Communities in New Jersey, 2019-2021.

Bioaccumulation of Perfluoroalkyl Sulfonamides (FASA).

Occurrence and prevalence of per- and polyfluoroalkyl substances in the sediment pore water of mariculture sites: Novel findings of PFASs from the Bohai and Yellow Seas using a newly established analytical method.

Identifying PFAS hotspots in surface waters of South Carolina using a new optimized total organic fluorine method and target LC-MS/MS.

Incidence of per- and polyfluoroalkyl substances (PFAS) in private drinking water supplies in Southwest Virginia, USA.

Flame Retardants

Polybrominated diphenyl ethers in student dormitory microenvironments: concentrations, sources, and human exposure.

Pesticides

Urinary biomonitoring of glyphosate exposure among male farmers and nonfarmers in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study.

Metals/Metalloids

Associations Between Prenatal Blood Metals and Vitamins and Cord Blood Peptide Hormone Concentrations.

Concentrations and influencing factors of 17 elements in placenta, cord blood, and maternal blood of women from an e-waste recycling area.

Systematic literature review of heavy metal contamination of the Nigerian environment from E-waste management: associated health and carcinogenic risk assessment.

Microplastics/Nanomaterials

Microplastic and PTFE contamination of food from cookware.

From the Caribbean to the Arctic, the most abundant microplastic particles in the ocean have escaped detection.

The effect of water ozonation in the presence of microplastics on water quality and microplastics degradation.

Global prevalence of microplastics in tap water systems: Abundance, characteristics, drivers and knowledge gaps.

Microplastic Human Dietary Uptake from 1990 to 2018 Grew across 109 Major Developing and Industrialized Countries but Can Be Halved by Plastic Debris Removal.

——-

This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!