EDC Science Weekly, Apr. 14 – 20, 2021

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events,Methods/Tools/Screening, Commentaries/Conference Summaries, Reviews, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Interesting Article of the Week

Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.

Events

April 21 Virtual Town Hall: EPA’s Lead & Copper Rule: What Schools and Child Care Need to Know (Children’s Environmental Health Network)

April 22 Earth Day Symposium: John P. Wyatt, M.D. Environment & Health Symposium (University of Kentucky)

April 28 Webinar: Protecting Your Child’s Health with Dr. Ruth Etzel (CHE-Alaska)

Apr. 28 Webinar: 5th Annual Mind the Store Retailer Report Card (Mind the Store and Toxic Free Future)

May 11 Webinar: Suspect Screening, Prioritization, and Confirmation of Environmental Chemicals in Maternal-Newborn Pairs from San Francisco (EDC Strategies Partnership)

May 30: Applications due for The Science Communication Fellowship Program for early career scientists (Science Communication Network)

Methods/Tools/Screening

Deep Learning Model for Identifying Critical Structural Motifs in Potential Endocrine Disruptors.

Commentaries/Conference Summaries

The EU Green Deal’s ambition for a toxic-free environment: filling the gap for science-based policy making.

The Role of Behavioral Ecotoxicology in Environmental Protection. [consensus statement from an international workshop]

Historical perspective on the role of cell proliferation in carcinogenesis for DNA-reactive and non-DNA-reactive carcinogens: Arsenic as an example.

Reviews

Numerous EDCs

Exposure to endocrine disruptors and risk of breast cancer: a systematic review.

Endocrine-Disrupting Chemicals: Introduction to the Theme.

Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease.

Environmental pollutants exposure and male reproductive toxicity: the role of epigenetic modifications.

A Review on the Mechanism Between Different Factors and the Occurrence of Autism and ADHD.

BPA/Phenols

Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review.

Phthalates

The impact of phthalate on reproductive function in women with endometriosis.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Prenatal exposure to persistent organic pollutants as a risk factor of offspring metabolic syndrome development during childhood.

Perfluoroalkyl Substances

Systemic PFOS and PFOA exposure and disturbed lipid homeostasis in humans: what do we know and what not?

Flame Retardants

Endocrine disrupting potential of replacement flame retardants – Review of current knowledge for nuclear receptors associated with reproductive outcomes.

Pesticides

Effects of pyrethroids on brain development and behavior: Deltamethrin.

The threat of veterinary medicinal products and biocides on pollinators: A One Health perspective.

Potentially Toxic Elements

The gut microbiome and arsenic-induced disease-iAs metabolism in mice.

Neurodevelopment and exposure to neurotoxic metal(loid)s in environments polluted by mining, metal scrapping and smelters, and e-waste recycling in low and middle-income countries.

Arsenic and Human Health: Genotoxicity, Epigenomic Effects, and Cancer Signaling.

Ins and outs of cadmium-induced carcinogenesis: Mechanism and prevention.

Are cadmium and lead levels linked to the development of anxiety and depression? – A systematic review of observational studies.

Microplastics

Adsorption behavior of organic pollutants on microplastics.

Air Pollution

Systematic review of the association between long-term exposure to fine particulate matter and mortality.

The first 1000 days of life: traffic-related air pollution and development of wheezing and asthma in childhood. A systematic review of birth cohort studies.

Miscellaneous

Does the environmental inequality matter? A literature review.

Environmental health situation in Nigeria: current status and future needs.

Chemical risk in hospital settings: Overview on monitoring strategies and international regulatory aspects.

Water and Soil Pollution: Ecological Environmental Study Methodologies Useful for Public Health Projects. A Literature Review.

Human Health Studies

Phthalates

Effect of prenatal exposure to phthalates on epigenome-wide DNA methylations in cord blood and implications for fetal growth: The Hokkaido Study on Environment and Children’s Health.

Urinary phthalate metabolite concentrations and adolescent sleep duration.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Determination of organic pollutants in meconium and its relationship with fetal growth. Case control study in Northwestern Spain.

DNA methylation in the adipose tissue and whole blood of Agent Orange-exposed Operation Ranch Hand veterans: a pilot study.

Decreased serum testosterone levels associated with 17β-hydroxysteroid dehydrogenase activity in 7-year-old children from a dioxin-exposed area of Vietnam.

Environmental Contaminant Body Burdens and the Relationship with Blood Pressure Measures Among Indigenous Adults.

Pesticides

Exploring the risk of hypospadias in children born from mothers living close to a vineyard.

Prenatal organophosphate exposure can cause adverse birth outcomes to humans.

Potentially Toxic Elements

Machine-learning models predicting osteoarthritis associated with the lead blood level.

Relationship between gestational diabetes and serum trace element levels in pregnant women from Eastern Iran: a multivariate approach.

A cohort study of the association between prenatal arsenic exposure and age at menarche in a rural area, Bangladesh.

Burden of osteoporosis and costs associated with human biomonitored cadmium exposure in three European countries: France, Spain and Belgium.

Drinking water contaminants in California and hypertensive disorders in pregnancy.

Identifying sensitive windows of airborne lead exposure associated with behavioral outcomes at age 12.

Heavy metal-associated oxidative stress and glutathione S-transferase polymorphisms among E-waste workers in Pakistan.

The mediation effect of placental weight change in the association between prenatal exposure to selenium and birth weight: Evidence from a prospective birth cohort study in China.

Serum selenium and non-alcoholic fatty liver disease (NAFLD) in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2011-2016.

Air Pollution

Air pollution and meteorological conditions during gestation and type 1 diabetes in offspring.

Exposure to ambient air pollution during pregnancy and inflammatory biomarkers in maternal and umbilical cord blood: The Healthy Start study.

Are the effects of air pollution on birth weight modified by infant sex and neighborhood socioeconomic deprivation? A multilevel analysis in Paris (France).

Childhood traffic-related air pollution and adverse changes in subclinical atherosclerosis measures from childhood to adulthood.

Particulate air pollution and survival after stroke in older adults: A retrospective cohort study in Korea.

Short-, Mid- and Long-Term Associations between PM2.5 and Stroke Incidence in Taiwan.

Pandemic meets pollution: Poor air quality increases deaths by COVID-19.

Air pollution, physical activity and ischaemic heart disease: a prospective cohort study of interaction effects.

The relationship between air pollutants and maternal socioeconomic factors on preterm birth in California urban counties.

Air pollution, methane super-emitters, and oil and gas wells in Northern California: the relationship with migraine headache prevalence and exacerbation.

Early childhood traffic-related air pollution and risk of allergic rhinitis at 2-4 years of age modification by family stress and male gender: a case-control study in Shenyang, China.

Associations between air pollution exposure and birth defects: a time series analysis.

Highlighting the compound risk of COVID-19 and environmental pollutants using geospatial technology.

Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS – Air Pollution Study).

All-Cause Mortality Risk and Attributable Deaths Associated with Long-Term Exposure to Ambient PM_2.5 in Chinese Adults.

Ambient air pollution and post-transplant outcomes among kidney transplant recipients.

Estimating PM2.5-related premature mortality and morbidity associated with future wildfire emissions in the western US.

Miscellaneous

Urinary polycyclic aromatic hydrocarbons and sex hormones in children and adolescents: Evidence from NHANES.

Laboratory Studies

BPA/Phenols

Bisphenol F and bisphenol S promote lipid accumulation and adipogenesis in human adipose-derived stem cells.

Ameliorative effect of Alpinia officinarum Hance extract on nonylphenol-induced reproductive toxicity in male rats.

Role of dietary selenium in alleviating bisphenol A toxicity of liver albino rats: Histological, ultrastructural, and biomarker assessments.

ERα-agonist and ERβ-antagonist bifunctional next-generation bisphenols with no halogens: BPAP, BPB, and BPZ.

Exposure to xenoestrogens alters the expression of key morphoregulatory proteins of oviduct adenogenesis in the broad-snouted caiman (Caiman latirostris).

Paternal Inheritance of Bisphenol A Cardiotoxic Effects: The Implications of Sperm Epigenome.

BPA and BPA alternatives BPS, BPAF, and TMBPF, induce cytotoxicity and apoptosis in rat and human stem cells.

Phthalates

Developmental, behavioral and endocrine alterations in male rats at early and late postnatal life following in utero exposure to low dose di-n-butylphthalate.

Parabens/Triclosan/Antimicrobials

Toxicity and sublethal effects of methylparaben on zebrafish (Danio rerio) larvae and adults.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The effect of DDE and dieldrin and their parental substances (DDT and aldrin) on PGE2 and PGF2α release from bovine endometrial explants collected during 120 to 180 days of the gestational period.

Perfluoroalkyl Substances

Perfluorooctanoic acid inhibits the maturation rate of mouse oocytes cultured in vitro by triggering mitochondrial and DNA damage.

Flame Retardants

The brominated flame retardants TBECH and DPTE alter prostate growth, histology and gene expression patterns in the mouse.

Organotins

Dibutyltin (DBT) inhibits in vitro androgen biosynthesis of rat immature Leydig cells.

Pesticides

Chronic chlorpyrifos exposure induces oxidative stress, apoptosis and immune dysfunction in largemouth bass (Micropterus salmoides).

Difenoconazole induces cardiovascular toxicity through oxidative stress-mediated apoptosis in early life stages of zebrafish (Danio rerio).

Long-term exposure to p-Nitrophenol induces hepatotoxicity via accelerating apoptosis and glycogen accumulation in male Japanese quails.

Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in rats.

Bioallethrin enhances generation of ROS, damages DNA, impairs the redox system and causes mitochondrial dysfunction in human lymphocytes.

Epigenetic effects of insecticides on early differentiation of mouse embryonic stem cells.

Organophosphorus pesticides exert estrogen receptor agonistic effect determined using Organization for Economic Cooperation and Development PBTG455, and induce estrogen receptor-dependent adipogenesis of 3T3-L1 adipocytes.

Developmental Neurotoxicity of Fipronil and Rotenone on a Human Neuronal In Vitro Test System.

Neurotoxic responses of rainbow trout (Oncorhynchus mykiss) exposed to fipronil: multi-biomarker approach to illuminate the mechanism in brain.

Acute toxicity and morphology alterations of glyphosate-based herbicides to Daphnia magna and Cyclops vicinus.

Protective effect of fisetin against subchronic chlorpyrifos-induced toxicity on oxidative stress biomarkers and neurobehavioral parameters in adult male albino mice.

Potentially Toxic Elements

Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure.

Inter- and Transgenerational Effects of Paternal Exposure to Inorganic Arsenic.

Microplastics

A dosage-effect assessment of acute toxicology tests of microplastic exposure in filter-feeding fish.

Green toxicology approach involving polylactic acid biomicroplastics and neotropical tadpoles: (Eco)toxicological safety or environmental hazard?

The toxic impacts of microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) on haematic parameters in a marine bivalve species and their potential mechanisms of action.

Mixtures

Individual and combined hepatocytotoxicity of DDT and cadmium in vitro.

Assessing Indoor Dust Interference with Human Nuclear Hormone Receptors in Cell-Based Luciferase Reporter Assays.

Combined hepatotoxicity of imidacloprid and microplastics in adult zebrafish: Endpoints at gene transcription.

Miscellaneous

Aspartame and cancer – new evidence for causation.

Exposure/Environment Studies

BPA/Phenols/Parabens

Parabens and bisphenol A and its structural analogues in over-the-counter medicines from China.

Determination of prenatal exposure to parabens and triclosan and estimation of maternal and fetal burden.

Dietary quality and bisphenols: trends in bisphenol A, F, and S exposure in relation to the Healthy Eating Index using representative data from the NHANES 2007-2016.

Phthalates

Indoor exposure to phthalates and polycyclic aromatic hydrocarbons (PAHs) to Canadian children: the Kingston allergy birth cohort.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Free-range eggs from a very polluted site in central Italy: levels of Polychlorinated Dibenzo-p-Dioxins/Furans and Polychlorinated Biphenyls and estimated human dietary exposure.

Spatial Distribution, Bioconversion and Ecological Risk of PCBs and PBDEs in the Surface Sediment of Contaminated Urban Rivers: A Nationwide Study in China.

Main sources controlling atmospheric burdens of persistent organic pollutants on a national scale.

Perfluoroalkyl Substances

Environmental, human health, and economic implications of landfill leachate treatment for per- and polyfluoroalkyl substance removal.

Legacy and Emerging Poly- and Perfluoroalkyl Substances in Finless Porpoises from East China Sea: Temporal Trends and Tissue-Specific Accumulation.

Occurrence, spatiotemporal distribution, seasonal and annual variation, and source apportionment of poly- and perfluoroalkyl substances (PFASs) in the northwest of Tai Lake Basin, China.

Perfluoroalkyl substances (PFASs) in the Ugandan waters of Lake Victoria: Spatial distribution, catchment release and public exposure risk via municipal water consumption.

Controlling the self-assembly of perfluorinated surfactants in aqueous environments.

Flame Retardants

Insights into Persistent Toxic Substances in Protective Cases of Mobile Phones: Occurrence, Health Risks, and Implications. [flame retardants, metals, and more]

Previously identified and unidentified polybrominated biphenyl congeners in serum from people living in an electronic waste dismantling area in China.

Spatio-temporal variations and input patterns on the legacy and novel brominated flame retardants (BFRs) in coastal rivers of North China.

Pesticides

The 2019 European Union report on pesticide residues in food.

Potentially Toxic Elements

Fish tissues for biomonitoring toxic and essential trace elements in the Lower Amazon.

Total mercury and methylmercury in river dolphins (Cetacea: Iniidae: Inia spp.) in the Madeira River Basin, Western Amazon.

Trends and Sources of Heavy Metal Pollution in Global River and Lake Sediments from 1970 to 2018.

Microplastics

Quantification and exposure assessment of microplastics in Australian indoor house dust.

Microplastics generated from a biodegradable plastic in freshwater and seawater.

Pharmaceuticals/Personal Care Products

Suspect screening of pharmaceuticals in fish livers based on QuEChERS extraction coupled with high resolution mass spectrometry.

Mixtures

Chemical Pollution Levels in a River Explain Site-Specific Sensitivities to Micropollutants within a Genetically Homogeneous Population of Freshwater Amphipods.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different than dates added to PubMed. To see the searchable archives, please email me at Sa…@healthandenvironment.org and ask to join the group EDC_re…@googlegroups.com. Archives are at https://groups.google.com/d/forum/edc_research. Compiled by Sarah Howard, Diabetes and Environment Program and HEEDS at Commonweal.

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Sarah Howard

Diabetes and the Environment

Healthy Environment and Endocrine Disruptor Strategies (HEEDS)