EDC Science Weekly, Apr. 12-18, 2024

Post author:HEEDS
Post published:April 18, 2024
Post category:EDC Science Weekly

A summary of articles on endocrine disrupting chemicals (EDCs) added to PubMed this week.

Contents: Events, Regulations/Policy, Methods/Tools/Screening, Commentaries, Reviews/Meta-Analyses, Human Health Studies, Laboratory Studies, Exposure/Environment Studies

Highlights:

Protecting the global plastics treaty from corporate interference; scientific statement from the American Heart Association on pediatric cardiology and the environment; main achievements from HBM4EU on phthalates and substitute plasticizers; emerging plasticizers: toxicology, environment, regrettable substitution dilemma, green solutions and future perspectives; is there a seismic shift in the PFAS uses?

More science highlights

Events

Apr. 18 webinar (today!): Chemicals in plastics: Human health costs [EDC Strategies Partnership]

Apr. 24 workshop: Improved methods for assessment of metabolic effects of endocrine disruptors [EDCMET]

Apr. 30 and May 7 workshop: Horizon Scanning: Sharing strategies to move from reactive to proactive approaches to identify new environmental concerns [NIEHS]

May 2 webinar: Plastics and your health [Beyond Plastics]

May 7 webinar: Endocrine disruptors and hormone levels during pregnancy [HEEDS Young EDC Scientists Showcase and EDC Strategies Partnership]

May 8 webinar: Reducing PFAS in products: progress and challenges [EPA]

May 20 symposium: Brain and environment [Univ of Rochester/in Washington DC]

May 21 seminar: Silent Spring 2.0: Adverse impacts of neonicotinoid pesticides on human and wildlife health [CACHET and HEEDS. Virtual and in-person in Chicago. See the ChicAgo Center for Health and EnvironmentT (CACHET) website for additional seminars.]

May 29: Webinaire dédié au rassemblement de la communauté française sur les perturbateurs endocriniens [in French]

June 10-11 workshop: Complementary and integrative interventions to prevent and mitigate the effects of endocrine-disrupting chemicals [NCCIH]

June 10-12: National PFAS Conference in Ann Arbor, MI

June 23-28: Gordon Research Conference on EDCs in Tuscany, Italy

Oct. 14-16: 8th Annual meeting of the U.S. DOHaD Society: exploring translational DOHaD science: from cells to communities in Chapel Hill, NC [abstracts due Aug. 1]

More events

Regulations/Policy

We must protect the global plastics treaty from corporate interference

Modeling the implications of policy reforms on pesticide risk for Switzerland.

Assessing the suitability of leachability-based screening levels for per- and polyfluoroalkyl substances (PFAS) risk assessment.

Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards.

Proposal for a tiered regulatory framework for the aquatic risk assessment of pesticides in Brazil.

More EDC policy and regulations open for comment

Methods/Tools/Screening

Building an adverse outcome pathway network for estrogen-, androgen- and steroidogenesis-mediated reproductive toxicity.

Computational framework for identifying and evaluating mutagenic and xenoestrogenic potential of food additives.

Organophosphate toxicity patterns: A new approach for assessing organophosphate neurotoxicity.

Public views of animal testing and alternatives in chemical risk assessment.

PERform: assessing model performance with predictivity and explainability readiness formula.

Dataset of in vitro measured chemicals neurotoxicity.

Benchmarking of BMDC Assay and related QSAR Study for Identifying Sensitizing Chemicals

How the Xenopus eleutheroembryonic thyroid assay compares to the amphibian metamorphosis assay for detecting thyroid active chemicals

Interlaboratory study on zebrafish in toxicology: Systematic Evaluation of the Application of Zebrafish in Toxicology’s (SEAZIT’s) evaluation of developmental toxicity

60 Years of the 3Rs symposium: Lessons learned and the road ahead.

Commentaries

Is a Seismic Shift in the Landscape of PFAS Uses Occurring?

Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association.

Household Air Pollution Interventions to Improve Health in Low- and Middle-Income Countries: An Official American Thoracic Society Research Statement.

Estimating Intervention Impact: Racial Disparities in Phthalate Exposure and Preterm Birth.

Environmental plastics in the context of UV radiation, climate change, and the Montreal Protocol.

Time to Recognize and Address the Serious Arsenic Problem.

Reviews/Meta-Analyses

Numerous Chemicals/Mixtures

Global environmental and toxicological data of emerging plasticizers: current knowledge, regrettable substitution dilemma, green solution and future perspectives

Advances in understanding the reproductive toxicity of endocrine-disrupting chemicals in women.

Environmental Factors as the Main Hormonal Disruptors of Male Fertility.

Exposure to Endocrine-Disrupting Chemicals and Congenital Heart Diseases: The Pooled Results Based on the Current Evidence.

The Body, the Brain, the Environment, and Parkinson’s Disease.

Causes of obesity: a review.

The Role of Endocrine Disruption Chemical-Regulated Aryl Hydrocarbon Receptor Activity in the Pathogenesis of Pancreatic Diseases and Cancer.

Phthalates

Phthalates and substitute plasticizers: Main achievements from the European human biomonitoring initiative HBM4EU.

Association of phthalate exposure with reproductive outcomes among infertile couples undergoing in vitro fertilization: A systematic review.

Pesticides

Pesticides impacts on human health and the environment with their mechanisms of action and possible countermeasures.

Metals/Metalloids

Relationship Between Arsenic in Biological Media and Breast Cancer: A Systematic Review and Meta-Analysis.

Microplastics/Nanomaterials

The effects of micro- and nanoplastic on the central nervous system: A New Threat to Humanity?

Plastic pollution and degradation pathways: A review on the treatment technologies.

Meta-analysis unravels the complex combined toxicity of microplastics and antibiotics in aquatic ecosystems.

Air Pollution

The use of honey bees (Apis mellifera L.) to monitor airborne particulate matter and assess health effects on pollinators.

Miscellaneous

An explicit review and proposal of an integrated framework system to mitigate the baffling complexities induced by road dust-associated contaminants.

Human Health Studies

Numerous Chemicals/Mixtures

Exploring Prenatal Exposure to Halogenated Compounds and Its Relationship with Birth Outcomes Using Nontarget Analysis.

Association between endocrine-disrupting chemical mixtures and non-alcoholic fatty liver disease with metabolic syndrome as a mediator among adults: A population-based study in Korea.

8-OHdG mediates the association of co-exposure to fifty-five typical endocrine-disrupting chemicals with renal function: a cross-section investigation in Southern Chinese adults.

Gender-Specific Abdominal Fat Distribution and Insulin Resistance Associated with Organophosphate Esters and Phthalate Metabolites Exposure.

Non-persistent Endocrine Disrupting Chemical Mixtures and Uterine Leiomyomata in the Study of Environment, Lifestyle and Fibroids (SELF).

Phthalates

Urinary phthalate/DINCH metabolites associations with kisspeptin and reproductive hormones in teenagers: A cross-sectional study from the HBM4EU aligned studies.

Parabens/Triclosan/Antimicrobials

Time-varying associations of gestational and childhood triclosan with pubertal and adrenarchal outcomes in early adolescence.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Effects of DDT and DDE on Placental Cholinergic Receptors.

Serum concentration of polychlorinated biphenyls and the risk of type 2 diabetes: a 10-year follow-up historical cohort study.

PFAS

All-cause, cardiovascular disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980-2018).

Associations of Serum Perfluoroalkyl Substances and Placental Human Chorionic Gonadotropin in Early Pregnancy, Measured in the UPSIDE Study in Rochester, New York.

Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) and associations with hypertensive disorders of pregnancy in the Atlanta African American Maternal-Child Cohort.

Associations of per- and polyfluoroalkyl substances (PFAS) and their mixture with risk of rheumatoid arthritis in the U.S. adult population.

Association between Per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: a nested case-control study in northwest China.

Serum untargeted lipidomic characterization in a general Chinese cohort with residual per-/polyfluoroalkyl substances by liquid chromatography-drift tube ion mobility-mass spectrometry.

Flame Retardants

Prenatal organophosphate esters exposure and neurodevelopment trajectory in infancy: Evidence from the Shanghai Maternal-Child Pairs Cohort.

Exploring autism spectrum disorder (ASD) and attention deficit disorder (ADD/ADHD) in children exposed to polybrominated biphenyl.

Pesticides

Pesticide exposure, birth size, and gestational age in the ISA birth cohort, Costa Rica.

Ambient long-term exposure to organophosphorus pesticides and the human gut microbiome: an observational study.

Farming activities and risk of inflammatory bowel disease: a French nationwide population-based cohort study.

Metals/Metalloids

Baseline characteristics including blood and urine metal levels in the Trial to Assess Chelation Therapy 2 (TACT2). [see related in Medpage Today, Chelation Flops for Cardio Health After Heart Attack]

Cadmium Exposure was Associated with Sex-Specific Thyroid Dysfunction: Consistent Evidence from Two Independent Cross-Sectional Studies Based on Urinary and Blood Cadmium Measurements.

The impact of prenatal mercury on neurobehavioral functioning longitudinally assessed from a young age to pre-adolescence in a Spanish birth cohort.

Association of Blood Total Mercury with Dyslipidemia in a sample of U.S. Adolescents: Results from the National Health and Nutrition Examination Survey Database, 2011-2018.

Exposure to low levels of heavy metals and chronic kidney disease in the US population: A cross sectional study.

Risk of heavy metal(loid) compositions in fine particulate matter on acute cardiovascular mortality: a poisson analysis in Anyang, China.

Air Pollution

Causal association between air pollution and autoimmune diseases: a two-sample Mendelian randomization study.

Air pollution, traffic noise, greenness, and temperature and the risk of incident type 2 diabetes: Results from the KORA cohort study.

Longitudinal associations between ambient PM_2.5 exposure and lipid levels in two Indian cities.

The Associations of Prenatal Exposure to Fine Particulate Matter and Its Chemical Components with Allergic Rhinitis in Children and the Modification Effect of Polyunsaturated Fatty Acids: A Birth Cohort Study.

Miscellaneous

Ambient polycyclic aromatic hydrocarbon exposure and breast cancer risk in a population-based Canadian case-control study.

Laboratory Studies

Numerous Chemicals/Mixtures

Prenatal co-exposure to diisodecyl phthalate and ozone contribute to depressive behavior in offspring mice through oxidative stress and TWIST1 participation.

BPA/Phenols

Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells.

Reproductive and transgenerational toxicity of bisphenol S exposure in pregnant rats: Insights into hormonal imbalance and steroid biosynthesis pathway disruption.

Estradiol-17β and bisphenol A affect growth and mineralization in early life stages of seabass.

Bisphenol Z exposure inhibits oocyte meiotic maturation by rupturing mitochondrial function.

Bisphenol S impairs mitochondrial function by targeting Myo19/oxidative phosphorylation pathway contributing to axonal and dendritic injury.

Long-term exposure of endangered Danube sturgeon (Acipenser gueldenstaedtii) to bisphenol A (BPA): growth, behavioral, histological, genotoxic, and hematological evaluation.

Description of Solvent-Extractable Chemicals in Thermal Receipts and Toxicological Assessment of Bisphenol S and Diphenyl Sulfone.

Nonylphenol ethoxylate degradation in detergents during shelf time, a new exposure pathway, and a perspective on their substitution.

Phthalates

A novel perspective on di-hexyl phthalate (2-ethylhexyl)-induced reproductive toxicity in females: Lipopolysaccharide synergizes with mono-2-ethylhexyl ester to cause inflammatory apoptosis rather than autophagy in ovarian granulosa cells.

Neurotoxicity of dibutyl phthalate in zebrafish larvae: Decreased energy acquisition by neurons.

Phthalates Boost Natural Transformation of Extracellular Antibiotic Resistance Genes through Enhancing Bacterial Motility and DNA Environmental Persistence.

Di-n-butyl phthalate induces toxicity in male fetal mouse testicular development by regulating the MAPK signaling pathway.

In vitro and in vivo exposure of endothelial cells to dibutyl phthalate promotes monocyte adhesion.

Short-term exposure to di(2-ethylhexyl)phthalate may disrupt hepatic lipid metabolism through modulating the oxidative stress in male adolescent rats.

Parabens/Triclosan/Antimicrobials

Repeated-dose toxicity and toxicokinetic study of isobutylparaben in rats subcutaneously treated for 13 weeks.

Triclocarban induces lipid droplet accumulation and oxidative stress responses by inhibiting mitochondrial fatty acid oxidation in HepaRG cells.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

Molecular insights into PCB neurotoxicity: Comparing transcriptomic responses across dopaminergic neurons, population blood cells, and Parkinson’s disease pathology.

Reproductive toxicity of DDT in the Japanese medaka fish model: Revisiting the impacts of DDT+ on female reproductive health.

Multiomics Analysis of PCB126’s Effect on a Mouse Chronic-Binge Alcohol Feeding Model.

Developmental toxicity of short-chain chlorinated paraffins on early-stage chicken embryos in a shell-less (ex-ovo) incubation system.

PFAS

An environmentally relevant mixture of Perfluoroalkyl Substances (PFAS) impacts proliferation, steroid hormone synthesis, and gene transcription in primary human granulosa cells.

Metabolomic changes following GenX and PFBS exposure in developing zebrafish.

Metabolic, neurotoxic and immunotoxic effects of PFAAs and their mixtures on the proteome of the head kidney and plasma from rainbow trout (Oncorhynchus mykiss).

Autophagy-dependent lysosomal calcium overload and the ATP5B-regulated lysosomes-mitochondria calcium transmission induce liver insulin resistance under perfluorooctane sulfonate exposure.

Binding of Per- and Polyfluoroalkyl Substances to β-Lactoglobulin from Bovine Milk.

Flame Retardants

House Dust-Derived Mixtures of Organophosphate Esters Alter the Phenotype, Function, Transcriptome, and Lipidome of KGN Human Ovarian Granulosa Cells.

Organotins

Maternal exposure to tributyltin alters the breast milk, hormonal profile, and thyroid morphology of dams and induces sex-specific changes in neonate rat offspring.

Evaluation of Lipids and Lipid-Related Transcripts in Human and Ovine Theca Cells and an in Vitro Mouse Model Exposed to the Obesogen Chemical Tributyltin.

Pesticides

Molecular docking analysis of chlorpyrifos at the human α7-nAChR and its potential relationship with neurocytoxicity in SH-SY5Y cells.

Multi-biomarker approach to evaluate the toxicity of chlorpyrifos (active ingredient and a commercial formulation) on different stages of Biomphalaria straminea.

Glyphosate-induced changes in the expression of galanin and GALR1, GALR2 and GALR3 receptors in the porcine small intestine wall.

The effects of a glyphosate-based herbicide on the bovine gametes during an in vitro embryo production model.

Exposure to toxicologically relevant atrazine concentrations impair the glycolytic function of mouse Sertoli cells through the downregulation of lactate dehydrogenase.

The Nrf2/ARE pathway as a potential target to ameliorate atrazine-induced endocrine disruption in granulosa cells.

Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio).

The Protective Effect of N-acetylcysteine against Deltamethrin-Induced Hepatotoxicity in Mice.

Neuroprotective effect of Withania somnifera leaves extract nanoemulsion against penconazole-induced neurotoxicity in albino rats via modulating TGF-β1/Smad2 signaling pathway.

Imidacloprid reduces the mating success of males in bumblebees.

Metals/Metalloids

Testicular dysfunction and “its recovery effect” after cadmium exposure.

Anthocyanins from blueberry ameliorated arsenic-induced memory impairment, oxidative stress, and mitochondrial-biosynthesis imbalance in rat hippocampal neurons.

MSC-derived exosomes mitigate cadmium-induced male reproductive injury by ameliorating DNA damage and autophagic flux.

Microplastics/Nanomaterials

In Vivo Tissue Distribution of Polystyrene or Mixed Polymer Microspheres and Metabolomic Analysis after Oral Exposure in Mice.

Effects of polystyrene nano- and microplastics and of microplastics with sorbed polycyclic aromatic hydrocarbons in adult zebrafish.

Identification of hazardous organic compounds in e-waste plastic using non-target and suspect screening approaches.

UV-aged polystyrene nanoplastics aggravate intestinal barrier damage by overproduction of ROS.

Nanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (Danio rerio).

Assessment of human dermal absorption of flame retardant additives in polyethylene and polypropylene microplastics using 3D human skin equivalent models.

Air Pollution

PM_2.5, component cause of severe metabolically abnormal obesity: An in silico, observational and analytical study.

Miscellaneous

The combined effects of preservative chemicals in consumer products: an analysis using embryonic and adult zebrafish.

Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Induced Carcinogenesis and Tumorigenesis by Omega-3 Fatty Acids in Mice In Vivo.

Benzo[a]pyrene exposure causes exonal switch resulting in reduced surface CD5 expression in an AHR-dependent manner.

The Protective Effect of Crocin on Rat Bone Marrow Mesenchymal Stem Cells Exposed to Aluminum Chloride as an Endocrine Disruptor.

Exposure/Environment Studies

Numerous Chemicals/Mixtures

Distribution, migration patterns, and food chain human health risks of endocrine-disrupting chemicals in water, sediments, and fish in the Xiangjiang River.

Persistent Organic Pollutants: PCBs, Dioxin, OCPs

The red listed eagle owl (Bubo bubo) population in Norway is exposed to POP levels exceeding threshold values for adverse health effects.

PFAS

Nationwide distribution of perfluoroalkyl ether carboxylic acids in Chinese diets: An emerging concern.

Determination of per- and polyfluoroalkyl compounds in paper recycling grades using ultra-high-performance liquid chromatography-high-resolution mass spectrometry.

PFAS assessment in fish – Samples from Illinois waters.

Spatial distribution, compositional characteristics, and source apportionment of legacy and novel per- and polyfluoroalkyl substances in farmland soil: A nationwide study in mainland China.

Flame Retardants

Variations in thyroid hormone levels in endangered St. Lawrence Estuary belugas: Potential linkage with stress and organohalogen contaminant exposure. [PBDEs and other POPs]

Pesticides

Transfer and bioaccumulation of pesticides in terrestrial arthropods and food webs: state of knowledge and perspectives for future research.

Ambient air concentrations of Plant Protection Products: data collection for the Combined Air Concentration Database and associated risk assessment.

The fate and transport of neonicotinoid insecticides and their metabolites through municipal wastewater treatment plants in South China.

Metals/Metalloids

Possible Risk Factors and Their Potential Associations with Combined Heavy Metal Exposures in Pregnant Women in the Republic of Suriname.

Microplastics/Nanomaterials

White tides: The plastic nurdles problem.

Soil erosion is a major drive for nano & micro-plastics to enter riverine systems from cultivated land.

Microplastic contamination in salt-cured fish and commercial sea salts: an emerging food safety threat in relation to UN Sustainable Development Goals (SDGs).

Characterization of microplastics in skim-milk powders.

Life starts with plastic: High occurrence of plastic pieces in fledglings of northern fulmars.

Microplastics in Asian Rivers: geographical distribution, most detected types, and inconsistency in methodologies.

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This list is not meant to be exhaustive, and generally does not include studies on detection, remediation, or treatment of EDCs. Note that journal publication dates may be different from dates added to PubMed. To see the searchable archives, please email me and ask to join the EDC Science Weekly group EDC_research@googlegroups.com. The searchable archives are at https://groups.google.com/d/forum/edc_research or online at https://heeds.org/category/edc-science-weekly/. Feel free to forward this email. Compiled by Sarah Howard of Healthy Environment and Endocrine Disruptor Strategies (HEEDS), a program of Environmental Health Sciences.

If you enjoy this newsletter, please feel free to donate here! Thank you!

EHN EHN

Lou Guillette Jr. Memorial Symposium
by Sarah Howard on December 16, 2024 at 3:52 pm
On March 14-15, 2025, HEEDS is hosting the Lou Guillette Jr. Memorial Symposium on endocrine disrupting science at the University of Florida. It will celebrate the life and legacy of Dr. Guillette, gather together his trainees and colleagues, and focus on the research topics that Lou made famous. Information here.
Endocrine-disrupting chemicals: hazards and opportunities (ECHO) course
by Sarah Howard on December 16, 2024 at 3:50 pm
This course focuses on the chemical, biological, and societal challenges of endocrine-disrupting chemicals (EDCs) and new opportunities for moving forward. ECHO is a two-week intensive bootcamp-style career development course for graduate students, postdoctoral fellows, and professionals in the field. It is held at Woods Hole, Massachusetts.
Webinar: EDC exposure and gonadal function: consequences and interventions
by Sarah Howard on December 16, 2024 at 3:36 pm
This two part webinar series is sponsored by the Endocrine Society's Special Interest Group (SIG) on endocrine disrupting chemicals (EDCs). The first webinar is scheduled for Jan. 30, 2025, and the second for Feb. 13.

EHN EHN

The plastics crisis: A neuropsychiatric problem hidden in plain sight
by EHN Curators on December 18, 2024 at 7:47 pm
The impact of plastics on health is an area of increasing concern.
Scientists lay out new framework to identify toxics contributing to metabolic disorders
by Katherine McMahon,Sarah Howard on December 17, 2024 at 10:00 am
A new consensus statement published in Nature Reviews Endocrinology proposes a set of 12 characteristics that can be used to identify metabolic-disrupting agents - chemicals, pharmaceuticals, and environmental hazards that increase the risk of metabolic disorders like diabetes and obesity. “This approach will enable a more comprehensive mechanistic understanding of how environmental chemicals and other agents disrupt metabolism and cause adverse outcomes.”
2024 Lou Guillette Jr Outstanding Young Investigator Award Winner: Dr. Chris Kassotis
by Sarah Howard on December 16, 2024 at 4:00 pm
Chris Kassotis, Ph.D., is the 2024 winner of the Lou Guillette, Jr. Outstanding Young Investigator Award, sponsored by Healthy Environment and Endocrine Disruptor Strategies (HEEDS). The award, in honor of scientist and mentor Lou Guillette, Jr., is given to an early-career scientist working in some aspect of endocrine disruptor research. The Kassotis lab focuses on understanding endocrine disrupting chemicals (EDCs) and mixtures, and their potential impacts on human and animal health, with a particular focus on metabolic health. He takes on critical public health issues, such as the health effects of chemicals found in fracking fluids and in artificial turf.

EHN EHN

Pesticide industry fights state efforts to regulate PFAS in farming
by EHN Curators on December 19, 2024 at 11:21 am
Pesticide trade groups are using lobbyists and grassroots networks to delay state laws aimed at curbing PFAS contamination in food and water, citing economic concerns. Lisa Held reports for Civil Eats.
Safe drinking water law marks 50 years, but challenges persist
by EHN Curators on December 19, 2024 at 11:19 am
Fifty years after the Safe Drinking Water Act became law, millions still lack reliable access to clean water, particularly in marginalized communities and small towns. Brett Walton reports for Circle of Blue.
RFK Jr. plans to eliminate fluoride in water, but states hold the power
by EHN Curators on December 18, 2024 at 11:47 am
President-elect Donald Trump's health appointee, Robert F. Kennedy Jr., aims to end fluoride in drinking water nationwide, but many states maintain mandates that the federal government cannot override. Hannah Recht reports for The Washington Post.